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The map label for this gene is hmuU [H]

Identifier: 110633796

GI number: 110633796

Start: 1537076

End: 1538173

Strand: Direct

Name: hmuU [H]

Synonym: Meso_1443

Alternate gene names: 110633796

Gene position: 1537076-1538173 (Clockwise)

Preceding gene: 110633795

Following gene: 110633797

Centisome position: 34.84

GC content: 65.66

Gene sequence:

>1098_bases
ATGAGCCAAGTGGCAGAAACAATCCTCGTCCGACGCATCGCCGCGGGGCCGGAAGGGGACCGTTCCGCGCGGGCGAGGTT
TGTGCTGGCTCTGCTCATCCTGCTGCTCTTGGCAGTCACCGCAATGAGCATTGCCACCGGAGCTTCCGATGCATCGGTAA
TCGGGGTTCTTGAAGGCTGGCTCGGCGGCGGGGCTGAAAGCGCGCTTTCGGCGCGCGACCGCCTCATCATCAACGAGATT
CGGCTGCCGCGCATCGCGCTCGGCATGTTTGTGGGCGCGGCATTGGCGGTCTCCGGCGCTCTGATGCAGGGGCTTTTCCG
CAATCCGCTCGCTGATCCCGGTATCATCGGCGTATCCGCCGGGGCTGCGCTGGGCGCGATTTCCGTCATCGTGCTTGGCC
ACACCCTCCTTGCACCTGCGGTTGGCTTGCTGGGCATCTATGCGTTACCGCTCGCGGCCTTCGTCGGCGGGCTGGCGACA
ACCCTCATTCTTTATAGTGTGGCCACAAGGCGGGGCCAAACCTCCATCGCCACCATGCTGCTCGCAGGCATCGCGCTGGC
GGCATTGGCCGGCGCGCTCTCCGGCATCCTCATCTATATCGCTGACGACCGCCAGCTGCGCGACCTCACATTCTGGCAGC
TCGGCTCTCTCGGCGGCGCGACATGGACCAAGATCGGGGCGGCAGCGCCAGTCATCGCGGTGGCGCTTGCCGTCACGCCG
TTTCTCGCCCGCGGACTCAATGCGCTAGCTCTGGGCGAGCCTTCCGCCCGGCATCTTGGCGTGGCGGTTCAGTGCATCAA
GGCGCTGGCGATTCTGGCGGTGGCGGCGGCCACGGGGGCGTCCGTGGCGTTTACCGGCGGCATCGGCTTCGTCGGCATCG
TTGTGCCGCATCTGCTTCGTCTCGTGATCGGCCCGGACCACCGTTATCTGCTTCCCGCTTCCGCCCTTTTGGGCGCCAGC
CTTTTGCTGATCGCCGACGCCGTAAGCCGCACCATTGTTGCGCCGGCGGAACTGCCGATCGGCATTGTCACTGCCGTCTT
CGGCGCGCCCTTTTTCCTCTGGGTGCTTTTGCGCAGGCGCGGCATCCTCGACCTTTGA

Upstream 100 bases:

>100_bases
GCATGGACGGCAGCTATTTGCTCGGGTTCGGGCCGCGCACGGCCGGAGCCATTCGTGATCTGGCCGCCGCACTTTACGGC
GCTTCCATCGCCAACCGACC

Downstream 100 bases:

>100_bases
GCAGAAGCATGATCGAAGCACGGGACCTTAACGTTTCCATAGGCGGAAAGCGCATTCTTTCCCATGTGAACTTTGCCGCC
GAGCCGGGCATCGTCACCGC

Product: transport system permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSQVAETILVRRIAAGPEGDRSARARFVLALLILLLLAVTAMSIATGASDASVIGVLEGWLGGGAESALSARDRLIINEI
RLPRIALGMFVGAALAVSGALMQGLFRNPLADPGIIGVSAGAALGAISVIVLGHTLLAPAVGLLGIYALPLAAFVGGLAT
TLILYSVATRRGQTSIATMLLAGIALAALAGALSGILIYIADDRQLRDLTFWQLGSLGGATWTKIGAAAPVIAVALAVTP
FLARGLNALALGEPSARHLGVAVQCIKALAILAVAAATGASVAFTGGIGFVGIVVPHLLRLVIGPDHRYLLPASALLGAS
LLLIADAVSRTIVAPAELPIGIVTAVFGAPFFLWVLLRRRGILDL

Sequences:

>Translated_365_residues
MSQVAETILVRRIAAGPEGDRSARARFVLALLILLLLAVTAMSIATGASDASVIGVLEGWLGGGAESALSARDRLIINEI
RLPRIALGMFVGAALAVSGALMQGLFRNPLADPGIIGVSAGAALGAISVIVLGHTLLAPAVGLLGIYALPLAAFVGGLAT
TLILYSVATRRGQTSIATMLLAGIALAALAGALSGILIYIADDRQLRDLTFWQLGSLGGATWTKIGAAAPVIAVALAVTP
FLARGLNALALGEPSARHLGVAVQCIKALAILAVAAATGASVAFTGGIGFVGIVVPHLLRLVIGPDHRYLLPASALLGAS
LLLIADAVSRTIVAPAELPIGIVTAVFGAPFFLWVLLRRRGILDL
>Mature_364_residues
SQVAETILVRRIAAGPEGDRSARARFVLALLILLLLAVTAMSIATGASDASVIGVLEGWLGGGAESALSARDRLIINEIR
LPRIALGMFVGAALAVSGALMQGLFRNPLADPGIIGVSAGAALGAISVIVLGHTLLAPAVGLLGIYALPLAAFVGGLATT
LILYSVATRRGQTSIATMLLAGIALAALAGALSGILIYIADDRQLRDLTFWQLGSLGGATWTKIGAAAPVIAVALAVTPF
LARGLNALALGEPSARHLGVAVQCIKALAILAVAAATGASVAFTGGIGFVGIVVPHLLRLVIGPDHRYLLPASALLGASL
LLIADAVSRTIVAPAELPIGIVTAVFGAPFFLWVLLRRRGILDL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=301, Percent_Identity=45.514950166113, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1790740, Length=285, Percent_Identity=41.7543859649123, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790741, Length=287, Percent_Identity=36.2369337979094, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1786805, Length=307, Percent_Identity=39.0879478827362, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786804, Length=286, Percent_Identity=33.9160839160839, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786347, Length=283, Percent_Identity=34.982332155477, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36985; Mature: 36853

Theoretical pI: Translated: 10.87; Mature: 10.87

Prosite motif: PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVAETILVRRIAAGPEGDRSARARFVLALLILLLLAVTAMSIATGASDASVIGVLEGW
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGGGAESALSARDRLIINEIRLPRIALGMFVGAALAVSGALMQGLFRNPLADPGIIGVSA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
GAALGAISVIVLGHTLLAPAVGLLGIYALPLAAFVGGLATTLILYSVATRRGQTSIATML
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAGIALAALAGALSGILIYIADDRQLRDLTFWQLGSLGGATWTKIGAAAPVIAVALAVTP
HHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FLARGLNALALGEPSARHLGVAVQCIKALAILAVAAATGASVAFTGGIGFVGIVVPHLLR
HHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
LVIGPDHRYLLPASALLGASLLLIADAVSRTIVAPAELPIGIVTAVFGAPFFLWVLLRRR
HHHCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GILDL
CCCCC
>Mature Secondary Structure 
SQVAETILVRRIAAGPEGDRSARARFVLALLILLLLAVTAMSIATGASDASVIGVLEGW
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGGGAESALSARDRLIINEIRLPRIALGMFVGAALAVSGALMQGLFRNPLADPGIIGVSA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
GAALGAISVIVLGHTLLAPAVGLLGIYALPLAAFVGGLATTLILYSVATRRGQTSIATML
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAGIALAALAGALSGILIYIADDRQLRDLTFWQLGSLGGATWTKIGAAAPVIAVALAVTP
HHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FLARGLNALALGEPSARHLGVAVQCIKALAILAVAAATGASVAFTGGIGFVGIVVPHLLR
HHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
LVIGPDHRYLLPASALLGASLLLIADAVSRTIVAPAELPIGIVTAVFGAPFFLWVLLRRR
HHHCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GILDL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]