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The map label for this gene is paaF [C]

Identifier: 110633483

GI number: 110633483

Start: 1237923

End: 1238972

Strand: Direct

Name: paaF [C]

Synonym: Meso_1130

Alternate gene names: 110633483

Gene position: 1237923-1238972 (Clockwise)

Preceding gene: 110633479

Following gene: 110633484

Centisome position: 28.06

GC content: 60.76

Gene sequence:

>1050_bases
TTGGTCCAGGACATGAGCAGCGGCGGCGAGGTGCGTTTCGAGCGGCGCGGTGGAGCGGGTCTGATCGCGCTCAACCGGCC
CTCGGCGCTGAATGCGCTGAACCACGGCATGATCCGGGCTCTGAGCCGGACGCTTTCGCAGTGGGAGGCGGACAGCTCCA
TTCGCTTCGTCGTCATCATGGGCGAGGGCAGGGCTTTTTCTGCAGGCGGAGATATTGTCGACGTCTATAGGGCCGGGCTC
GCCGGCAAGGCATCTCCCGCCTTCTTCGCTGACGAATATCGGCTGAATGCCCATATCGCCCGCTTCGGCAAGCCATACAT
AGCCTTGATGGACGGCATTGTGATGGGCGGAGGGGTCGGCGTGTCCTGCCACGGTTCCCACCGGGTGATGACGGAAAAGG
CAGTCTTCGCCATGCCGGAGGTTGGTATCGGCTTTTTCCCCGATGTGGGGGGCAGCTATCTGCTCTCGCGCCTGGGGGCC
TACGGAATGTATCTCGCGCTTACCGGCAATCGGATCGGCCATGGCGAGGCCCTGCGAACCGGTATCGCAACCCACGCGGT
GGATTCGGCCGATATGCCGGCCCTGCTTGAAAAGCTGGTCGAGGCGTCAGACCCGGACGAGGCGCTGGCCGGCTTCACGA
AAGACGTTCCGGCCGGAGGCGATGAGGCGAGCTTTCACGCCATCGAGAAGCATTTTTCGCTGGGGAGCTTGGAGGATTGC
ATTCTGAGCCTCGAAACCGCCGCTGGCGAAGGGGACGATTTTGCGAGTGAGACACTTCGCACGATCCGAACGCGTTCGCC
GACCAGCCTTCATGTGACCTTTCGCGCAGTAAGCTATGGCGCCATGCTCTCCATGGATGAATGCATGCGAATGGAGTTCA
GGATCCTGAACCGTATGCTCAAAAACCATGATTTCTATGAAGGAATCCGCGCAGCTGTCATCGAAAAGACCAAGGACCCG
GCCTGGAAGCCGACCTCCATTGACCAGGTTCAACCGGCGGCGGTCGAAGCCTTTTTCGCTCCTCTGCCCGAAGGAGAATT
GGAACTGTGA

Upstream 100 bases:

>100_bases
TTTCGCCGCAGGAGATGAAAGGGAGAGACCGGATTGACGCGACTCGGCCTCACACCTAATCACCTCTTTATGGTAACCCG
GTTTTGCGGGAGGAAGCGGT

Downstream 100 bases:

>100_bases
GCGACGACGTCGCTACCCGGTTGCCCATCCGTCCATCTCCCTATGAGCATGCGTTGGAGTTGCTCCAGCGCGGCGTGGCG
CTGGCTTGCCTGGTGGAAGG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MVQDMSSGGEVRFERRGGAGLIALNRPSALNALNHGMIRALSRTLSQWEADSSIRFVVIMGEGRAFSAGGDIVDVYRAGL
AGKASPAFFADEYRLNAHIARFGKPYIALMDGIVMGGGVGVSCHGSHRVMTEKAVFAMPEVGIGFFPDVGGSYLLSRLGA
YGMYLALTGNRIGHGEALRTGIATHAVDSADMPALLEKLVEASDPDEALAGFTKDVPAGGDEASFHAIEKHFSLGSLEDC
ILSLETAAGEGDDFASETLRTIRTRSPTSLHVTFRAVSYGAMLSMDECMRMEFRILNRMLKNHDFYEGIRAAVIEKTKDP
AWKPTSIDQVQPAAVEAFFAPLPEGELEL

Sequences:

>Translated_349_residues
MVQDMSSGGEVRFERRGGAGLIALNRPSALNALNHGMIRALSRTLSQWEADSSIRFVVIMGEGRAFSAGGDIVDVYRAGL
AGKASPAFFADEYRLNAHIARFGKPYIALMDGIVMGGGVGVSCHGSHRVMTEKAVFAMPEVGIGFFPDVGGSYLLSRLGA
YGMYLALTGNRIGHGEALRTGIATHAVDSADMPALLEKLVEASDPDEALAGFTKDVPAGGDEASFHAIEKHFSLGSLEDC
ILSLETAAGEGDDFASETLRTIRTRSPTSLHVTFRAVSYGAMLSMDECMRMEFRILNRMLKNHDFYEGIRAAVIEKTKDP
AWKPTSIDQVQPAAVEAFFAPLPEGELEL
>Mature_349_residues
MVQDMSSGGEVRFERRGGAGLIALNRPSALNALNHGMIRALSRTLSQWEADSSIRFVVIMGEGRAFSAGGDIVDVYRAGL
AGKASPAFFADEYRLNAHIARFGKPYIALMDGIVMGGGVGVSCHGSHRVMTEKAVFAMPEVGIGFFPDVGGSYLLSRLGA
YGMYLALTGNRIGHGEALRTGIATHAVDSADMPALLEKLVEASDPDEALAGFTKDVPAGGDEASFHAIEKHFSLGSLEDC
ILSLETAAGEGDDFASETLRTIRTRSPTSLHVTFRAVSYGAMLSMDECMRMEFRILNRMLKNHDFYEGIRAAVIEKTKDP
AWKPTSIDQVQPAAVEAFFAPLPEGELEL

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=362, Percent_Identity=40.0552486187845, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI37594469, Length=308, Percent_Identity=41.8831168831169, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI194097323, Length=228, Percent_Identity=32.4561403508772, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI68989263, Length=172, Percent_Identity=31.9767441860465, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787659, Length=182, Percent_Identity=32.967032967033, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787660, Length=236, Percent_Identity=30.9322033898305, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI221142681, Length=186, Percent_Identity=31.1827956989247, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144160, Length=350, Percent_Identity=40, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI25144157, Length=354, Percent_Identity=39.5480225988701, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI25145438, Length=181, Percent_Identity=33.1491712707182, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17554946, Length=180, Percent_Identity=32.7777777777778, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=183, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=195, Percent_Identity=27.1794871794872, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=208, Percent_Identity=29.8076923076923, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25144276, Length=161, Percent_Identity=29.8136645962733, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=161, Percent_Identity=29.8136645962733, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=161, Percent_Identity=29.8136645962733, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=182, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=385, Percent_Identity=31.4285714285714, Blast_Score=185, Evalue=8e-48,
Organism=Drosophila melanogaster, GI28571730, Length=347, Percent_Identity=41.4985590778098, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI28571729, Length=333, Percent_Identity=42.6426426426426, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI20129971, Length=174, Percent_Identity=35.632183908046, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24653477, Length=174, Percent_Identity=35.632183908046, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24653139, Length=192, Percent_Identity=28.125, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 37512; Mature: 37512

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQDMSSGGEVRFERRGGAGLIALNRPSALNALNHGMIRALSRTLSQWEADSSIRFVVIM
CCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
GEGRAFSAGGDIVDVYRAGLAGKASPAFFADEYRLNAHIARFGKPYIALMDGIVMGGGVG
ECCEEECCCCCHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
VSCHGSHRVMTEKAVFAMPEVGIGFFPDVGGSYLLSRLGAYGMYLALTGNRIGHGEALRT
EEECCCCCEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
GIATHAVDSADMPALLEKLVEASDPDEALAGFTKDVPAGGDEASFHAIEKHFSLGSLEDC
HHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHH
ILSLETAAGEGDDFASETLRTIRTRSPTSLHVTFRAVSYGAMLSMDECMRMEFRILNRML
HHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEHHCHHCCHHHHHHHHHHHHHHHH
KNHDFYEGIRAAVIEKTKDPAWKPTSIDQVQPAAVEAFFAPLPEGELEL
HCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVQDMSSGGEVRFERRGGAGLIALNRPSALNALNHGMIRALSRTLSQWEADSSIRFVVIM
CCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
GEGRAFSAGGDIVDVYRAGLAGKASPAFFADEYRLNAHIARFGKPYIALMDGIVMGGGVG
ECCEEECCCCCHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEE
VSCHGSHRVMTEKAVFAMPEVGIGFFPDVGGSYLLSRLGAYGMYLALTGNRIGHGEALRT
EEECCCCCEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
GIATHAVDSADMPALLEKLVEASDPDEALAGFTKDVPAGGDEASFHAIEKHFSLGSLEDC
HHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHH
ILSLETAAGEGDDFASETLRTIRTRSPTSLHVTFRAVSYGAMLSMDECMRMEFRILNRML
HHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEHHCHHCCHHHHHHHHHHHHHHHH
KNHDFYEGIRAAVIEKTKDPAWKPTSIDQVQPAAVEAFFAPLPEGELEL
HCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA