Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 110633416

GI number: 110633416

Start: 1165305

End: 1166975

Strand: Reverse

Name: ilvG [H]

Synonym: Meso_1062

Alternate gene names: 110633416

Gene position: 1166975-1165305 (Counterclockwise)

Preceding gene: 110633417

Following gene: 110633415

Centisome position: 26.45

GC content: 62.48

Gene sequence:

>1671_bases
ATGAACATGGATCAATATCAGGGCGCCCAGGGAACGAAAGAACGCACGGGCGCGCAGGTGCTGATCGATTCACTTATCGC
TCAAGGGGCAGACCTTGCCTTCTGCGTTCCCGGCGAAAGCTATCTGGCCGCGCTCGACGCGATGCACGACGTGCAGGATA
AATTCCGTCTCATCGTGTGCAGGCATGAGGCAAGCGCCGCGAATATGGCGGAAGCGAGCGGAAAGCTGACCGGCCGGCCT
GGCATCTGCTTCGTCACCCGCGGGCCGGGCTCCTCCCAAGGATCTGTCGGCGTGCATACGGCGCAGCAGGATTCGACACC
GCTCATCTATTTCGTCGGCCAGGTGAGCTATGGCGACCTGGGGCGCGAGGCGTTCCAGGAAGTCGACTATGTGGCGATGT
ATTCCAAGTTCGCCAAATGGGCCGTGCAGATCGACGACGTGGCTCGCATCCCGGAAATCATCAGCCGCGCCTACCATGTT
GCGGTGAATGGCCGGGCGGGCCCGGTGGTCATTGCTATTCCCGAGGACGTGCTGAAAAAGCCCTGCCCGAATCCTCCGGC
GCCCCCCTTCACCCCTGTCCGCGCCGCGCCAGGCAAAGCGGCGCTCGATGAGCTGGAGAAGATGCTGGCCGCGGCGGAAA
GGCCGCTTCTGGTGCTCGGCGGCGGCAGCTGGGATGCCCATTCGGTGGCTCAAATGCAGGCCTTCGCCGAAAAGCACCAT
TTGCCCGCCGCCGTCGGCTTCCGCCGTCAGGATCTGTTCGACAACACCCATCCGAACTATGTGGGCGATCTCGGCCTCGG
CATCGATGCGGCGCTGGCGGAGATGGTGAAAGCCTCGGACCTGATCATCTCCGTCGGGGAGCGCCTGGGCGACGCCTCGA
CCAAGGGATATACCCTGCTCGACATTCCGCAGCCCGCGCAGAAACTGGTGCATGTCCATCCCGGGCCGGAAGAGCTCGGC
ATGGTCTACCGCGCCGATCTTGCGATCGGTGCGACGCCACGCGACTTCGCAGAGGCGGTAAGCGACATCAAGGCCGGTTC
GAAGACCCGCGAACAGTGGATCGCCAACGGACGCGCCGCATATGAGCGGAAAATCACGCCCAAGCCGAACAGCCTGCCCA
TCGACGTGGCGGAGGTGGTGAAATATCTCAGGGAGTCGCTCCCAGACGATGCCATCGTCACAAATGGCGCCGGAACCTAC
ACGGGCTATGTCCACCGCTACTACGTCTTCCGGAAATTCCGGACGCAGCTTGCGCCAACCAGCGGCGCGATGGGTTACGG
CTTCCCGGCGGCGATCGCCGCGCAGCTCGTTCATCCCGACCGCACGGTGGTCTGCTTTGCGGGCGACGGCTGTTTCCTCA
TGGCTTCCCAGGAGCTTGCCACGGCGATCCGGTATGATCTGCCGATGGTCGTGATACTGGTGAACAATTCGAGCTATGGC
TCCATCCGCATGCACCAGGAGCGCGAATACCCAGGACGCGTGTTCGCGACCGGCCTTAACAACCCGGATTTCGTTGCGCT
GGCGAAAGCCTATGGCGCCTATGGCGAGCTGGTCGAGCGGACCGCGGATTTCCCTGCGGCCTTTGAGAGAGCAAAGGAAT
CAGGAAAGCCGGCGCTGCTCGAACTCAGGATAGATATTGAAGCCATGATGGCCGCCAATCCACGCAAATAA

Upstream 100 bases:

>100_bases
CCGAGGCAAGCCGGCACAAGGATATCTCCGCCGGCGTTCCTGTTCCCGATCTTGCCAATCGCGCCGGCGCCTTCACCATG
CCCACACAGGACAAGCAGAA

Downstream 100 bases:

>100_bases
ACAAAAGGGAATTCCACAAGCAAGACAAGAAAGAACGTGCTGCGCCCGGCCATCCAGTTGACATGTGGTCCGCTTCCCTC
CACATCGCATACAACGGTCC

Product: acetolactate synthase, large subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MNMDQYQGAQGTKERTGAQVLIDSLIAQGADLAFCVPGESYLAALDAMHDVQDKFRLIVCRHEASAANMAEASGKLTGRP
GICFVTRGPGSSQGSVGVHTAQQDSTPLIYFVGQVSYGDLGREAFQEVDYVAMYSKFAKWAVQIDDVARIPEIISRAYHV
AVNGRAGPVVIAIPEDVLKKPCPNPPAPPFTPVRAAPGKAALDELEKMLAAAERPLLVLGGGSWDAHSVAQMQAFAEKHH
LPAAVGFRRQDLFDNTHPNYVGDLGLGIDAALAEMVKASDLIISVGERLGDASTKGYTLLDIPQPAQKLVHVHPGPEELG
MVYRADLAIGATPRDFAEAVSDIKAGSKTREQWIANGRAAYERKITPKPNSLPIDVAEVVKYLRESLPDDAIVTNGAGTY
TGYVHRYYVFRKFRTQLAPTSGAMGYGFPAAIAAQLVHPDRTVVCFAGDGCFLMASQELATAIRYDLPMVVILVNNSSYG
SIRMHQEREYPGRVFATGLNNPDFVALAKAYGAYGELVERTADFPAAFERAKESGKPALLELRIDIEAMMAANPRK

Sequences:

>Translated_556_residues
MNMDQYQGAQGTKERTGAQVLIDSLIAQGADLAFCVPGESYLAALDAMHDVQDKFRLIVCRHEASAANMAEASGKLTGRP
GICFVTRGPGSSQGSVGVHTAQQDSTPLIYFVGQVSYGDLGREAFQEVDYVAMYSKFAKWAVQIDDVARIPEIISRAYHV
AVNGRAGPVVIAIPEDVLKKPCPNPPAPPFTPVRAAPGKAALDELEKMLAAAERPLLVLGGGSWDAHSVAQMQAFAEKHH
LPAAVGFRRQDLFDNTHPNYVGDLGLGIDAALAEMVKASDLIISVGERLGDASTKGYTLLDIPQPAQKLVHVHPGPEELG
MVYRADLAIGATPRDFAEAVSDIKAGSKTREQWIANGRAAYERKITPKPNSLPIDVAEVVKYLRESLPDDAIVTNGAGTY
TGYVHRYYVFRKFRTQLAPTSGAMGYGFPAAIAAQLVHPDRTVVCFAGDGCFLMASQELATAIRYDLPMVVILVNNSSYG
SIRMHQEREYPGRVFATGLNNPDFVALAKAYGAYGELVERTADFPAAFERAKESGKPALLELRIDIEAMMAANPRK
>Mature_556_residues
MNMDQYQGAQGTKERTGAQVLIDSLIAQGADLAFCVPGESYLAALDAMHDVQDKFRLIVCRHEASAANMAEASGKLTGRP
GICFVTRGPGSSQGSVGVHTAQQDSTPLIYFVGQVSYGDLGREAFQEVDYVAMYSKFAKWAVQIDDVARIPEIISRAYHV
AVNGRAGPVVIAIPEDVLKKPCPNPPAPPFTPVRAAPGKAALDELEKMLAAAERPLLVLGGGSWDAHSVAQMQAFAEKHH
LPAAVGFRRQDLFDNTHPNYVGDLGLGIDAALAEMVKASDLIISVGERLGDASTKGYTLLDIPQPAQKLVHVHPGPEELG
MVYRADLAIGATPRDFAEAVSDIKAGSKTREQWIANGRAAYERKITPKPNSLPIDVAEVVKYLRESLPDDAIVTNGAGTY
TGYVHRYYVFRKFRTQLAPTSGAMGYGFPAAIAAQLVHPDRTVVCFAGDGCFLMASQELATAIRYDLPMVVILVNNSSYG
SIRMHQEREYPGRVFATGLNNPDFVALAKAYGAYGELVERTADFPAAFERAKESGKPALLELRIDIEAMMAANPRK

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=578, Percent_Identity=25.4325259515571, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI21361361, Length=557, Percent_Identity=24.2369838420108, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI87081685, Length=543, Percent_Identity=30.2025782688766, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1790104, Length=551, Percent_Identity=30.6715063520871, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786717, Length=537, Percent_Identity=27.0018621973929, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787096, Length=552, Percent_Identity=24.8188405797101, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788716, Length=565, Percent_Identity=24.7787610619469, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17531301, Length=561, Percent_Identity=25.1336898395722, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17531299, Length=561, Percent_Identity=25.1336898395722, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17542570, Length=562, Percent_Identity=22.9537366548043, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323755, Length=556, Percent_Identity=27.8776978417266, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6320816, Length=548, Percent_Identity=23.5401459854015, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922626, Length=492, Percent_Identity=28.2520325203252, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60007; Mature: 60007

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMDQYQGAQGTKERTGAQVLIDSLIAQGADLAFCVPGESYLAALDAMHDVQDKFRLIVC
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCEEEEEE
RHEASAANMAEASGKLTGRPGICFVTRGPGSSQGSVGVHTAQQDSTPLIYFVGQVSYGDL
ECCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCC
GREAFQEVDYVAMYSKFAKWAVQIDDVARIPEIISRAYHVAVNGRAGPVVIAIPEDVLKK
CHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHEEEEECCCCCCEEEECCHHHHHC
PCPNPPAPPFTPVRAAPGKAALDELEKMLAAAERPLLVLGGGSWDAHSVAQMQAFAEKHH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCC
LPAAVGFRRQDLFDNTHPNYVGDLGLGIDAALAEMVKASDLIISVGERLGDASTKGYTLL
CCHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DIPQPAQKLVHVHPGPEELGMVYRADLAIGATPRDFAEAVSDIKAGSKTREQWIANGRAA
ECCCHHHHHEECCCCHHHHCEEEEECEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCHH
YERKITPKPNSLPIDVAEVVKYLRESLPDDAIVTNGAGTYTGYVHRYYVFRKFRTQLAPT
HHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCC
SGAMGYGFPAAIAAQLVHPDRTVVCFAGDGCFLMASQELATAIRYDLPMVVILVNNSSYG
CCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHCCCCEEEEEEECCCCC
SIRMHQEREYPGRVFATGLNNPDFVALAKAYGAYGELVERTADFPAAFERAKESGKPALL
EEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEE
ELRIDIEAMMAANPRK
EEEECHHHHCCCCCCC
>Mature Secondary Structure
MNMDQYQGAQGTKERTGAQVLIDSLIAQGADLAFCVPGESYLAALDAMHDVQDKFRLIVC
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCEEEEEE
RHEASAANMAEASGKLTGRPGICFVTRGPGSSQGSVGVHTAQQDSTPLIYFVGQVSYGDL
ECCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEECCCCCCC
GREAFQEVDYVAMYSKFAKWAVQIDDVARIPEIISRAYHVAVNGRAGPVVIAIPEDVLKK
CHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHEEEEECCCCCCEEEECCHHHHHC
PCPNPPAPPFTPVRAAPGKAALDELEKMLAAAERPLLVLGGGSWDAHSVAQMQAFAEKHH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCC
LPAAVGFRRQDLFDNTHPNYVGDLGLGIDAALAEMVKASDLIISVGERLGDASTKGYTLL
CCHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DIPQPAQKLVHVHPGPEELGMVYRADLAIGATPRDFAEAVSDIKAGSKTREQWIANGRAA
ECCCHHHHHEECCCCHHHHCEEEEECEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCHH
YERKITPKPNSLPIDVAEVVKYLRESLPDDAIVTNGAGTYTGYVHRYYVFRKFRTQLAPT
HHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCC
SGAMGYGFPAAIAAQLVHPDRTVVCFAGDGCFLMASQELATAIRYDLPMVVILVNNSSYG
CCCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHCCCCEEEEEEECCCCC
SIRMHQEREYPGRVFATGLNNPDFVALAKAYGAYGELVERTADFPAAFERAKESGKPALL
EEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEE
ELRIDIEAMMAANPRK
EEEECHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]