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The map label for this gene is accA1 [H]

Identifier: 110633272

GI number: 110633272

Start: 1017113

End: 1019065

Strand: Reverse

Name: accA1 [H]

Synonym: Meso_0918

Alternate gene names: 110633272

Gene position: 1019065-1017113 (Counterclockwise)

Preceding gene: 110633273

Following gene: 110633270

Centisome position: 23.1

GC content: 67.08

Gene sequence:

>1953_bases
ATGTTCGCAAAGATCCTGATCGCCAACCGCGGCGAGATCGCCGTCCGTATCATCGGCACGGCCAGGCGGATGGGGATATC
CACGGTCGCTGTTTATTCCGATGCGGACGCGCAGGCGATGCATGTGGCCATGGCCGACGAGGCGGTGCATATCGGCCCCG
CGCCCGCCGCCGAAAGCTATCTTGACGGCGCACGCATCATCGAGGCGGCTAAGGCCAGCGGCGCCGAGGCGATCCATCCT
GGTTACGGCTTCCTCTCGGAGAGCCCCGAATTCGCGGAGGCGACGGAGAAGGCGGGCCTCGCCTTTATCGGCCCGTCGGC
AAAGGCGATCCGCGCCATGGGCCACAAGGACGCCGCCAAGCGCCTGATGGAGAAGGCGGGCGTTCCCGTGGTGCCCGGCT
ATCACGGCGAGGCGCAGGAGCTTGTGGTGCTCGCCACAAAGGCGCGCGAGATCGGCTATCCCGTGCTTATCAAGGCGCGG
GCGGGCGGCGGGGGCAAGGGAATGCGCCGCGTCGACGATCCGGACCAGTTCGCCGATGCGCTCGCCGCCGCCAGGCGTGA
GGCCAAGGCTGCGTTCGGCGATGCCCATGTGCTGGTCGAAAAGTGGATCGAAAAGCCGCGCCACATCGAGGTGCAGGTCT
TCGGCGACAAGCACGGCAATGTGGTTCACCTCTTCGAGCGGGACTGCTCCGCCCAACGCCGCCACCAGAAGGTGATCGAG
GAAGCTCCCGCCCCCGGCATGACCGTAGCGATGCGCGCGGCCATGACGCAGGCCGCCATCAAAGCCGCGCAGGCGATCGG
CTATTGCGGCGCGGGCACCATCGAGTTCATCGTGGATGCGGCCAGAGGGCTCAAGCCAGACCGCTTCTGGTTCATGGAAA
TGAACACCCGCCTTCAGGTGGAGCATCCCGTGACCGAGATGGTGACGGGGATCGACCTTGTGGAGTGGCAGATCCGCGTG
GCGGCCGGCGAGGCGCTTCCCAAAAACCAGGAAGAGATCGCGCTTTCCGGCCACGCCTTTGAGGCGCGCATTTACGCCGA
GGACCCGGCGCGGGACTTCCTGCCCGCGACCGGCCGTCTCCACCATCTGCGCTTTCCAGACGGGACGCCGGGCGCGGCCT
TGCGCGTGGAAACCGGCGTGCGGGAGGGCGATGTCATCACACCCTATTATGATCCGCTGATCGCAAAGCTGGCGGTGCAT
GCGGAAAACCGCCGGACCGCGCTTGCCGTCCTCGCCGCAGCCCTGGACGAGACGGAGGTGGCGGGCTCGACGGTCAATAC
AGGCTTTCTTGCGAAGCTCGCGCGTGATCCGGATTTCGCGGCGGGGCAGCTGGACACCGGCCTTATCGCACGCAAGCAGG
AGGCACTGACGGCGCTGGCCGAGCCTGCCCCTCGCCTGGCCGCCATGGCTGCGCTCGCGGCCTCCGGCGCCGGATATTCA
CCGGATGCGCCCGATCCCTTCGATGCGATCTCGGCCTATGGGCACTTTCACCCCCTCACCCACCGGATAGCCCTCGATCA
CGGCGAGCGCGCATTGACCTTTGCGATCACGGGCAAGGGCGACGGCAGCTTCGGCGTAAAGCAGGAAGGTGGCGAGGCCT
TCCAGCTATCGGCCCGCGACGCCCCGCGCATGACCCGCTGGCCGGGACATCTCACCGTCTTTGACGGTGCGGCAAGCCAC
ACCTTCCGGCTGCGCGATCCCCTGTCCCTCGCCGGGGAGCAGGCTGCCGCAGGCGAAAGCCTGCGCGCGCCGATGCCGGG
GCTTGTCAAGCTTGTGCGGGCAGCGCCGGGCCAAGCCGTCAAGAAAGGCCAGCCGCTTCTCGTTCTCGAAGCCATGAAGA
TGGAGCACACCATCACCGCCCCCCATGACGGCCTGATCGCCGAAATCGCCGCCGAGGGGATGCAGGTGAATGACGGGGCA
GTGCTGGTGCGGTTTGAGGAGGAAGGGCAGTAG

Upstream 100 bases:

>100_bases
TGCCGGTTGTTCCGGCCCGCCTCCAGCATTGCGGGTTCCCCCCGACCGGAACGGTGAGCTATAGATTTGCTCATGGAGCG
GCAAGCGCAGAGGAGGCGGG

Downstream 100 bases:

>100_bases
AACCGAAACGCCGCGGGCGGCCTCAGGCCTCCGCGGCGTCGTTTCGGCGCTAGATCCTTTTCAGTGTCGTGAAAACACTG
AATGATCTAAGTTTTTGATC

Product: 3-methylcrotonoyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MFAKILIANRGEIAVRIIGTARRMGISTVAVYSDADAQAMHVAMADEAVHIGPAPAAESYLDGARIIEAAKASGAEAIHP
GYGFLSESPEFAEATEKAGLAFIGPSAKAIRAMGHKDAAKRLMEKAGVPVVPGYHGEAQELVVLATKAREIGYPVLIKAR
AGGGGKGMRRVDDPDQFADALAAARREAKAAFGDAHVLVEKWIEKPRHIEVQVFGDKHGNVVHLFERDCSAQRRHQKVIE
EAPAPGMTVAMRAAMTQAAIKAAQAIGYCGAGTIEFIVDAARGLKPDRFWFMEMNTRLQVEHPVTEMVTGIDLVEWQIRV
AAGEALPKNQEEIALSGHAFEARIYAEDPARDFLPATGRLHHLRFPDGTPGAALRVETGVREGDVITPYYDPLIAKLAVH
AENRRTALAVLAAALDETEVAGSTVNTGFLAKLARDPDFAAGQLDTGLIARKQEALTALAEPAPRLAAMAALAASGAGYS
PDAPDPFDAISAYGHFHPLTHRIALDHGERALTFAITGKGDGSFGVKQEGGEAFQLSARDAPRMTRWPGHLTVFDGAASH
TFRLRDPLSLAGEQAAAGESLRAPMPGLVKLVRAAPGQAVKKGQPLLVLEAMKMEHTITAPHDGLIAEIAAEGMQVNDGA
VLVRFEEEGQ

Sequences:

>Translated_650_residues
MFAKILIANRGEIAVRIIGTARRMGISTVAVYSDADAQAMHVAMADEAVHIGPAPAAESYLDGARIIEAAKASGAEAIHP
GYGFLSESPEFAEATEKAGLAFIGPSAKAIRAMGHKDAAKRLMEKAGVPVVPGYHGEAQELVVLATKAREIGYPVLIKAR
AGGGGKGMRRVDDPDQFADALAAARREAKAAFGDAHVLVEKWIEKPRHIEVQVFGDKHGNVVHLFERDCSAQRRHQKVIE
EAPAPGMTVAMRAAMTQAAIKAAQAIGYCGAGTIEFIVDAARGLKPDRFWFMEMNTRLQVEHPVTEMVTGIDLVEWQIRV
AAGEALPKNQEEIALSGHAFEARIYAEDPARDFLPATGRLHHLRFPDGTPGAALRVETGVREGDVITPYYDPLIAKLAVH
AENRRTALAVLAAALDETEVAGSTVNTGFLAKLARDPDFAAGQLDTGLIARKQEALTALAEPAPRLAAMAALAASGAGYS
PDAPDPFDAISAYGHFHPLTHRIALDHGERALTFAITGKGDGSFGVKQEGGEAFQLSARDAPRMTRWPGHLTVFDGAASH
TFRLRDPLSLAGEQAAAGESLRAPMPGLVKLVRAAPGQAVKKGQPLLVLEAMKMEHTITAPHDGLIAEIAAEGMQVNDGA
VLVRFEEEGQ
>Mature_650_residues
MFAKILIANRGEIAVRIIGTARRMGISTVAVYSDADAQAMHVAMADEAVHIGPAPAAESYLDGARIIEAAKASGAEAIHP
GYGFLSESPEFAEATEKAGLAFIGPSAKAIRAMGHKDAAKRLMEKAGVPVVPGYHGEAQELVVLATKAREIGYPVLIKAR
AGGGGKGMRRVDDPDQFADALAAARREAKAAFGDAHVLVEKWIEKPRHIEVQVFGDKHGNVVHLFERDCSAQRRHQKVIE
EAPAPGMTVAMRAAMTQAAIKAAQAIGYCGAGTIEFIVDAARGLKPDRFWFMEMNTRLQVEHPVTEMVTGIDLVEWQIRV
AAGEALPKNQEEIALSGHAFEARIYAEDPARDFLPATGRLHHLRFPDGTPGAALRVETGVREGDVITPYYDPLIAKLAVH
AENRRTALAVLAAALDETEVAGSTVNTGFLAKLARDPDFAAGQLDTGLIARKQEALTALAEPAPRLAAMAALAASGAGYS
PDAPDPFDAISAYGHFHPLTHRIALDHGERALTFAITGKGDGSFGVKQEGGEAFQLSARDAPRMTRWPGHLTVFDGAASH
TFRLRDPLSLAGEQAAAGESLRAPMPGLVKLVRAAPGQAVKKGQPLLVLEAMKMEHTITAPHDGLIAEIAAEGMQVNDGA
VLVRFEEEGQ

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=678, Percent_Identity=47.3451327433628, Blast_Score=583, Evalue=1e-166,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=49.1111111111111, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=450, Percent_Identity=49.1111111111111, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=682, Percent_Identity=39.5894428152493, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=456, Percent_Identity=44.078947368421, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI106049295, Length=456, Percent_Identity=44.078947368421, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI106049292, Length=456, Percent_Identity=44.078947368421, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI38679974, Length=727, Percent_Identity=28.8858321870702, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI38679971, Length=727, Percent_Identity=28.8858321870702, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI38679960, Length=727, Percent_Identity=28.8858321870702, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI38679977, Length=727, Percent_Identity=28.8858321870702, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI38679967, Length=727, Percent_Identity=28.8858321870702, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI134142062, Length=727, Percent_Identity=27.9229711141678, Blast_Score=221, Evalue=2e-57,
Organism=Escherichia coli, GI1789654, Length=453, Percent_Identity=48.3443708609272, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=662, Percent_Identity=46.5256797583082, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17567343, Length=688, Percent_Identity=40.6976744186046, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17562816, Length=453, Percent_Identity=43.2671081677704, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=720, Percent_Identity=26.1111111111111, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71997168, Length=536, Percent_Identity=27.2388059701493, Blast_Score=212, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=536, Percent_Identity=27.4253731343284, Blast_Score=209, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6319685, Length=469, Percent_Identity=44.5628997867804, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319695, Length=454, Percent_Identity=43.6123348017621, Blast_Score=334, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=453, Percent_Identity=43.9293598233996, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6324343, Length=732, Percent_Identity=27.7322404371585, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=689, Percent_Identity=28.011611030479, Blast_Score=231, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24651757, Length=676, Percent_Identity=46.7455621301775, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24651759, Length=638, Percent_Identity=45.9247648902821, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=45.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI161076409, Length=722, Percent_Identity=27.5623268698061, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24586458, Length=722, Percent_Identity=27.5623268698061, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161076407, Length=722, Percent_Identity=27.5623268698061, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24586460, Length=722, Percent_Identity=27.5623268698061, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 69111; Mature: 69111

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAKILIANRGEIAVRIIGTARRMGISTVAVYSDADAQAMHVAMADEAVHIGPAPAAESY
CCEEEEEECCCCEEEEEEECHHHCCCEEEEEECCCCCCEEEEEECCCEEECCCCCCHHHH
LDGARIIEAAKASGAEAIHPGYGFLSESPEFAEATEKAGLAFIGPSAKAIRAMGHKDAAK
HCHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
RLMEKAGVPVVPGYHGEAQELVVLATKAREIGYPVLIKARAGGGGKGMRRVDDPDQFADA
HHHHHCCCCCCCCCCCCCCEEEEEEECHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
LAAARREAKAAFGDAHVLVEKWIEKPRHIEVQVFGDKHGNVVHLFERDCSAQRRHQKVIE
HHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
EAPAPGMTVAMRAAMTQAAIKAAQAIGYCGAGTIEFIVDAARGLKPDRFWFMEMNTRLQV
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCEEEE
EHPVTEMVTGIDLVEWQIRVAAGEALPKNQEEIALSGHAFEARIYAEDPARDFLPATGRL
CCCHHHHHHCCEEEEEEEEEEECCCCCCCCCCEEECCCEEEEEEEECCCCHHCCCCCCCE
HHLRFPDGTPGAALRVETGVREGDVITPYYDPLIAKLAVHAENRRTALAVLAAALDETEV
EEEECCCCCCCCEEEEECCCCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHH
AGSTVNTGFLAKLARDPDFAAGQLDTGLIARKQEALTALAEPAPRLAAMAALAASGAGYS
CCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
PDAPDPFDAISAYGHFHPLTHRIALDHGERALTFAITGKGDGSFGVKQEGGEAFQLSARD
CCCCCHHHHHHHCCCCCCHHEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCC
APRMTRWPGHLTVFDGAASHTFRLRDPLSLAGEQAAAGESLRAPMPGLVKLVRAAPGQAV
CCCCCCCCCEEEEECCCCCCEEEECCCHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCCHH
KKGQPLLVLEAMKMEHTITAPHDGLIAEIAAEGMQVNDGAVLVRFEEEGQ
HCCCCEEEEEECCCCCEECCCCCCHHHHHHHCCEEECCCEEEEEEECCCC
>Mature Secondary Structure
MFAKILIANRGEIAVRIIGTARRMGISTVAVYSDADAQAMHVAMADEAVHIGPAPAAESY
CCEEEEEECCCCEEEEEEECHHHCCCEEEEEECCCCCCEEEEEECCCEEECCCCCCHHHH
LDGARIIEAAKASGAEAIHPGYGFLSESPEFAEATEKAGLAFIGPSAKAIRAMGHKDAAK
HCHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
RLMEKAGVPVVPGYHGEAQELVVLATKAREIGYPVLIKARAGGGGKGMRRVDDPDQFADA
HHHHHCCCCCCCCCCCCCCEEEEEEECHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
LAAARREAKAAFGDAHVLVEKWIEKPRHIEVQVFGDKHGNVVHLFERDCSAQRRHQKVIE
HHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
EAPAPGMTVAMRAAMTQAAIKAAQAIGYCGAGTIEFIVDAARGLKPDRFWFMEMNTRLQV
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEECCEEEE
EHPVTEMVTGIDLVEWQIRVAAGEALPKNQEEIALSGHAFEARIYAEDPARDFLPATGRL
CCCHHHHHHCCEEEEEEEEEEECCCCCCCCCCEEECCCEEEEEEEECCCCHHCCCCCCCE
HHLRFPDGTPGAALRVETGVREGDVITPYYDPLIAKLAVHAENRRTALAVLAAALDETEV
EEEECCCCCCCCEEEEECCCCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHH
AGSTVNTGFLAKLARDPDFAAGQLDTGLIARKQEALTALAEPAPRLAAMAALAASGAGYS
CCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
PDAPDPFDAISAYGHFHPLTHRIALDHGERALTFAITGKGDGSFGVKQEGGEAFQLSARD
CCCCCHHHHHHHCCCCCCHHEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCC
APRMTRWPGHLTVFDGAASHTFRLRDPLSLAGEQAAAGESLRAPMPGLVKLVRAAPGQAV
CCCCCCCCCEEEEECCCCCCEEEECCCHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCCHH
KKGQPLLVLEAMKMEHTITAPHDGLIAEIAAEGMQVNDGAVLVRFEEEGQ
HCCCCEEEEEECCCCCEECCCCCCHHHHHHHCCEEECCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]