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The map label for this gene is mscS [H]

Identifier: 110633309

GI number: 110633309

Start: 1053150

End: 1054046

Strand: Reverse

Name: mscS [H]

Synonym: Meso_0955

Alternate gene names: 110633309

Gene position: 1054046-1053150 (Counterclockwise)

Preceding gene: 110633312

Following gene: 110633298

Centisome position: 23.89

GC content: 61.87

Gene sequence:

>897_bases
ATGGACTTCGATGCTGCAGAAAACAACATCCTCACGACTGCCGAAGCTGCGTGGCTCCAGGTTCAGGAATTTGCAGTCTC
CTACGCCCTTTCCATCCTCGGCGCGATCATTCTCATTCTCGTCGGCTTTATCGCAGCTGGCATCCTGGCGCGCTGGACGC
GGGCCGCGCTTGGTCGCCTGCCGGGCGTCGACGAGACGCTGCGGCGCTTCCTCTCCAAGATCGTCCGCTATGCCGTGCTC
ATCCTCGTTGGCGTCACCGTTCTCGCGCAGTTCGGTGTTCAGACGGCCAGCATCATCGCTGCCCTCGGCGCTGTCGGCCT
CGCCATCGGCCTTGCACTTCAGGGCACGCTGCAGAACATCGCCGCCGGCATCATGCTGCTGGCGCTCAAGCCTTTCCGGG
TGGGCGAATATATAGACGCGGGCGGAATCGCCGGCACGGTGGAGGAAATCGGCCTCTTCGCCACGGAATTGCAGTCTGCC
GACGGGGTTTATGTGATGGCGCCGAACAGTGAGCTGTGGAACAAGGCCGTCACCAATTATTCGCGCAATGCCCTACGCCG
GAACGATATTGCCATTGGCATCGGTTATGAGGACGATATCGACCTCGCCCAGGAGCTCCTGCTGAAATTGGCGCAAGGCG
ACCAGAGGGTCCTCGCTGTACCAGCACCGGAAACCTTCGTCGGCGCGCTCGGCGACAGCGCCGTCATGGTAACGGTCCGC
TACTGGACCGCGACCACCGATTACTGGGCGGTGCGTTTCGATATCACCAAGGCCGCCAAGCAGGCATTTGACGCCAACGG
CATCTCCATCCCCTTCCCCCAACGGCAGATACATTTCGTGCAGGGCGAGGATACGCCTCCGCGCGCCAATACCAGCCAGA
AAGCCGCGGCAGGCTGA

Upstream 100 bases:

>100_bases
GCCGGACCATTAACCTGATCCTTATTGGCACCATACACGCGGCTGATTCGACTCTGCCTTTCCGCATTGTGTATACCGCC
GCTAAGATACGGAGGGATGC

Downstream 100 bases:

>100_bases
TCGCCTGCCCAACAGCAGGCTAGCCGAAAAGCAATGCGGGGCCCGAAGGCCCCGCACCAATCCATCAGATCAGACTGGCA
TCAGGCAGCGGCAATCTTGC

Product: MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MDFDAAENNILTTAEAAWLQVQEFAVSYALSILGAIILILVGFIAAGILARWTRAALGRLPGVDETLRRFLSKIVRYAVL
ILVGVTVLAQFGVQTASIIAALGAVGLAIGLALQGTLQNIAAGIMLLALKPFRVGEYIDAGGIAGTVEEIGLFATELQSA
DGVYVMAPNSELWNKAVTNYSRNALRRNDIAIGIGYEDDIDLAQELLLKLAQGDQRVLAVPAPETFVGALGDSAVMVTVR
YWTATTDYWAVRFDITKAAKQAFDANGISIPFPQRQIHFVQGEDTPPRANTSQKAAAG

Sequences:

>Translated_298_residues
MDFDAAENNILTTAEAAWLQVQEFAVSYALSILGAIILILVGFIAAGILARWTRAALGRLPGVDETLRRFLSKIVRYAVL
ILVGVTVLAQFGVQTASIIAALGAVGLAIGLALQGTLQNIAAGIMLLALKPFRVGEYIDAGGIAGTVEEIGLFATELQSA
DGVYVMAPNSELWNKAVTNYSRNALRRNDIAIGIGYEDDIDLAQELLLKLAQGDQRVLAVPAPETFVGALGDSAVMVTVR
YWTATTDYWAVRFDITKAAKQAFDANGISIPFPQRQIHFVQGEDTPPRANTSQKAAAG
>Mature_298_residues
MDFDAAENNILTTAEAAWLQVQEFAVSYALSILGAIILILVGFIAAGILARWTRAALGRLPGVDETLRRFLSKIVRYAVL
ILVGVTVLAQFGVQTASIIAALGAVGLAIGLALQGTLQNIAAGIMLLALKPFRVGEYIDAGGIAGTVEEIGLFATELQSA
DGVYVMAPNSELWNKAVTNYSRNALRRNDIAIGIGYEDDIDLAQELLLKLAQGDQRVLAVPAPETFVGALGDSAVMVTVR
YWTATTDYWAVRFDITKAAKQAFDANGISIPFPQRQIHFVQGEDTPPRANTSQKAAAG

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=267, Percent_Identity=40.4494382022472, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786670, Length=211, Percent_Identity=27.0142180094787, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787591, Length=237, Percent_Identity=27.4261603375527, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI2367355, Length=219, Percent_Identity=24.2009132420091, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 31793; Mature: 31793

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDAAENNILTTAEAAWLQVQEFAVSYALSILGAIILILVGFIAAGILARWTRAALGRL
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGVDETLRRFLSKIVRYAVLILVGVTVLAQFGVQTASIIAALGAVGLAIGLALQGTLQNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGIMLLALKPFRVGEYIDAGGIAGTVEEIGLFATELQSADGVYVMAPNSELWNKAVTNY
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
SRNALRRNDIAIGIGYEDDIDLAQELLLKLAQGDQRVLAVPAPETFVGALGDSAVMVTVR
HHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEEEE
YWTATTDYWAVRFDITKAAKQAFDANGISIPFPQRQIHFVQGEDTPPRANTSQKAAAG
EEEECCCEEEEEEEHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFDAAENNILTTAEAAWLQVQEFAVSYALSILGAIILILVGFIAAGILARWTRAALGRL
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGVDETLRRFLSKIVRYAVLILVGVTVLAQFGVQTASIIAALGAVGLAIGLALQGTLQNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGIMLLALKPFRVGEYIDAGGIAGTVEEIGLFATELQSADGVYVMAPNSELWNKAVTNY
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
SRNALRRNDIAIGIGYEDDIDLAQELLLKLAQGDQRVLAVPAPETFVGALGDSAVMVTVR
HHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEEEE
YWTATTDYWAVRFDITKAAKQAFDANGISIPFPQRQIHFVQGEDTPPRANTSQKAAAG
EEEECCCEEEEEEEHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]