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The map label for this gene is metC [H]

Identifier: 110633465

GI number: 110633465

Start: 1214498

End: 1215664

Strand: Reverse

Name: metC [H]

Synonym: Meso_1112

Alternate gene names: 110633465

Gene position: 1215664-1214498 (Counterclockwise)

Preceding gene: 110633470

Following gene: 110633461

Centisome position: 27.55

GC content: 59.9

Gene sequence:

>1167_bases
ATGGCCTCGGATAAAAGCGGCGGCATAAACACCAGGCTTGCCCATATGGGCAATGATCCCTTGTCGTTCCACGGCTTTGT
CAATCCGCCTGTAGTGCACGGCTCGACGGTGCTTTTTCCCGACAGTGCGACAATGGCTTCGCGGAGCCAGAAATATACCT
ACGGGACGCGTGGGACGCCTACAACAGATGCGCTGGCAACCGCCATCAACGAACTCGAAGGCTCTGCCGGTACGATCATT
GTGCCGTCGGGGCTGGCGGCGGTGACAGTCCCGCTGCTCGCTTTTTTATCAGCCGGCGACCACGTGCTCATCGTCGATTC
CGTCTACCATCCGACACGCCGCTTCGCCGACACGATGCTCAAGGGTTTCGGCGTGGAGGTGGAGTATTACGATCCTCTCG
TGGGCGGGGAGATCGAAGCCCTGATGAAGCCCAATACGAGGGTGGTCTTCACCGAATCCCCGGGTTCAAACACAATGGAG
ATTCAGGATATTCCAGCCATAGCCGCCGCGGCGCGTGCACGCGGCGCCATTGTGATGATGGACAATACCTGGGCGACGCC
GCTCCTTTTCCGCCCGCTGGACCACGGAGTCGACGTATCGATCCACGCAGCCACCAAATATCCCGGCGGGCACTCGGACG
TTCTCCTCGGCACGGTCTCCGCCAACGAAAGCTCCTGGGAACGATTGCACGATGCCTTCATTACCCTCGGCACCTGCGCT
GGGCCCGACGATGTCTACCAGGTGCTGAGGGGGCTTCGCACGATGGGCATCCGGCTTGAGCGCCATCAGGAAAGCGCGCT
CGAAATCGCGCGTTGGCTGGAAGGCATGCCAGGCGTGGCAAGGGTGCTCCATCCCGCCCTCCCCTCGCATCCGGGACACG
CAATCTGGAAACGAGATTTTTCGGGCGCGAGCGGCCTTTTTTCCTTCGTTCTCTCTGGCGGTGGAGAGAAGGAGGCGCAC
GCATTTCTCGATACGCTGAAAATTTTTGGGCTCGGCTATTCCTGGGGCGGATTTGAAAGCCTCGCGGTCCATGTTTCGCT
GGCCGATCGCAGGGTTGCAAAGGGCAATTTTCCAGGGCCGGTGATCCGGCTTCAGATTGGGCTGGAAGACGCGGCTGACC
TCAAGGCCGATATCGAAAATGGGCTTAGAGCAACGGGATTACGCTAG

Upstream 100 bases:

>100_bases
GAGCTTACGCGCATATGAGGTACATTCCCGCCTTGTTAAGGCACGCTTTAGGAATTAAGCCCGAAATCATACCGCAAGGG
ATTGAGGGAGAAGTGTTGAA

Downstream 100 bases:

>100_bases
AGCCTTTGGCGCGCTACTCGCTCCGTTCGATCAGCACCGCCTGGCCGTCATGATCACCCGTTGTTAGATGGGCATTTCCG
ACAATTGCGTTCCCCATGTC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MASDKSGGINTRLAHMGNDPLSFHGFVNPPVVHGSTVLFPDSATMASRSQKYTYGTRGTPTTDALATAINELEGSAGTII
VPSGLAAVTVPLLAFLSAGDHVLIVDSVYHPTRRFADTMLKGFGVEVEYYDPLVGGEIEALMKPNTRVVFTESPGSNTME
IQDIPAIAAAARARGAIVMMDNTWATPLLFRPLDHGVDVSIHAATKYPGGHSDVLLGTVSANESSWERLHDAFITLGTCA
GPDDVYQVLRGLRTMGIRLERHQESALEIARWLEGMPGVARVLHPALPSHPGHAIWKRDFSGASGLFSFVLSGGGEKEAH
AFLDTLKIFGLGYSWGGFESLAVHVSLADRRVAKGNFPGPVIRLQIGLEDAADLKADIENGLRATGLR

Sequences:

>Translated_388_residues
MASDKSGGINTRLAHMGNDPLSFHGFVNPPVVHGSTVLFPDSATMASRSQKYTYGTRGTPTTDALATAINELEGSAGTII
VPSGLAAVTVPLLAFLSAGDHVLIVDSVYHPTRRFADTMLKGFGVEVEYYDPLVGGEIEALMKPNTRVVFTESPGSNTME
IQDIPAIAAAARARGAIVMMDNTWATPLLFRPLDHGVDVSIHAATKYPGGHSDVLLGTVSANESSWERLHDAFITLGTCA
GPDDVYQVLRGLRTMGIRLERHQESALEIARWLEGMPGVARVLHPALPSHPGHAIWKRDFSGASGLFSFVLSGGGEKEAH
AFLDTLKIFGLGYSWGGFESLAVHVSLADRRVAKGNFPGPVIRLQIGLEDAADLKADIENGLRATGLR
>Mature_387_residues
ASDKSGGINTRLAHMGNDPLSFHGFVNPPVVHGSTVLFPDSATMASRSQKYTYGTRGTPTTDALATAINELEGSAGTIIV
PSGLAAVTVPLLAFLSAGDHVLIVDSVYHPTRRFADTMLKGFGVEVEYYDPLVGGEIEALMKPNTRVVFTESPGSNTMEI
QDIPAIAAAARARGAIVMMDNTWATPLLFRPLDHGVDVSIHAATKYPGGHSDVLLGTVSANESSWERLHDAFITLGTCAG
PDDVYQVLRGLRTMGIRLERHQESALEIARWLEGMPGVARVLHPALPSHPGHAIWKRDFSGASGLFSFVLSGGGEKEAHA
FLDTLKIFGLGYSWGGFESLAVHVSLADRRVAKGNFPGPVIRLQIGLEDAADLKADIENGLRATGLR

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=335, Percent_Identity=37.0149253731343, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI299473759, Length=335, Percent_Identity=32.8358208955224, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI25453487, Length=334, Percent_Identity=33.2335329341317, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1789383, Length=387, Percent_Identity=45.2196382428941, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI1790375, Length=374, Percent_Identity=33.6898395721925, Blast_Score=196, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71980708, Length=388, Percent_Identity=32.2164948453608, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17560056, Length=369, Percent_Identity=34.6883468834688, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17538055, Length=368, Percent_Identity=35.3260869565217, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI193202265, Length=103, Percent_Identity=33.9805825242718, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321170, Length=331, Percent_Identity=46.8277945619335, Blast_Score=322, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6319307, Length=398, Percent_Identity=30.9045226130653, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=390, Percent_Identity=27.4358974358974, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323333, Length=383, Percent_Identity=26.1096605744125, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321254, Length=361, Percent_Identity=27.1468144044321, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922554, Length=386, Percent_Identity=37.0466321243523, Blast_Score=227, Evalue=9e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41402; Mature: 41270

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDKSGGINTRLAHMGNDPLSFHGFVNPPVVHGSTVLFPDSATMASRSQKYTYGTRGTP
CCCCCCCCCCEEEEECCCCCCEECCCCCCCEECCCEEEECCCHHHHHCCCCEECCCCCCC
TTDALATAINELEGSAGTIIVPSGLAAVTVPLLAFLSAGDHVLIVDSVYHPTRRFADTML
CHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
KGFGVEVEYYDPLVGGEIEALMKPNTRVVFTESPGSNTMEIQDIPAIAAAARARGAIVMM
HHCCCEEEEECCCCCCCHHEEECCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCEEEEE
DNTWATPLLFRPLDHGVDVSIHAATKYPGGHSDVLLGTVSANESSWERLHDAFITLGTCA
CCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHEECCCC
GPDDVYQVLRGLRTMGIRLERHQESALEIARWLEGMPGVARVLHPALPSHPGHAIWKRDF
CHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHEECCC
SGASGLFSFVLSGGGEKEAHAFLDTLKIFGLGYSWGGFESLAVHVSLADRRVAKGNFPGP
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEECCCCCCCC
VIRLQIGLEDAADLKADIENGLRATGLR
EEEEEECCCCHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
ASDKSGGINTRLAHMGNDPLSFHGFVNPPVVHGSTVLFPDSATMASRSQKYTYGTRGTP
CCCCCCCCCEEEEECCCCCCEECCCCCCCEECCCEEEECCCHHHHHCCCCEECCCCCCC
TTDALATAINELEGSAGTIIVPSGLAAVTVPLLAFLSAGDHVLIVDSVYHPTRRFADTML
CHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
KGFGVEVEYYDPLVGGEIEALMKPNTRVVFTESPGSNTMEIQDIPAIAAAARARGAIVMM
HHCCCEEEEECCCCCCCHHEEECCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCEEEEE
DNTWATPLLFRPLDHGVDVSIHAATKYPGGHSDVLLGTVSANESSWERLHDAFITLGTCA
CCCCCCCEEECCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHEECCCC
GPDDVYQVLRGLRTMGIRLERHQESALEIARWLEGMPGVARVLHPALPSHPGHAIWKRDF
CHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHEECCC
SGASGLFSFVLSGGGEKEAHAFLDTLKIFGLGYSWGGFESLAVHVSLADRRVAKGNFPGP
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEECCCCCCCC
VIRLQIGLEDAADLKADIENGLRATGLR
EEEEEECCCCHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]