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The map label for this gene is mmgC [H]

Identifier: 110633285

GI number: 110633285

Start: 1028341

End: 1029501

Strand: Reverse

Name: mmgC [H]

Synonym: Meso_0931

Alternate gene names: 110633285

Gene position: 1029501-1028341 (Counterclockwise)

Preceding gene: 110633287

Following gene: 110633284

Centisome position: 23.33

GC content: 64.0

Gene sequence:

>1161_bases
ATGTACACGAACACAATGAATTTCGGGCTCGGCGAGGACATCGACGCGCTGCGGGACATGGTGGGCCGCTTCGCCCGCGA
GCGGATCGGGCCCATCGCGGCCGAGATCGACCGCGAAAACGAGTTCCCTGCCCATCTCTGGAAGGAAATGGGTGATCTTG
GCCTGCTCGGCATCACCGTCGAGCCCGAGTTTGGCGGCTCAGGCCTCGGCTATCTTGCCCATGTGGTTGCGATGGAGGAG
ATTTCGCGCGCCTCCGCCTCAGTCGGGCTCTCCTATGGCGCGCATTCCAATCTCTGCGTCAACCAGATCCGCCGCTGGGG
CACGCCCGAGCAGAAGCAGAACTATCTCCCGGCCTTGTGCGCCGGCCAAACTGTCGGCGCGCTCGCCATGTCCGAGACGG
GGGCTGGCTCAGACGTGGTCTCGATGAAGCTCAGGGCAGAAAAGAAAAACGACCGCTTCGTGCTCAACGGCTCTAAGATG
TGGATCACCAACGGACCGGATGCCGGCACGCTCGTGGTCTACGCCACGACTGATCTCGCGGTCGGGCCGCGTGGCATAAC
CGCCTTCATCGTCGAGCGCTCCATGCCCGGTTTCTCGGTGGCGCAAAAGCTAGATAAGCTGGGGATGCGCGGCTCCAACA
CGGGCGAGCTGGTTTTCGAGGATGTCGAGGTGCCTTTCGAAAATATGCTTGGCGAGGAAGGGCACGGCGTGGAGATCCTC
ATGTCCGGCCTTGACTATGAGCGCGTGGTGCTCTCGGGCGGGCCGCTCGGCATCATGGCCGCCTGCCTGGACGCCACCGT
GCCCTATGTGCGCGAGCGCCAGCAATTCGGCCAGCCCGTCGGCTCTTTCCAGCTCGTGCAGGGCAAGCTCGCCGACATGT
ACACAACGCTTAATGCCTGCCGCGCTTACGTCTACGCCGTCGCTGCTGCCTGCGATCGCGGCGAAACCACCCGCAAGGAT
GCCGCCGGCTGTATTCTCTACGCCGCCGAGCGCGCCACCCGCATGGCGCTCGACGCCATCCAGCTTCTGGGCGGGAACGG
GTATATCAACGAGTTCCCCACCGGCCGGCTGCTGCGCGACGCCAAGCTCTACGAGATTGGCGCGGGAACGAGCGAGATCA
GACGATGGCTGATCGGCCGGGAGATCGTGGCGGAGAACTGA

Upstream 100 bases:

>100_bases
TGCGGAGCGGCATTGGGTTCCCTCACATCATTGGAGTGGCTCTTTCCGAACCCGCCGACGCAGAATACCTATGGAAAGGC
CAGAGCGCGTGGGAGGAGTG

Downstream 100 bases:

>100_bases
TCGCGCGCCCGAAACGCCCTATCGAGGAACACTCACCCGCGAGAGAAGGAAACCATGCCCGTCATCCCCTCCCAGCTCTC
CACCGCTGCCGAATCTTTCC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MYTNTMNFGLGEDIDALRDMVGRFARERIGPIAAEIDRENEFPAHLWKEMGDLGLLGITVEPEFGGSGLGYLAHVVAMEE
ISRASASVGLSYGAHSNLCVNQIRRWGTPEQKQNYLPALCAGQTVGALAMSETGAGSDVVSMKLRAEKKNDRFVLNGSKM
WITNGPDAGTLVVYATTDLAVGPRGITAFIVERSMPGFSVAQKLDKLGMRGSNTGELVFEDVEVPFENMLGEEGHGVEIL
MSGLDYERVVLSGGPLGIMAACLDATVPYVRERQQFGQPVGSFQLVQGKLADMYTTLNACRAYVYAVAAACDRGETTRKD
AAGCILYAAERATRMALDAIQLLGGNGYINEFPTGRLLRDAKLYEIGAGTSEIRRWLIGREIVAEN

Sequences:

