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The map label for this gene is hpcH [H]

Identifier: 110633432

GI number: 110633432

Start: 1182042

End: 1182836

Strand: Reverse

Name: hpcH [H]

Synonym: Meso_1078

Alternate gene names: 110633432

Gene position: 1182836-1182042 (Counterclockwise)

Preceding gene: 110633436

Following gene: 110633431

Centisome position: 26.81

GC content: 62.89

Gene sequence:

>795_bases
ATGCATGCGAATCTTTTGAAGCACAGGCTCGGCTCTGGCGAGCCGACATTCGTTTTCTCGGTGCGCATGGCGCGCACGGT
CAACATCGTCTCGATGGCGCAGGCGGCGGGCTATCACGGGCTTTATGTGGACCTGCAGCACAGCTCGATCTCGATCGACA
CTGCCGCGCAGATCTTCTCCACCGCCCTGCACAGCGAGGTGACGGCCTTCGCGCGCGTGCCGAGCCTGGAGCCGGGGCTG
GTATCACGCGTGCTCGATGCGGGCGCCCAGGGCATTCTCGCTCCCGATATCCGCTCGGCCGCCGAGGCAAAGGCACTGGT
CCAGGCAGCGCTGATTGCGCCCAAGGGCGACCGCTCCGTCGGCAGCGGCATCCCCAATCCGCGTTTCAAAGGCCTTTCGG
GTGGCGCACTGGCCGCCGCCATCAACGATGCTACCTTGCTCATCGCCATGATCGAAACCGAGGAGGCGGCAGAGAGGGCT
GGGGAAATCATCGGCGTCGACGGCATCGACGCAATCCAGATCGGCAGCAATGATCTCACCACCTCCATGGGCATACCTGG
CCAATACAAGCACGATCGGGTCCAGACAGTCTATGGAAAGGTTATCGCCGCCTGCAAGGCCGCCGGAAAACCCCTGATCA
TCGGCGGCATCCGCAAGAGCGATGAACTGGAGCCATATGTGCGGATGGGTGCCTCGCGCTGCTACTTTACCGGCGCGGAC
ACCAACTTTTTGATCGAGGGGGCAATGAAATTCATGGCCGAGGCGAAAGCCGCCGACGCCGCGATCGTCGGCTGA

Upstream 100 bases:

>100_bases
ATCCACTCTTGTATTTTTCTGTCGACCTTTGTATTCAAAGAAAGACAGGCCTGCAAGATTGCGGCTGGCGAAAAGTGCGT
CGGCGCCGAGGGAGGAACGA

Downstream 100 bases:

>100_bases
ACATCACGACAAACATGACCGGGAGGAACTGATGAAAACGATTTTCTTGGCTGCAGGCGCCGCGGCGCTTGCACTCTTTG
CGACCGCGGCTTCCGCCGAA

Product: HpcH/HpaI aldolase

Products: NA

Alternate protein names: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MHANLLKHRLGSGEPTFVFSVRMARTVNIVSMAQAAGYHGLYVDLQHSSISIDTAAQIFSTALHSEVTAFARVPSLEPGL
VSRVLDAGAQGILAPDIRSAAEAKALVQAALIAPKGDRSVGSGIPNPRFKGLSGGALAAAINDATLLIAMIETEEAAERA
GEIIGVDGIDAIQIGSNDLTTSMGIPGQYKHDRVQTVYGKVIAACKAAGKPLIIGGIRKSDELEPYVRMGASRCYFTGAD
TNFLIEGAMKFMAEAKAADAAIVG

Sequences:

>Translated_264_residues
MHANLLKHRLGSGEPTFVFSVRMARTVNIVSMAQAAGYHGLYVDLQHSSISIDTAAQIFSTALHSEVTAFARVPSLEPGL
VSRVLDAGAQGILAPDIRSAAEAKALVQAALIAPKGDRSVGSGIPNPRFKGLSGGALAAAINDATLLIAMIETEEAAERA
GEIIGVDGIDAIQIGSNDLTTSMGIPGQYKHDRVQTVYGKVIAACKAAGKPLIIGGIRKSDELEPYVRMGASRCYFTGAD
TNFLIEGAMKFMAEAKAADAAIVG
>Mature_264_residues
MHANLLKHRLGSGEPTFVFSVRMARTVNIVSMAQAAGYHGLYVDLQHSSISIDTAAQIFSTALHSEVTAFARVPSLEPGL
VSRVLDAGAQGILAPDIRSAAEAKALVQAALIAPKGDRSVGSGIPNPRFKGLSGGALAAAINDATLLIAMIETEEAAERA
GEIIGVDGIDAIQIGSNDLTTSMGIPGQYKHDRVQTVYGKVIAACKAAGKPLIIGGIRKSDELEPYVRMGASRCYFTGAD
TNFLIEGAMKFMAEAKAADAAIVG

Specific function: Catalyzes the reversible retro-aldol cleavage of 4- hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde [H]

COG id: COG3836

COG function: function code G; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1788578, Length=209, Percent_Identity=31.1004784688995, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789514, Length=176, Percent_Identity=27.8409090909091, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR012689
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: NA

Molecular weight: Translated: 27478; Mature: 27478

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHANLLKHRLGSGEPTFVFSVRMARTVNIVSMAQAAGYHGLYVDLQHSSISIDTAAQIFS
CCCHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCEECHHHHHHHHH
TALHSEVTAFARVPSLEPGLVSRVLDAGAQGILAPDIRSAAEAKALVQAALIAPKGDRSV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
GSGIPNPRFKGLSGGALAAAINDATLLIAMIETEEAAERAGEIIGVDGIDAIQIGSNDLT
CCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCHHHHHHCCCEEECCCCCEEEECCCCCE
TSMGIPGQYKHDRVQTVYGKVIAACKAAGKPLIIGGIRKSDELEPYVRMGASRCYFTGAD
ECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHCCCCEEEEECCC
TNFLIEGAMKFMAEAKAADAAIVG
CCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHANLLKHRLGSGEPTFVFSVRMARTVNIVSMAQAAGYHGLYVDLQHSSISIDTAAQIFS
CCCHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCEECHHHHHHHHH
TALHSEVTAFARVPSLEPGLVSRVLDAGAQGILAPDIRSAAEAKALVQAALIAPKGDRSV
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
GSGIPNPRFKGLSGGALAAAINDATLLIAMIETEEAAERAGEIIGVDGIDAIQIGSNDLT
CCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCHHHHHHCCCEEECCCCCEEEECCCCCE
TSMGIPGQYKHDRVQTVYGKVIAACKAAGKPLIIGGIRKSDELEPYVRMGASRCYFTGAD
ECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHCCCCEEEEECCC
TNFLIEGAMKFMAEAKAADAAIVG
CCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA