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The map label for this gene is ppx [H]

Identifier: 110633473

GI number: 110633473

Start: 1224499

End: 1226019

Strand: Direct

Name: ppx [H]

Synonym: Meso_1120

Alternate gene names: 110633473

Gene position: 1224499-1226019 (Clockwise)

Preceding gene: 110633472

Following gene: 110633475

Centisome position: 27.75

GC content: 61.21

Gene sequence:

>1521_bases
GTGGGCATTAAGACTTCGCAAGGTCGGCTTCAGGACCGGCGTCCCGTTTCGGTCATCGATATCGGCTCGAACTCCATCCG
GCTTGTGATTTATGAGGGGATCGCACGCGCGCCGACCGTCCTGTTCAACGAAAAGATGCTCGCCGGCCTGGGGCGGAGGA
TCGTCACCACCGGGGAACTCGATCCTGAGGGCGTGAGCCGCGCAGTGGAGGAATTCCGCCGCTTCCGTGCGCTTTCCGAT
CAGGCAGGCGCCCAATCTTTGCATGTGGTGGCAACGGCCGCCGCCCGTGAGGCGAAGAACGGCCCGGACTTCATTCGCCG
TGCCGAGGAGATCCTGGGGACCAGCATCAAAGTCTTGTCCGGTCGCGAGGAGGCCTATTATTCGGCGCTCGGCGTAATTT
CCGCCTTCTATAAGGCTGATGGCATCGTGGGAGACCTGGGCGGGGGCAGCCTCGAACTGGTCGATGTGAAGGACCACTGC
ATCGGCGAGGGTATCACCCTGCCATTGGGCGGTCTCAGGCTTCGCGACATGGCGGGCGCGTCGTTGACGGCGGCATCTGA
TATCGTGCGCCAGGAGATCGCGCGCGCCTCGTGGCTCGACGGTGGGCAGGGCCGGGCCTTCTACTGCGTTGGCGGTACCT
GGCGAAACCTCGCTCGGCTCCACATGTGCACCTCGCATTATCCGCTTGAGGTTATGCACAACTACGAAATGGACCCAGCC
GGCTCCACTGCTTTCCTGAAGCGTGTCGCACGTGGCGATATCGAGAATATGCGGGGGATCGAAAGCGTCTCGAAAAGCCG
CAGGGCCTTGCTTCCCTATGGAGCGACGGTGCTTTTGGAAATCATCCACGCCGCCAATCCGTCAAAGATCATCATCTCTG
CCAATGGCGTGCGCGAAGGTTATCTCTATTCTCTTCTTTCCAAGGAGGATCAGGCAGCCGACCCGTTGATTTCCGCGGCG
GAGGAACTGGCGCTTTTGCGCTCACGCTCCTTCACCCACGTCCATGAACTGGCCGAATGGACAGGAGAGGCATTCGCCGC
ACTCGGCATCGATGAGACTGAAGTCGAGGCGCGTTATCGTCGCGCCGCCTGCCTGCTGGCGGATATCGGCTGGCGCGCGC
ATCCGGAATATCGTGGCACCCAGTCCCTCAATATCATAGCCCATGGCTCCTTTATCGGCATCGATCATCCCGGTCGCGCT
TTTATCGCGCTCACCAGCCTGTTTCGCCACGAAGGGCTGTTTGATGATGCGCTTTCACCGGAGATGCGCAAGCTTGCCAC
GCCTCTTTACGCCGAGCGGGCGCGCCTTCTCGGCGGCTTGATGCGTGTGGTTTATCTGCTCTCGGCTTCCATGCCGGGTG
TCATTCCGCGGCTCAAATGGGAAAAAGGGACCGACGGATCCTTGGCACTCCTCATTCCGCGGGACTGTGCCAGCCTGATG
GGCGAACGACCGCAAGGCCGCATGGCGCAGCTGGCCAAGCTCACGGGCAAGAGCCTCGTGCTGAAGGTGGCGAAAGACTA
G

Upstream 100 bases:

>100_bases
CCCAGCCTGTCGGGTCGAGGAGAAGCTTTGAAGTCTCATGCGCCAAAGCGGATCGCCGCCTTCAAGCGGCGAAAAAAGGC
TGTAGCCGTCGGCTAACAGC

Downstream 100 bases:

>100_bases
CTATTCCGCCGCGCTGCGCATCTGGTCCGCGGGCGCGAAGGTTTCAATGCGACGGTTGGCGAAGCGCAGTGCGATCTCCC
CGCGCAGGAGCTTGAGCGCC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MGIKTSQGRLQDRRPVSVIDIGSNSIRLVIYEGIARAPTVLFNEKMLAGLGRRIVTTGELDPEGVSRAVEEFRRFRALSD
QAGAQSLHVVATAAAREAKNGPDFIRRAEEILGTSIKVLSGREEAYYSALGVISAFYKADGIVGDLGGGSLELVDVKDHC
IGEGITLPLGGLRLRDMAGASLTAASDIVRQEIARASWLDGGQGRAFYCVGGTWRNLARLHMCTSHYPLEVMHNYEMDPA
GSTAFLKRVARGDIENMRGIESVSKSRRALLPYGATVLLEIIHAANPSKIIISANGVREGYLYSLLSKEDQAADPLISAA
EELALLRSRSFTHVHELAEWTGEAFAALGIDETEVEARYRRAACLLADIGWRAHPEYRGTQSLNIIAHGSFIGIDHPGRA
FIALTSLFRHEGLFDDALSPEMRKLATPLYAERARLLGGLMRVVYLLSASMPGVIPRLKWEKGTDGSLALLIPRDCASLM
GERPQGRMAQLAKLTGKSLVLKVAKD

Sequences:

>Translated_506_residues
MGIKTSQGRLQDRRPVSVIDIGSNSIRLVIYEGIARAPTVLFNEKMLAGLGRRIVTTGELDPEGVSRAVEEFRRFRALSD
QAGAQSLHVVATAAAREAKNGPDFIRRAEEILGTSIKVLSGREEAYYSALGVISAFYKADGIVGDLGGGSLELVDVKDHC
IGEGITLPLGGLRLRDMAGASLTAASDIVRQEIARASWLDGGQGRAFYCVGGTWRNLARLHMCTSHYPLEVMHNYEMDPA
GSTAFLKRVARGDIENMRGIESVSKSRRALLPYGATVLLEIIHAANPSKIIISANGVREGYLYSLLSKEDQAADPLISAA
EELALLRSRSFTHVHELAEWTGEAFAALGIDETEVEARYRRAACLLADIGWRAHPEYRGTQSLNIIAHGSFIGIDHPGRA
FIALTSLFRHEGLFDDALSPEMRKLATPLYAERARLLGGLMRVVYLLSASMPGVIPRLKWEKGTDGSLALLIPRDCASLM
GERPQGRMAQLAKLTGKSLVLKVAKD
>Mature_505_residues
GIKTSQGRLQDRRPVSVIDIGSNSIRLVIYEGIARAPTVLFNEKMLAGLGRRIVTTGELDPEGVSRAVEEFRRFRALSDQ
AGAQSLHVVATAAAREAKNGPDFIRRAEEILGTSIKVLSGREEAYYSALGVISAFYKADGIVGDLGGGSLELVDVKDHCI
GEGITLPLGGLRLRDMAGASLTAASDIVRQEIARASWLDGGQGRAFYCVGGTWRNLARLHMCTSHYPLEVMHNYEMDPAG
STAFLKRVARGDIENMRGIESVSKSRRALLPYGATVLLEIIHAANPSKIIISANGVREGYLYSLLSKEDQAADPLISAAE
ELALLRSRSFTHVHELAEWTGEAFAALGIDETEVEARYRRAACLLADIGWRAHPEYRGTQSLNIIAHGSFIGIDHPGRAF
IALTSLFRHEGLFDDALSPEMRKLATPLYAERARLLGGLMRVVYLLSASMPGVIPRLKWEKGTDGSLALLIPRDCASLMG
ERPQGRMAQLAKLTGKSLVLKVAKD

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=303, Percent_Identity=26.4026402640264, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788848, Length=150, Percent_Identity=30, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321185, Length=441, Percent_Identity=26.3038548752834, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55002; Mature: 54871

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIKTSQGRLQDRRPVSVIDIGSNSIRLVIYEGIARAPTVLFNEKMLAGLGRRIVTTGEL
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCC
DPEGVSRAVEEFRRFRALSDQAGAQSLHVVATAAAREAKNGPDFIRRAEEILGTSIKVLS
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHHHHCCCCHHHHHHHHHHHCCCEEEEC
GREEAYYSALGVISAFYKADGIVGDLGGGSLELVDVKDHCIGEGITLPLGGLRLRDMAGA
CCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCHHHCCCCCCCCCCCEEEHHHCCC
SLTAASDIVRQEIARASWLDGGQGRAFYCVGGTWRNLARLHMCTSHYPLEVMHNYEMDPA
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCCCC
GSTAFLKRVARGDIENMRGIESVSKSRRALLPYGATVLLEIIHAANPSKIIISANGVREG
CCHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCEEEEEECCCCCH
YLYSLLSKEDQAADPLISAAEELALLRSRSFTHVHELAEWTGEAFAALGIDETEVEARYR
HHHHHHCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHEECCCCHHHHHHHHH
RAACLLADIGWRAHPEYRGTQSLNIIAHGSFIGIDHPGRAFIALTSLFRHEGLFDDALSP
HHHHHHHHCCCCCCCCCCCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHCCCCCCCCCH
EMRKLATPLYAERARLLGGLMRVVYLLSASMPGVIPRLKWEKGTDGSLALLIPRDCASLM
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHC
GERPQGRMAQLAKLTGKSLVLKVAKD
CCCCCHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure 
GIKTSQGRLQDRRPVSVIDIGSNSIRLVIYEGIARAPTVLFNEKMLAGLGRRIVTTGEL
CCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCC
DPEGVSRAVEEFRRFRALSDQAGAQSLHVVATAAAREAKNGPDFIRRAEEILGTSIKVLS
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEHHHHHHCCCCHHHHHHHHHHHCCCEEEEC
GREEAYYSALGVISAFYKADGIVGDLGGGSLELVDVKDHCIGEGITLPLGGLRLRDMAGA
CCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCHHHCCCCCCCCCCCEEEHHHCCC
SLTAASDIVRQEIARASWLDGGQGRAFYCVGGTWRNLARLHMCTSHYPLEVMHNYEMDPA
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCCCC
GSTAFLKRVARGDIENMRGIESVSKSRRALLPYGATVLLEIIHAANPSKIIISANGVREG
CCHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCEEEEEECCCCCH
YLYSLLSKEDQAADPLISAAEELALLRSRSFTHVHELAEWTGEAFAALGIDETEVEARYR
HHHHHHCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHEECCCCHHHHHHHHH
RAACLLADIGWRAHPEYRGTQSLNIIAHGSFIGIDHPGRAFIALTSLFRHEGLFDDALSP
HHHHHHHHCCCCCCCCCCCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHCCCCCCCCCH
EMRKLATPLYAERARLLGGLMRVVYLLSASMPGVIPRLKWEKGTDGSLALLIPRDCASLM
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHC
GERPQGRMAQLAKLTGKSLVLKVAKD
CCCCCHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]