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The map label for this gene is ilvA [H]

Identifier: 110633774

GI number: 110633774

Start: 1518507

End: 1519763

Strand: Direct

Name: ilvA [H]

Synonym: Meso_1421

Alternate gene names: 110633774

Gene position: 1518507-1519763 (Clockwise)

Preceding gene: 110633773

Following gene: 110633775

Centisome position: 34.41

GC content: 59.9

Gene sequence:

>1257_bases
ATGAGCGCTTTCATAGGGCGCGTCGGGAGAGCAGCGCAGGCGCTGCGCGACCTGTTTCCCGAGACGCCGCTCCAGAAAAA
CGATTATCTCTCCAGGAAGACGGGCGCGAGGGTCTTCCTCAAGCGAGAAGACCTGACCCCCGTGCGCTCTTACAAGCTGC
GCGGTGCGTTCAACTTCATGCGCAAGGCAATCGCGGCCGGTGCGGGGGCGGATGGCTTCGTCTGTGCCTCGGCGGGCAAT
CACGCCCAGGGCTTCGCGTACGCCTGTCGGCACTTCTCCCGCAAGGGTGTGGTGTTCATGCCGGTTACAACGCCACAGCA
GAAGATCGAAAAGACGATGCTTTTCGGCGGAGAATGGATCGAGGTTCGGCTCGTGGGCGATTTCTTCGAGGATTGCTATG
AGGCGGCGAAGGAGTTTGCCGATACTAACCATGCGCTGATGGTCCCGCCTTTCGACCACAGCGATATCATCGAAGGACAG
GCGACGGTTGCCCAGGAACTGGCCGACCAGTTGGGAAAGGGTCTGGAGGGCGCGACGATCATCCTGCCGGTGGGCGGCGG
CGGCCTTGCTGCCGGAATCACTGCCTTCCTGCAGGAAAGCGGTATCGGCGCGCGATATGCCTTTGCCGAACCGGCCGGCG
CGCCAAGTCTTGCGCTCAGCCTTTCGGCCGGCAAAAGAGTAAAGCTGCCGCAGGTGGACAATTTCGTGGACGGCGCTGCT
GTTGCCGAGATCGGGCGCGAGCCGTTCAAGCGTCTTAAGAACTTTTCTGCTCAAGATGTTCATAAAATACCGGAAAATCG
CCTTTGCTCGACGATCCTCGAAATGCTGAACATAGAAGGTGTGGTGCTCGAGCCTGCAGGGGCGCTGGCGATTGACGCCC
TCAAGGATTTTTCACGGCGGGAGATCCGTGGGAGCACGATCGTCGCTGTCGTTTCCGGTGGCAACTTTGATTTCGAGCGG
CTGCCGGATGTGAAGGAGCGCTCGCTGCGTTTCGAGGGCTTGAAGAAGTACTTCATCTTCCGTTTTCCCCAACGCCCCGG
CGCGCTGCGGGATTTCCTCGATCTGCTGGGGCCGGACGACGATATCACCCGCTTCGAATATCTGAAAAAATCCGCGCGCA
ATTTCGGCTCGGTGCTGATCGGCATCGAGACCAAGGACCCGCGGAACTTTGCCCTGCTGGGGCGTCGTTTTGACGAGGCC
GGCTGGGGGTATCAGGACATCACCCAAGACGAGACGATCGCGAATCTCCTCATATGA

Upstream 100 bases:

>100_bases
CCTGATCCTGCCTTTGGCGGAAGAAATGCAAAGTGGCCTCAGCCTGTTCGATATGCAATAGCATCGTGATTGCCGAGCTT
TCCGGCCTGAGGAGAATTGT

Downstream 100 bases:

>100_bases
CGGCGGGAACGGCCTATATCGTGCTCTTTCGCGGCGTGGGCGGCGCCACGCAGCTTCCTGTGGCGCGGCTGCGGGAGGTG
CTTCCGCAGGCGGGCTTCCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSAFIGRVGRAAQALRDLFPETPLQKNDYLSRKTGARVFLKREDLTPVRSYKLRGAFNFMRKAIAAGAGADGFVCASAGN
HAQGFAYACRHFSRKGVVFMPVTTPQQKIEKTMLFGGEWIEVRLVGDFFEDCYEAAKEFADTNHALMVPPFDHSDIIEGQ
ATVAQELADQLGKGLEGATIILPVGGGGLAAGITAFLQESGIGARYAFAEPAGAPSLALSLSAGKRVKLPQVDNFVDGAA
VAEIGREPFKRLKNFSAQDVHKIPENRLCSTILEMLNIEGVVLEPAGALAIDALKDFSRREIRGSTIVAVVSGGNFDFER
LPDVKERSLRFEGLKKYFIFRFPQRPGALRDFLDLLGPDDDITRFEYLKKSARNFGSVLIGIETKDPRNFALLGRRFDEA
GWGYQDITQDETIANLLI

Sequences:

>Translated_418_residues
MSAFIGRVGRAAQALRDLFPETPLQKNDYLSRKTGARVFLKREDLTPVRSYKLRGAFNFMRKAIAAGAGADGFVCASAGN
HAQGFAYACRHFSRKGVVFMPVTTPQQKIEKTMLFGGEWIEVRLVGDFFEDCYEAAKEFADTNHALMVPPFDHSDIIEGQ
ATVAQELADQLGKGLEGATIILPVGGGGLAAGITAFLQESGIGARYAFAEPAGAPSLALSLSAGKRVKLPQVDNFVDGAA
VAEIGREPFKRLKNFSAQDVHKIPENRLCSTILEMLNIEGVVLEPAGALAIDALKDFSRREIRGSTIVAVVSGGNFDFER
LPDVKERSLRFEGLKKYFIFRFPQRPGALRDFLDLLGPDDDITRFEYLKKSARNFGSVLIGIETKDPRNFALLGRRFDEA
GWGYQDITQDETIANLLI
>Mature_417_residues
SAFIGRVGRAAQALRDLFPETPLQKNDYLSRKTGARVFLKREDLTPVRSYKLRGAFNFMRKAIAAGAGADGFVCASAGNH
AQGFAYACRHFSRKGVVFMPVTTPQQKIEKTMLFGGEWIEVRLVGDFFEDCYEAAKEFADTNHALMVPPFDHSDIIEGQA
TVAQELADQLGKGLEGATIILPVGGGGLAAGITAFLQESGIGARYAFAEPAGAPSLALSLSAGKRVKLPQVDNFVDGAAV
AEIGREPFKRLKNFSAQDVHKIPENRLCSTILEMLNIEGVVLEPAGALAIDALKDFSRREIRGSTIVAVVSGGNFDFERL
PDVKERSLRFEGLKKYFIFRFPQRPGALRDFLDLLGPDDDITRFEYLKKSARNFGSVLIGIETKDPRNFALLGRRFDEAG
WGYQDITQDETIANLLI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI33469958, Length=323, Percent_Identity=31.2693498452012, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=26.813880126183, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI19923959, Length=307, Percent_Identity=26.7100977198697, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790207, Length=392, Percent_Identity=32.1428571428571, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=28.2539682539683, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71991565, Length=345, Percent_Identity=28.9855072463768, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17537387, Length=404, Percent_Identity=26.980198019802, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508781, Length=288, Percent_Identity=26.3888888888889, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320930, Length=369, Percent_Identity=32.7913279132791, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322631, Length=315, Percent_Identity=26.3492063492064, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319788, Length=291, Percent_Identity=26.4604810996564, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355833, Length=349, Percent_Identity=25.5014326647564, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 45850; Mature: 45719

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFIGRVGRAAQALRDLFPETPLQKNDYLSRKTGARVFLKREDLTPVRSYKLRGAFNFM
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
RKAIAAGAGADGFVCASAGNHAQGFAYACRHFSRKGVVFMPVTTPQQKIEKTMLFGGEWI
HHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEE
EVRLVGDFFEDCYEAAKEFADTNHALMVPPFDHSDIIEGQATVAQELADQLGKGLEGATI
EEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHCCCHHHHHHHHHHHHCCCCCCCEE
ILPVGGGGLAAGITAFLQESGIGARYAFAEPAGAPSLALSLSAGKRVKLPQVDNFVDGAA
EEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEECCCCEECCCCCCCHHCHHH
VAEIGREPFKRLKNFSAQDVHKIPENRLCSTILEMLNIEGVVLEPAGALAIDALKDFSRR
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHH
EIRGSTIVAVVSGGNFDFERLPDVKERSLRFEGLKKYFIFRFPQRPGALRDFLDLLGPDD
HCCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCC
DITRFEYLKKSARNFGSVLIGIETKDPRNFALLGRRFDEAGWGYQDITQDETIANLLI
CHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHHHCC
>Mature Secondary Structure 
SAFIGRVGRAAQALRDLFPETPLQKNDYLSRKTGARVFLKREDLTPVRSYKLRGAFNFM
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
RKAIAAGAGADGFVCASAGNHAQGFAYACRHFSRKGVVFMPVTTPQQKIEKTMLFGGEWI
HHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEE
EVRLVGDFFEDCYEAAKEFADTNHALMVPPFDHSDIIEGQATVAQELADQLGKGLEGATI
EEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHCCCHHHHHHHHHHHHCCCCCCCEE
ILPVGGGGLAAGITAFLQESGIGARYAFAEPAGAPSLALSLSAGKRVKLPQVDNFVDGAA
EEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEECCCCEECCCCCCCHHCHHH
VAEIGREPFKRLKNFSAQDVHKIPENRLCSTILEMLNIEGVVLEPAGALAIDALKDFSRR
HHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHH
EIRGSTIVAVVSGGNFDFERLPDVKERSLRFEGLKKYFIFRFPQRPGALRDFLDLLGPDD
HCCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCC
DITRFEYLKKSARNFGSVLIGIETKDPRNFALLGRRFDEAGWGYQDITQDETIANLLI
CHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]