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The map label for this gene is thrS

Identifier: 109947952

GI number: 109947952

Start: 1261748

End: 1263586

Strand: Reverse

Name: thrS

Synonym: Hac_1457

Alternate gene names: 109947952

Gene position: 1263586-1261748 (Counterclockwise)

Preceding gene: 109947953

Following gene: 109947951

Centisome position: 81.32

GC content: 40.02

Gene sequence:

>1839_bases
ATGAGTGCGGAATTGATTGCCGTTTATAAAGACGAGCAAATAATAGATTTGGAGAGCGCGAAAGTTTTAGGACTAAGCGA
TGGGGTTAAGGCGTTAAAAGGGAGCGAGCCGATATATTTTGATGATTCGCCTTTGGCTTTAGAAGTGATCAGGCATTCAT
GTGCACACTTGCTTGCACAAAGCTTGAAAGCCCTTTATCCGGACGCGAAATTTTTTGTAGGCCCTGTGGTGGAAGAAGGC
TTTTATTATGATTTCAAAACCGCTTCAAAAATCAGCGAAGAAGATTTGCCTAAAATTGAAGCGAAAATGAAAGAGTTTGC
AAAATCAAAGCTCGCTATCACTAAAGAAGTTTTAACCAAAGAGCAAGCCTTGGAGCGTTTTAAGGGCGATGAATTAAAGC
ATGCGGTCATGAGTAAAATCAGTGGCGATGCATTTGGCGTGTATCAACAAGGCGGGTTTGAAGATTTGTGTAAGGGACCG
CACCTCCCAAACACTCGCTTTTTAAACCATTTCAAGCTCACTAAATTAGCTGGGGCTTATTTGGGTGGCGATGAAAAAAA
TGAAATGCTTATTAGGATTTATGGCATCGCTTTTGCCACTAAAGAGGGCTTAAAAGACTATCTTTTTCAAATAGAAGAAG
CAAAAAAACGAGATCACAGAAAGCTAGGCGTGGAGCTAGGGCTTTTTAGCTTTGATGATGAAATAGGGGCGGGCTTGCCT
TTGTGGTTGCCTAAAGGGGCAAGGCTTAGGAAACGCATAGAGGATTTATTGAGTAAGGCGTTACTTTTAAGAGGCTATGA
GCCGGTCAAAGGCCCTGAGATCTTAAAAAGCGATGTGTGGAAAATCAGCGGGCATTATGACAATTACAAAGAAAACATGT
ATTTCACCACGATTGATGAGCAAGAATACGGCATAAAGCCTATGAATTGCGTGGGGCATATTAAAGTCTATCAAAGTGCT
TTACACAGTTATAGAGACTTGCCTTTAAGGTTTTATGAATACGGCGTGGTGCATCGGCATGAAAAAAGCGGCGTGTTGCA
TGGGCTTTTAAGGGTTAGGGAATTTACCCAAGATGATGCACATATTTTTTGCTCTTTTGAACAGATTCAAAGCGAAGTGA
GCGCGATTTTAGATTTTACGCATAAGATCATGAAAGCGTTTGATTTTAGCTATGAAATGGAGCTTTCCACAAGGCCAGCT
AAATCCATAGGCGATGATAAAGTCTGGGAAAAGGCCACCAACGCTTTAAAAGAAGCCTTGAAAGAGCATCACATTAATTA
TAAGATTGATGAAGGGGGAGGGGCTTTTTATGGGCCTAAGATTGATATTAAAATCACCGACGCTTTGAAGCGCAAATGGC
AGTGCGGCACGATCCAAGTGGATATGAATTTGCCTGAACGCTTCAAACTCGCTTTTACGAATGAGCATAATAACGCTGAA
CAGCCTGTGATGATCCACAGAGCGATTTTAGGCTCGTTTGAAAGGTTTATTGCGATTTTAAGCGAACATTTTTGGGGGAA
TTTCCCTTTCTTTGTCGCACCCACTCAAATCGTTCTCATTCCTATTAATGAAGAGCATCATGTTTTTGCTTTGAAATTAA
AAGAAGAACTAAAAAAGCGCGATATTTTTGTAGAAGTGCTGGATAAAAATGACAGCTTGAATAAAAAAGTGCGTTTAGCC
GAAAAACAAAAAATCCCTATGATTCTAGTTTTAGGGAATGAGGAAATGGAGACAGAAATCTTATCCATTAGAGACAGAGA
AAAACAAGCTCAATATAAAATGCCCTTAAAGGAGTTTTTAAACATGGTTGAATCTAAAATGCAAGAGGTTAGTTTTTGA

Upstream 100 bases:

>100_bases
AAGCTGAGAAAGTGGATGCACAAGTGCAATGCGGGTTTGGCTCAAAAGATTGCTAAAAGCATCAAAAAAGTATTAAGAAA
GGAAACATAAGTTTTAAAGA

Downstream 100 bases:

>100_bases
GTAGAAACGAAGTGTTGTTAAATGGAGACATTAATTTTAAAGAAGTGCGTTGCGTGGGTGATAATGGCGAAGTGTATGGG
ATCATTTCTTCTAGAGAAGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MSAELIAVYKDEQIIDLESAKVLGLSDGVKALKGSEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEG
FYYDFKTASKISEEDLPKIEAKMKEFAKSKLAITKEVLTKEQALERFKGDELKHAVMSKISGDAFGVYQQGGFEDLCKGP
HLPNTRFLNHFKLTKLAGAYLGGDEKNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLP
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSA
LHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMKAFDFSYEMELSTRPA
KSIGDDKVWEKATNALKEALKEHHINYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNNAE
QPVMIHRAILGSFERFIAILSEHFWGNFPFFVAPTQIVLIPINEEHHVFALKLKEELKKRDIFVEVLDKNDSLNKKVRLA
EKQKIPMILVLGNEEMETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF

Sequences:

>Translated_612_residues
MSAELIAVYKDEQIIDLESAKVLGLSDGVKALKGSEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEG
FYYDFKTASKISEEDLPKIEAKMKEFAKSKLAITKEVLTKEQALERFKGDELKHAVMSKISGDAFGVYQQGGFEDLCKGP
HLPNTRFLNHFKLTKLAGAYLGGDEKNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLP
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSA
LHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMKAFDFSYEMELSTRPA
KSIGDDKVWEKATNALKEALKEHHINYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNNAE
QPVMIHRAILGSFERFIAILSEHFWGNFPFFVAPTQIVLIPINEEHHVFALKLKEELKKRDIFVEVLDKNDSLNKKVRLA
EKQKIPMILVLGNEEMETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF
>Mature_611_residues
SAELIAVYKDEQIIDLESAKVLGLSDGVKALKGSEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEGF
YYDFKTASKISEEDLPKIEAKMKEFAKSKLAITKEVLTKEQALERFKGDELKHAVMSKISGDAFGVYQQGGFEDLCKGPH
LPNTRFLNHFKLTKLAGAYLGGDEKNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLPL
WLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSAL
HSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMKAFDFSYEMELSTRPAK
SIGDDKVWEKATNALKEALKEHHINYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNNAEQ
PVMIHRAILGSFERFIAILSEHFWGNFPFFVAPTQIVLIPINEEHHVFALKLKEELKKRDIFVEVLDKNDSLNKKVRLAE
KQKIPMILVLGNEEMETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=623, Percent_Identity=36.115569823435, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI38570111, Length=578, Percent_Identity=39.1003460207612, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI20070344, Length=577, Percent_Identity=34.1421143847487, Blast_Score=355, Evalue=7e-98,
Organism=Escherichia coli, GI1788013, Length=572, Percent_Identity=41.6083916083916, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1786392, Length=160, Percent_Identity=28.125, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984184, Length=570, Percent_Identity=39.1228070175439, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71984192, Length=570, Percent_Identity=39.1228070175439, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6322112, Length=560, Percent_Identity=41.0714285714286, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=392, Percent_Identity=37.7551020408163, Blast_Score=262, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24583839, Length=603, Percent_Identity=37.4792703150912, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24583842, Length=603, Percent_Identity=37.4792703150912, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI28574141, Length=603, Percent_Identity=37.4792703150912, Blast_Score=422, Evalue=1e-118,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_HELAH (Q17VZ5)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_665180.1
- ProteinModelPortal:   Q17VZ5
- SMR:   Q17VZ5
- STRING:   Q17VZ5
- GeneID:   4177477
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1457
- NMPDR:   fig|382638.8.peg.1411
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   EVIRHSC
- PhylomeDB:   Q17VZ5
- ProtClustDB:   PRK12305
- BioCyc:   HACI382638:HAC_1457-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 70261; Mature: 70130

