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The map label for this gene is purC

Identifier: 110633634

GI number: 110633634

Start: 1374399

End: 1375190

Strand: Reverse

Name: purC

Synonym: Meso_1281

Alternate gene names: 110633634

Gene position: 1375190-1374399 (Counterclockwise)

Preceding gene: 110633636

Following gene: 110633633

Centisome position: 31.17

GC content: 57.07

Gene sequence:

>792_bases
ATGAATCGTCGCCGCCGCATTTACGAAGGCAAGGCCAAAATCCTTTACGAAGGCCCCGAGCCAGGTACGCTCATTCAGTT
CTTTAAGGACGATGCCACGGCCTTCAACAAGAAAAAGCACGAGGTCGTCGACGGCAAGGGCGTGCTGAACAACCGGATTT
CGGAGTATATTTTCGAGCATCTGAACCGGATAGGAATTCCCACCCATTTCATCCGCCGGCTCAATATGCGCGAGCAGCTG
ATCAAGGAAGTGGAGATCGTTCCGCTCGAAATCGTGGTGCGCAATATTGCCGCAGGCTCTCTCGCCAAAAGGCTCGGCAT
TGAGGAAGGCACCGTGCTGCCGCGCTCGATCATCGAGTTCTACTACAAGGCGGATGCGCTCGACGATCCCATGGTTTCGG
AAGAGCATATCACGGCTTTCGGCTGGGCAAGCCCCCAGGAGATCGACGACATCATGGCGCTTTCCATTCGCGTCAATGAT
TTCCTCACCGGTCTTTTCCTCGGTGTTGGCATCCAGCTTGTGGATTTCAAGATCGAATGCGGCCGCCTTTGGGAAGGCGA
CATGATGCGGATCGTGGTAGCGGACGAGATTTCGCCGGATTCCTGCCGCCTATGGGACATCAACACACGGGACAAGCTGG
ACAAGGACCGGTTCCGCCGCGATATGGGCGGGTTGGTGGAAGCCTATCAGGAGGTGGCACGCCGCCTCGGCATCATGAAT
GAAAATGAGCCGCCGAAGCCCGCCGGGCCCGTGCTCGTCTCTTCCAAGCCTGACGGCGAAACCCGTCACTGA

Upstream 100 bases:

>100_bases
TTTGCGCTAGAGACCGCAGGAGCCAGCTGGCTCCTCCCTCTTGCCGAGTCGGGCCCATGACCATCACGTTAGGACCGGCA
CACGAAACCCAGAGAAAGCC

Downstream 100 bases:

>100_bases
CAAACACAGGGGCAAAGAGTGATCAAGGCACGCGTCATCGTCACGCTCAAGAACGGCGTGCTCGACCCGCAAGGCAAGGC
CATAGAAGGCGCGCTGAGGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEYIFEHLNRIGIPTHFIRRLNMREQL
IKEVEIVPLEIVVRNIAAGSLAKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQEIDDIMALSIRVND
FLTGLFLGVGIQLVDFKIECGRLWEGDMMRIVVADEISPDSCRLWDINTRDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENEPPKPAGPVLVSSKPDGETRH

Sequences:

>Translated_263_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEYIFEHLNRIGIPTHFIRRLNMREQL
IKEVEIVPLEIVVRNIAAGSLAKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQEIDDIMALSIRVND
FLTGLFLGVGIQLVDFKIECGRLWEGDMMRIVVADEISPDSCRLWDINTRDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENEPPKPAGPVLVSSKPDGETRH
>Mature_263_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEYIFEHLNRIGIPTHFIRRLNMREQL
IKEVEIVPLEIVVRNIAAGSLAKRLGIEEGTVLPRSIIEFYYKADALDDPMVSEEHITAFGWASPQEIDDIMALSIRVND
FLTGLFLGVGIQLVDFKIECGRLWEGDMMRIVVADEISPDSCRLWDINTRDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
ENEPPKPAGPVLVSSKPDGETRH

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=230, Percent_Identity=33.4782608695652, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI5453539, Length=230, Percent_Identity=33.4782608695652, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI119220559, Length=239, Percent_Identity=32.6359832635983, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=45.3781512605042, Blast_Score=211, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=231, Percent_Identity=32.4675324675325, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=28.6919831223629, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24583917, Length=250, Percent_Identity=24.8, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_MESSB (Q11IU8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673842.1
- ProteinModelPortal:   Q11IU8
- SMR:   Q11IU8
- STRING:   Q11IU8
- GeneID:   4180540
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1281
- NMPDR:   fig|266779.1.peg.2307
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q11IU8
- ProtClustDB:   PRK09362
- BioCyc:   MSP266779:MESO_1281-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 30065; Mature: 30065

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEYIFEH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
LNRIGIPTHFIRRLNMREQLIKEVEIVPLEIVVRNIAAGSLAKRLGIEEGTVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKADALDDPMVSEEHITAFGWASPQEIDDIMALSIRVNDFLTGLFLGVGIQLVDFKIEC
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHEEHHHHHHHHHHHHCCEEEEEEEEEC
GRLWEGDMMRIVVADEISPDSCRLWDINTRDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
CCCCCCCEEEEEEECCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPPKPAGPVLVSSKPDGETRH
CCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVVDGKGVLNNRISEYIFEH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHH
LNRIGIPTHFIRRLNMREQLIKEVEIVPLEIVVRNIAAGSLAKRLGIEEGTVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
YYKADALDDPMVSEEHITAFGWASPQEIDDIMALSIRVNDFLTGLFLGVGIQLVDFKIEC
HHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHEEHHHHHHHHHHHHCCEEEEEEEEEC
GRLWEGDMMRIVVADEISPDSCRLWDINTRDKLDKDRFRRDMGGLVEAYQEVARRLGIMN
CCCCCCCEEEEEEECCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPPKPAGPVLVSSKPDGETRH
CCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA