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The map label for this gene is slt [H]

Identifier: 110633294

GI number: 110633294

Start: 1036781

End: 1038823

Strand: Reverse

Name: slt [H]

Synonym: Meso_0940

Alternate gene names: 110633294

Gene position: 1038823-1036781 (Counterclockwise)

Preceding gene: 110633297

Following gene: 110633292

Centisome position: 23.54

GC content: 63.83

Gene sequence:

>2043_bases
ATGAAAAAGGCTGCGCTCACGGCGTTAGCGATCGTGCTTTCCAACGGAAGCGCTGCGTACGCATTTGAATTGCCGGCGGA
CGCTCCCCTGCCGCAATCCAGACCCTATGCCCCCATGGACAAGGCGGCTGCCGCGGCCTCTCTCCCCTTTACGGCCGGAC
TTCTTCTGGAAGAGCACCTCGAAAGCTTGAAGGAAGGGCTCGATGCCCTGGAGAGCGGCGATATCGCCGGAGCAAAGCAG
GCGCGCAGCGCGCTGGCACCCGATTCCCTCGATTACCGGATCCTTTCCTGGGCTATCGCCATGTCGGGCGGTACCGGAAG
CGCGGAGATCGCCGACATTGCCGACATGCTTTCCGGCTGGCCGGGGAAATCACGGCTGCGGGAGAACAGCGAACGCGCCC
TTTATTGGGAAAAGCCGACGGCGCAACAGGTGATCGCAGCCTTCGGCCGCTCGCGGCCCAGCACTTATCAAGGAGCGGTT
GCGCTCGCCCGCGCCCATCTGGAACTCGGGAACACCGATGCCGCGCAGGCGGCGCTTTCTCCCCTGTGGCGGGAGGAGAC
GCTGGACCCCAAGCAGGAAGTGGCAATCCTCAATGAATTCGGCGATGTGATTCCCGTTTCCGATCACCGGCACCGCATAG
AGCGCATGCTCTATGAGGAACGCATCCGTTCCGCCGAGCGCGTCGCCGAGCGCGCGGGAGCCGAGGCGTTGGTAAAGGCT
TGGGCAGCCGTTATTCGCGGCGAAGCCAAGGCCGGAGAGCTTTTGGACGCGGTGCCCGCCGCGCAGCGGTCTGCCGGGTA
TTATTTCGCCAAGGCACGCCACCTGCGCCGGGCGGAGAAATTCAGCGAAGCGGCCGAGGCGATGCTTGCTGCCCCGCGCG
ACGCCTCCATGCTGATCGATGCCGATGAGATGTGGTTCGAACGGCGGGTTCTTTCGCGGGAGCTTCTGGATCACGGCGAT
GCACGCCTTGCCTATCGCATTGCCGCCGCTCATCTGGGCGGCAGCAAGGCCAGCATGGCCGATGCCGCGTTCCACGCCGG
CTGGTATGCGCTGCGGAGCCTGAACGACGCCAAATTGGCGGAGCCTCACTTTGCCCGCATCGCGAAGATCGCCGATGGTC
CGATTTCCAAGGCACGCGCCTATTATTGGCTTGGCCGCGCGGCTGACGCGGGCGCTCCGGGAGACGCCACCCGCTTTTAC
GAGCAGGCCGCCGCCTATGGAGCGACCTTCTACGGCCAGCTTTCAGCAGCCCGCCTCGGACGCAAGATCATCGCCGGGAG
CCCGGATCCCAGCGCAACGGACCGGAAGAATTTCTCGGCGCGGGAACCTGTTCTTGCCATCGCCCGGCTGGAAAAAGCCG
GCCAAATACGCCTCGCCGGCATTCTCTACCGCGATCTCGCACAAGAACTTTCGAGCACGGGAGAGCTGGCGCTGCTTGGA
CAGCTCGCAGAGCGGAAAGGCGACCATAATCTCGCATTGCGTGTGGGCAAGATAGCCGCCGCGCGCGGCCTCGAAATCGG
CGCCCTGGCGCATCCGATCGGCGCCATCCCGGAAAAGGCGTCCATAGAAGGCGCCGGCAAGGCACTCGCTTATGCGATCG
CTCGCCAGGAAAGCGAGTTCAATGCAGAGGCTGTCTCCCACGCCGGAGCGCGCGGCCTCCTGCAACTCATGCCGGCGACG
GCCAAAATGGTGGCGAAAAAGGAAGGCCTGCCCTACTCGGCCGCGAAGCTTACTTCGGATGCCGGCTACAATGCCACGCT
CGGCGCGGCCTATCTGAGCGACCAGCTCGAACGCTTCGACGGCTCCTATATTCTCACCTTCATCGGCTACAATGCCGGGC
CCAGCCGCGCCAACGAATGGATGGAGCGCTATGGCGATCCGCGCGGAAAGCCAATCGAGGAGGTGGTCGACTGGATCGAG
CGCATCCCCTTCACCGAAACGCGCAATTATGTGCAGCGCGTGATGGAGAATTACCAAGTCTACAAGATGCGGCTCACGGG
CCGGTTCGATATCGTGGAAGACCTGGTGAGCGGGCGCGGATAG