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELIAVYKDEQIIDLESAKVLGLSDGVKALKGSEPIYFDDSPLALEVIRHSCAHLLAQ
CCCCEEEEECCCEEEEECCCEEEECCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
SLKALYPDAKFFVGPVVEEGFYYDFKTASKISEEDLPKIEAKMKEFAKSKLAITKEVLTK
HHHHHCCCCHHEECHHHHCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQALERFKGDELKHAVMSKISGDAFGVYQQGGFEDLCKGPHLPNTRFLNHFKLTKLAGAY
HHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LGGDEKNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLP
CCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCC
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDE
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCCCCCEEEEEECC
QEYGIKPMNCVGHIKVYQSALHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEECCHHHHHHHHHHHHHHCCCCC
HIFCSFEQIQSEVSAILDFTHKIMKAFDFSYEMELSTRPAKSIGDDKVWEKATNALKEAL
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KEHHINYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNNAE
HHCCCCEEEECCCCEEECCEEEEEEEHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCC
QPVMIHRAILGSFERFIAILSEHFWGNFPFFVAPTQIVLIPINEEHHVFALKLKEELKKR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCEEEEEHHHHHHHH
DIFVEVLDKNDSLNKKVRLAEKQKIPMILVLGNEEMETEILSIRDREKQAQYKMPLKEFL
CEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
NMVESKMQEVSF
HHHHHHHHHCCC
>Mature Secondary Structure 
SAELIAVYKDEQIIDLESAKVLGLSDGVKALKGSEPIYFDDSPLALEVIRHSCAHLLAQ
CCCEEEEECCCEEEEECCCEEEECCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHH
SLKALYPDAKFFVGPVVEEGFYYDFKTASKISEEDLPKIEAKMKEFAKSKLAITKEVLTK
HHHHHCCCCHHEECHHHHCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EQALERFKGDELKHAVMSKISGDAFGVYQQGGFEDLCKGPHLPNTRFLNHFKLTKLAGAY
HHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LGGDEKNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLP
CCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCC
LWLPKGARLRKRIEDLLSKALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDE
EECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCCCCCEEEEEECC
QEYGIKPMNCVGHIKVYQSALHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEECCHHHHHHHHHHHHHHCCCCC
HIFCSFEQIQSEVSAILDFTHKIMKAFDFSYEMELSTRPAKSIGDDKVWEKATNALKEAL
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
KEHHINYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEHNNAE
HHCCCCEEEECCCCEEECCEEEEEEEHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCC
QPVMIHRAILGSFERFIAILSEHFWGNFPFFVAPTQIVLIPINEEHHVFALKLKEELKKR
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCEEEEEHHHHHHHH
DIFVEVLDKNDSLNKKVRLAEKQKIPMILVLGNEEMETEILSIRDREKQAQYKMPLKEFL
CEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHH
NMVESKMQEVSF
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA