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The map label for this gene is moeZ [H]

Identifier: 110632366

GI number: 110632366

Start: 4049

End: 4810

Strand: Direct

Name: moeZ [H]

Synonym: Meso_0004

Alternate gene names: 110632366

Gene position: 4049-4810 (Clockwise)

Preceding gene: 110632365

Following gene: 110632372

Centisome position: 0.09

GC content: 63.25

Gene sequence:

>762_bases
ATGAACGATACGATCCTTTCCGACGAAGAGCTTGAGCGCTACGCGCGCCATATCGTGCTGCCCGAGATCGGCGGCGCGGG
CCAGCAGAAACTGAAGCGCGCCCGGGTTCTGGTGCTGGGTGCAGGCGGGCTTGGAGCTCCCGTCTTGCAGTATCTGGCGG
CCGCAGGCGTGGGGACACTCGGCATCGTAGACGACGACCATGTCTCGCTGTCGAATCTGCAGCGGCAGATCATCCATGAG
ACGAAAGCGGTCGGGCTACCCAAGACCGAGAGCGCTAAGACCGCCATCGAACGCCTCAACCCTCACACAAAAGTCGAGTC
ACACGTCCGTCGGCTCGATCCCGCGAATGCCGGTCCGCTGATCGCGCGCTATCACGTGGTGGTGGATGGTTCCGACAATT
TCGAGACGCGCTATACGCTCGCCGATACCTGCGCGGAACAGAAGGTGCCGCTGATCACGGCGGCGGTGGGGCGTTTCGAC
GGCTCCCTCACTGTGCTGAAGCCCTATGAAACGACAGCGGATGGCCGACCGCTGCCTTCCTATCGGGACCTGTTCCCGGA
GGCGCCGCCGCCTGGAATGGTGCCCACCTGCGCGGAAGCGGGAATCGTCGGCGCTCTCACCGGTGTCATGGGAACATTGC
AGGCGATGGAAGCCATCAAGCTCATCACAGGCATCGGTGAACCCTTGATAGGGCGCCTGCTCCTCTACGACGCGCTGGCC
TGCCGCTTCGAGATTGTCCGCTACGGGCCGAAACAGGCCTGA

Upstream 100 bases:

>100_bases
GAGGGCCGGGCCCAATTTCTCGCCGTATCGGGCGGCGCAATTCAGTCGGTTTGAGCGCGGCGCACCTGACAAGCCGCCTC
CGGCGAAGTATGGTCCCGCC

Downstream 100 bases:

>100_bases
AACAGCGGCTATTCAACGGCCGTCCTGATGGCGGCAATGTTCTGCCGGTAGGCGTCCTCCCCATTTCCTTTAAAGATCGA
GGAGCCAGCCACAAGCACAT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MNDTILSDEELERYARHIVLPEIGGAGQQKLKRARVLVLGAGGLGAPVLQYLAAAGVGTLGIVDDDHVSLSNLQRQIIHE
TKAVGLPKTESAKTAIERLNPHTKVESHVRRLDPANAGPLIARYHVVVDGSDNFETRYTLADTCAEQKVPLITAAVGRFD
GSLTVLKPYETTADGRPLPSYRDLFPEAPPPGMVPTCAEAGIVGALTGVMGTLQAMEAIKLITGIGEPLIGRLLLYDALA
CRFEIVRYGPKQA

Sequences:

>Translated_253_residues
MNDTILSDEELERYARHIVLPEIGGAGQQKLKRARVLVLGAGGLGAPVLQYLAAAGVGTLGIVDDDHVSLSNLQRQIIHE
TKAVGLPKTESAKTAIERLNPHTKVESHVRRLDPANAGPLIARYHVVVDGSDNFETRYTLADTCAEQKVPLITAAVGRFD
GSLTVLKPYETTADGRPLPSYRDLFPEAPPPGMVPTCAEAGIVGALTGVMGTLQAMEAIKLITGIGEPLIGRLLLYDALA
CRFEIVRYGPKQA
>Mature_253_residues
MNDTILSDEELERYARHIVLPEIGGAGQQKLKRARVLVLGAGGLGAPVLQYLAAAGVGTLGIVDDDHVSLSNLQRQIIHE
TKAVGLPKTESAKTAIERLNPHTKVESHVRRLDPANAGPLIARYHVVVDGSDNFETRYTLADTCAEQKVPLITAAVGRFD
GSLTVLKPYETTADGRPLPSYRDLFPEAPPPGMVPTCAEAGIVGALTGVMGTLQAMEAIKLITGIGEPLIGRLLLYDALA
CRFEIVRYGPKQA

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=238, Percent_Identity=46.218487394958, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI38045948, Length=168, Percent_Identity=34.5238095238095, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI23510338, Length=214, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI23510340, Length=214, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4885649, Length=154, Percent_Identity=30.5194805194805, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI150417996, Length=201, Percent_Identity=26.3681592039801, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI38045944, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI38045942, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787048, Length=241, Percent_Identity=46.0580912863071, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI87082356, Length=239, Percent_Identity=42.2594142259414, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1789177, Length=150, Percent_Identity=29.3333333333333, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17540406, Length=242, Percent_Identity=39.6694214876033, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI86565433, Length=184, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI86565431, Length=184, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193203301, Length=140, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71984476, Length=190, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=240, Percent_Identity=42.0833333333333, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320598, Length=151, Percent_Identity=29.1390728476821, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24582879, Length=249, Percent_Identity=45.3815261044177, Blast_Score=223, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24660640, Length=141, Percent_Identity=29.7872340425532, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28573937, Length=194, Percent_Identity=26.8041237113402, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129973, Length=184, Percent_Identity=29.3478260869565, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27066; Mature: 27066

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTILSDEELERYARHIVLPEIGGAGQQKLKRARVLVLGAGGLGAPVLQYLAAAGVGTL
CCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEE
GIVDDDHVSLSNLQRQIIHETKAVGLPKTESAKTAIERLNPHTKVESHVRRLDPANAGPL
EECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCE
IARYHVVVDGSDNFETRYTLADTCAEQKVPLITAAVGRFDGSLTVLKPYETTADGRPLPS
EEEEEEEEECCCCCCEEEHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
YRDLFPEAPPPGMVPTCAEAGIVGALTGVMGTLQAMEAIKLITGIGEPLIGRLLLYDALA
HHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
CRFEIVRYGPKQA
HHHHHHHCCCCCC
>Mature Secondary Structure
MNDTILSDEELERYARHIVLPEIGGAGQQKLKRARVLVLGAGGLGAPVLQYLAAAGVGTL
CCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHCCCCEE
GIVDDDHVSLSNLQRQIIHETKAVGLPKTESAKTAIERLNPHTKVESHVRRLDPANAGPL
EECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCE
IARYHVVVDGSDNFETRYTLADTCAEQKVPLITAAVGRFDGSLTVLKPYETTADGRPLPS
EEEEEEEEECCCCCCEEEHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
YRDLFPEAPPPGMVPTCAEAGIVGALTGVMGTLQAMEAIKLITGIGEPLIGRLLLYDALA
HHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
CRFEIVRYGPKQA
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]