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The map label for this gene is yngE [H]

Identifier: 110633284

GI number: 110633284

Start: 1026679

End: 1028286

Strand: Reverse

Name: yngE [H]

Synonym: Meso_0930

Alternate gene names: 110633284

Gene position: 1028286-1026679 (Counterclockwise)

Preceding gene: 110633285

Following gene: 110633283

Centisome position: 23.3

GC content: 64.24

Gene sequence:

>1608_bases
ATGCCCGTCATCCCCTCCCAGCTCTCCACCGCTGCCGAATCTTTCCGCGCCAACGAAGCGCGTATGAAGTCGCTGGTCTC
CGAAATGGCCGAGAAGGCTGCAGCCATCGAGCGCGGCGGCTCCGACGAAGCCCGTGCCCGGCACACCGCGCGCGGCAAGC
TCTTGCCGCGTGAGCGCCTAGCGCAGCTCCTCGATGTGGGGGCGCCCCTCCTGGAGATCGGGCAGTTCGCCGCCTTCGGC
CTGTATGAGGGCGACATCGCGTCGGCCGGGCTCATTGCCGGCATAGGCCGCGTCGAGGGCCGCGAGGTGATGGTCGTCGT
CAACGATGCCACTGTGAAGGGCGGAACCTATTATCCCCTCACCGTGAAAAAGCACCTGCGCGCGCAGGAGATCGCGCTCG
AGAACAATCTGCCCTGCATCTATCTGGTCGATTCGGGCGGTGCGAACCTGCCCAACCAGGACGAGGTTTTCCCGGACCGC
GACCATTTCGGCCGCATTTTCTATAACCAGGCCACGATGTCGGCGCGGGGCATCCCGCAGATCGCCTGCGTTATGGGCTC
GTGCACGGCAGGCGGCGCCTATGTGCCAGCCATGTCCGACGAGACCGTGATGGTGAAGGGCAACGCCACCATCTTCCTCG
GCGGCCCTCCCCTCGTGAAGGCAGCCACCGGCGAGGTGGTGACGGCGGAAGAATTAGGCGGCGCCGAAGTGCACACGCGC
CTTTCAGGCGTCGCCGACCACTACGCGGTGAACGATGAACACGCTCTCGCCATCGTCCGACGCATCGTCAAAAACCTGAA
TCGGAAGAAGACGATCGGGCTCGATCTTCAGAAAGTGATTCCGCCGCTTTACGACCCGCGCGAGATCTACGGCATCATCC
CGGCCGATGTGCGCCAGCCCTACGATGTGCGAGAGGTGATCGCGCGCATCGTCGACGGCTCGGAGCTCGACGAGTTCAAG
CAGAACTACGGCGCGACACTCGTGACCGGCTTTGCCCATCTGCACGGCATGCCCGTCGGCATCATCGCAAACAACGGCGT
GCTGTTCTCCGAATCCGCGCTCAAGGGCGCGCACTTCATCGAGCTTTGCTGCCAGCGCAAGATCCCCCTCCTCTTCCTCC
AGAACATCACGGGGTTCATGGTCGGGGCGAAATACGAGGCGGGCGGCATTGCCAAGGACGGCGCCAAGCTCGTCACCGCC
GTCGCCACGGCCCAGGTGCCGAAGATCACAGCCATCATCGGCGGCTCCTTTGGGGCTGGGAATTACGGCATGTGCGGCCG
CGCCTTCTCGCCGCGCTTCTTATGGATGTGGCCCAACGCGCGCATCTCCGTCATGGGCGGAGAGCAGGCCGCGACGGTGC
TTGCCATCGTCAAGCGTGAGGGCATTGAGCGAAAGGGCGGCTCATGGACTGCCGAGGAGGAAGCCGAGTTCAAGAAGCCG
ATCCTCGAAAAATATGAGCGCGAAGGCCACCCGCTCTATTCCTCCGCGCGGCTGTGGGACGACGGCATCATCGATCCGGC
GAAGACACGCGACGTCCTTGCGCTCTCCCTATCCGCCGCCCTCAACGCGCCGATCGGGGAGACGCGGTTCGGTGTGTTCA
GGATGTGA

