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The map label for this gene is czcD [H]

Identifier: 110633112

GI number: 110633112

Start: 828599

End: 829552

Strand: Reverse

Name: czcD [H]

Synonym: Meso_0755

Alternate gene names: 110633112

Gene position: 829552-828599 (Counterclockwise)

Preceding gene: 110633113

Following gene: 110633111

Centisome position: 18.8

GC content: 60.06

Gene sequence:

>954_bases
ATGAAAACGTATATGGATACCGATTCCTTCGGGCACGACCATGTCTTTCTGGGCGAGAGTCACAGGCGCAACGAGCGCCG
CGTATGGCTCGTCATCGCTCTTACCGCCGCGATGATGCTGATCGAGATCGCCGCTGGCGTGATGTTCGGCTCCATGGCAT
TGCTGGCCGATGGCTTTCACATGTCGACCCATGCGGCGGCCATGCTGATCGCGGCAGGTGCCTATTACTACGCGCGCAAG
CATGCTCATAATCCACGCTTTACTTTCGGCACCGGCAAATTCGGGGATCTTGCCGGCTTTGCGAGTGCAGTGATCCTGGC
GCTGATCGCTCTTTTCATCGGTTACGAAAGCGTCATGCGCCTGACCGATCCCATTCCCATATCCTTCGGCCAGGCAATCG
CCGTGGCCGTCGTCGGCCTTGTGGTGAACCTTGTCAGCGCATGGGTTTTAGGTGGTGATCAATCGCACAGCCACGGCCCT
GCCCATCACGGACACCATCATCACCATGGCCACGAGAAGCACGGCACCGATCACAATATCCGCGCGGCCTATCTCCACGT
TCTTGCGGATGCGCTGACATCCGCGCTCGCAATCATCGCGCTGACGCTTGGCAGCCTCTACGGCTGGATCTGGCTCGACC
CGATCATGGGCGTGGTCGGCGCGCTGGTGATTGCCCGCTGGTCTTGGGGGCTTATCCGCCAGGCAGGCGCCGTTCTGCTC
GACTATCTGCCGGAGGAGGAAGAACTGCCACAGGAAATTCGCGAGGCGATCGAGGCGGAGGGGGACCGGATCTCGGATCT
TCATGTCTGGCAGATTGGCCCCGGCCATCATGCCGCGATCGTGTCGGTCGTTACCGAAGAACCGCGCTCCCTTTCCTTCT
ATCGGCAGAAGCTCGCACATATCCATGAACTGTCGCATCTGACGGTGGAGGTCGAGAGGCTTCAGCCGGCCTGA

Upstream 100 bases:

>100_bases
ATCCGCTTTCATGTCGTTGATCCGGACGGGGAGGCCCCTTCCGCCGAAGGCGCGGCGGAGCTCATTGCGGCGCTGCGCAC
CTATATGAAGTGAGGGACCG

Downstream 100 bases:

>100_bases
AATTCGGCACAGGGATTGTGATGAATGCCACGCTGGAGAGAATCAGGGTTTGGGCGAAGGCGCTCAAGCGCGACGTGCTG
GCGCTCTGGATCGCAGCGGG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKTYMDTDSFGHDHVFLGESHRRNERRVWLVIALTAAMMLIEIAAGVMFGSMALLADGFHMSTHAAAMLIAAGAYYYARK
HAHNPRFTFGTGKFGDLAGFASAVILALIALFIGYESVMRLTDPIPISFGQAIAVAVVGLVVNLVSAWVLGGDQSHSHGP
AHHGHHHHHGHEKHGTDHNIRAAYLHVLADALTSALAIIALTLGSLYGWIWLDPIMGVVGALVIARWSWGLIRQAGAVLL
DYLPEEEELPQEIREAIEAEGDRISDLHVWQIGPGHHAAIVSVVTEEPRSLSFYRQKLAHIHELSHLTVEVERLQPA

Sequences:

>Translated_317_residues
MKTYMDTDSFGHDHVFLGESHRRNERRVWLVIALTAAMMLIEIAAGVMFGSMALLADGFHMSTHAAAMLIAAGAYYYARK
HAHNPRFTFGTGKFGDLAGFASAVILALIALFIGYESVMRLTDPIPISFGQAIAVAVVGLVVNLVSAWVLGGDQSHSHGP
AHHGHHHHHGHEKHGTDHNIRAAYLHVLADALTSALAIIALTLGSLYGWIWLDPIMGVVGALVIARWSWGLIRQAGAVLL
DYLPEEEELPQEIREAIEAEGDRISDLHVWQIGPGHHAAIVSVVTEEPRSLSFYRQKLAHIHELSHLTVEVERLQPA
>Mature_317_residues
MKTYMDTDSFGHDHVFLGESHRRNERRVWLVIALTAAMMLIEIAAGVMFGSMALLADGFHMSTHAAAMLIAAGAYYYARK
HAHNPRFTFGTGKFGDLAGFASAVILALIALFIGYESVMRLTDPIPISFGQAIAVAVVGLVVNLVSAWVLGGDQSHSHGP
AHHGHHHHHGHEKHGTDHNIRAAYLHVLADALTSALAIIALTLGSLYGWIWLDPIMGVVGALVIARWSWGLIRQAGAVLL
DYLPEEEELPQEIREAIEAEGDRISDLHVWQIGPGHHAAIVSVVTEEPRSLSFYRQKLAHIHELSHLTVEVERLQPA

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=344, Percent_Identity=28.7790697674419, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI222080086, Length=298, Percent_Identity=25.8389261744966, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI40255009, Length=298, Percent_Identity=25.8389261744966, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21359890, Length=275, Percent_Identity=24.7272727272727, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786966, Length=253, Percent_Identity=34.3873517786561, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32564488, Length=301, Percent_Identity=32.5581395348837, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193210990, Length=324, Percent_Identity=27.1604938271605, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555794, Length=282, Percent_Identity=26.5957446808511, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17555796, Length=273, Percent_Identity=26.7399267399267, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=211, Percent_Identity=28.436018957346, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=148, Percent_Identity=31.0810810810811, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24645863, Length=292, Percent_Identity=26.027397260274, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656728, Length=328, Percent_Identity=24.6951219512195, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656724, Length=328, Percent_Identity=24.6951219512195, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656720, Length=328, Percent_Identity=24.6951219512195, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656715, Length=328, Percent_Identity=24.6951219512195, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357035, Length=328, Percent_Identity=24.6951219512195, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34721; Mature: 34721

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYMDTDSFGHDHVFLGESHRRNERRVWLVIALTAAMMLIEIAAGVMFGSMALLADGFH
CCCCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MSTHAAAMLIAAGAYYYARKHAHNPRFTFGTGKFGDLAGFASAVILALIALFIGYESVMR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTDPIPISFGQAIAVAVVGLVVNLVSAWVLGGDQSHSHGPAHHGHHHHHGHEKHGTDHNI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RAAYLHVLADALTSALAIIALTLGSLYGWIWLDPIMGVVGALVIARWSWGLIRQAGAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYLPEEEELPQEIREAIEAEGDRISDLHVWQIGPGHHAAIVSVVTEEPRSLSFYRQKLAH
HCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
IHELSHLTVEVERLQPA
HHHHHHHEEEHCCCCCC
>Mature Secondary Structure
MKTYMDTDSFGHDHVFLGESHRRNERRVWLVIALTAAMMLIEIAAGVMFGSMALLADGFH
CCCCCCCCCCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MSTHAAAMLIAAGAYYYARKHAHNPRFTFGTGKFGDLAGFASAVILALIALFIGYESVMR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LTDPIPISFGQAIAVAVVGLVVNLVSAWVLGGDQSHSHGPAHHGHHHHHGHEKHGTDHNI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RAAYLHVLADALTSALAIIALTLGSLYGWIWLDPIMGVVGALVIARWSWGLIRQAGAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYLPEEEELPQEIREAIEAEGDRISDLHVWQIGPGHHAAIVSVVTEEPRSLSFYRQKLAH
HCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
IHELSHLTVEVERLQPA
HHHHHHHEEEHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]