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The map label for this gene is folK [H]

Identifier: 110633767

GI number: 110633767

Start: 1512775

End: 1513326

Strand: Direct

Name: folK [H]

Synonym: Meso_1414

Alternate gene names: 110633767

Gene position: 1512775-1513326 (Clockwise)

Preceding gene: 110633766

Following gene: 110633772

Centisome position: 34.28

GC content: 61.23

Gene sequence:

>552_bases
TTGACTGGCCCCAATAGGAAAGCACGCGCCTTTTTGTGCCTGGGCGGCAATCTGGGCGAGCCGGAACGCGCCATGGCAGA
GGCGCTGCAGGTTCTTGATGCCAGCCCCGAGACCTGCGTCATCCGTGTTTCTTCGGTCTATCGAACGCCGCCCTGGGGCA
AGCTGGATCAGCCGGAGTTTCTCAACGCGGCCGCCGAAATTGAGACCGGGCTTACCCCGCACGAACTGCTTTCGCAGTGT
CTGGCAATCGAGCGCATGCTGAAAAGGGAGCGCCGCGACCGGTGGGGCCCACGCGTCATCGATATCGACATCTTGACCTA
TGATGATGAGCGGATTGCCGACGCCATGCTTGAAATTCCGCACCCGCGGATGCTCCAGCGCGCTTTCGTGCTGCTGCCAC
TGGCCGAAATCGCGCCTGGCCTTGTGCTCGAAGGAAAGTCGATCAGTGAACATATGGCACGGCTCGATGCTTCCGGCGTC
GAGCCGGTCAAGACCGGCGGCGAGTGGTGGAAGAATGAGGCTATTCGCCCGTTAACGCGCTCACCGTCTTAG

Upstream 100 bases:

>100_bases
TCGCTATGCGCAAGATTCCCTCAAATCAAGCATGCAACGATCACGGTTCGAAAGCCGTCCGCGCCCATTGCCGGCGTCTT
GGATTATGTCGAGGTAACGG

Downstream 100 bases:

>100_bases
CGTCCACGCGCTTCAGCGTCATGCCGATCACCGGGACGAGGTCCTCATCCACATGGACGGAGATCGTCACATTCATCGTG
TTCTTGTCCGAAAGCTGCGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTGPNRKARAFLCLGGNLGEPERAMAEALQVLDASPETCVIRVSSVYRTPPWGKLDQPEFLNAAAEIETGLTPHELLSQC
LAIERMLKRERRDRWGPRVIDIDILTYDDERIADAMLEIPHPRMLQRAFVLLPLAEIAPGLVLEGKSISEHMARLDASGV
EPVKTGGEWWKNEAIRPLTRSPS

Sequences:

>Translated_183_residues
MTGPNRKARAFLCLGGNLGEPERAMAEALQVLDASPETCVIRVSSVYRTPPWGKLDQPEFLNAAAEIETGLTPHELLSQC
LAIERMLKRERRDRWGPRVIDIDILTYDDERIADAMLEIPHPRMLQRAFVLLPLAEIAPGLVLEGKSISEHMARLDASGV
EPVKTGGEWWKNEAIRPLTRSPS
>Mature_182_residues
TGPNRKARAFLCLGGNLGEPERAMAEALQVLDASPETCVIRVSSVYRTPPWGKLDQPEFLNAAAEIETGLTPHELLSQCL
AIERMLKRERRDRWGPRVIDIDILTYDDERIADAMLEIPHPRMLQRAFVLLPLAEIAPGLVLEGKSISEHMARLDASGVE
PVKTGGEWWKNEAIRPLTRSPS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=135, Percent_Identity=45.9259259259259, Blast_Score=120, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324073, Length=164, Percent_Identity=37.1951219512195, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20432; Mature: 20301

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPNRKARAFLCLGGNLGEPERAMAEALQVLDASPETCVIRVSSVYRTPPWGKLDQPEF
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCHHH
LNAAAEIETGLTPHELLSQCLAIERMLKRERRDRWGPRVIDIDILTYDDERIADAMLEIP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHCC
HPRMLQRAFVLLPLAEIAPGLVLEGKSISEHMARLDASGVEPVKTGGEWWKNEAIRPLTR
CHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCC
SPS
CCC
>Mature Secondary Structure 
TGPNRKARAFLCLGGNLGEPERAMAEALQVLDASPETCVIRVSSVYRTPPWGKLDQPEF
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCHHH
LNAAAEIETGLTPHELLSQCLAIERMLKRERRDRWGPRVIDIDILTYDDERIADAMLEIP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHCC
HPRMLQRAFVLLPLAEIAPGLVLEGKSISEHMARLDASGVEPVKTGGEWWKNEAIRPLTR
CHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCC
SPS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]