Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 109947987

GI number: 109947987

Start: 1297098

End: 1298132

Strand: Reverse

Name: msrA [H]

Synonym: Hac_1495

Alternate gene names: 109947987

Gene position: 1298132-1297098 (Counterclockwise)

Preceding gene: 109947988

Following gene: 109947986

Centisome position: 83.54

GC content: 40.48

Gene sequence:

>1035_bases
ATGGGAGCGATTATGCAAGCGAATGAAAACATGGGATCTAAACTCCCTAAAACCGATGGAAAAGTGATTTATTTGGCTGG
GGGGTGCTTTTGGGGGCTAGAGGCGTATATGGAGAGGATTTATGGCGTTATAGACGCAAGCTCTGGTTACGCTAACGGCA
AGACTCAAAGCACGAATTATCAAAAGTTGCATGAAAGTGATCATGCTGAGAGCGTGAAAGTGGTTTATGATCCTAAAAAA
ATCAGTTTGGACAAATTGCTACGCTATTATTTTAAAGTGGTTGATCCGGTGAGCGTGAATAAGCAGGGTAATGATGTGGG
CAGGCAGTATCGCACAGGGATTTATTATGTGGATAATGCGGATAAAAAGGTGATAGACAACGCCTTAAAAGAATTGCAAA
AAAGCGTGAAAGGTAAGATCGCCATTGAGGTAGAGCCTTTAAAAAATTATGTGAGGGCTGAAGAATACCACCAAGACTAT
TTGAAAAAAAATCCTAACGGCTATTGCCATATTGATTTGAAAAAGGCGGATGAAGTGATTGTGGATAGCGATAAATACAC
CAAACCAAGCGATGAAGTTTTAAAGAAAAAGCTCACCCAACTCCAGTATGAAGTGACTCAAAACAAACGCACTGAGAAAC
CCTTTGAAAACGAGTATTACAACAAAGAAGAAGAGGGCATTTATGTGGATATTACCACAGGCGAGCCGTTATTTTCTTCA
GCGGATAAATACGACTCTGGTTGCGGTTGGCCAAGCTTTTCTAAACCTATCAGTAAGGATGTGGTGAAATACGAAGACGA
CGAGAGTCTTAATATGAGGCGCACTGAAGTGTTGAGCCGTATTGGTAAGGCGCATTTAGGGCATGTGTTTAATGATGGGC
CTAAAGAGTTGGGGGGTTTAAGGTATTGTATCAATAGCGCATCTTTAAGATTTATCCCTTTAAAAGACATGGAAAAAGAG
GGCTATGGCGAGTTTATCCCCTACATTAAAAAGGGTGAATTGAAAAAATACATCCACGATAAAAAAACGCATTAA

Upstream 100 bases:

>100_bases
AACAAAATTTAGTTATAATAACAGGCATCATTAAAATCAAAATAAAGGTTATTTGGTGAAAATGTTGCATTATTTAAAAA
TTTTTTATCTTTTTTTACTA

Downstream 100 bases:

>100_bases
GAAGCAACGCTTAACCCCTCTAATTTTGGGGTAGTTAAGCGTTTGGATTGTCTCAAAAACGCTAAAAACTGCCTTAACTA
TTCATTTTTTTACTCTTAAT

Product: hypothetical protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MGAIMQANENMGSKLPKTDGKVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTQSTNYQKLHESDHAESVKVVYDPKK
ISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVDNADKKVIDNALKELQKSVKGKIAIEVEPLKNYVRAEEYHQDY
LKKNPNGYCHIDLKKADEVIVDSDKYTKPSDEVLKKKLTQLQYEVTQNKRTEKPFENEYYNKEEEGIYVDITTGEPLFSS
ADKYDSGCGWPSFSKPISKDVVKYEDDESLNMRRTEVLSRIGKAHLGHVFNDGPKELGGLRYCINSASLRFIPLKDMEKE
GYGEFIPYIKKGELKKYIHDKKTH

Sequences:

>Translated_344_residues
MGAIMQANENMGSKLPKTDGKVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTQSTNYQKLHESDHAESVKVVYDPKK
ISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVDNADKKVIDNALKELQKSVKGKIAIEVEPLKNYVRAEEYHQDY
LKKNPNGYCHIDLKKADEVIVDSDKYTKPSDEVLKKKLTQLQYEVTQNKRTEKPFENEYYNKEEEGIYVDITTGEPLFSS
ADKYDSGCGWPSFSKPISKDVVKYEDDESLNMRRTEVLSRIGKAHLGHVFNDGPKELGGLRYCINSASLRFIPLKDMEKE
GYGEFIPYIKKGELKKYIHDKKTH
>Mature_343_residues
GAIMQANENMGSKLPKTDGKVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTQSTNYQKLHESDHAESVKVVYDPKKI
SLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVDNADKKVIDNALKELQKSVKGKIAIEVEPLKNYVRAEEYHQDYL
KKNPNGYCHIDLKKADEVIVDSDKYTKPSDEVLKKKLTQLQYEVTQNKRTEKPFENEYYNKEEEGIYVDITTGEPLFSSA
DKYDSGCGWPSFSKPISKDVVKYEDDESLNMRRTEVLSRIGKAHLGHVFNDGPKELGGLRYCINSASLRFIPLKDMEKEG
YGEFIPYIKKGELKKYIHDKKTH

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=50, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=50, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=50, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=50, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=34.9693251533742, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI117606353, Length=128, Percent_Identity=46.875, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI208609995, Length=161, Percent_Identity=35.4037267080745, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI208609993, Length=118, Percent_Identity=35.5932203389831, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=50.8064516129032, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=34.2105263157895, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=119, Percent_Identity=44.5378151260504, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17553450, Length=111, Percent_Identity=45.945945945946, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17533973, Length=137, Percent_Identity=35.036496350365, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=42.7672955974843, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319816, Length=135, Percent_Identity=38.5185185185185, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645799, Length=122, Percent_Identity=50, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45553335, Length=122, Percent_Identity=50, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21356369, Length=122, Percent_Identity=50, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=48.3606557377049, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=46.5116279069767, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24645804, Length=133, Percent_Identity=45.1127819548872, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645801, Length=133, Percent_Identity=45.1127819548872, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664627, Length=139, Percent_Identity=31.6546762589928, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=31.6546762589928, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 39391; Mature: 39260

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAIMQANENMGSKLPKTDGKVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTQSTNY
CCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
QKLHESDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVDNA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEEEEECC
DKKVIDNALKELQKSVKGKIAIEVEPLKNYVRAEEYHQDYLKKNPNGYCHIDLKKADEVI
CHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
VDSDKYTKPSDEVLKKKLTQLQYEVTQNKRTEKPFENEYYNKEEEGIYVDITTGEPLFSS
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEEEECCCCHHCC
ADKYDSGCGWPSFSKPISKDVVKYEDDESLNMRRTEVLSRIGKAHLGHVFNDGPKELGGL
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHHHHH
RYCINSASLRFIPLKDMEKEGYGEFIPYIKKGELKKYIHDKKTH
HHHHCCCCEEEEECCCCCCCCCCCCCCCHHCCHHHHHHHHCCCC
>Mature Secondary Structure 
GAIMQANENMGSKLPKTDGKVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTQSTNY
CCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
QKLHESDHAESVKVVYDPKKISLDKLLRYYFKVVDPVSVNKQGNDVGRQYRTGIYYVDNA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEEEEECC
DKKVIDNALKELQKSVKGKIAIEVEPLKNYVRAEEYHQDYLKKNPNGYCHIDLKKADEVI
CHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
VDSDKYTKPSDEVLKKKLTQLQYEVTQNKRTEKPFENEYYNKEEEGIYVDITTGEPLFSS
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEEEECCCCHHCC
ADKYDSGCGWPSFSKPISKDVVKYEDDESLNMRRTEVLSRIGKAHLGHVFNDGPKELGGL
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHCCCHHHHHHH
RYCINSASLRFIPLKDMEKEGYGEFIPYIKKGELKKYIHDKKTH
HHHHCCCCEEEEECCCCCCCCCCCCCCCHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]