Upstream 100 bases:

>100_bases
GATCAGACGATGGCTGATCGGCCGGGAGATCGTGGCGGAGAACTGATCGCGCGCCCGAAACGCCCTATCGAGGAACACTC
ACCCGCGAGAGAAGGAAACC

Downstream 100 bases:

>100_bases
GATGTAACAAGAAAATTTTCCTAGTTTTATCCCCACTCTTTTCCGCCCGCTTACACTTCCCGCCACGCAACGGGCGTGGC
GGGAAGGATGATGGAAGATA

Product: carboxyl transferase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPVIPSQLSTAAESFRANEARMKSLVSEMAEKAAAIERGGSDEARARHTARGKLLPRERLAQLLDVGAPLLEIGQFAAFG
LYEGDIASAGLIAGIGRVEGREVMVVVNDATVKGGTYYPLTVKKHLRAQEIALENNLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQATMSARGIPQIACVMGSCTAGGAYVPAMSDETVMVKGNATIFLGGPPLVKAATGEVVTAEELGGAEVHTR
LSGVADHYAVNDEHALAIVRRIVKNLNRKKTIGLDLQKVIPPLYDPREIYGIIPADVRQPYDVREVIARIVDGSELDEFK
QNYGATLVTGFAHLHGMPVGIIANNGVLFSESALKGAHFIELCCQRKIPLLFLQNITGFMVGAKYEAGGIAKDGAKLVTA
VATAQVPKITAIIGGSFGAGNYGMCGRAFSPRFLWMWPNARISVMGGEQAATVLAIVKREGIERKGGSWTAEEEAEFKKP
ILEKYEREGHPLYSSARLWDDGIIDPAKTRDVLALSLSAALNAPIGETRFGVFRM

Sequences:

>Translated_535_residues
MPVIPSQLSTAAESFRANEARMKSLVSEMAEKAAAIERGGSDEARARHTARGKLLPRERLAQLLDVGAPLLEIGQFAAFG
LYEGDIASAGLIAGIGRVEGREVMVVVNDATVKGGTYYPLTVKKHLRAQEIALENNLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQATMSARGIPQIACVMGSCTAGGAYVPAMSDETVMVKGNATIFLGGPPLVKAATGEVVTAEELGGAEVHTR
LSGVADHYAVNDEHALAIVRRIVKNLNRKKTIGLDLQKVIPPLYDPREIYGIIPADVRQPYDVREVIARIVDGSELDEFK
QNYGATLVTGFAHLHGMPVGIIANNGVLFSESALKGAHFIELCCQRKIPLLFLQNITGFMVGAKYEAGGIAKDGAKLVTA
VATAQVPKITAIIGGSFGAGNYGMCGRAFSPRFLWMWPNARISVMGGEQAATVLAIVKREGIERKGGSWTAEEEAEFKKP
ILEKYEREGHPLYSSARLWDDGIIDPAKTRDVLALSLSAALNAPIGETRFGVFRM
>Mature_534_residues
PVIPSQLSTAAESFRANEARMKSLVSEMAEKAAAIERGGSDEARARHTARGKLLPRERLAQLLDVGAPLLEIGQFAAFGL
YEGDIASAGLIAGIGRVEGREVMVVVNDATVKGGTYYPLTVKKHLRAQEIALENNLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQATMSARGIPQIACVMGSCTAGGAYVPAMSDETVMVKGNATIFLGGPPLVKAATGEVVTAEELGGAEVHTRL
SGVADHYAVNDEHALAIVRRIVKNLNRKKTIGLDLQKVIPPLYDPREIYGIIPADVRQPYDVREVIARIVDGSELDEFKQ
NYGATLVTGFAHLHGMPVGIIANNGVLFSESALKGAHFIELCCQRKIPLLFLQNITGFMVGAKYEAGGIAKDGAKLVTAV
ATAQVPKITAIIGGSFGAGNYGMCGRAFSPRFLWMWPNARISVMGGEQAATVLAIVKREGIERKGGSWTAEEEAEFKKPI
LEKYEREGHPLYSSARLWDDGIIDPAKTRDVLALSLSAALNAPIGETRFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=531, Percent_Identity=63.8418079096045, Blast_Score=704, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=540, Percent_Identity=33.1481481481482, Blast_Score=236, Evalue=6e-62,
Organism=Homo sapiens, GI295821216, Length=560, Percent_Identity=31.9642857142857, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=55.3030303030303, Blast_Score=143, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=61.5384615384615, Blast_Score=696, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=527, Percent_Identity=32.8273244781784, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI25147359, Length=531, Percent_Identity=32.9566854990584, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=62, Blast_Score=692, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57562; Mature: 57431

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIPSQLSTAAESFRANEARMKSLVSEMAEKAAAIERGGSDEARARHTARGKLLPRERL
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHH
AQLLDVGAPLLEIGQFAAFGLYEGDIASAGLIAGIGRVEGREVMVVVNDATVKGGTYYPL
HHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCEECCCEEEEE
TVKKHLRAQEIALENNLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQATMSARGIPQ
EHHHHCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEECHHHCCCCCCC
IACVMGSCTAGGAYVPAMSDETVMVKGNATIFLGGPPLVKAATGEVVTAEELGGAEVHTR
EEHEECCCCCCCEEECCCCCCEEEEECCEEEEECCCCEEEECCCCEEEHHHCCCHHHHHH
LSGVADHYAVNDEHALAIVRRIVKNLNRKKTIGLDLQKVIPPLYDPREIYGIIPADVRQP
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCEEEECCHHCCCC
YDVREVIARIVDGSELDEFKQNYGATLVTGFAHLHGMPVGIIANNGVLFSESALKGAHFI
CCHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHCCCEEEEEECCCEEEECHHHCCHHHH
ELCCQRKIPLLFLQNITGFMVGAKYEAGGIAKDGAKLVTAVATAQVPKITAIIGGSFGAG
HHHHHCCCCEEEHHCCCCEEEECEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAFSPRFLWMWPNARISVMGGEQAATVLAIVKREGIERKGGSWTAEEEAEFKKP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ILEKYEREGHPLYSSARLWDDGIIDPAKTRDVLALSLSAALNAPIGETRFGVFRM
HHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHEEEEHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
PVIPSQLSTAAESFRANEARMKSLVSEMAEKAAAIERGGSDEARARHTARGKLLPRERL
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHH
AQLLDVGAPLLEIGQFAAFGLYEGDIASAGLIAGIGRVEGREVMVVVNDATVKGGTYYPL
HHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCEECCCEEEEE
TVKKHLRAQEIALENNLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQATMSARGIPQ
EHHHHCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEECHHHCCCCCCC
IACVMGSCTAGGAYVPAMSDETVMVKGNATIFLGGPPLVKAATGEVVTAEELGGAEVHTR
EEHEECCCCCCCEEECCCCCCEEEEECCEEEEECCCCEEEECCCCEEEHHHCCCHHHHHH
LSGVADHYAVNDEHALAIVRRIVKNLNRKKTIGLDLQKVIPPLYDPREIYGIIPADVRQP
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCEEEECCHHCCCC
YDVREVIARIVDGSELDEFKQNYGATLVTGFAHLHGMPVGIIANNGVLFSESALKGAHFI
CCHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHCCCEEEEEECCCEEEECHHHCCHHHH
ELCCQRKIPLLFLQNITGFMVGAKYEAGGIAKDGAKLVTAVATAQVPKITAIIGGSFGAG
HHHHHCCCCEEEHHCCCCEEEECEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCC
NYGMCGRAFSPRFLWMWPNARISVMGGEQAATVLAIVKREGIERKGGSWTAEEEAEFKKP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ILEKYEREGHPLYSSARLWDDGIIDPAKTRDVLALSLSAALNAPIGETRFGVFRM
HHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHEEEEHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]