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The map label for this gene is mdlC [H]

Identifier: 110633158

GI number: 110633158

Start: 889461

End: 891245

Strand: Reverse

Name: mdlC [H]

Synonym: Meso_0801

Alternate gene names: 110633158

Gene position: 891245-889461 (Counterclockwise)

Preceding gene: 110633169

Following gene: 110633155

Centisome position: 20.2

GC content: 65.43

Gene sequence:

>1785_bases
ATGACGGTGGATGAGACGGTGGAGCCACGGGAAAAGACTGCTGCGCCGATCTTCGGGAGCGACGTCATTGCGGCGGCACT
GCGTGAGCAGGAGCTCCCCTATATCTGCCTCAATCCGGGCGCCAGTTACCGCGGCTTGCACGATAGTCTCGTCAACTATC
TCGGCAACGAAAGACCGAAGATCGTGCTCTGCCTTCACGAGGAGCATGCCGCCGCCATTGCCCATGGCTACGCCGCCGCC
ACCGGAAGGCCGCTCGCGGTCGCGGTTCACAGCACGGTTGGCCTCATGCATGCGAGCATGGCTATTTTCAACGCCTGGTG
CGCGCGCGTGCCGATGCTCATCATCGGAGCGACGGGACCTGTCGATGCTGCCAAACGCCGGCCATGGATCGACTGGATTC
ACACGGCTGCGGATCAGGGCGCGCTGGTCCGCGACTATACCAAATGGGACGATCAGCCGGCCTCTCCCGCCGCCGCGGTG
GAATCGATCCGTCGTGGGATGATGCTGTCGACCACTTCGCCGGCAGCGCCGGTCTACATCAACCTCGACGCCACGATCCA
GGAAGAGGAACTGCGGCAGTGGCCGCCCCAGCGCGATCTTTCCGCCTATGCGAGACCAGCCGATGCCGAACCGGGCCGCG
AGGAGCTGTCCGTGCTCGCCACCGCCATCCGGGAGGCTCGGGACATCGTGATCCTATCGGGGCGAATGGAGCGCAGCCTC
TCAGACTGGAACAAGCGCCAGGAGTTCGCCGAGCGCATCGGTGCGCGCGTCTTGACGGACGTGAAGGATCCCGGAAGCTT
CTCCACCTCGCACCCGCTGCACCTCGGCGAGACGACCGTGCGGCTCAAGCCCGAGATTGCCCGGCGATTGAAGTCTGCCG
ACCTGATCATCGCACTCGATTGGATCGATCTCGCCGGCACGCTGGAGCAGCTCTACGATCCCGAAAGTCCGCTGCCCCGC
ATCGTAACCATCTCCAATGATTTTCATCTGCATCGTGGCTGGAGCGCCGATTACCAGGGCTTGCCGCCCGCATCGCAGTG
GATCGCGACCACGCCCGCCGCTGCGACACGCGCCCTTCTCAGGATCTTGCCGGCGGGCGAGCGTCGACCACTCCCACCAG
CGCGCCCCACCGAACCCGACCGGGAACCCGCCAATAGCCTGCGACCGGGCGGCGGCATGGGCATCGCCGACCTCGCGCGC
GCGTTTCGTATCGCAAGCGCCGGCCTCCCCCTCAGCATAATGAGCCGGCCGATCGGATGGCCGCTCGATGCGAACCCCAT
CGAGCATCCGCTCGATTTCCTGGGGCGCGCTGCGGGAGGCGGCATTGGAGCCGGCCCGGGAATGATCGTCGGCGCCGCGC
TCGCCCTGCGCGACATGGGCAACGAGCGGCTGCCCGTCGCCATTCTCGGCGACGGCGACTACATGATGGGTCTGACAGCG
CTGTGGACTGCAGCGGTCGAGCGCATTCCGCTTCTCGTCATCATTGCCAACAATCGATCCTACTACAATGACGAAGAGCA
CCAGAAGCATGTCGCACGCTATCGCGGACGCCCGGAGGAGAACGCTCCGATCGGACAGCGCCTCGAAGGCGCCACGCTTG
ATCTTGCCTTCCTGGCACGTGGCCAGGGACTGGACGCGGCCGGTCCGATCGAAGATCCGGCGGAACTGCCCGAAGCGCTC
CGCCGTGCATTCGCCGCCGTTCAAGCAGGCGGAAGCTATGTGCTCGATGTCATCGTTCGGCCGGAATACGATAACCGCTC
GCTGGCCGGCCGCAAGTCGGCGTGA

Upstream 100 bases:

>100_bases
ATGCCTGCCCGGCATAGCAGGAATGCGCCGTAGCTTTGAGACAAGAGCCTTCCTCCCCGCATAGGTTGCGCGCAAGGAGC
ACCTTAAGAGGAGGGAACGG

Downstream 100 bases:

>100_bases
CTCTGCGTTACCCCGCCGCCCTGGCGAGCGGCAGGGCCCAACGGGCGGGCGCCTCATGACGGTTTGCCGCCACAGGGCCA
ACCGTGGCAGCGGCGGAATA

Product: thiamine pyrophosphate enzyme-like TPP-binding

Products: NA

Alternate protein names: BFD; BFDC [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MTVDETVEPREKTAAPIFGSDVIAAALREQELPYICLNPGASYRGLHDSLVNYLGNERPKIVLCLHEEHAAAIAHGYAAA
TGRPLAVAVHSTVGLMHASMAIFNAWCARVPMLIIGATGPVDAAKRRPWIDWIHTAADQGALVRDYTKWDDQPASPAAAV
ESIRRGMMLSTTSPAAPVYINLDATIQEEELRQWPPQRDLSAYARPADAEPGREELSVLATAIREARDIVILSGRMERSL
SDWNKRQEFAERIGARVLTDVKDPGSFSTSHPLHLGETTVRLKPEIARRLKSADLIIALDWIDLAGTLEQLYDPESPLPR
IVTISNDFHLHRGWSADYQGLPPASQWIATTPAAATRALLRILPAGERRPLPPARPTEPDREPANSLRPGGGMGIADLAR
AFRIASAGLPLSIMSRPIGWPLDANPIEHPLDFLGRAAGGGIGAGPGMIVGAALALRDMGNERLPVAILGDGDYMMGLTA
LWTAAVERIPLLVIIANNRSYYNDEEHQKHVARYRGRPEENAPIGQRLEGATLDLAFLARGQGLDAAGPIEDPAELPEAL
RRAFAAVQAGGSYVLDVIVRPEYDNRSLAGRKSA

Sequences:

>Translated_594_residues
MTVDETVEPREKTAAPIFGSDVIAAALREQELPYICLNPGASYRGLHDSLVNYLGNERPKIVLCLHEEHAAAIAHGYAAA
TGRPLAVAVHSTVGLMHASMAIFNAWCARVPMLIIGATGPVDAAKRRPWIDWIHTAADQGALVRDYTKWDDQPASPAAAV
ESIRRGMMLSTTSPAAPVYINLDATIQEEELRQWPPQRDLSAYARPADAEPGREELSVLATAIREARDIVILSGRMERSL
SDWNKRQEFAERIGARVLTDVKDPGSFSTSHPLHLGETTVRLKPEIARRLKSADLIIALDWIDLAGTLEQLYDPESPLPR
IVTISNDFHLHRGWSADYQGLPPASQWIATTPAAATRALLRILPAGERRPLPPARPTEPDREPANSLRPGGGMGIADLAR
AFRIASAGLPLSIMSRPIGWPLDANPIEHPLDFLGRAAGGGIGAGPGMIVGAALALRDMGNERLPVAILGDGDYMMGLTA
LWTAAVERIPLLVIIANNRSYYNDEEHQKHVARYRGRPEENAPIGQRLEGATLDLAFLARGQGLDAAGPIEDPAELPEAL
RRAFAAVQAGGSYVLDVIVRPEYDNRSLAGRKSA
>Mature_593_residues
TVDETVEPREKTAAPIFGSDVIAAALREQELPYICLNPGASYRGLHDSLVNYLGNERPKIVLCLHEEHAAAIAHGYAAAT
GRPLAVAVHSTVGLMHASMAIFNAWCARVPMLIIGATGPVDAAKRRPWIDWIHTAADQGALVRDYTKWDDQPASPAAAVE
SIRRGMMLSTTSPAAPVYINLDATIQEEELRQWPPQRDLSAYARPADAEPGREELSVLATAIREARDIVILSGRMERSLS
DWNKRQEFAERIGARVLTDVKDPGSFSTSHPLHLGETTVRLKPEIARRLKSADLIIALDWIDLAGTLEQLYDPESPLPRI
VTISNDFHLHRGWSADYQGLPPASQWIATTPAAATRALLRILPAGERRPLPPARPTEPDREPANSLRPGGGMGIADLARA
FRIASAGLPLSIMSRPIGWPLDANPIEHPLDFLGRAAGGGIGAGPGMIVGAALALRDMGNERLPVAILGDGDYMMGLTAL
WTAAVERIPLLVIIANNRSYYNDEEHQKHVARYRGRPEENAPIGQRLEGATLDLAFLARGQGLDAAGPIEDPAELPEALR
RAFAAVQAGGSYVLDVIVRPEYDNRSLAGRKSA

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.7 [H]

Molecular weight: Translated: 64376; Mature: 64245

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDETVEPREKTAAPIFGSDVIAAALREQELPYICLNPGASYRGLHDSLVNYLGNERPK
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCCE
IVLCLHEEHAAAIAHGYAAATGRPLAVAVHSTVGLMHASMAIFNAWCARVPMLIIGATGP
EEEEEECCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
VDAAKRRPWIDWIHTAADQGALVRDYTKWDDQPASPAAAVESIRRGMMLSTTSPAAPVYI
CCHHHCCCHHHHHHHHCCCCCEEECHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEE
NLDATIQEEELRQWPPQRDLSAYARPADAEPGREELSVLATAIREARDIVILSGRMERSL
EECCCCCHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCHHHHHH
SDWNKRQEFAERIGARVLTDVKDPGSFSTSHPLHLGETTVRLKPEIARRLKSADLIIALD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEEECHHHHHHHCCCCEEEEEE
WIDLAGTLEQLYDPESPLPRIVTISNDFHLHRGWSADYQGLPPASQWIATTPAAATRALL
HHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHH
RILPAGERRPLPPARPTEPDREPANSLRPGGGMGIADLARAFRIASAGLPLSIMSRPIGW
HHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCC
PLDANPIEHPLDFLGRAAGGGIGAGPGMIVGAALALRDMGNERLPVAILGDGDYMMGLTA
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHH
LWTAAVERIPLLVIIANNRSYYNDEEHQKHVARYRGRPEENAPIGQRLEGATLDLAFLAR
HHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHCC
GQGLDAAGPIEDPAELPEALRRAFAAVQAGGSYVLDVIVRPEYDNRSLAGRKSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TVDETVEPREKTAAPIFGSDVIAAALREQELPYICLNPGASYRGLHDSLVNYLGNERPK
CCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCCE
IVLCLHEEHAAAIAHGYAAATGRPLAVAVHSTVGLMHASMAIFNAWCARVPMLIIGATGP
EEEEEECCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
VDAAKRRPWIDWIHTAADQGALVRDYTKWDDQPASPAAAVESIRRGMMLSTTSPAAPVYI
CCHHHCCCHHHHHHHHCCCCCEEECHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEE
NLDATIQEEELRQWPPQRDLSAYARPADAEPGREELSVLATAIREARDIVILSGRMERSL
EECCCCCHHHHHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCHHHHHH
SDWNKRQEFAERIGARVLTDVKDPGSFSTSHPLHLGETTVRLKPEIARRLKSADLIIALD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEEECHHHHHHHCCCCEEEEEE
WIDLAGTLEQLYDPESPLPRIVTISNDFHLHRGWSADYQGLPPASQWIATTPAAATRALL
HHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHH
RILPAGERRPLPPARPTEPDREPANSLRPGGGMGIADLARAFRIASAGLPLSIMSRPIGW
HHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCC
PLDANPIEHPLDFLGRAAGGGIGAGPGMIVGAALALRDMGNERLPVAILGDGDYMMGLTA
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHH
LWTAAVERIPLLVIIANNRSYYNDEEHQKHVARYRGRPEENAPIGQRLEGATLDLAFLAR
HHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEHCC
GQGLDAAGPIEDPAELPEALRRAFAAVQAGGSYVLDVIVRPEYDNRSLAGRKSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2271624; 7663351; 9665697 [H]