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The map label for this gene is mutB [H]

Identifier: 110633213

GI number: 110633213

Start: 948096

End: 950240

Strand: Reverse

Name: mutB [H]

Synonym: Meso_0856

Alternate gene names: 110633213

Gene position: 950240-948096 (Counterclockwise)

Preceding gene: 110633214

Following gene: 110633212

Centisome position: 21.54

GC content: 63.92

Gene sequence:

>2145_bases
ATGATCCCCGACTTTTCCGCCATGGCCTGGTCACCGCCGGCCAAGACGGAAGAGAAATGGCCGGCGGACCGGTGGCAAAC
GCCCGAGGGCATCGCCATCCGCCACGCCTATGGCAAGGCGGACATCAACAAGCTGCGCTGGCTGGACACCTTTCCGGGGC
TGGCGCCGTTCATCCGCGGCCCCTACCCCACCATGTATGTCCAGCGCCCCTGGACAATCCGCCAATATGCGGGCTTCTCC
ACGGCGGAGGAATCCAATGCCTTCTACCGGCGCAACCTCGCCGCCGGCCAAAAGGGCCTTTCCATCGCCTTCGACCTGGC
CACCCATCGCGGCTATGACAGCGACCATCCGCGCGTTGCCGGCGATGTCGGCATGGCGGGCGTCGCCATCGATTCCATTC
TCGACATGCGCCAGCTCTTTGACGGGATCCCGCTTGACGAGATAACCGTGTCGATGACGATGAACGGCGCGGTGCTGCCG
ATCCTGGCGCTCTATATCGTGGCAGCCGAGGAACAGGGCGTGGCGCAGAAGGACCTCGCCGGGACCATCCAGAACGACAT
CCTCAAGGAGTTCATGGTCCGCAACACCTATATCTACCCGCCCAGGCCGTCGATGCGGATCATTTCGGACATCTTCGCCT
ATACGGCGGAGCACATGCCGAAATTCAACTCCATCTCCATTTCCGGCTATCACATGCAAGAAGCGGGAGCGACGGCGGAT
CTGGAGCTGGCCTATACGATCGCCGACGGCATCGAATATGCGCGCGCGGGCCTTTCTGCCGGGCTCGATATCGACCAGTT
CGCGCCCAGGCTTTCCTTCTTCTGGGCCACCGGCATGAATTTCTTCATGGAAGTGGCCAAGATGCGGGCTGCGCGCCTCC
TCTGGGCCGCTCTCATCAAGAAGAATTTCTCCCCGAAAGACCCGCGCTCGCTTGCGCTCAGAACCCATTGCCAGACCTCG
GGATGGTCGCTTGCCGCGCAGGACCCGTACAACAACATCGTGCGCACCATGGTCGAGGCAATGGCGGCGGCGCAGGGGCA
TACGCAGTCGCTTCACACCAATTCCTTTGACGAGGCCCTGGCGCTGCCGACGGACCACTCCGCCCGCGTTGCCCGCAACA
CCCAGCTCGTGCTGCAGGTGGAATCCGGCACCACGCGCATCATCGACCCCTGGGGCGGTTCGTTCTTCGTGGAGCGGCTT
ACCCATGATCTCGCTGCCCGCGCCCTCTCCCATATCGAGGAGGTGGAAAGCCTCGGAGGCATGGCCGCGGCGATCGAGAA
AGGCGTGCCCAAGCTGCGCGTGGAGGAAGCAGCGGCGCGCACGCAGGCCCGCATCGATTCCGGCGAACAGCCGGTCATCG
GCGTAAACCAGTTCCGCCCGGAAGAGGACATCCAGGTGGATGTGCTCAAAATCGACAATTCGCAAGTGCGGGCGCGCCAG
CTTTCCAAGCTGCAACAGCTCAAGGGCACGCGCGACGTGGCGAAGGTGGAGAACGCGCTGGACGAGCTGACGAAAGCGGC
CAAAACAGACGGAAACCTGCTCGAATTCGCCATCCGCGCCGCCCGCGCGCAGGCGACCGTCGGCGAGATTTCGCTGGCGC
TGGAGAAGGTTTTTGGACGCCACGTCGCGGATATCCGCACGATCTCGGGCGTTTACCGCAAAGAGATCGGCGAGAACGAT
GCCGTGAAAGAGGCTGAGAGGAAGGTGGCCGCCTTCCGCCAGAAGACCGGTGGATCGCCGCGCATCCTCATCGCCAAGAT
CGGCCAGGACGGGCACGACCGCGGGCAGAAAGTGATCGCGACCGCGTTCGCGGACCTGGGTTTCGACGTGACGGTGGGGG
CGATGTTCCAAACGCCGGCGGAGGTCGCCAGGCTTGCGGCCGAAAAGGACGTGCACATCGTCGGGGTCTCCTCGCTCGCC
GCCGGGCATCTCACCCTCATCCCCGAACTGAGCCAGGCGCTCGAAAAGCTTGGCCGCCAGGATATCCTGATCGTTGCCGG
CGGCGTTATTCCCCCCGGCGATTTCGAGGCGGTCCGAAAGGCGGGCGCGGCTGATATCTTTCCGCCCGGCACGGTGATCG
CCGAGGCGGCTGTCCGGCTCCTCGACCGGCTGCTTGAACGGATCGGAAACCTTTCGGCCGCATAA

Upstream 100 bases:

>100_bases
CAACGCTTCCTGCCGCGCGACAGCCGATCCCGACGGACGGGGCGGTGACCTGCATTCCGCTTGCCGCCTCCCGCATCGAC
GAAGGGCTTGGAGAGCCCAC

Downstream 100 bases:

>100_bases
GCTTTTGCCGGCACTTTCCCTGGGATTCCAATGCCATGATCCAAGTCTACACACTCGATGGCGATCGCCTCACCGGCGCT
GAGGTAAAGGTCGGTGATCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MIPDFSAMAWSPPAKTEEKWPADRWQTPEGIAIRHAYGKADINKLRWLDTFPGLAPFIRGPYPTMYVQRPWTIRQYAGFS
TAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPLDEITVSMTMNGAVLP
ILALYIVAAEEQGVAQKDLAGTIQNDILKEFMVRNTYIYPPRPSMRIISDIFAYTAEHMPKFNSISISGYHMQEAGATAD
LELAYTIADGIEYARAGLSAGLDIDQFAPRLSFFWATGMNFFMEVAKMRAARLLWAALIKKNFSPKDPRSLALRTHCQTS
GWSLAAQDPYNNIVRTMVEAMAAAQGHTQSLHTNSFDEALALPTDHSARVARNTQLVLQVESGTTRIIDPWGGSFFVERL
THDLAARALSHIEEVESLGGMAAAIEKGVPKLRVEEAAARTQARIDSGEQPVIGVNQFRPEEDIQVDVLKIDNSQVRARQ
LSKLQQLKGTRDVAKVENALDELTKAAKTDGNLLEFAIRAARAQATVGEISLALEKVFGRHVADIRTISGVYRKEIGEND
AVKEAERKVAAFRQKTGGSPRILIAKIGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPAEVARLAAEKDVHIVGVSSLA
AGHLTLIPELSQALEKLGRQDILIVAGGVIPPGDFEAVRKAGAADIFPPGTVIAEAAVRLLDRLLERIGNLSAA

Sequences:

>Translated_714_residues
MIPDFSAMAWSPPAKTEEKWPADRWQTPEGIAIRHAYGKADINKLRWLDTFPGLAPFIRGPYPTMYVQRPWTIRQYAGFS
TAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPLDEITVSMTMNGAVLP
ILALYIVAAEEQGVAQKDLAGTIQNDILKEFMVRNTYIYPPRPSMRIISDIFAYTAEHMPKFNSISISGYHMQEAGATAD
LELAYTIADGIEYARAGLSAGLDIDQFAPRLSFFWATGMNFFMEVAKMRAARLLWAALIKKNFSPKDPRSLALRTHCQTS
GWSLAAQDPYNNIVRTMVEAMAAAQGHTQSLHTNSFDEALALPTDHSARVARNTQLVLQVESGTTRIIDPWGGSFFVERL
THDLAARALSHIEEVESLGGMAAAIEKGVPKLRVEEAAARTQARIDSGEQPVIGVNQFRPEEDIQVDVLKIDNSQVRARQ
LSKLQQLKGTRDVAKVENALDELTKAAKTDGNLLEFAIRAARAQATVGEISLALEKVFGRHVADIRTISGVYRKEIGEND
AVKEAERKVAAFRQKTGGSPRILIAKIGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPAEVARLAAEKDVHIVGVSSLA
AGHLTLIPELSQALEKLGRQDILIVAGGVIPPGDFEAVRKAGAADIFPPGTVIAEAAVRLLDRLLERIGNLSAA
>Mature_714_residues
MIPDFSAMAWSPPAKTEEKWPADRWQTPEGIAIRHAYGKADINKLRWLDTFPGLAPFIRGPYPTMYVQRPWTIRQYAGFS
TAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFDGIPLDEITVSMTMNGAVLP
ILALYIVAAEEQGVAQKDLAGTIQNDILKEFMVRNTYIYPPRPSMRIISDIFAYTAEHMPKFNSISISGYHMQEAGATAD
LELAYTIADGIEYARAGLSAGLDIDQFAPRLSFFWATGMNFFMEVAKMRAARLLWAALIKKNFSPKDPRSLALRTHCQTS
GWSLAAQDPYNNIVRTMVEAMAAAQGHTQSLHTNSFDEALALPTDHSARVARNTQLVLQVESGTTRIIDPWGGSFFVERL
THDLAARALSHIEEVESLGGMAAAIEKGVPKLRVEEAAARTQARIDSGEQPVIGVNQFRPEEDIQVDVLKIDNSQVRARQ
LSKLQQLKGTRDVAKVENALDELTKAAKTDGNLLEFAIRAARAQATVGEISLALEKVFGRHVADIRTISGVYRKEIGEND
AVKEAERKVAAFRQKTGGSPRILIAKIGQDGHDRGQKVIATAFADLGFDVTVGAMFQTPAEVARLAAEKDVHIVGVSSLA
AGHLTLIPELSQALEKLGRQDILIVAGGVIPPGDFEAVRKAGAADIFPPGTVIAEAAVRLLDRLLERIGNLSAA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=710, Percent_Identity=62.3943661971831, Blast_Score=922, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=684, Percent_Identity=59.2105263157895, Blast_Score=816, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=682, Percent_Identity=63.9296187683284, Blast_Score=922, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77903; Mature: 77903

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPDFSAMAWSPPAKTEEKWPADRWQTPEGIAIRHAYGKADINKLRWLDTFPGLAPFIRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHCC
PYPTMYVQRPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVA
CCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCCCC
GDVGMAGVAIDSILDMRQLFDGIPLDEITVSMTMNGAVLPILALYIVAAEEQGVAQKDLA
CCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHH
GTIQNDILKEFMVRNTYIYPPRPSMRIISDIFAYTAEHMPKFNSISISGYHMQEAGATAD
HHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEECCCCCCCC
LELAYTIADGIEYARAGLSAGLDIDQFAPRLSFFWATGMNFFMEVAKMRAARLLWAALIK
EEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNFSPKDPRSLALRTHCQTSGWSLAAQDPYNNIVRTMVEAMAAAQGHTQSLHTNSFDEAL
CCCCCCCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
ALPTDHSARVARNTQLVLQVESGTTRIIDPWGGSFFVERLTHDLAARALSHIEEVESLGG
CCCCCCCHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH
MAAAIEKGVPKLRVEEAAARTQARIDSGEQPVIGVNQFRPEEDIQVDVLKIDNSQVRARQ
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEECHHCCCCCCCCEEEEEEECCHHHHHHH
LSKLQQLKGTRDVAKVENALDELTKAAKTDGNLLEFAIRAARAQATVGEISLALEKVFGR
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVADIRTISGVYRKEIGENDAVKEAERKVAAFRQKTGGSPRILIAKIGQDGHDRGQKVIA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
TAFADLGFDVTVGAMFQTPAEVARLAAEKDVHIVGVSSLAAGHLTLIPELSQALEKLGRQ
HHHHHCCCCEEEHHHHCCHHHHHHHHHCCCEEEEEEHHHCCCCCEEHHHHHHHHHHHCCC
DILIVAGGVIPPGDFEAVRKAGAADIFPPGTVIAEAAVRLLDRLLERIGNLSAA
CEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIPDFSAMAWSPPAKTEEKWPADRWQTPEGIAIRHAYGKADINKLRWLDTFPGLAPFIRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHCC
PYPTMYVQRPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVA
CCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEEHHCCCCCCCCCCCC
GDVGMAGVAIDSILDMRQLFDGIPLDEITVSMTMNGAVLPILALYIVAAEEQGVAQKDLA
CCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHH
GTIQNDILKEFMVRNTYIYPPRPSMRIISDIFAYTAEHMPKFNSISISGYHMQEAGATAD
HHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEECCCCCCCC
LELAYTIADGIEYARAGLSAGLDIDQFAPRLSFFWATGMNFFMEVAKMRAARLLWAALIK
EEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNFSPKDPRSLALRTHCQTSGWSLAAQDPYNNIVRTMVEAMAAAQGHTQSLHTNSFDEAL
CCCCCCCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
ALPTDHSARVARNTQLVLQVESGTTRIIDPWGGSFFVERLTHDLAARALSHIEEVESLGG
CCCCCCCHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH
MAAAIEKGVPKLRVEEAAARTQARIDSGEQPVIGVNQFRPEEDIQVDVLKIDNSQVRARQ
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEECHHCCCCCCCCEEEEEEECCHHHHHHH
LSKLQQLKGTRDVAKVENALDELTKAAKTDGNLLEFAIRAARAQATVGEISLALEKVFGR
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVADIRTISGVYRKEIGENDAVKEAERKVAAFRQKTGGSPRILIAKIGQDGHDRGQKVIA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
TAFADLGFDVTVGAMFQTPAEVARLAAEKDVHIVGVSSLAAGHLTLIPELSQALEKLGRQ
HHHHHCCCCEEEHHHHCCHHHHHHHHHCCCEEEEEEHHHCCCCCEEHHHHHHHHHHHCCC
DILIVAGGVIPPGDFEAVRKAGAADIFPPGTVIAEAAVRLLDRLLERIGNLSAA
CEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]