Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 109947960

GI number: 109947960

Start: 1271700

End: 1272614

Strand: Reverse

Name: cysK [H]

Synonym: Hac_1465

Alternate gene names: 109947960

Gene position: 1272614-1271700 (Counterclockwise)

Preceding gene: 109947962

Following gene: 109947959

Centisome position: 81.9

GC content: 43.5

Gene sequence:

>915_bases
ATGATTATCACCGCAATGCAAGACGCCATTGGCCACACTCCCATTTTTAAATTCACTAGAAATTACCCTATCCCAAAAAA
TTCTGTCATTTACGCCAAACTAGAGCATCTAAACCCAGGAGGGAGCGTTAAAGACCGCTTAGGCCAATATCTCATAAAAG
AAGCGTTTAGAACGCACAAAATCACTCCCACAACAACCATTATTGAGCCTACTGCGGGCAATACCGGCATCGCTCTAGCG
TTAGTTGCGCTCAAACACCATCTTAAAACGATCTTTGTTGTCCCAGAAAAATTTAGTGTAGAAAAACAACAAATCATGAA
AGCTTTGGGAGCTACAGTAATCAACACGCCTACTAGTGAGGGGATTTCTGGAGCCATTAAAAAAAGTAAAGAGTTAGCCA
AAAGTATCCCTGATAGCTATTTGCCCTTACAATTTGAAAACTTTGACAATCCTAATGCCTACTACCACACTTTAGCCCCT
GAGATTTTCCAAAAATTAGGCACAGGGCTTACGAGCTTTGTAGCTGGGATAGGTAGCGGTGGCACTTTTGCGGGCACAGC
CGCCTATTTAAAAGAACGCATTCCTACTATTCGCTTGATTGGCGTAGAGCCGGAGGGTTCTATTTTGAATGGGGGAGAGC
CTGGACCTCATGAAATTGAGGGCATTGGCGTGGAGTTTATCCCTCCGTTTTTTGCAAACTTGGATATTGATGGCTTTGAA
ACGATCTCAGATGAAGAGGGTTTTCATTACACTAGGGAATTAGCCAAAAAAAACGGCTTGTTGGTGGGGAGCTCTAGTGG
GGCAGTTTTTGCGGCAGCGTTACGAGAAGTGCAACGCCTCCCCAATGGTAGCCAAGTTTTAACCATTTTTCCGGATGTTG
CCGATCGTTATCTCTCAAAAGGTATTTATTCATAA

Upstream 100 bases:

>100_bases
AAATGTTTAGGGGTTCTAATCAAAACCCCTTACTCCATTTAATGAGTTTAGGCATAATAATAAAAATTATTGCTACCCTT
TATTATTATTAGGAGGAATG

Downstream 100 bases:

>100_bases
AAAATTCAATAAAAAAGGAAAAATCATGCACATGCAAACCAAATTGATCCATGGGGGCATTAGTGAGGACGCAACAACGG
GGGCGGTAAGCGTGCCTATT

Product: hypothetical protein

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MIITAMQDAIGHTPIFKFTRNYPIPKNSVIYAKLEHLNPGGSVKDRLGQYLIKEAFRTHKITPTTTIIEPTAGNTGIALA
LVALKHHLKTIFVVPEKFSVEKQQIMKALGATVINTPTSEGISGAIKKSKELAKSIPDSYLPLQFENFDNPNAYYHTLAP
EIFQKLGTGLTSFVAGIGSGGTFAGTAAYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGFE
TISDEEGFHYTRELAKKNGLLVGSSSGAVFAAALREVQRLPNGSQVLTIFPDVADRYLSKGIYS

Sequences:

>Translated_304_residues
MIITAMQDAIGHTPIFKFTRNYPIPKNSVIYAKLEHLNPGGSVKDRLGQYLIKEAFRTHKITPTTTIIEPTAGNTGIALA
LVALKHHLKTIFVVPEKFSVEKQQIMKALGATVINTPTSEGISGAIKKSKELAKSIPDSYLPLQFENFDNPNAYYHTLAP
EIFQKLGTGLTSFVAGIGSGGTFAGTAAYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGFE
TISDEEGFHYTRELAKKNGLLVGSSSGAVFAAALREVQRLPNGSQVLTIFPDVADRYLSKGIYS
>Mature_304_residues
MIITAMQDAIGHTPIFKFTRNYPIPKNSVIYAKLEHLNPGGSVKDRLGQYLIKEAFRTHKITPTTTIIEPTAGNTGIALA
LVALKHHLKTIFVVPEKFSVEKQQIMKALGATVINTPTSEGISGAIKKSKELAKSIPDSYLPLQFENFDNPNAYYHTLAP
EIFQKLGTGLTSFVAGIGSGGTFAGTAAYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGFE
TISDEEGFHYTRELAKKNGLLVGSSSGAVFAAALREVQRLPNGSQVLTIFPDVADRYLSKGIYS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=301, Percent_Identity=39.8671096345515, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI295821200, Length=301, Percent_Identity=39.8671096345515, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557415, Length=301, Percent_Identity=39.8671096345515, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=35.4304635761589, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788754, Length=310, Percent_Identity=40, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=36.6336633663366, Blast_Score=183, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17562970, Length=310, Percent_Identity=36.4516129032258, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI115535073, Length=302, Percent_Identity=38.4105960264901, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI32566674, Length=304, Percent_Identity=36.8421052631579, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=36.7924528301887, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=36.3924050632911, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=303, Percent_Identity=36.963696369637, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566672, Length=216, Percent_Identity=36.1111111111111, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=38.0952380952381, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=32.1100917431193, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643623, Length=304, Percent_Identity=37.828947368421, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI20129101, Length=304, Percent_Identity=37.828947368421, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32901; Mature: 32901

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITAMQDAIGHTPIFKFTRNYPIPKNSVIYAKLEHLNPGGSVKDRLGQYLIKEAFRTHK
CEEECCHHHHCCCCHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
ITPTTTIIEPTAGNTGIALALVALKHHLKTIFVVPEKFSVEKQQIMKALGATVINTPTSE
CCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCCCEECCCCCC
GISGAIKKSKELAKSIPDSYLPLQFENFDNPNAYYHTLAPEIFQKLGTGLTSFVAGIGSG
CHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHCCCC
GTFAGTAAYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGFE
CCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCC
TISDEEGFHYTRELAKKNGLLVGSSSGAVFAAALREVQRLPNGSQVLTIFPDVADRYLSK
CCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHC
GIYS
CCCC
>Mature Secondary Structure
MIITAMQDAIGHTPIFKFTRNYPIPKNSVIYAKLEHLNPGGSVKDRLGQYLIKEAFRTHK
CEEECCHHHHCCCCHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
ITPTTTIIEPTAGNTGIALALVALKHHLKTIFVVPEKFSVEKQQIMKALGATVINTPTSE
CCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCCCEECCCCCC
GISGAIKKSKELAKSIPDSYLPLQFENFDNPNAYYHTLAPEIFQKLGTGLTSFVAGIGSG
CHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHCCCC
GTFAGTAAYLKERIPTIRLIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFANLDIDGFE
CCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCC
TISDEEGFHYTRELAKKNGLLVGSSSGAVFAAALREVQRLPNGSQVLTIFPDVADRYLSK
CCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHC
GIYS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]