| Definition | Helicobacter acinonychis str. Sheeba chromosome, complete genome. |
|---|---|
| Accession | NC_008229 |
| Length | 1,553,927 |
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The map label for this gene is polA [H]
Identifier: 109948187
GI number: 109948187
Start: 1491205
End: 1493868
Strand: Reverse
Name: polA [H]
Synonym: Hac_1719
Alternate gene names: 109948187
Gene position: 1493868-1491205 (Counterclockwise)
Preceding gene: 109948190
Following gene: 109948186
Centisome position: 96.14
GC content: 36.22
Gene sequence:
>2664_bases ATGGAACAGCCAATCACTAAAGAAGGGACTTTAGCTTTAATTGATACTTTTGCGTATTTGTTTAGAAGCTATTACATGAG TGCTAAAACGAAGCCTTTAACCAACGATAAGGGCTTTCCAACAGGGCTTTTAATGGGGCTTGTGGGCATGATTAAAAAAT TTTATAAAGACAGAAAAAACATGCCTTTTATCGTGTTTGCCCTAGAAAGCCAAACTAAAACGAAACGATCTGAAAAACTG GGCGAATACAAACAAAATCGTAAAGACGCCCCTAAAGAAATGCTTTTACAAATCCCTATCGCATTAGAATGGTTGCAAAA AATGGGTTTTACTTGCGTGGAAGTGAGTGGGTTTGAAGCTGATGATGTTATCGCCAGTTTAGCCACGCTAAGCCCTTATA AAACCCGCATTTATTCTAAAGACAAGGATTTTAACCAGCTTTTGAACGATAAAATCGCGCTTTTTGATGGTAAAACGGAG TTTTTAGCAAAAGATTGCGTGGAAAAATACGGGATTTTGCCCAGTCAATTCACTGATTATCAAGGCATTGTAGGGGATAG CAGCGATAATTATAAGGGGGTTAAAGGCATTGGGAGCAAGAACGCTAAAGAATTGTTGCAACAATTAGGGAGTTTGGAAA AAATCTATAACAATTTAGATCTAGCGAAAAATTTACTCAGCCCTAAAATGTATCAAGCCCTTATACATGATAAAGAGAGC GCGTTTTTAAGTAAAGAATTAGCCACTTTAGAGAGAGAGTGTATTAAAGAATTTGATTTTTTAAGTTGCGCTTTTCCTAG TGAAAACCCTTTATGGAAAATTAAAGATGAATTGAAAGAATATGGCTTTATTTCTACTTTAAGGGATTTAGAAAATACCC CTATGCCTTTAATTTTAGATGAAACCCCTCTATTAGACAGCGCTCCTACAAAATCAAGCATGATCATTTTAGAAAATACC GCACCATTTAGCGCGTTTTTAGAAAAATTAGAAAATTCTAGTGCAAGGGTTTTTGCGCGTTTGGTGCTGAATAAAGAAAA AGAAATTCTAGCCCTAGCGTTTTTATTTGAATGTCAAGGCTATTTTTTACCCCTAGAAGAAGCGTTATTTTCGCCCTTTT CTTTAGAGTTTTTGCAAAACGCTTTTTCTAAAATGTTACAGCACGCGTGCATCATAGGGCATGATTTAAAACCCTTGTTA AGCTTTTTAAAAGCCAAATATCAGGTTTCTTTGGAAAACATTCATATCCAAGACACTCAAATTTTAGCGTTTTTGAAAAA TCCAGAAAAAGTTGGGTTTGATGAGGTTTTAAAGGAATATTTAAAAGAAGATTTAATTTTGCATGAAAAGATCAAAGATT TTAAGACAAAAAGCAAGGCGGAAAAGTTAGAGCGCTTGAATGTGGAATTAAACGCTTTAAAGCGTTTGTGCGAGTATTTT GAAAAAGAGGGGCTAGAAGAGGATTTACTTTCTTTAGCTAAAGAGATTGAAATGCCGTTTATGAAAGTCTTAATGAATAT GGAATTTCAAGGCTTTAAAATTGATGCACCTTATTTTAAGCGCTTAGAGCAGGAGTTTAAAGATGAATTAAAAGTTTTAG AGCGTCAAATTTTGGATTTAATCGGCGAGGATTTTAACCTCAATTCGCCCAAACAACTCAGTGGAGTTTTGTATGAAAAA TTAAACCTTCCTAAAAATAAAAGCCACTCCACCGATGAAAAAAACTTATTAAAGATTATGGATAAGCACCCAAGCATCCC TTTGATTTTAGAATACAGAGAATTGAACAAGCTTTCTAACACTTATATCACCCCCTTGTTACGCCTAAAAGACAAAGACG ATAAAATCCATACCACTTTCATTCAAACCGGCACAGCTACGGGGCGTTTAAGCTCGCATTCGCCTAATTTGCAAAATATC CCAGTGCGATCTTCTAAAGGCTTACTCATTCGTAAGGGCTTTATTTCTAGCTCCAAAGAATATTGTTTGTTAGGGGTGGA TTATTCGCAGATTGAATTGCGTTTGTTAGCCCATTTTAGCCAGGATAAGGATTTAATGGAGGCGTTTTTAAAGGGGCGAG ACATCCATTTAGAAACTTCTAGGGCGTTGTTTGGCGAAAATTCAGCTAAAGAAAAACGATCGATCGCTAAAAGCATTAAT TTTGGGCTTGTGTATGGCATGGGGAGTAAGAAATTGAGCGAAACTTTAAATATCCCTTTAAACGAGGCTAAAAGCTATAT AGAAGCGTATTTCAAACGATTCCCTAGCATCAAAGATTATTTAAATAACATGCAAGAAGAGATTTTAAAAACTTCTAAAG CTTTCACTTTGCTTGGGCGTTATAGGGTGTTTGACTTTAATGGCGTTAATGATTATGTTAAGGGTAATTATTTGCGAGAG GGCGTGAATGCGATCTTTCAAGGGAGTGCGAGCGATTTATTGAAACTGGGCATGCTCAAAGTGAGCGAGCGTTTTAAAAA TGATTCTTCAGTGAGGCTGCTTTTACAAGTGCATGACGAATTGATTTTTGAGATTGAAGAAAAAAACGCCCTAGAGTTGC AGCAAGAAATCCAACGCATTCTCAACAATGAAGTGTATGCTTTAAGAGTGCCGCTAGAAACAAGCGCGTTTATTGCAAAG CGTTGGAATGATCTAAAAGGTTAG
Upstream 100 bases:
>100_bases AAAGTGAGAGAATTATAGCGTAAAAGTTTAAGATTGGATTTAGGGGTGCAAGCTTGTGTTACAATTAAATTTGAAATTTG CTTGATTTAAGAGAGATTCA
Downstream 100 bases:
>100_bases TTTTTTAATTGAGTTTAAGAAAAAATATATTATTATTCCACTATAAGTAATACTTTGTGGTATTAAGCTAATTATAGAAA GAACAAAGGGAAAAGACTGA
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 887; Mature: 887
Protein sequence:
>887_residues MEQPITKEGTLALIDTFAYLFRSYYMSAKTKPLTNDKGFPTGLLMGLVGMIKKFYKDRKNMPFIVFALESQTKTKRSEKL GEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEADDVIASLATLSPYKTRIYSKDKDFNQLLNDKIALFDGKTE FLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQQLGSLEKIYNNLDLAKNLLSPKMYQALIHDKES AFLSKELATLERECIKEFDFLSCAFPSENPLWKIKDELKEYGFISTLRDLENTPMPLILDETPLLDSAPTKSSMIILENT APFSAFLEKLENSSARVFARLVLNKEKEILALAFLFECQGYFLPLEEALFSPFSLEFLQNAFSKMLQHACIIGHDLKPLL SFLKAKYQVSLENIHIQDTQILAFLKNPEKVGFDEVLKEYLKEDLILHEKIKDFKTKSKAEKLERLNVELNALKRLCEYF EKEGLEEDLLSLAKEIEMPFMKVLMNMEFQGFKIDAPYFKRLEQEFKDELKVLERQILDLIGEDFNLNSPKQLSGVLYEK LNLPKNKSHSTDEKNLLKIMDKHPSIPLILEYRELNKLSNTYITPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNI PVRSSKGLLIRKGFISSSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSRALFGENSAKEKRSIAKSIN FGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNNMQEEILKTSKAFTLLGRYRVFDFNGVNDYVKGNYLRE GVNAIFQGSASDLLKLGMLKVSERFKNDSSVRLLLQVHDELIFEIEEKNALELQQEIQRILNNEVYALRVPLETSAFIAK RWNDLKG
Sequences:
>Translated_887_residues MEQPITKEGTLALIDTFAYLFRSYYMSAKTKPLTNDKGFPTGLLMGLVGMIKKFYKDRKNMPFIVFALESQTKTKRSEKL GEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEADDVIASLATLSPYKTRIYSKDKDFNQLLNDKIALFDGKTE FLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQQLGSLEKIYNNLDLAKNLLSPKMYQALIHDKES AFLSKELATLERECIKEFDFLSCAFPSENPLWKIKDELKEYGFISTLRDLENTPMPLILDETPLLDSAPTKSSMIILENT APFSAFLEKLENSSARVFARLVLNKEKEILALAFLFECQGYFLPLEEALFSPFSLEFLQNAFSKMLQHACIIGHDLKPLL SFLKAKYQVSLENIHIQDTQILAFLKNPEKVGFDEVLKEYLKEDLILHEKIKDFKTKSKAEKLERLNVELNALKRLCEYF EKEGLEEDLLSLAKEIEMPFMKVLMNMEFQGFKIDAPYFKRLEQEFKDELKVLERQILDLIGEDFNLNSPKQLSGVLYEK LNLPKNKSHSTDEKNLLKIMDKHPSIPLILEYRELNKLSNTYITPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNI PVRSSKGLLIRKGFISSSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSRALFGENSAKEKRSIAKSIN FGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNNMQEEILKTSKAFTLLGRYRVFDFNGVNDYVKGNYLRE GVNAIFQGSASDLLKLGMLKVSERFKNDSSVRLLLQVHDELIFEIEEKNALELQQEIQRILNNEVYALRVPLETSAFIAK RWNDLKG >Mature_887_residues