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The map label for this gene is alsR [H]

Identifier: 110632936

GI number: 110632936

Start: 638146

End: 639042

Strand: Reverse

Name: alsR [H]

Synonym: Meso_0578

Alternate gene names: 110632936

Gene position: 639042-638146 (Counterclockwise)

Preceding gene: 110632938

Following gene: 110632931

Centisome position: 14.48

GC content: 61.43

Gene sequence:

>897_bases
ATGGACATTCGTTCGCTTGCTTGCTTTGTTGCCGTCGCTGAAGATCTCCATTTCCGGAGGGCTGCCGAACGCCTTCACAT
CACGCAACCGGCTTTAAGTCAGCGCATTCGAACACTTGAGCACGAGGTTGGAGCGGCGCTTCTGGAGCGAGATCGACGCC
ATGTGCAGCTCACGGCAGCCGGTGCAGCGTTCCTCGAGCCCGCGCGTACGGCGGTGGCCAACGCCGCCCAGGCAAAGGCA
CAAGCACTGAGAGCCGTCCGTGGTGAGGTCGGCCGGCTCCGGCTCGGGTTTACGGTGATAGCCTTCTACAGCGCTCTTCC
CGAGGCCGTGCGGCTTTATCGGAATCGATTCCCGGATGTTGCCGTCGAACTCGCGGAGATGAACTCCCCAACGCTGGAAC
GATCTCTCGCTGCCGGCGAAATCGATCTCGGCATTCTTCATCCGCCAATCGAGACTCCTGGTCTGTCGGTTCGAGCGCTT
CGATCGGAGAGGCTCATGCTCGCCTTGCCGGAACACCACGTTTTGGCGGCACAGCAAACCATTTCCGTGCGTGATCTCGA
CCGTCAGCCGTTCCTCATGGCACCTCGGGAAATCGGGCCCAGTATCCACGATCGAACTGTCGCTCTGTTCAGGAACGAGG
GCATCAGCCCGCACATCGTGCAGTATGTCACCCCGATGACGACCCTGGTCGGGCTGGCCGCGGCTGGTACCGGCGTCGGG
TTTGTAACGGAAGGCATGGCCAACGCAGGCCGGCCCGGAGTGGCATTTCGTCCCGTATCTCCCGCCGCTCCGTCTTTACC
GGTTGCCGCCGCTTGGGCAGGATCGTTACCTTCTGTGACTGCGGAACGATTTTTCGAAGTGGTGGCCAGCCTTGAACCCG
AACTGGACGAGCGCTGA

Upstream 100 bases:

>100_bases
TTCGACGAGGCTTCGTCAGATTGAGTGGACGATGCCACGGGTACTGATTAGTATCCAATTCGAATACCCCGCCCTGTGAT
AAGGCAATGCTTTCTCCGCC

Downstream 100 bases:

>100_bases
GGTTCGCTAGTCCCTTTAGCTAACACGCAGGAGCCTGCGGTTCGAAGGAGCGGTTCCAGTGCAGCCATGCGTCCAGGTAG
CGCTGCGGCGTGACGCCGAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MDIRSLACFVAVAEDLHFRRAAERLHITQPALSQRIRTLEHEVGAALLERDRRHVQLTAAGAAFLEPARTAVANAAQAKA
QALRAVRGEVGRLRLGFTVIAFYSALPEAVRLYRNRFPDVAVELAEMNSPTLERSLAAGEIDLGILHPPIETPGLSVRAL
RSERLMLALPEHHVLAAQQTISVRDLDRQPFLMAPREIGPSIHDRTVALFRNEGISPHIVQYVTPMTTLVGLAAAGTGVG
FVTEGMANAGRPGVAFRPVSPAAPSLPVAAAWAGSLPSVTAERFFEVVASLEPELDER

Sequences:

>Translated_298_residues
MDIRSLACFVAVAEDLHFRRAAERLHITQPALSQRIRTLEHEVGAALLERDRRHVQLTAAGAAFLEPARTAVANAAQAKA
QALRAVRGEVGRLRLGFTVIAFYSALPEAVRLYRNRFPDVAVELAEMNSPTLERSLAAGEIDLGILHPPIETPGLSVRAL
RSERLMLALPEHHVLAAQQTISVRDLDRQPFLMAPREIGPSIHDRTVALFRNEGISPHIVQYVTPMTTLVGLAAAGTGVG
FVTEGMANAGRPGVAFRPVSPAAPSLPVAAAWAGSLPSVTAERFFEVVASLEPELDER
>Mature_298_residues
MDIRSLACFVAVAEDLHFRRAAERLHITQPALSQRIRTLEHEVGAALLERDRRHVQLTAAGAAFLEPARTAVANAAQAKA
QALRAVRGEVGRLRLGFTVIAFYSALPEAVRLYRNRFPDVAVELAEMNSPTLERSLAAGEIDLGILHPPIETPGLSVRAL
RSERLMLALPEHHVLAAQQTISVRDLDRQPFLMAPREIGPSIHDRTVALFRNEGISPHIVQYVTPMTTLVGLAAAGTGVG
FVTEGMANAGRPGVAFRPVSPAAPSLPVAAAWAGSLPSVTAERFFEVVASLEPELDER

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=272, Percent_Identity=36.7647058823529, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1787879, Length=243, Percent_Identity=38.6831275720165, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI2367136, Length=271, Percent_Identity=32.1033210332103, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790399, Length=242, Percent_Identity=31.8181818181818, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI157672245, Length=218, Percent_Identity=30.7339449541284, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081904, Length=218, Percent_Identity=31.651376146789, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790208, Length=247, Percent_Identity=29.9595141700405, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI145693105, Length=185, Percent_Identity=28.6486486486486, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788748, Length=242, Percent_Identity=26.8595041322314, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788297, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=24.5059288537549, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789204, Length=270, Percent_Identity=24.8148148148148, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=117, Percent_Identity=35.042735042735, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32211; Mature: 32211

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRSLACFVAVAEDLHFRRAAERLHITQPALSQRIRTLEHEVGAALLERDRRHVQLTAA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GAAFLEPARTAVANAAQAKAQALRAVRGEVGRLRLGFTVIAFYSALPEAVRLYRNRFPDV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVELAEMNSPTLERSLAAGEIDLGILHPPIETPGLSVRALRSERLMLALPEHHVLAAQQT
HHHHHHCCCCHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCEEEECCCCHHHHHHHH
ISVRDLDRQPFLMAPREIGPSIHDRTVALFRNEGISPHIVQYVTPMTTLVGLAAAGTGVG
HHHHHCCCCCCEECCHHHCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
FVTEGMANAGRPGVAFRPVSPAAPSLPVAAAWAGSLPSVTAERFFEVVASLEPELDER
HHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDIRSLACFVAVAEDLHFRRAAERLHITQPALSQRIRTLEHEVGAALLERDRRHVQLTAA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GAAFLEPARTAVANAAQAKAQALRAVRGEVGRLRLGFTVIAFYSALPEAVRLYRNRFPDV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVELAEMNSPTLERSLAAGEIDLGILHPPIETPGLSVRALRSERLMLALPEHHVLAAQQT
HHHHHHCCCCHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCEEEECCCCHHHHHHHH
ISVRDLDRQPFLMAPREIGPSIHDRTVALFRNEGISPHIVQYVTPMTTLVGLAAAGTGVG
HHHHHCCCCCCEECCHHHCCCHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
FVTEGMANAGRPGVAFRPVSPAAPSLPVAAAWAGSLPSVTAERFFEVVASLEPELDER
HHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]