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The map label for this gene is uppS [H]

Identifier: 110633738

GI number: 110633738

Start: 1477727

End: 1478440

Strand: Direct

Name: uppS [H]

Synonym: Meso_1385

Alternate gene names: 110633738

Gene position: 1477727-1478440 (Clockwise)

Preceding gene: 110633737

Following gene: 110633739

Centisome position: 33.49

GC content: 61.62

Gene sequence:

>714_bases
GTGAAACCCGCGCATATCGCGATCATCATGGATGGAAACGGCCGCTGGGCGCGCGCCCGCGGTCTTCCGCGAAGCGCTGG
TCATCGCGCGGGCGTCGAGGCGCTGCGCCGGACGGTGCGTGCCGCCGGCGAGATGGGTATCCGGTGGCTCACCGTCTACG
CTTTTTCGTCCGAGAACTGGTCGCGGCCGAAATCGGAAATCAGCGACCTCATGGGGCTTTTGAAGCTGTTCATTCGCCGC
GACCTGGCGGAACTGCATCAAAGCGGCGTGCGGGTGCGCATCGTCGGCAGTCGTGAGGGCCTGGAGCCCGATATTTCGGC
GCTTCTGCTGGAAGCAGAGAACCTGACCGCCGGCAACACCAACATGAACCTCGCCGTCGCTTTTAACTATGGCTCACGCG
ATGAGATTCTGCGCGCGGCGCGCGCGGTGGCCTTGGAAGCCAAGGCAGGCCGACTCGATCCTGAGAAGATGACGGCGGAA
GAATTTTCCGCGCGCCTTGATACCGTCGGGATGCCCGATCCCGATCTCATTATCCGGACGAGTGGAGAGCAGAGGCTTTC
CAATTTCCTTCTTTGGCAAGCTGCTTATACGGAATTCGTGTTTCTTCCCTGCCATTGGCCGGACTTCGGTCCGGGCGATC
TGGCGGCGGCCATCAGCCTTTTTGAAGAAAGGGACCGCCGCTTCGGCAGTATCGCTCAAGAAGCGGCCTCATGA

Upstream 100 bases:

>100_bases
GCCGCGATCGACAAGCTCCTTGCTGAAAAGGAAGTGGAGATCTTGCAGGTCTGATGGCCGCATAGAGCGGGCATCATCAC
CACAAAAGGGGATTCGAGCG

Downstream 100 bases:

>100_bases
GCGAGGCTGCTTCGCCGCTTGGCAGCCCCGGAACGGGCCCGAGCAACCTGACGCTTCGTATTGTTTCTGCCATCATACTG
GCGCTGCTGGCGCTGGGGCT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKPAHIAIIMDGNGRWARARGLPRSAGHRAGVEALRRTVRAAGEMGIRWLTVYAFSSENWSRPKSEISDLMGLLKLFIRR
DLAELHQSGVRVRIVGSREGLEPDISALLLEAENLTAGNTNMNLAVAFNYGSRDEILRAARAVALEAKAGRLDPEKMTAE
EFSARLDTVGMPDPDLIIRTSGEQRLSNFLLWQAAYTEFVFLPCHWPDFGPGDLAAAISLFEERDRRFGSIAQEAAS

Sequences:

>Translated_237_residues
MKPAHIAIIMDGNGRWARARGLPRSAGHRAGVEALRRTVRAAGEMGIRWLTVYAFSSENWSRPKSEISDLMGLLKLFIRR
DLAELHQSGVRVRIVGSREGLEPDISALLLEAENLTAGNTNMNLAVAFNYGSRDEILRAARAVALEAKAGRLDPEKMTAE
EFSARLDTVGMPDPDLIIRTSGEQRLSNFLLWQAAYTEFVFLPCHWPDFGPGDLAAAISLFEERDRRFGSIAQEAAS
>Mature_237_residues
MKPAHIAIIMDGNGRWARARGLPRSAGHRAGVEALRRTVRAAGEMGIRWLTVYAFSSENWSRPKSEISDLMGLLKLFIRR
DLAELHQSGVRVRIVGSREGLEPDISALLLEAENLTAGNTNMNLAVAFNYGSRDEILRAARAVALEAKAGRLDPEKMTAE
EFSARLDTVGMPDPDLIIRTSGEQRLSNFLLWQAAYTEFVFLPCHWPDFGPGDLAAAISLFEERDRRFGSIAQEAAS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=40.3587443946188, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=40.3587443946188, Blast_Score=158, Evalue=3e-39,
Organism=Escherichia coli, GI1786371, Length=225, Percent_Identity=44, Blast_Score=202, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71993029, Length=221, Percent_Identity=36.6515837104072, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=36.697247706422, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=32.8767123287671, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=36.5638766519824, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26222; Mature: 26222

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAHIAIIMDGNGRWARARGLPRSAGHRAGVEALRRTVRAAGEMGIRWLTVYAFSSENW
CCCEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCC
SRPKSEISDLMGLLKLFIRRDLAELHQSGVRVRIVGSREGLEPDISALLLEAENLTAGNT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHEEECCCCCCCCC
NMNLAVAFNYGSRDEILRAARAVALEAKAGRLDPEKMTAEEFSARLDTVGMPDPDLIIRT
CEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEC
SGEQRLSNFLLWQAAYTEFVFLPCHWPDFGPGDLAAAISLFEERDRRFGSIAQEAAS
CCHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPAHIAIIMDGNGRWARARGLPRSAGHRAGVEALRRTVRAAGEMGIRWLTVYAFSSENW
CCCEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCC
SRPKSEISDLMGLLKLFIRRDLAELHQSGVRVRIVGSREGLEPDISALLLEAENLTAGNT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHEEECCCCCCCCC
NMNLAVAFNYGSRDEILRAARAVALEAKAGRLDPEKMTAEEFSARLDTVGMPDPDLIIRT
CEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEC
SGEQRLSNFLLWQAAYTEFVFLPCHWPDFGPGDLAAAISLFEERDRRFGSIAQEAAS
CCHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]