MEQPITKEGTLALIDTFAYLFRSYYMSAKTKPLTNDKGFPTGLLMGLVGMIKKFYKDRKNMPFIVFALESQTKTKRSEKL GEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEADDVIASLATLSPYKTRIYSKDKDFNQLLNDKIALFDGKTE FLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQQLGSLEKIYNNLDLAKNLLSPKMYQALIHDKES AFLSKELATLERECIKEFDFLSCAFPSENPLWKIKDELKEYGFISTLRDLENTPMPLILDETPLLDSAPTKSSMIILENT APFSAFLEKLENSSARVFARLVLNKEKEILALAFLFECQGYFLPLEEALFSPFSLEFLQNAFSKMLQHACIIGHDLKPLL SFLKAKYQVSLENIHIQDTQILAFLKNPEKVGFDEVLKEYLKEDLILHEKIKDFKTKSKAEKLERLNVELNALKRLCEYF EKEGLEEDLLSLAKEIEMPFMKVLMNMEFQGFKIDAPYFKRLEQEFKDELKVLERQILDLIGEDFNLNSPKQLSGVLYEK LNLPKNKSHSTDEKNLLKIMDKHPSIPLILEYRELNKLSNTYITPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNI PVRSSKGLLIRKGFISSSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSRALFGENSAKEKRSIAKSIN FGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNNMQEEILKTSKAFTLLGRYRVFDFNGVNDYVKGNYLRE GVNAIFQGSASDLLKLGMLKVSERFKNDSSVRLLLQVHDELIFEIEEKNALELQQEIQRILNNEVYALRVPLETSAFIAK RWNDLKG
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=519, Percent_Identity=28.3236994219653, Blast_Score=194, Evalue=4e-49, Organism=Homo sapiens, GI139394648, Length=648, Percent_Identity=24.0740740740741, Blast_Score=151, Evalue=3e-36, Organism=Escherichia coli, GI1790294, Length=939, Percent_Identity=32.1618743343983, Blast_Score=385, Evalue=1e-108, Organism=Escherichia coli, GI226510970, Length=194, Percent_Identity=35.0515463917526, Blast_Score=104, Evalue=2e-23, Organism=Caenorhabditis elegans, GI86563272, Length=443, Percent_Identity=30.2483069977427, Blast_Score=198, Evalue=1e-50, Organism=Drosophila melanogaster, GI17933644, Length=555, Percent_Identity=29.009009009009, Blast_Score=186, Evalue=7e-47,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 101842; Mature: 101842
Theoretical pI: Translated: 7.32; Mature: 7.32
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEQPITKEGTLALIDTFAYLFRSYYMSAKTKPLTNDKGFPTGLLMGLVGMIKKFYKDRKN CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC MPFIVFALESQTKTKRSEKLGEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEA CCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCH DDVIASLATLSPYKTRIYSKDKDFNQLLNDKIALFDGKTEFLAKDCVEKYGILPSQFTDY HHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCC QGIVGDSSDNYKGVKGIGSKNAKELLQQLGSLEKIYNNLDLAKNLLSPKMYQALIHDKES CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCHHH AFLSKELATLERECIKEFDFLSCAFPSENPLWKIKDELKEYGFISTLRDLENTPMPLILD HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCEEEC ETPLLDSAPTKSSMIILENTAPFSAFLEKLENSSARVFARLVLNKEKEILALAFLFECQG CCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC YFLPLEEALFSPFSLEFLQNAFSKMLQHACIIGHDLKPLLSFLKAKYQVSLENIHIQDTQ CEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEECHHH ILAFLKNPEKVGFDEVLKEYLKEDLILHEKIKDFKTKSKAEKLERLNVELNALKRLCEYF HEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH EKEGLEEDLLSLAKEIEMPFMKVLMNMEFQGFKIDAPYFKRLEQEFKDELKVLERQILDL HHCCCHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH IGEDFNLNSPKQLSGVLYEKLNLPKNKSHSTDEKNLLKIMDKHPSIPLILEYRELNKLSN HCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHH TYITPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNIPVRSSKGLLIRKGFISSSKE HHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC YCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSRALFGENSAKEKRSIAKSIN EEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHCCCCHHHHHHHHHHCC FGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNNMQEEILKTSKAFTLLGR CEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC YRVFDFNGVNDYVKGNYLREGVNAIFQGSASDLLKLGMLKVSERFKNDSSVRLLLQVHDE EEEEEECCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH LIFEIEEKNALELQQEIQRILNNEVYALRVPLETSAFIAKRWNDLKG HHHEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCC >Mature Secondary Structure MEQPITKEGTLALIDTFAYLFRSYYMSAKTKPLTNDKGFPTGLLMGLVGMIKKFYKDRKN CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC MPFIVFALESQTKTKRSEKLGEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVSGFEA CCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCH DDVIASLATLSPYKTRIYSKDKDFNQLLNDKIALFDGKTEFLAKDCVEKYGILPSQFTDY HHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCC QGIVGDSSDNYKGVKGIGSKNAKELLQQLGSLEKIYNNLDLAKNLLSPKMYQALIHDKES CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCHHH AFLSKELATLERECIKEFDFLSCAFPSENPLWKIKDELKEYGFISTLRDLENTPMPLILD HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCEEEC ETPLLDSAPTKSSMIILENTAPFSAFLEKLENSSARVFARLVLNKEKEILALAFLFECQG CCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC YFLPLEEALFSPFSLEFLQNAFSKMLQHACIIGHDLKPLLSFLKAKYQVSLENIHIQDTQ CEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEECHHH ILAFLKNPEKVGFDEVLKEYLKEDLILHEKIKDFKTKSKAEKLERLNVELNALKRLCEYF HEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH EKEGLEEDLLSLAKEIEMPFMKVLMNMEFQGFKIDAPYFKRLEQEFKDELKVLERQILDL HHCCCHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH IGEDFNLNSPKQLSGVLYEKLNLPKNKSHSTDEKNLLKIMDKHPSIPLILEYRELNKLSN HCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHH TYITPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNIPVRSSKGLLIRKGFISSSKE HHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC YCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSRALFGENSAKEKRSIAKSIN EEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEHHHHHHCCCCHHHHHHHHHHCC FGLVYGMGSKKLSETLNIPLNEAKSYIEAYFKRFPSIKDYLNNMQEEILKTSKAFTLLGR CEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC YRVFDFNGVNDYVKGNYLREGVNAIFQGSASDLLKLGMLKVSERFKNDSSVRLLLQVHDE EEEEEECCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH LIFEIEEKNALELQQEIQRILNNEVYALRVPLETSAFIAKRWNDLKG HHHEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9923682 [H]