>Translated_386_residues
MYTNTMNFGLGEDIDALRDMVGRFARERIGPIAAEIDRENEFPAHLWKEMGDLGLLGITVEPEFGGSGLGYLAHVVAMEE
ISRASASVGLSYGAHSNLCVNQIRRWGTPEQKQNYLPALCAGQTVGALAMSETGAGSDVVSMKLRAEKKNDRFVLNGSKM
WITNGPDAGTLVVYATTDLAVGPRGITAFIVERSMPGFSVAQKLDKLGMRGSNTGELVFEDVEVPFENMLGEEGHGVEIL
MSGLDYERVVLSGGPLGIMAACLDATVPYVRERQQFGQPVGSFQLVQGKLADMYTTLNACRAYVYAVAAACDRGETTRKD
AAGCILYAAERATRMALDAIQLLGGNGYINEFPTGRLLRDAKLYEIGAGTSEIRRWLIGREIVAEN
>Mature_386_residues
MYTNTMNFGLGEDIDALRDMVGRFARERIGPIAAEIDRENEFPAHLWKEMGDLGLLGITVEPEFGGSGLGYLAHVVAMEE
ISRASASVGLSYGAHSNLCVNQIRRWGTPEQKQNYLPALCAGQTVGALAMSETGAGSDVVSMKLRAEKKNDRFVLNGSKM
WITNGPDAGTLVVYATTDLAVGPRGITAFIVERSMPGFSVAQKLDKLGMRGSNTGELVFEDVEVPFENMLGEEGHGVEIL
MSGLDYERVVLSGGPLGIMAACLDATVPYVRERQQFGQPVGSFQLVQGKLADMYTTLNACRAYVYAVAAACDRGETTRKD
AAGCILYAAERATRMALDAIQLLGGNGYINEFPTGRLLRDAKLYEIGAGTSEIRRWLIGREIVAEN

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=64.5669291338583, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=67.2514619883041, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=41.5143603133159, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI4501859, Length=369, Percent_Identity=37.940379403794, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=35.0267379679144, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=35.1706036745407, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=35.1706036745407, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=32.1148825065274, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI21361497, Length=375, Percent_Identity=33.6, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=33.2467532467532, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=33.2467532467532, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI4503943, Length=383, Percent_Identity=31.0704960835509, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI7669494, Length=379, Percent_Identity=31.6622691292876, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=26.7605633802817, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=26.7605633802817, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI38505218, Length=378, Percent_Identity=23.015873015873, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=29.9479166666667, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=30.4909560723514, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87082384, Length=285, Percent_Identity=27.719298245614, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081702, Length=333, Percent_Identity=24.9249249249249, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=61.0526315789474, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17506239, Length=364, Percent_Identity=35.989010989011, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=35.5795148247978, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.1706036745407, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=35, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=32.6370757180157, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=321, Percent_Identity=36.4485981308411, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=30.8900523560209, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.5714285714286, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.7664233576642, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.961038961039, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=31.8801089918256, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=30.6666666666667, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=34.5070422535211, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=29.5514511873351, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=31.1475409836066, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21355753, Length=387, Percent_Identity=62.5322997416021, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=40.9574468085106, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.2978723404255, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=36.4611260053619, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=38.2198952879581, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI281363737, Length=347, Percent_Identity=37.1757925072046, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=28.7564766839378, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41739; Mature: 41739

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTNTMNFGLGEDIDALRDMVGRFARERIGPIAAEIDRENEFPAHLWKEMGDLGLLGITV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCEEEEEEE
EPEFGGSGLGYLAHVVAMEEISRASASVGLSYGAHSNLCVNQIRRWGTPEQKQNYLPALC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHCCCCHHH
AGQTVGALAMSETGAGSDVVSMKLRAEKKNDRFVLNGSKMWITNGPDAGTLVVYATTDLA
CCCCHHHEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCE
VGPRGITAFIVERSMPGFSVAQKLDKLGMRGSNTGELVFEDVEVPFENMLGEEGHGVEIL
ECCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCEEE
MSGLDYERVVLSGGPLGIMAACLDATVPYVRERQQFGQPVGSFQLVQGKLADMYTTLNAC
ECCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYVYAVAAACDRGETTRKDAAGCILYAAERATRMALDAIQLLGGNGYINEFPTGRLLRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRWLIGREIVAEN
CEEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYTNTMNFGLGEDIDALRDMVGRFARERIGPIAAEIDRENEFPAHLWKEMGDLGLLGITV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHCCCCEEEEEEE
EPEFGGSGLGYLAHVVAMEEISRASASVGLSYGAHSNLCVNQIRRWGTPEQKQNYLPALC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHCCCCHHH
AGQTVGALAMSETGAGSDVVSMKLRAEKKNDRFVLNGSKMWITNGPDAGTLVVYATTDLA
CCCCHHHEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCE
VGPRGITAFIVERSMPGFSVAQKLDKLGMRGSNTGELVFEDVEVPFENMLGEEGHGVEIL
ECCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCEEE
MSGLDYERVVLSGGPLGIMAACLDATVPYVRERQQFGQPVGSFQLVQGKLADMYTTLNAC
ECCCCEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RAYVYAVAAACDRGETTRKDAAGCILYAAERATRMALDAIQLLGGNGYINEFPTGRLLRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRWLIGREIVAEN
CEEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]