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The map label for this gene is lolC [H]

Identifier: 110633395

GI number: 110633395

Start: 1143464

End: 1144747

Strand: Direct

Name: lolC [H]

Synonym: Meso_1041

Alternate gene names: 110633395

Gene position: 1143464-1144747 (Clockwise)

Preceding gene: 110633394

Following gene: 110633396

Centisome position: 25.91

GC content: 59.19

Gene sequence:

>1284_bases
ATGAGCGGAGCCGAGGCGGCAAAAGGGGGTATTAAACCCTTCTCCTATTTCGAGCGCCTCGTCGCTTGGCGCTATCTGCG
CTCGCGCCGCAAGGAAACCGTCGTTTCCGTGATCGCGCTGATTTCATTTCTGGGCATCATGCTCGGAGTCGCCACTCTTA
TTGTGGTGATGGCGGTGATGAACGGCTTTCGCGGCGAACTCCTGACACGCATTCTGGGCGTGAACGGCCATATCATCGTG
CAGCCCGTCGATTCACCATTGAGCGACTATGATGCGGTCGCCGGACGCATCGCCCAGGTGCCAGGCGTGCGTGACGCAAT
GCCGATCGTGGAGGGGCAGGTGCTTGCCTCCGGTCGCAGCGGAGCCGGTAGCGGCGCGCTCGTCCGTGGTGTGCGTGCTG
AAGACCTCACCAAGATCGATCTGGTGGCAAAGAACATTCGTGTCGGCTCGCTGGTCGATTTTGCCGCGGGGCAGGGGGTC
GCAATCGGGTCTCGCATGGCGCAGAGCCTCGGACTGGCGGTGGGTGATTCCATCACCCTTGTTGCGCCGGAAGGCGATGT
GACGCCCTTTGGCACGACACCCCGCGTGAAAAGCTATCCCGTCACGGCTGTCTTCGAGATCGGCATGTCGGAATATGATG
CCTCCATCATATATATGCCGCTGGAGGAGGCGCAGCTCTTCTTCAATGTCGAAGGCCTGGTACAGTTCATCGAAGTATTC
GCTGATCATCCCGACAATGTCGGCACCTTGCGTCCACTGGTGGAGGAGGCGGCCATGCGCCCGGTCTCCATTAGCGACTG
GCGCCAGCGAAATCAGGTGTTCTTCTCCGCCCTTCAGGTCGAGCGGAACGTTATGTTCATGATCCTGACCATGATTGTGC
TGGTGGCGGCGCTCAACATCATTTCCGGCATGATCATGCTGGTGAAGGACAAGAGCCACGACATAGCCATTCTGCGCACG
ATGGGAGCCACCAGCGGCTCTATCATGCGCATCTTCCTGATGGCGGGTGCTTCGATCGGTGTGGCGGGAACCTTCGCCGG
CCTTGTGCTCGGGTCGATGCTCTGCCTGAACGTGGAATCCATCCGGGAGTTCTTCACCTGGTTATCAGGCACGGTGATCT
TCGATCCGGAAGTGTATTTCCTGAGCCAGTTGCCCGCCGATATGGAAAGTGGCGAAACCATTTCCGTGGTCTTGATGGCC
CTCATCCTTTCCTTCCTTGCAACTCTGTTTCCGGCCTGGCGCGCTTCGCGCCTCGATCCCGTGGACGCCTTGAGATACGA
GTAG

Upstream 100 bases:

>100_bases
GTGGAATAGCCGCCGGAGAAGTTGAAGTGAAGAACCGAGCCACGGGAGAGCGTGAGAATTTGCCTATTTCGGCAGTACCC
GGGCGGTTCGGCGCGCGTCG

Downstream 100 bases:

>100_bases
ATGCCGACAAGCGTATTGGAATTGAAGTCGGTCGACCGGCACTATGTTCAGGGACAGAACACGCTCACCATCCTGAAAGC
TGCCGATTTCACGCTCGCGC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSGAEAAKGGIKPFSYFERLVAWRYLRSRRKETVVSVIALISFLGIMLGVATLIVVMAVMNGFRGELLTRILGVNGHIIV
QPVDSPLSDYDAVAGRIAQVPGVRDAMPIVEGQVLASGRSGAGSGALVRGVRAEDLTKIDLVAKNIRVGSLVDFAAGQGV
AIGSRMAQSLGLAVGDSITLVAPEGDVTPFGTTPRVKSYPVTAVFEIGMSEYDASIIYMPLEEAQLFFNVEGLVQFIEVF
ADHPDNVGTLRPLVEEAAMRPVSISDWRQRNQVFFSALQVERNVMFMILTMIVLVAALNIISGMIMLVKDKSHDIAILRT
MGATSGSIMRIFLMAGASIGVAGTFAGLVLGSMLCLNVESIREFFTWLSGTVIFDPEVYFLSQLPADMESGETISVVLMA
LILSFLATLFPAWRASRLDPVDALRYE

Sequences:

>Translated_427_residues
MSGAEAAKGGIKPFSYFERLVAWRYLRSRRKETVVSVIALISFLGIMLGVATLIVVMAVMNGFRGELLTRILGVNGHIIV
QPVDSPLSDYDAVAGRIAQVPGVRDAMPIVEGQVLASGRSGAGSGALVRGVRAEDLTKIDLVAKNIRVGSLVDFAAGQGV
AIGSRMAQSLGLAVGDSITLVAPEGDVTPFGTTPRVKSYPVTAVFEIGMSEYDASIIYMPLEEAQLFFNVEGLVQFIEVF
ADHPDNVGTLRPLVEEAAMRPVSISDWRQRNQVFFSALQVERNVMFMILTMIVLVAALNIISGMIMLVKDKSHDIAILRT
MGATSGSIMRIFLMAGASIGVAGTFAGLVLGSMLCLNVESIREFFTWLSGTVIFDPEVYFLSQLPADMESGETISVVLMA
LILSFLATLFPAWRASRLDPVDALRYE
>Mature_426_residues
SGAEAAKGGIKPFSYFERLVAWRYLRSRRKETVVSVIALISFLGIMLGVATLIVVMAVMNGFRGELLTRILGVNGHIIVQ
PVDSPLSDYDAVAGRIAQVPGVRDAMPIVEGQVLASGRSGAGSGALVRGVRAEDLTKIDLVAKNIRVGSLVDFAAGQGVA
IGSRMAQSLGLAVGDSITLVAPEGDVTPFGTTPRVKSYPVTAVFEIGMSEYDASIIYMPLEEAQLFFNVEGLVQFIEVFA
DHPDNVGTLRPLVEEAAMRPVSISDWRQRNQVFFSALQVERNVMFMILTMIVLVAALNIISGMIMLVKDKSHDIAILRTM
GATSGSIMRIFLMAGASIGVAGTFAGLVLGSMLCLNVESIREFFTWLSGTVIFDPEVYFLSQLPADMESGETISVVLMAL
ILSFLATLFPAWRASRLDPVDALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=407, Percent_Identity=31.4496314496315, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1787360, Length=421, Percent_Identity=30.4038004750594, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46036; Mature: 45904

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAEAAKGGIKPFSYFERLVAWRYLRSRRKETVVSVIALISFLGIMLGVATLIVVMAVM
CCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFRGELLTRILGVNGHIIVQPVDSPLSDYDAVAGRIAQVPGVRDAMPIVEGQVLASGRS
CCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCEEEECCCC
GAGSGALVRGVRAEDLTKIDLVAKNIRVGSLVDFAAGQGVAIGSRMAQSLGLAVGDSITL
CCCCCHHEECCCHHCCHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCEECCCEEE
VAPEGDVTPFGTTPRVKSYPVTAVFEIGMSEYDASIIYMPLEEAQLFFNVEGLVQFIEVF
ECCCCCCCCCCCCCCCCCCCCHHHEECCHHHCCCEEEEEEHHHHHHHCCHHHHHHHHHHH
ADHPDNVGTLRPLVEEAAMRPVSISDWRQRNQVFFSALQVERNVMFMILTMIVLVAALNI
HCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISGMIMLVKDKSHDIAILRTMGATSGSIMRIFLMAGASIGVAGTFAGLVLGSMLCLNVES
HHCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IREFFTWLSGTVIFDPEVYFLSQLPADMESGETISVVLMALILSFLATLFPAWRASRLDP
HHHHHHHHCCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VDALRYE
HHHHCCC
>Mature Secondary Structure 
SGAEAAKGGIKPFSYFERLVAWRYLRSRRKETVVSVIALISFLGIMLGVATLIVVMAVM
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFRGELLTRILGVNGHIIVQPVDSPLSDYDAVAGRIAQVPGVRDAMPIVEGQVLASGRS
CCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCEEEECCCC
GAGSGALVRGVRAEDLTKIDLVAKNIRVGSLVDFAAGQGVAIGSRMAQSLGLAVGDSITL
CCCCCHHEECCCHHCCHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHCCEECCCEEE
VAPEGDVTPFGTTPRVKSYPVTAVFEIGMSEYDASIIYMPLEEAQLFFNVEGLVQFIEVF
ECCCCCCCCCCCCCCCCCCCCHHHEECCHHHCCCEEEEEEHHHHHHHCCHHHHHHHHHHH
ADHPDNVGTLRPLVEEAAMRPVSISDWRQRNQVFFSALQVERNVMFMILTMIVLVAALNI
HCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISGMIMLVKDKSHDIAILRTMGATSGSIMRIFLMAGASIGVAGTFAGLVLGSMLCLNVES
HHCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
IREFFTWLSGTVIFDPEVYFLSQLPADMESGETISVVLMALILSFLATLFPAWRASRLDP
HHHHHHHHCCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VDALRYE
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]