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The map label for this gene is fgs [H]

Identifier: 110633019

GI number: 110633019

Start: 740791

End: 742113

Strand: Reverse

Name: fgs [H]

Synonym: Meso_0662

Alternate gene names: 110633019

Gene position: 742113-740791 (Counterclockwise)

Preceding gene: 110633020

Following gene: 110633018

Centisome position: 16.82

GC content: 65.38

Gene sequence:

>1323_bases
ATGAGTGCCGCCGAGCGCGCCATTGACCGCCTGATGGCGCTCCACCCGAAGGGGTTCGACCTCTCGTTGGAGCGCGTCGG
CCGCCTGCTGCAGCGCCTTGGCGACCCGCAGGAGAAGCTGCCGCCTGTCATCCATATCGCCGGCACGAACGGCAAAGGCT
CCGCCGCAGCCTTCTCGCGGGCGCTGCTGGAGGCATCGGGCCGGACGGTCCATGTCCATACCTCGCCTCACCTGGTGCGC
TGGCACGAGCGTTTTCGCTTGGGAAAGCCGACCGGCGGCGAATTCGTGGACGACGACGTTCTCGCTGATGCGGTGGAGCG
CGTTGCGGAAGCCAATCGCGGCGAACAGATCACCGTGTTCGAGATTCTCACGGCAGTGATGTTCGTGCTTTTCTCCGAGC
ATCCGGCCGATGCCGCCGTCGTGGAAGTCGGCCTCGGGGGCCGCTTCGATGCAACGAATGTGATCCGGCATCCGGCAACA
AGCCTGATCATGCCGATCTCGCTGGATCATGAAGCCTATTTGGGCGACCGGGTGGAACTCATCGCGGCGGAGAAGGCGGG
GATCATTAAGCCGGGCTCGCCCGTCGTAATCGGCCAGCAGGAATGGGACGCCGCGCGCGAAGTGCTCCTCGAGACCGCGG
AACGGCTGGACGTGCCCTTCGAAGTTTACGGTCAGGATTTCATCGCCGTCGAGGAAAACGGGCGCATGGTCTATCAGGAT
GAGGACGGCCTGATGGACCTGCCGCTGCCGCGCCTTGTCGGGCGGCACCAGCTTGCCAACGCGGCGGCTGCCATTGCCGC
CGTGAAGGCTGCCGGCTTTTCCATTACCGTCCCCGCGGCCGAACAGGCGATGCTCGGCGTTTCCTGGCCCGGCCGCATGC
AGCGGCTCACCGAGGGCCGCCTGGTGGACCTCGCACCCGAAGGCGCGGAAATCTGGCTCGATGGCGGGCACAATCCAGGC
GCGGGCGCGGTAATCGCCGAGGCCATGGCAGAAGCGGAGGAGAAACGACCGCGTCCGCTGGTGCTGATCTCGGGCATGAT
CAACACCAAGGACCAAAAGGGCTATTTCAGCGCTTTTGAAGGAATGGCCCGGCATGTCTACACGGTGCCGGTGCATATGA
GCGAGGCGGGCGTGCCTAACAGCGAGCTATCCGCCCGCGCGATAGCAGCCGGCCTGTCCGCCGAGCCGGTCAACTCCGTG
TCCAATGCTCTGAAGCTCCTGCGCGACACCTGGGATGACCCGATGCCGCCGCGCATCCTCATCAGCGGCTCGCTATACCT
TGCGGGCGAAGTGCTGGCGGAGAACGGCACGCCACCGCAGTAA

Upstream 100 bases:

>100_bases
CCGAGGAAAACGGGAGCCGGCGACTGCCTGCGCCGGAGGCCGCCGTTGTGGAAGCCGCGGTGAACGCCTGATCCCCCCGC
GCAAGGTTTCGAGATCCTCT

Downstream 100 bases:

>100_bases
TAAATGGTGCGCAAGGGGGTAAGCCTCTAAATTGGCGTCTTGATTCAACGACTCGGCCGAAAGGCGTATAGAGACGCTGT
GAAAGGTCGAAGGAGAGGGT

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSAAERAIDRLMALHPKGFDLSLERVGRLLQRLGDPQEKLPPVIHIAGTNGKGSAAAFSRALLEASGRTVHVHTSPHLVR
WHERFRLGKPTGGEFVDDDVLADAVERVAEANRGEQITVFEILTAVMFVLFSEHPADAAVVEVGLGGRFDATNVIRHPAT
SLIMPISLDHEAYLGDRVELIAAEKAGIIKPGSPVVIGQQEWDAAREVLLETAERLDVPFEVYGQDFIAVEENGRMVYQD
EDGLMDLPLPRLVGRHQLANAAAAIAAVKAAGFSITVPAAEQAMLGVSWPGRMQRLTEGRLVDLAPEGAEIWLDGGHNPG
AGAVIAEAMAEAEEKRPRPLVLISGMINTKDQKGYFSAFEGMARHVYTVPVHMSEAGVPNSELSARAIAAGLSAEPVNSV
SNALKLLRDTWDDPMPPRILISGSLYLAGEVLAENGTPPQ

Sequences:

>Translated_440_residues
MSAAERAIDRLMALHPKGFDLSLERVGRLLQRLGDPQEKLPPVIHIAGTNGKGSAAAFSRALLEASGRTVHVHTSPHLVR
WHERFRLGKPTGGEFVDDDVLADAVERVAEANRGEQITVFEILTAVMFVLFSEHPADAAVVEVGLGGRFDATNVIRHPAT
SLIMPISLDHEAYLGDRVELIAAEKAGIIKPGSPVVIGQQEWDAAREVLLETAERLDVPFEVYGQDFIAVEENGRMVYQD
EDGLMDLPLPRLVGRHQLANAAAAIAAVKAAGFSITVPAAEQAMLGVSWPGRMQRLTEGRLVDLAPEGAEIWLDGGHNPG
AGAVIAEAMAEAEEKRPRPLVLISGMINTKDQKGYFSAFEGMARHVYTVPVHMSEAGVPNSELSARAIAAGLSAEPVNSV
SNALKLLRDTWDDPMPPRILISGSLYLAGEVLAENGTPPQ
>Mature_439_residues
SAAERAIDRLMALHPKGFDLSLERVGRLLQRLGDPQEKLPPVIHIAGTNGKGSAAAFSRALLEASGRTVHVHTSPHLVRW
HERFRLGKPTGGEFVDDDVLADAVERVAEANRGEQITVFEILTAVMFVLFSEHPADAAVVEVGLGGRFDATNVIRHPATS
LIMPISLDHEAYLGDRVELIAAEKAGIIKPGSPVVIGQQEWDAAREVLLETAERLDVPFEVYGQDFIAVEENGRMVYQDE
DGLMDLPLPRLVGRHQLANAAAAIAAVKAAGFSITVPAAEQAMLGVSWPGRMQRLTEGRLVDLAPEGAEIWLDGGHNPGA
GAVIAEAMAEAEEKRPRPLVLISGMINTKDQKGYFSAFEGMARHVYTVPVHMSEAGVPNSELSARAIAAGLSAEPVNSVS
NALKLLRDTWDDPMPPRILISGSLYLAGEVLAENGTPPQ

Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=328, Percent_Identity=30.7926829268293, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI66932984, Length=328, Percent_Identity=30.7926829268293, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1788654, Length=366, Percent_Identity=32.7868852459016, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71984923, Length=334, Percent_Identity=27.2455089820359, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17553148, Length=334, Percent_Identity=27.2455089820359, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17553150, Length=334, Percent_Identity=27.2455089820359, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323760, Length=438, Percent_Identity=29.9086757990868, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324815, Length=302, Percent_Identity=26.8211920529801, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24641571, Length=444, Percent_Identity=23.8738738738739, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24581568, Length=201, Percent_Identity=28.8557213930348, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 47293; Mature: 47161

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01012 FOLYLPOLYGLU_SYNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAERAIDRLMALHPKGFDLSLERVGRLLQRLGDPQEKLPPVIHIAGTNGKGSAAAFSR
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCCCEEEEECCCCCCHHHHHHH
ALLEASGRTVHVHTSPHLVRWHERFRLGKPTGGEFVDDDVLADAVERVAEANRGEQITVF
HHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHH
EILTAVMFVLFSEHPADAAVVEVGLGGRFDATNVIRHPATSLIMPISLDHEAYLGDRVEL
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCHHHCCCCEEE
IAAEKAGIIKPGSPVVIGQQEWDAAREVLLETAERLDVPFEVYGQDFIAVEENGRMVYQD
EEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEECCCEEEEEC
EDGLMDLPLPRLVGRHQLANAAAAIAAVKAAGFSITVPAAEQAMLGVSWPGRMQRLTEGR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHEEECCCCHHHHHHCCCC
LVDLAPEGAEIWLDGGHNPGAGAVIAEAMAEAEEKRPRPLVLISGMINTKDQKGYFSAFE
EEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
GMARHVYTVPVHMSEAGVPNSELSARAIAAGLSAEPVNSVSNALKLLRDTWDDPMPPRIL
HHHHEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
ISGSLYLAGEVLAENGTPPQ
EECCEEEEEEEEECCCCCCC
>Mature Secondary Structure 
SAAERAIDRLMALHPKGFDLSLERVGRLLQRLGDPQEKLPPVIHIAGTNGKGSAAAFSR
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCCCEEEEECCCCCCHHHHHHH
ALLEASGRTVHVHTSPHLVRWHERFRLGKPTGGEFVDDDVLADAVERVAEANRGEQITVF
HHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHH
EILTAVMFVLFSEHPADAAVVEVGLGGRFDATNVIRHPATSLIMPISLDHEAYLGDRVEL
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCHHHCCCCEEE
IAAEKAGIIKPGSPVVIGQQEWDAAREVLLETAERLDVPFEVYGQDFIAVEENGRMVYQD
EEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEECCCEEEEEC
EDGLMDLPLPRLVGRHQLANAAAAIAAVKAAGFSITVPAAEQAMLGVSWPGRMQRLTEGR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHEEECCCCHHHHHHCCCC
LVDLAPEGAEIWLDGGHNPGAGAVIAEAMAEAEEKRPRPLVLISGMINTKDQKGYFSAFE
EEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
GMARHVYTVPVHMSEAGVPNSELSARAIAAGLSAEPVNSVSNALKLLRDTWDDPMPPRIL
HHHHEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
ISGSLYLAGEVLAENGTPPQ
EECCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2105929; 9618466 [H]