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The map label for this gene is yqjC [H]

Identifier: 110633392

GI number: 110633392

Start: 1140937

End: 1141341

Strand: Direct

Name: yqjC [H]

Synonym: Meso_1038

Alternate gene names: 110633392

Gene position: 1140937-1141341 (Clockwise)

Preceding gene: 110633391

Following gene: 110633393

Centisome position: 25.86

GC content: 62.96

Gene sequence:

>405_bases
ATGCTCAAGCGGCTCAATCACGTTGCGATCGCTGTGCCCGATCTTGAGGCAGCCGCCGCCACCTATCGTGACGTGTTGGG
CGCCACCGTCTCGCCGCCACAGGCCCTGCCTGAGCACGGGGTCACGGTCGTCTTCGTCGAACTCGGCAACACGAAGGTGG
AGCTGATCGAGCCGCTGGGCGAAAATTCACCGATCGCCGGTTTTCTCGAGAAGAGCCCGGCGGGCGGCATGCACCACATA
TGCTACGAAGTGGACGACATCATCGTTGCCCGCGATCGGCTGGTGGCTGGCGGCGCCCGTGTGTTGGGCGATGGCGAGCC
GAAGACAGGCGCTCACGGCAAGCCGGTGCTTTTTCTGCATCCCAAGGACTTTTGCGGCACGCTCGTGGAGCTTGAAGAAG
TGTGA

Upstream 100 bases:

>100_bases
TCGTGGGCGAGGCGGTGCGGCGCGCGGTGCGTGCGGCCGCCAGTGACGCCTGGGGCAAGAAGCCGATCGTGACGGTCTTT
GTCACCCAGTAAGGAGGGAG

Downstream 100 bases:

>100_bases
CGGCACGCCGCGCCGTCGGTGGTTTCAAACCGCCGGCTTAGGCGCTATTTATAGAACGGCAGTTTTATAGCTGAACGGCG
TAGCCGGGCTCGAAGTGTCG

Product: methylmalonyl-CoA epimerase

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MLKRLNHVAIAVPDLEAAAATYRDVLGATVSPPQALPEHGVTVVFVELGNTKVELIEPLGENSPIAGFLEKSPAGGMHHI
CYEVDDIIVARDRLVAGGARVLGDGEPKTGAHGKPVLFLHPKDFCGTLVELEEV

Sequences:

>Translated_134_residues
MLKRLNHVAIAVPDLEAAAATYRDVLGATVSPPQALPEHGVTVVFVELGNTKVELIEPLGENSPIAGFLEKSPAGGMHHI
CYEVDDIIVARDRLVAGGARVLGDGEPKTGAHGKPVLFLHPKDFCGTLVELEEV
>Mature_134_residues
MLKRLNHVAIAVPDLEAAAATYRDVLGATVSPPQALPEHGVTVVFVELGNTKVELIEPLGENSPIAGFLEKSPAGGMHHI
CYEVDDIIVARDRLVAGGARVLGDGEPKTGAHGKPVLFLHPKDFCGTLVELEEV

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI188035928, Length=132, Percent_Identity=66.6666666666667, Blast_Score=168, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17506387, Length=133, Percent_Identity=56.390977443609, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR018146
- InterPro:   IPR017515 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 14196; Mature: 14196

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRLNHVAIAVPDLEAAAATYRDVLGATVSPPQALPEHGVTVVFVELGNTKVELIEPLG
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCC
ENSPIAGFLEKSPAGGMHHICYEVDDIIVARDRLVAGGARVLGDGEPKTGAHGKPVLFLH
CCCCCEEEECCCCCCCHHEEEEECCCEEEECCEEEECCEEEECCCCCCCCCCCCCEEEEC
PKDFCGTLVELEEV
CHHHHHHHEEEECC
>Mature Secondary Structure
MLKRLNHVAIAVPDLEAAAATYRDVLGATVSPPQALPEHGVTVVFVELGNTKVELIEPLG
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCC
ENSPIAGFLEKSPAGGMHHICYEVDDIIVARDRLVAGGARVLGDGEPKTGAHGKPVLFLH
CCCCCEEEECCCCCCCHHEEEEECCCEEEECCEEEECCEEEECCCCCCCCCCCCCEEEEC
PKDFCGTLVELEEV
CHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]