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The map label for this gene is parC [H]

Identifier: 110633477

GI number: 110633477

Start: 1230629

End: 1232881

Strand: Direct

Name: parC [H]

Synonym: Meso_1124

Alternate gene names: 110633477

Gene position: 1230629-1232881 (Clockwise)

Preceding gene: 110633475

Following gene: 110633479

Centisome position: 27.89

GC content: 62.81

Gene sequence:

>2253_bases
ATGGGAAAAGAGGTACTTCCGCCCGGCAATGGTGATTCGGCGTCCCCGGTCGACCTGAAGAAGGCGCTCGAGGAGCGCTA
CCTGGCCTATGCGCTGTCAACCATTATGCATCGCGCGCTGCCCGATGTGCGCGATGGCCTCAAGCCCGTGCATCGGCGCA
TTATGCACACGATGCGGCTTCTGCGCCTCAATCCCGAGCAGGGTTTCGCCAAATGCGCCCGCATCGTGGGCGATGTGATG
GGTAAGTTCCATCCGCATGGCGACCAGTCGATCTATGACGCGTTGGTGCGCCTCGCACAGCCCTTCGCCATGCGATATCC
GCTGGTGGACGGTCAGGGCAATTTCGGCAATATCGACGGCGATAACGCCGCCGCCATGCGCTACACCGAAGCGCGGATGA
CGGAAGTGGCGGCGGAATTGCTCTCCGGCATCACGGAAGACGCGGTCGATTTCCGCCCGACCTACAACGAGGAGGACGAG
GAGCCGATCGTGCTCCCCGGCGCCTTCCCGAATCTGCTGTGCAACGGCTCCTCCGGCATTGCCGTGGGCATGGCGACCTC
CGTGCCGCCGCACAATGCGGCGGAGGTCTGCGACGCGGCACTCGCTTTAATCGACGATCCGGACGTGCCGGTCTCCCGGC
TTCTCGATTTCGTGCAGGGGCCGGATTTCCCGACCGGCGGCATCATTGTGGAGGGCCGCGCCTCGATCCGCGAGGCTTAT
GAGACCGGCCGCGGCGGCTTCCGGCTGCGCGCGCGCTGGCACAAGGAGGACCAGGGCCGCGGCACGTGGAACGTGGTTGT
TACCGAGATCCCCTATGGCGTGCAGAAGTCGCGGCTGATCGAGAAAATCGCCGAACTGATCCTGGCGCGCAAGCTGCCGC
TTCTGGAAGACGTGCGCGACGAGAGCGCGGAGGACATCCGCGTCGTGCTCGTTCCCAAGAGCCGCGCGGTCGAACCCGAG
CTTCTGATGGAATCGCTCTTCCGCCTGACGGATCTTGAGACGCGCTTCCCGCTCAACATGAACGTCTTGTCGCGCGGCAA
GGTGCCTTCGGTGCTGTCGCTCAAGGACGTGCTGCGCGAGTGGCTTGATCACCGTCGCGAGGTGCTTGTCCGTCGTTCGC
AGCATCGGCTGGCCGAAATCGAGAAACGGCTTGAGATACTTGCCGGCTATCTCGTCGCCTATCTGAACATCGACGAGGTG
ATCGGCATCATCCGTGAAGAGGATGAGCCGAAGCCGGTGATGATGGAGCGCTTCAACCTGACGGACAATCAGGCCGAAGC
CATCCTCAACATGCGCCTGCGGGCCCTGCGCAAGCTCGAAGAATTCGAAATCCGCACCGAGTTCGACAAGCTTTCGGAGG
AGAAGACGCAGATCGAGGCGCTGCTCGCCTCCGAGGCGAAACAGTGGAAGACCGTGCGCTGGGAGGTGGCGAAGGTTCGC
CAGACCTTCGATCCGGAGAAGAATCCTGCTCTCGGCCGCCGCCGCACAACCTTTGGCGATGCGCCGTCGCACGATCTGGA
GGACGTGCAGCAGGCCATGATCGAGCGCGAGCCGATCACGGTGATCCTGTCGGAGAAGGGTTGGCTGCGCGCCATGAAGG
GCCATCTGACGGATCTTTCCACGGTGGTTTTCAAAGAGGGAGACAGCCTGAAGCTCTCTTTCCATGCCCAGACCACGGAC
AAGATCCTGCTCTTCACCACCGGCGGCAAGTTCTACACGATCGGCGGTGACCGTCTGCCAGGCGGGCGAGGCCACGGTGA
GCCCGTGCGCATCATGGTCGACATGGAGAACGATCAGGCCGTCGTCACTGCCTTCGCGCATGATCCCGAACGCAGGCTGC
TGATCGCCTCCTATGCCGGCAATGGCTTCATCGTTCCGGAGAAGGAAGTGGTGGCCAACACCCGTAAGGGCAAGCAGATC
ATGAACGTCAAAACGCCGGACGAGGCGCGGCTTTGCATTCCGGTTTCGGGCGATCATGCGGCGATCGTCGGTGAGAACCG
CAAGCTGCTGGTCTTCCCGCTTGAGCAAGTGCCCGAGATGGTGCGTGGCAAGGGCGTGCGCCTGCAGCGCTATAAGGACG
GTGGCATCGCCGATCTCAAGACTTTCGCGATCGCCGACGGCCTTACCTGGCAGGATTCGGCTGACCGCACCTTCACGCGC
AGCAAGGACGAACTTGCCGAATGGATTGGCGATCGCGCTGCCGCGGGGCGAATGGCGCCCAAGGGCTTTCCGAGAACAGG
CAAGTTCGGCTGA

Upstream 100 bases:

>100_bases
TCTTGCAACCGGCGGGGATCGGCAACCCGACCGTGGAAAGCCCCCTCTCGTGCCACAACGCGCACTTGTCCTGGGCGGCG
ATGTCCGTTAACCCCAACTC

Downstream 100 bases:

>100_bases
GCGGGAGTAAGCGAAAGACGGCCCGCCGTCCGGAACCGCCTGCACGGCTGAAATAAGAACCCCCGCTGCAGCGGGGGTCC
TGGAACTATCGTTATTTTAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MGKEVLPPGNGDSASPVDLKKALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHTMRLLRLNPEQGFAKCARIVGDVM
GKFHPHGDQSIYDALVRLAQPFAMRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAAELLSGITEDAVDFRPTYNEEDE
EPIVLPGAFPNLLCNGSSGIAVGMATSVPPHNAAEVCDAALALIDDPDVPVSRLLDFVQGPDFPTGGIIVEGRASIREAY
ETGRGGFRLRARWHKEDQGRGTWNVVVTEIPYGVQKSRLIEKIAELILARKLPLLEDVRDESAEDIRVVLVPKSRAVEPE
LLMESLFRLTDLETRFPLNMNVLSRGKVPSVLSLKDVLREWLDHRREVLVRRSQHRLAEIEKRLEILAGYLVAYLNIDEV
IGIIREEDEPKPVMMERFNLTDNQAEAILNMRLRALRKLEEFEIRTEFDKLSEEKTQIEALLASEAKQWKTVRWEVAKVR
QTFDPEKNPALGRRRTTFGDAPSHDLEDVQQAMIEREPITVILSEKGWLRAMKGHLTDLSTVVFKEGDSLKLSFHAQTTD
KILLFTTGGKFYTIGGDRLPGGRGHGEPVRIMVDMENDQAVVTAFAHDPERRLLIASYAGNGFIVPEKEVVANTRKGKQI
MNVKTPDEARLCIPVSGDHAAIVGENRKLLVFPLEQVPEMVRGKGVRLQRYKDGGIADLKTFAIADGLTWQDSADRTFTR
SKDELAEWIGDRAAAGRMAPKGFPRTGKFG

Sequences:

>Translated_750_residues
MGKEVLPPGNGDSASPVDLKKALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHTMRLLRLNPEQGFAKCARIVGDVM
GKFHPHGDQSIYDALVRLAQPFAMRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAAELLSGITEDAVDFRPTYNEEDE
EPIVLPGAFPNLLCNGSSGIAVGMATSVPPHNAAEVCDAALALIDDPDVPVSRLLDFVQGPDFPTGGIIVEGRASIREAY
ETGRGGFRLRARWHKEDQGRGTWNVVVTEIPYGVQKSRLIEKIAELILARKLPLLEDVRDESAEDIRVVLVPKSRAVEPE
LLMESLFRLTDLETRFPLNMNVLSRGKVPSVLSLKDVLREWLDHRREVLVRRSQHRLAEIEKRLEILAGYLVAYLNIDEV
IGIIREEDEPKPVMMERFNLTDNQAEAILNMRLRALRKLEEFEIRTEFDKLSEEKTQIEALLASEAKQWKTVRWEVAKVR
QTFDPEKNPALGRRRTTFGDAPSHDLEDVQQAMIEREPITVILSEKGWLRAMKGHLTDLSTVVFKEGDSLKLSFHAQTTD
KILLFTTGGKFYTIGGDRLPGGRGHGEPVRIMVDMENDQAVVTAFAHDPERRLLIASYAGNGFIVPEKEVVANTRKGKQI
MNVKTPDEARLCIPVSGDHAAIVGENRKLLVFPLEQVPEMVRGKGVRLQRYKDGGIADLKTFAIADGLTWQDSADRTFTR
SKDELAEWIGDRAAAGRMAPKGFPRTGKFG
>Mature_749_residues
GKEVLPPGNGDSASPVDLKKALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHTMRLLRLNPEQGFAKCARIVGDVMG
KFHPHGDQSIYDALVRLAQPFAMRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVAAELLSGITEDAVDFRPTYNEEDEE
PIVLPGAFPNLLCNGSSGIAVGMATSVPPHNAAEVCDAALALIDDPDVPVSRLLDFVQGPDFPTGGIIVEGRASIREAYE
TGRGGFRLRARWHKEDQGRGTWNVVVTEIPYGVQKSRLIEKIAELILARKLPLLEDVRDESAEDIRVVLVPKSRAVEPEL
LMESLFRLTDLETRFPLNMNVLSRGKVPSVLSLKDVLREWLDHRREVLVRRSQHRLAEIEKRLEILAGYLVAYLNIDEVI
GIIREEDEPKPVMMERFNLTDNQAEAILNMRLRALRKLEEFEIRTEFDKLSEEKTQIEALLASEAKQWKTVRWEVAKVRQ
TFDPEKNPALGRRRTTFGDAPSHDLEDVQQAMIEREPITVILSEKGWLRAMKGHLTDLSTVVFKEGDSLKLSFHAQTTDK
ILLFTTGGKFYTIGGDRLPGGRGHGEPVRIMVDMENDQAVVTAFAHDPERRLLIASYAGNGFIVPEKEVVANTRKGKQIM
NVKTPDEARLCIPVSGDHAAIVGENRKLLVFPLEQVPEMVRGKGVRLQRYKDGGIADLKTFAIADGLTWQDSADRTFTRS
KDELAEWIGDRAAAGRMAPKGFPRTGKFG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789396, Length=685, Percent_Identity=42.043795620438, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI1788562, Length=640, Percent_Identity=39.53125, Blast_Score=431, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324241, Length=357, Percent_Identity=26.0504201680672, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83923; Mature: 83792

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKEVLPPGNGDSASPVDLKKALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHTMRL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LRLNPEQGFAKCARIVGDVMGKFHPHGDQSIYDALVRLAQPFAMRYPLVDGQGNFGNIDG
HHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHCCCEECCCCCCCCCCC
DNAAAMRYTEARMTEVAAELLSGITEDAVDFRPTYNEEDEEPIVLPGAFPNLLCNGSSGI
CCCHHEEHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCEEECCCCCHHEECCCCCE
AVGMATSVPPHNAAEVCDAALALIDDPDVPVSRLLDFVQGPDFPTGGIIVEGRASIREAY
EEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHH
ETGRGGFRLRARWHKEDQGRGTWNVVVTEIPYGVQKSRLIEKIAELILARKLPLLEDVRD
HCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHC
ESAEDIRVVLVPKSRAVEPELLMESLFRLTDLETRFPLNMNVLSRGKVPSVLSLKDVLRE
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHH
WLDHRREVLVRRSQHRLAEIEKRLEILAGYLVAYLNIDEVIGIIREEDEPKPVMMERFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCC
TDNQAEAILNMRLRALRKLEEFEIRTEFDKLSEEKTQIEALLASEAKQWKTVRWEVAKVR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTFDPEKNPALGRRRTTFGDAPSHDLEDVQQAMIEREPITVILSEKGWLRAMKGHLTDLS
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
TVVFKEGDSLKLSFHAQTTDKILLFTTGGKFYTIGGDRLPGGRGHGEPVRIMVDMENDQA
HHEEECCCCEEEEEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEEECCCCE
VVTAFAHDPERRLLIASYAGNGFIVPEKEVVANTRKGKQIMNVKTPDEARLCIPVSGDHA
EEEEECCCCCCEEEEEEECCCEEECCCHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCE
AIVGENRKLLVFPLEQVPEMVRGKGVRLQRYKDGGIADLKTFAIADGLTWQDSADRTFTR
EEEECCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCC
SKDELAEWIGDRAAAGRMAPKGFPRTGKFG
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKEVLPPGNGDSASPVDLKKALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHTMRL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LRLNPEQGFAKCARIVGDVMGKFHPHGDQSIYDALVRLAQPFAMRYPLVDGQGNFGNIDG
HHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHCCCEECCCCCCCCCCC
DNAAAMRYTEARMTEVAAELLSGITEDAVDFRPTYNEEDEEPIVLPGAFPNLLCNGSSGI
CCCHHEEHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCEEECCCCCHHEECCCCCE
AVGMATSVPPHNAAEVCDAALALIDDPDVPVSRLLDFVQGPDFPTGGIIVEGRASIREAY
EEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHH
ETGRGGFRLRARWHKEDQGRGTWNVVVTEIPYGVQKSRLIEKIAELILARKLPLLEDVRD
HCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHC
ESAEDIRVVLVPKSRAVEPELLMESLFRLTDLETRFPLNMNVLSRGKVPSVLSLKDVLRE
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHH
WLDHRREVLVRRSQHRLAEIEKRLEILAGYLVAYLNIDEVIGIIREEDEPKPVMMERFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCC
TDNQAEAILNMRLRALRKLEEFEIRTEFDKLSEEKTQIEALLASEAKQWKTVRWEVAKVR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTFDPEKNPALGRRRTTFGDAPSHDLEDVQQAMIEREPITVILSEKGWLRAMKGHLTDLS
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
TVVFKEGDSLKLSFHAQTTDKILLFTTGGKFYTIGGDRLPGGRGHGEPVRIMVDMENDQA
HHEEECCCCEEEEEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEEECCCCE
VVTAFAHDPERRLLIASYAGNGFIVPEKEVVANTRKGKQIMNVKTPDEARLCIPVSGDHA
EEEEECCCCCCEEEEEEECCCEEECCCHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCE
AIVGENRKLLVFPLEQVPEMVRGKGVRLQRYKDGGIADLKTFAIADGLTWQDSADRTFTR
EEEECCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCC
SKDELAEWIGDRAAAGRMAPKGFPRTGKFG
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]