Upstream 100 bases:

>100_bases
CCTTTGCGATTACGCTCGTCAGCAAGCGTTTCACCTCTCGGGCGGGTAAAAGGGGGCGGGCATCTTCGCCATCAAGAGCC
CGAACATACGGGGTTGTTCC

Downstream 100 bases:

>100_bases
CCGCTGAAGAGCAGATCATTTATCGCGACAACAAAGCGTTCTTCAAAGAAAAACCCGGCGGGCAAGCCCGCCGGGTCTTT
TAGGCTTTCTTCTAAATCAG

Product: lytic transglycosylase, catalytic

Products: 1,6-Anhydrobond [C]

Alternate protein names: Peptidoglycan lytic exotransglycosylase [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MKKAALTALAIVLSNGSAAYAFELPADAPLPQSRPYAPMDKAAAAASLPFTAGLLLEEHLESLKEGLDALESGDIAGAKQ
ARSALAPDSLDYRILSWAIAMSGGTGSAEIADIADMLSGWPGKSRLRENSERALYWEKPTAQQVIAAFGRSRPSTYQGAV
ALARAHLELGNTDAAQAALSPLWREETLDPKQEVAILNEFGDVIPVSDHRHRIERMLYEERIRSAERVAERAGAEALVKA
WAAVIRGEAKAGELLDAVPAAQRSAGYYFAKARHLRRAEKFSEAAEAMLAAPRDASMLIDADEMWFERRVLSRELLDHGD
ARLAYRIAAAHLGGSKASMADAAFHAGWYALRSLNDAKLAEPHFARIAKIADGPISKARAYYWLGRAADAGAPGDATRFY
EQAAAYGATFYGQLSAARLGRKIIAGSPDPSATDRKNFSAREPVLAIARLEKAGQIRLAGILYRDLAQELSSTGELALLG
QLAERKGDHNLALRVGKIAAARGLEIGALAHPIGAIPEKASIEGAGKALAYAIARQESEFNAEAVSHAGARGLLQLMPAT
AKMVAKKEGLPYSAAKLTSDAGYNATLGAAYLSDQLERFDGSYILTFIGYNAGPSRANEWMERYGDPRGKPIEEVVDWIE
RIPFTETRNYVQRVMENYQVYKMRLTGRFDIVEDLVSGRG

Sequences:

>Translated_680_residues
MKKAALTALAIVLSNGSAAYAFELPADAPLPQSRPYAPMDKAAAAASLPFTAGLLLEEHLESLKEGLDALESGDIAGAKQ
ARSALAPDSLDYRILSWAIAMSGGTGSAEIADIADMLSGWPGKSRLRENSERALYWEKPTAQQVIAAFGRSRPSTYQGAV
ALARAHLELGNTDAAQAALSPLWREETLDPKQEVAILNEFGDVIPVSDHRHRIERMLYEERIRSAERVAERAGAEALVKA
WAAVIRGEAKAGELLDAVPAAQRSAGYYFAKARHLRRAEKFSEAAEAMLAAPRDASMLIDADEMWFERRVLSRELLDHGD
ARLAYRIAAAHLGGSKASMADAAFHAGWYALRSLNDAKLAEPHFARIAKIADGPISKARAYYWLGRAADAGAPGDATRFY
EQAAAYGATFYGQLSAARLGRKIIAGSPDPSATDRKNFSAREPVLAIARLEKAGQIRLAGILYRDLAQELSSTGELALLG
QLAERKGDHNLALRVGKIAAARGLEIGALAHPIGAIPEKASIEGAGKALAYAIARQESEFNAEAVSHAGARGLLQLMPAT
AKMVAKKEGLPYSAAKLTSDAGYNATLGAAYLSDQLERFDGSYILTFIGYNAGPSRANEWMERYGDPRGKPIEEVVDWIE
RIPFTETRNYVQRVMENYQVYKMRLTGRFDIVEDLVSGRG
>Mature_680_residues
MKKAALTALAIVLSNGSAAYAFELPADAPLPQSRPYAPMDKAAAAASLPFTAGLLLEEHLESLKEGLDALESGDIAGAKQ
ARSALAPDSLDYRILSWAIAMSGGTGSAEIADIADMLSGWPGKSRLRENSERALYWEKPTAQQVIAAFGRSRPSTYQGAV
ALARAHLELGNTDAAQAALSPLWREETLDPKQEVAILNEFGDVIPVSDHRHRIERMLYEERIRSAERVAERAGAEALVKA
WAAVIRGEAKAGELLDAVPAAQRSAGYYFAKARHLRRAEKFSEAAEAMLAAPRDASMLIDADEMWFERRVLSRELLDHGD
ARLAYRIAAAHLGGSKASMADAAFHAGWYALRSLNDAKLAEPHFARIAKIADGPISKARAYYWLGRAADAGAPGDATRFY
EQAAAYGATFYGQLSAARLGRKIIAGSPDPSATDRKNFSAREPVLAIARLEKAGQIRLAGILYRDLAQELSSTGELALLG
QLAERKGDHNLALRVGKIAAARGLEIGALAHPIGAIPEKASIEGAGKALAYAIARQESEFNAEAVSHAGARGLLQLMPAT
AKMVAKKEGLPYSAAKLTSDAGYNATLGAAYLSDQLERFDGSYILTFIGYNAGPSRANEWMERYGDPRGKPIEEVVDWIE
RIPFTETRNYVQRVMENYQVYKMRLTGRFDIVEDLVSGRG

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082441, Length=130, Percent_Identity=38.4615384615385, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011989
- InterPro:   IPR016026
- InterPro:   IPR008258
- InterPro:   IPR012289
- InterPro:   IPR008939
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 73467; Mature: 73467

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAALTALAIVLSNGSAAYAFELPADAPLPQSRPYAPMDKAAAAASLPFTAGLLLEEHL
CCHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
ESLKEGLDALESGDIAGAKQARSALAPDSLDYRILSWAIAMSGGTGSAEIADIADMLSGW
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHCCC
PGKSRLRENSERALYWEKPTAQQVIAAFGRSRPSTYQGAVALARAHLELGNTDAAQAALS
CCHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
PLWREETLDPKQEVAILNEFGDVIPVSDHRHRIERMLYEERIRSAERVAERAGAEALVKA
HHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
WAAVIRGEAKAGELLDAVPAAQRSAGYYFAKARHLRRAEKFSEAAEAMLAAPRDASMLID
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
ADEMWFERRVLSRELLDHGDARLAYRIAAAHLGGSKASMADAAFHAGWYALRSLNDAKLA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
EPHFARIAKIADGPISKARAYYWLGRAADAGAPGDATRFYEQAAAYGATFYGQLSAARLG
CHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHC
RKIIAGSPDPSATDRKNFSAREPVLAIARLEKAGQIRLAGILYRDLAQELSSTGELALLG
CHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCCHHHH
QLAERKGDHNLALRVGKIAAARGLEIGALAHPIGAIPEKASIEGAGKALAYAIARQESEF
HHHHCCCCCCEEEEEHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
NAEAVSHAGARGLLQLMPATAKMVAKKEGLPYSAAKLTSDAGYNATLGAAYLSDQLERFD
CHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCC
GSYILTFIGYNAGPSRANEWMERYGDPRGKPIEEVVDWIERIPFTETRNYVQRVMENYQV
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCEE
YKMRLTGRFDIVEDLVSGRG
EEEEECCCHHHHHHHHCCCC
>Mature Secondary Structure
MKKAALTALAIVLSNGSAAYAFELPADAPLPQSRPYAPMDKAAAAASLPFTAGLLLEEHL
CCHHHHHHHHHHEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHH
ESLKEGLDALESGDIAGAKQARSALAPDSLDYRILSWAIAMSGGTGSAEIADIADMLSGW
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHCCC
PGKSRLRENSERALYWEKPTAQQVIAAFGRSRPSTYQGAVALARAHLELGNTDAAQAALS
CCHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
PLWREETLDPKQEVAILNEFGDVIPVSDHRHRIERMLYEERIRSAERVAERAGAEALVKA
HHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
WAAVIRGEAKAGELLDAVPAAQRSAGYYFAKARHLRRAEKFSEAAEAMLAAPRDASMLID
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
ADEMWFERRVLSRELLDHGDARLAYRIAAAHLGGSKASMADAAFHAGWYALRSLNDAKLA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
EPHFARIAKIADGPISKARAYYWLGRAADAGAPGDATRFYEQAAAYGATFYGQLSAARLG
CHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHC
RKIIAGSPDPSATDRKNFSAREPVLAIARLEKAGQIRLAGILYRDLAQELSSTGELALLG
CHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCCCCCHHHH
QLAERKGDHNLALRVGKIAAARGLEIGALAHPIGAIPEKASIEGAGKALAYAIARQESEF
HHHHCCCCCCEEEEEHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
NAEAVSHAGARGLLQLMPATAKMVAKKEGLPYSAAKLTSDAGYNATLGAAYLSDQLERFD
CHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCC
GSYILTFIGYNAGPSRANEWMERYGDPRGKPIEEVVDWIERIPFTETRNYVQRVMENYQV
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCEE
YKMRLTGRFDIVEDLVSGRG
EEEEECCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]