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The map label for this gene is rnr [H]

Identifier: 110633706

GI number: 110633706

Start: 1443793

End: 1446090

Strand: Reverse

Name: rnr [H]

Synonym: Meso_1353

Alternate gene names: 110633706

Gene position: 1446090-1443793 (Counterclockwise)

Preceding gene: 110633707

Following gene: 110633705

Centisome position: 32.77

GC content: 64.49

Gene sequence:

>2298_bases
TTGGCGCGCAAGAACTCGAAAGCGGCAGGAGGGGAAGGTGCTTCCGCCAATCCTCACCTGCCTTCGCGCGAAGAGATCCT
GCGCTTCGTCAGCGAAAATCCCGACCAGGCCGGAAAGCGCGAGATCGCCAAGGCATTTTCGCTGAAGGGCGGCGACCGCA
TCTGGCTAAAGGAGATGCTGAGGGACATGCAAAATGACGGGCTTCTGAAACAGAAGCGCCGTCGGCTCTCCCGGCCGGGC
TCCCTTCCCCCGATGGTCGTCCTCGACATTTTCTCGCGGGATGCGGAAGGAGGGCTCCTGGCGCGGCCGGCTGAACTGGA
GGATGAGGACGGTCCCATCCCGCTCGTTTCCATCCGCCCGCAGCGGGGCGGCCGCTCCCCCGCAGCCGGCGTGGGCGACC
GTGTGCTCGCCCGCGTGTTTGCGAGCAAGGAGGAAGGCGGCCCGGCCTATACCGGCCGGGTGGTCAAGCTTTTCGAAAAG
CGCCGGCGGGCAGTGCTCGGGGTCTTCCGTGAAATGCCTGATGGTACCCTCCGCATAGAGCCGGTGGAGCGCCGCCAGCC
CGAGCTGGTCGTGGATGAGGCTTCCCGCAAGGGCGCGAAAAGTGGCGATCTCGTAGAGGTGGAGCCGCTATCGCAAGGGC
GCTACGGCCTGCCGCGCGCGAGGGTGCTGGAGGTGGTGGGGTCAATCACGACGGAAAAGGCGGTCTCGATGATCGCCATC
CATGCCCACGAGATCCCCCACATTTTTCCGGAAAGCGTGGTGAAAGAGGCCGAAAGCGTCAAGCCGGCCACGCTTGAAGG
ACGTGAGGATTGGCGCAAGCTGCCGCTTGTGACCATCGATCCGGCCGACGCCAAGGACCATGACGATGCGGTCTATGCCG
AGGCCGACACGGATGAGAAGAATCCGGGCGGCGTGGTGGTAACCGTCGCGATCGCCGACGTTGCCTGCTATGTGCGGCCC
GACTCCGCGCTCGACCGCGAGGCGCTTAACAGGGGAAATTCGGTTTATTTCCCCGACCGCGTCGTGCCGATGCTGCCCGA
GCGCATATCGAACGACCTGTGCTCGCTGCGCGAAGGGGAAGCCAGGCCCGCGCTTGCCGTGCGCATGCGCTTTACCTCGG
GCGGCCGCAAGATCGGGCACTCTTTTCATCGTGTCATGATGCGCTCCGCGGCGCGCCTTTCCTACGAACAGGCCCAGGCG
GCGATCGACGGACGGCCGGATGACAAGACAGGGCCGCTGCTTGAACCGGTGCTTCGCCCGCTCTGGAATGCCTATTCGGT
GCTCAAGCGCGGCAGGGAAGCGCGCGAGCCGCTGGAACTGGACCTGCCTGAACGGAAAATCATCCTGAAGCCCGATGGCA
CGGTGGATCGCGTGGTGGTGCCGCCGCGCCTCGATGCGCACAAGCTCATCGAAGAGTTCATGATCCAGGCGAATGTGGCG
GCGGCTGAAACACTGGAATCGGTCCGCCAGCCGCTCGTCTACCGCGTTCACGACGCCCCTTCCCTTGCAAAGCAGGAATC
GCTGCGCGAGTTCCTTGGCTCCCTGGAAATCTCGCTGGCGCATGGAGCGGCGTTGAGGCCGGCGCAGTTCAACCGCATCC
TCGCGCATGTGGCGGGCACTGAGCAGGAGCAGCTCGTCAACGAGGTGGTGCTGCGCTCGCAAAGCCAGGCGATCTATGCC
CGCGAGAATATCGGCCATTTCGGGCTCAACCTGCGCCGCTATGCGCATTTCACCTCGCCGATCCGCCGTTACGCGGACCT
CATCGTGCATCGGGCTTTGATCACGGCGATGAATTTCGGGCCGGACGGCTTGAGGGAGGCGGACGAGGAGCGGCTGGAGG
AAGTTTCCGCTCTCATCTCGGCGACCGAACGACGCGCCATGGCAGCCGAGCGGGAGACGGTGGACCGCCTTATCGCCGAG
CATCTGGCGGGCCGCATCAACGAGGAATTTTCCGCGCGGATTTCGGGCGTCACCAAGGCCGGGCTCTTCGTGCTCCTGCC
TCAATACGGCGCGGACGGCTTCGTTCCCGTTTCGTCGCTGGGGGACGACTACTATATCTTTGACGAGGTGCGCCATGCGC
TCGTCGGGCAGCGCAGTGGGTGCGGCTATCAGCTCGGCGACAGCGTGGATGTTCGTCTGCTAGAAGTAGCACCGCTTGCG
GGTGCCATGCGCTTTGAAGTCCTGACCAGCCCCACCCGCCTGCCCGGTTCCTCCAAATCTTTCCATAAGGCGAGACGCGG
ATCGGCCCGGAACCAGAAACGCCCAAGCCGCTCCACGGTTAGGGGCAGGAGACGATGA

Upstream 100 bases:

>100_bases
CGATGTCTTTGACCCGCGAGGAGGCGCTGGAACTCCTCGCTGCCAAGGCGGGAAAGACGGGCAAGAAGCCGGCGAAAAGC
AAGGCGAGGAGCTGACGGAT

Downstream 100 bases:

>100_bases
TGGAAGAACAGGTTTTCGGCGGCGGCGCCCATGCGAAACAGCACGATCGGTCTGTTGTCCGCGCCATGTGGCGCGGGTTC
CAGGGCAAATGCCCCCATTG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R [H]

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MARKNSKAAGGEGASANPHLPSREEILRFVSENPDQAGKREIAKAFSLKGGDRIWLKEMLRDMQNDGLLKQKRRRLSRPG
SLPPMVVLDIFSRDAEGGLLARPAELEDEDGPIPLVSIRPQRGGRSPAAGVGDRVLARVFASKEEGGPAYTGRVVKLFEK
RRRAVLGVFREMPDGTLRIEPVERRQPELVVDEASRKGAKSGDLVEVEPLSQGRYGLPRARVLEVVGSITTEKAVSMIAI
HAHEIPHIFPESVVKEAESVKPATLEGREDWRKLPLVTIDPADAKDHDDAVYAEADTDEKNPGGVVVTVAIADVACYVRP
DSALDREALNRGNSVYFPDRVVPMLPERISNDLCSLREGEARPALAVRMRFTSGGRKIGHSFHRVMMRSAARLSYEQAQA
AIDGRPDDKTGPLLEPVLRPLWNAYSVLKRGREAREPLELDLPERKIILKPDGTVDRVVVPPRLDAHKLIEEFMIQANVA
AAETLESVRQPLVYRVHDAPSLAKQESLREFLGSLEISLAHGAALRPAQFNRILAHVAGTEQEQLVNEVVLRSQSQAIYA
RENIGHFGLNLRRYAHFTSPIRRYADLIVHRALITAMNFGPDGLREADEERLEEVSALISATERRAMAAERETVDRLIAE
HLAGRINEEFSARISGVTKAGLFVLLPQYGADGFVPVSSLGDDYYIFDEVRHALVGQRSGCGYQLGDSVDVRLLEVAPLA
GAMRFEVLTSPTRLPGSSKSFHKARRGSARNQKRPSRSTVRGRRR

Sequences:

>Translated_765_residues
MARKNSKAAGGEGASANPHLPSREEILRFVSENPDQAGKREIAKAFSLKGGDRIWLKEMLRDMQNDGLLKQKRRRLSRPG
SLPPMVVLDIFSRDAEGGLLARPAELEDEDGPIPLVSIRPQRGGRSPAAGVGDRVLARVFASKEEGGPAYTGRVVKLFEK
RRRAVLGVFREMPDGTLRIEPVERRQPELVVDEASRKGAKSGDLVEVEPLSQGRYGLPRARVLEVVGSITTEKAVSMIAI
HAHEIPHIFPESVVKEAESVKPATLEGREDWRKLPLVTIDPADAKDHDDAVYAEADTDEKNPGGVVVTVAIADVACYVRP
DSALDREALNRGNSVYFPDRVVPMLPERISNDLCSLREGEARPALAVRMRFTSGGRKIGHSFHRVMMRSAARLSYEQAQA
AIDGRPDDKTGPLLEPVLRPLWNAYSVLKRGREAREPLELDLPERKIILKPDGTVDRVVVPPRLDAHKLIEEFMIQANVA
AAETLESVRQPLVYRVHDAPSLAKQESLREFLGSLEISLAHGAALRPAQFNRILAHVAGTEQEQLVNEVVLRSQSQAIYA
RENIGHFGLNLRRYAHFTSPIRRYADLIVHRALITAMNFGPDGLREADEERLEEVSALISATERRAMAAERETVDRLIAE
HLAGRINEEFSARISGVTKAGLFVLLPQYGADGFVPVSSLGDDYYIFDEVRHALVGQRSGCGYQLGDSVDVRLLEVAPLA
GAMRFEVLTSPTRLPGSSKSFHKARRGSARNQKRPSRSTVRGRRR
>Mature_764_residues
ARKNSKAAGGEGASANPHLPSREEILRFVSENPDQAGKREIAKAFSLKGGDRIWLKEMLRDMQNDGLLKQKRRRLSRPGS
LPPMVVLDIFSRDAEGGLLARPAELEDEDGPIPLVSIRPQRGGRSPAAGVGDRVLARVFASKEEGGPAYTGRVVKLFEKR
RRAVLGVFREMPDGTLRIEPVERRQPELVVDEASRKGAKSGDLVEVEPLSQGRYGLPRARVLEVVGSITTEKAVSMIAIH
AHEIPHIFPESVVKEAESVKPATLEGREDWRKLPLVTIDPADAKDHDDAVYAEADTDEKNPGGVVVTVAIADVACYVRPD
SALDREALNRGNSVYFPDRVVPMLPERISNDLCSLREGEARPALAVRMRFTSGGRKIGHSFHRVMMRSAARLSYEQAQAA
IDGRPDDKTGPLLEPVLRPLWNAYSVLKRGREAREPLELDLPERKIILKPDGTVDRVVVPPRLDAHKLIEEFMIQANVAA
AETLESVRQPLVYRVHDAPSLAKQESLREFLGSLEISLAHGAALRPAQFNRILAHVAGTEQEQLVNEVVLRSQSQAIYAR
ENIGHFGLNLRRYAHFTSPIRRYADLIVHRALITAMNFGPDGLREADEERLEEVSALISATERRAMAAERETVDRLIAEH
LAGRINEEFSARISGVTKAGLFVLLPQYGADGFVPVSSLGDDYYIFDEVRHALVGQRSGCGYQLGDSVDVRLLEVAPLAG
AMRFEVLTSPTRLPGSSKSFHKARRGSARNQKRPSRSTVRGRRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=548, Percent_Identity=27.5547445255474, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI190014623, Length=548, Percent_Identity=27.5547445255474, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI134288890, Length=473, Percent_Identity=29.5983086680761, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI19115966, Length=630, Percent_Identity=25.7142857142857, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI219521928, Length=630, Percent_Identity=25.7142857142857, Blast_Score=142, Evalue=8e-34,
Organism=Escherichia coli, GI87082383, Length=734, Percent_Identity=36.3760217983651, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1787542, Length=459, Percent_Identity=31.3725490196078, Blast_Score=165, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI212645896, Length=477, Percent_Identity=31.4465408805031, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17553506, Length=504, Percent_Identity=29.1666666666667, Blast_Score=157, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324552, Length=466, Percent_Identity=30.2575107296137, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24649634, Length=729, Percent_Identity=26.6117969821674, Blast_Score=158, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19922976, Length=389, Percent_Identity=29.0488431876607, Blast_Score=130, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24654597, Length=389, Percent_Identity=29.0488431876607, Blast_Score=130, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24654592, Length=389, Percent_Identity=29.0488431876607, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84633; Mature: 84501

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKNSKAAGGEGASANPHLPSREEILRFVSENPDQAGKREIAKAFSLKGGDRIWLKEML
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
RDMQNDGLLKQKRRRLSRPGSLPPMVVLDIFSRDAEGGLLARPAELEDEDGPIPLVSIRP
HHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEEECC
QRGGRSPAAGVGDRVLARVFASKEEGGPAYTGRVVKLFEKRRRAVLGVFREMPDGTLRIE
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PVERRQPELVVDEASRKGAKSGDLVEVEPLSQGRYGLPRARVLEVVGSITTEKAVSMIAI
CHHCCCCCEEEECHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HAHEIPHIFPESVVKEAESVKPATLEGREDWRKLPLVTIDPADAKDHDDAVYAEADTDEK
HHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCC
NPGGVVVTVAIADVACYVRPDSALDREALNRGNSVYFPDRVVPMLPERISNDLCSLREGE
CCCCEEEEEEEEEEEEEECCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCC
ARPALAVRMRFTSGGRKIGHSFHRVMMRSAARLSYEQAQAAIDGRPDDKTGPLLEPVLRP
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LWNAYSVLKRGREAREPLELDLPERKIILKPDGTVDRVVVPPRLDAHKLIEEFMIQANVA
HHHHHHHHHCCHHHCCCCCCCCCCCEEEECCCCCCCEEEECCCCCHHHHHHHHHHHCCHH
AAETLESVRQPLVYRVHDAPSLAKQESLREFLGSLEISLAHGAALRPAQFNRILAHVAGT
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCCC
EQEQLVNEVVLRSQSQAIYARENIGHFGLNLRRYAHFTSPIRRYADLIVHRALITAMNFG
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDGLREADEERLEEVSALISATERRAMAAERETVDRLIAEHLAGRINEEFSARISGVTKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHC
GLFVLLPQYGADGFVPVSSLGDDYYIFDEVRHALVGQRSGCGYQLGDSVDVRLLEVAPLA
CEEEEEECCCCCCCEEHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCC
GAMRFEVLTSPTRLPGSSKSFHKARRGSARNQKRPSRSTVRGRRR
CHHEEHEECCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
ARKNSKAAGGEGASANPHLPSREEILRFVSENPDQAGKREIAKAFSLKGGDRIWLKEML
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
RDMQNDGLLKQKRRRLSRPGSLPPMVVLDIFSRDAEGGLLARPAELEDEDGPIPLVSIRP
HHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEEECC
QRGGRSPAAGVGDRVLARVFASKEEGGPAYTGRVVKLFEKRRRAVLGVFREMPDGTLRIE
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
PVERRQPELVVDEASRKGAKSGDLVEVEPLSQGRYGLPRARVLEVVGSITTEKAVSMIAI
CHHCCCCCEEEECHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HAHEIPHIFPESVVKEAESVKPATLEGREDWRKLPLVTIDPADAKDHDDAVYAEADTDEK
HHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCEEEECCCCCCCCCCCEEEECCCCCC
NPGGVVVTVAIADVACYVRPDSALDREALNRGNSVYFPDRVVPMLPERISNDLCSLREGE
CCCCEEEEEEEEEEEEEECCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCC
ARPALAVRMRFTSGGRKIGHSFHRVMMRSAARLSYEQAQAAIDGRPDDKTGPLLEPVLRP
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LWNAYSVLKRGREAREPLELDLPERKIILKPDGTVDRVVVPPRLDAHKLIEEFMIQANVA
HHHHHHHHHCCHHHCCCCCCCCCCCEEEECCCCCCCEEEECCCCCHHHHHHHHHHHCCHH
AAETLESVRQPLVYRVHDAPSLAKQESLREFLGSLEISLAHGAALRPAQFNRILAHVAGT
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCCC
EQEQLVNEVVLRSQSQAIYARENIGHFGLNLRRYAHFTSPIRRYADLIVHRALITAMNFG
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PDGLREADEERLEEVSALISATERRAMAAERETVDRLIAEHLAGRINEEFSARISGVTKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCHHHC
GLFVLLPQYGADGFVPVSSLGDDYYIFDEVRHALVGQRSGCGYQLGDSVDVRLLEVAPLA
CEEEEEECCCCCCCEEHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCC
GAMRFEVLTSPTRLPGSSKSFHKARRGSARNQKRPSRSTVRGRRR
CHHEEHEECCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]