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The map label for this gene is nhaA [H]

Identifier: 110633065

GI number: 110633065

Start: 781145

End: 782005

Strand: Reverse

Name: nhaA [H]

Synonym: Meso_0708

Alternate gene names: 110633065

Gene position: 782005-781145 (Counterclockwise)

Preceding gene: 110633066

Following gene: 110633064

Centisome position: 17.72

GC content: 61.67

Gene sequence:

>861_bases
GTGAAAGAATCGCTGGCGCGCCTCCTGCCGAAGTCCCTTCGTTCCGACTCCGTTACCATCCCCGTTGTCCGGCTGCATGG
CACGATCATGGCAGGCGGCAGCCCCATGCGGCAGTCGCTTTCGCTGGCCTCGACGGCCGGCCTTCTCGAAAAGGCATTCT
CCTTCTCCGCGCCGGCGGTCGCGATCTCTATCAACTCGCCGGGCGGATCGCCCGTGCAATCGCGCCTGATCTATCGGCGG
ATTCGCGATCTGGCGGAGGAGAGAAAGAAGAACGTCTTTGTCTTCGTCGAGGATATCGCGGCGTCCGGCGGCTATATGAT
TGCGCTTGCGGGCGACGAAATCATCTCGGACCCCTCTTCCATCGTCGGCTCGATCGGCGTCGTTTCAGCGGGCTTCGGCT
TCCAGGATCTCATCAAGAAGATCGGCGTGGAACGGCGGGTGCACACATCCGGGCGCAACAAGGCCATTCTCGACCCTTTT
CAGCCGGAAAAGGAGGAGGATGTGGAGCGGCTCAAGGCACTGCAGGAGGAGGTGCATCAGACCTTCATCTCGCTTGTCAG
GGAGCGGCGCGGTGCGAAACTTGCCAACGATGACGATCTTTTCACCGGCCTCTTCTGGACAGGGGAAAGAGGATTGTCGC
TCGGCCTGGTGGACGCCGTCGGCGACATGCGCTCCTTCCTAAAGCACCGCTATGGGGAAAAGACACGCCTCAAGCTCGTG
AGCCCCCCGCGCGGCCTTTTCGGGCGAAGACTGGGATTTTTCGGCTTGGATATGAAGGAAACCGATATCGCCGCCGCTGC
CGCGAGCGGGCTTGTCCAGGCGCTCGAAGAGCAGGCGCTTTGGCGCCGCTATGGGCTTTGA

Upstream 100 bases:

>100_bases
CAGGGAAACACTTTTCGTTGAATGAAGTTGTGCCGGGACGCCCATTGCGTCCCCGATGCCGATGCCTACATGAACGCAAC
AAAGCCTGGAGACATCCTAC

Downstream 100 bases:

>100_bases
CGCCTTGCTGCGGTCGCAAAGTGCCATAATATGAGGGAGTCTGCCAAAGGAGGCATTCGGCCATGCCGCAAATCATCTTC
TTCGCCCTCATAGCCACCGT

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKESLARLLPKSLRSDSVTIPVVRLHGTIMAGGSPMRQSLSLASTAGLLEKAFSFSAPAVAISINSPGGSPVQSRLIYRR
IRDLAEERKKNVFVFVEDIAASGGYMIALAGDEIISDPSSIVGSIGVVSAGFGFQDLIKKIGVERRVHTSGRNKAILDPF
QPEKEEDVERLKALQEEVHQTFISLVRERRGAKLANDDDLFTGLFWTGERGLSLGLVDAVGDMRSFLKHRYGEKTRLKLV
SPPRGLFGRRLGFFGLDMKETDIAAAAASGLVQALEEQALWRRYGL

Sequences:

>Translated_286_residues
MKESLARLLPKSLRSDSVTIPVVRLHGTIMAGGSPMRQSLSLASTAGLLEKAFSFSAPAVAISINSPGGSPVQSRLIYRR
IRDLAEERKKNVFVFVEDIAASGGYMIALAGDEIISDPSSIVGSIGVVSAGFGFQDLIKKIGVERRVHTSGRNKAILDPF
QPEKEEDVERLKALQEEVHQTFISLVRERRGAKLANDDDLFTGLFWTGERGLSLGLVDAVGDMRSFLKHRYGEKTRLKLV
SPPRGLFGRRLGFFGLDMKETDIAAAAASGLVQALEEQALWRRYGL
>Mature_286_residues
MKESLARLLPKSLRSDSVTIPVVRLHGTIMAGGSPMRQSLSLASTAGLLEKAFSFSAPAVAISINSPGGSPVQSRLIYRR
IRDLAEERKKNVFVFVEDIAASGGYMIALAGDEIISDPSSIVGSIGVVSAGFGFQDLIKKIGVERRVHTSGRNKAILDPF
QPEKEEDVERLKALQEEVHQTFISLVRERRGAKLANDDDLFTGLFWTGERGLSLGLVDAVGDMRSFLKHRYGEKTRLKLV
SPPRGLFGRRLGFFGLDMKETDIAAAAASGLVQALEEQALWRRYGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=190, Percent_Identity=32.1052631578947, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788064, Length=208, Percent_Identity=28.8461538461538, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 31256; Mature: 31256

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESLARLLPKSLRSDSVTIPVVRLHGTIMAGGSPMRQSLSLASTAGLLEKAFSFSAPAV
CCHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEE
AISINSPGGSPVQSRLIYRRIRDLAEERKKNVFVFVEDIAASGGYMIALAGDEIISDPSS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHCCCCEEEEEECCHHHCCHHH
IVGSIGVVSAGFGFQDLIKKIGVERRVHTSGRNKAILDPFQPEKEEDVERLKALQEEVHQ
HHHHHHHHCCCCCHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TFISLVRERRGAKLANDDDLFTGLFWTGERGLSLGLVDAVGDMRSFLKHRYGEKTRLKLV
HHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEE
SPPRGLFGRRLGFFGLDMKETDIAAAAASGLVQALEEQALWRRYGL
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKESLARLLPKSLRSDSVTIPVVRLHGTIMAGGSPMRQSLSLASTAGLLEKAFSFSAPAV
CCHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEE
AISINSPGGSPVQSRLIYRRIRDLAEERKKNVFVFVEDIAASGGYMIALAGDEIISDPSS
EEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHCCCCEEEEEECCHHHCCHHH
IVGSIGVVSAGFGFQDLIKKIGVERRVHTSGRNKAILDPFQPEKEEDVERLKALQEEVHQ
HHHHHHHHCCCCCHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TFISLVRERRGAKLANDDDLFTGLFWTGERGLSLGLVDAVGDMRSFLKHRYGEKTRLKLV
HHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEE
SPPRGLFGRRLGFFGLDMKETDIAAAAASGLVQALEEQALWRRYGL
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA