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The map label for this gene is pdxH

Identifier: 110633081

GI number: 110633081

Start: 799888

End: 800517

Strand: Reverse

Name: pdxH

Synonym: Meso_0724

Alternate gene names: 110633081

Gene position: 800517-799888 (Counterclockwise)

Preceding gene: 110633086

Following gene: 110633079

Centisome position: 18.14

GC content: 58.25

Gene sequence:

>630_bases
ATGAGCAGAACGATGATTAAAAACGACTTAAAGCAGACCGACTTTACCGAGGCAGGAGAGCCATTCCGCCTGTTTGCCGA
ATGGCTTCGGGACGCAGAACAATCCGAACCCAACGACCCAAACGCCACCGCGCTCGCAACCGTGGACCCGGAGGGGATGC
CCAATGTGCGGATGGTCCTGCTCAAGGGATTCGATGAACAGGGATTCGTTTTCTATACCAACTTTGAAAGCGCAAAGGGA
CAAGAAATTTTGTCCTCTATGAAAGCCGCGATGTGTTTCCACTGGAAAAGCCTGCGCCGTCAGGTGCGGGTGCGTGGCCC
GGTGGAAAAAGTGACGGACGAGGAGGCCAACGCCTATTATGCTTCCCGGCCGCGCGGCAGCCGGATCGGCGCCTGGGCTT
CGAAGCAATCCCGGCCGCTGGAAGGTCGCTTCGCCCTCGAGAAGGCGGTTGCCGAGTACACGGCCAAATACGCGGTGGGG
GAAATACCCCGGCCCGACTACTGGTCAGGCTTCCGCATCAAGCCTGTGAGCATTGAATTCTGGCACGACCGCCCCTTCAG
GCTGCATGACCGCATTCTCTTCGAGCGGGAGAGCGGCGGGTTATGGACGAAAACGCGTCTTTATCCCTGA

Upstream 100 bases:

>100_bases
AAAGAGCCGCAGCCTTCCGAAGGGCGCGCAGGGCCAAACGGCCAACTGTTTCTGTCTCTTGCGTCACTCCCAACAATCGG
CAATCTCCCAATGACAATAG

Downstream 100 bases:

>100_bases
CAGGGCGAGCACACGCGCGGCGACGATCAGTACCGCCTCGCGGCGCTTCAGCCTGGATTTGACCGCTCATGCCATCTCTT
CCAGACCGTCTGCCGCCGCG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSRTMIKNDLKQTDFTEAGEPFRLFAEWLRDAEQSEPNDPNATALATVDPEGMPNVRMVLLKGFDEQGFVFYTNFESAKG
QEILSSMKAAMCFHWKSLRRQVRVRGPVEKVTDEEANAYYASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTAKYAVG
EIPRPDYWSGFRIKPVSIEFWHDRPFRLHDRILFERESGGLWTKTRLYP

Sequences:

>Translated_209_residues
MSRTMIKNDLKQTDFTEAGEPFRLFAEWLRDAEQSEPNDPNATALATVDPEGMPNVRMVLLKGFDEQGFVFYTNFESAKG
QEILSSMKAAMCFHWKSLRRQVRVRGPVEKVTDEEANAYYASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTAKYAVG
EIPRPDYWSGFRIKPVSIEFWHDRPFRLHDRILFERESGGLWTKTRLYP
>Mature_208_residues
SRTMIKNDLKQTDFTEAGEPFRLFAEWLRDAEQSEPNDPNATALATVDPEGMPNVRMVLLKGFDEQGFVFYTNFESAKGQ
EILSSMKAAMCFHWKSLRRQVRVRGPVEKVTDEEANAYYASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTAKYAVGE
IPRPDYWSGFRIKPVSIEFWHDRPFRLHDRILFERESGGLWTKTRLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=178, Percent_Identity=45.5056179775281, Blast_Score=157, Evalue=5e-39,
Organism=Escherichia coli, GI1787926, Length=209, Percent_Identity=42.1052631578947, Blast_Score=170, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17553712, Length=195, Percent_Identity=43.0769230769231, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319509, Length=198, Percent_Identity=40.4040404040404, Blast_Score=149, Evalue=3e-37,
Organism=Drosophila melanogaster, GI45551845, Length=188, Percent_Identity=42.0212765957447, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24644901, Length=188, Percent_Identity=42.0212765957447, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24644903, Length=168, Percent_Identity=27.3809523809524, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_MESSB (Q11KF1)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673289.1
- ProteinModelPortal:   Q11KF1
- SMR:   Q11KF1
- STRING:   Q11KF1
- GeneID:   4180202
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0724
- NMPDR:   fig|266779.1.peg.2862
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- PhylomeDB:   Q11KF1
- ProtClustDB:   PRK05679
- BioCyc:   MSP266779:MESO_0724-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24177; Mature: 24045

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 57-57 BINDING 60-60 BINDING 62-62 BINDING 79-79 BINDING 119-119 BINDING 123-123 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTMIKNDLKQTDFTEAGEPFRLFAEWLRDAEQSEPNDPNATALATVDPEGMPNVRMVL
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEE
LKGFDEQGFVFYTNFESAKGQEILSSMKAAMCFHWKSLRRQVRVRGPVEKVTDEEANAYY
EECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEE
ASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTAKYAVGEIPRPDYWSGFRIKPVSIEF
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEE
WHDRPFRLHDRILFERESGGLWTKTRLYP
ECCCCCEECCEEEEEECCCCCEEEECCCC
>Mature Secondary Structure 
SRTMIKNDLKQTDFTEAGEPFRLFAEWLRDAEQSEPNDPNATALATVDPEGMPNVRMVL
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEE
LKGFDEQGFVFYTNFESAKGQEILSSMKAAMCFHWKSLRRQVRVRGPVEKVTDEEANAYY
EECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEE
ASRPRGSRIGAWASKQSRPLEGRFALEKAVAEYTAKYAVGEIPRPDYWSGFRIKPVSIEF
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEE
WHDRPFRLHDRILFERESGGLWTKTRLYP
ECCCCCEECCEEEEEECCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA