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The map label for this gene is dut

Identifier: 109947753

GI number: 109947753

Start: 1063522

End: 1063959

Strand: Reverse

Name: dut

Synonym: Hac_1228

Alternate gene names: 109947753

Gene position: 1063959-1063522 (Counterclockwise)

Preceding gene: 109947754

Following gene: 109947752

Centisome position: 68.47

GC content: 43.15

Gene sequence:

>438_bases
ATGAAAATTAAAATCCAAAAAATCCACCCAAACGCCCTTATCCCTAAATACCAAACTGAAGGTTCTTCAGGCTTTGATTT
GCATGCGGTAGAAAATGCAGTGATCAAACCTCATAGCGTGGGGTTAGTGAGGATAGGGATTTGTTTGTCTTTAGAGGTGG
GGTATGAATTGCAGGTGCGTACCCGTAGCGGTCTAGCGTTGAACCATCAAGTGATGGTGTTGAATTCTCCTGGCACGGTG
GATAATGATTATAGGGGCGAAATTAAGGTCATTTTAGCGAATTTGAGCGATAAAGATTTTACAATCCAAGTAGGGGATAG
GATCGCTCAAGGGGTGGTTCAAAAAACTTATAAAGCCGAATTTATAGAATGCGAACAATTAGATGAAACTTCAAGGGGGA
GTGGGGGGTTTGGCAGCACAGGAGTGAGCAAGGCATGA

Upstream 100 bases:

>100_bases
TTGATCGGTAAGAGCAAGGGTGATGTGGCAAGCATTCAATTACCTAATGGGGAGAGCGATTTTGAAATTTTAGACATTTA
TTATAAAGAGATTTGTTTTG

Downstream 100 bases:

>100_bases
GTATTAAAGAAAATTTAGAGCAGGTTAAGAGTGAATTTAAAAGCGATGAAAAGCTTTTAGAGGGGGCGTTTAGATTAGAA
AAATTTTTCAAACGCTATAA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MKIKIQKIHPNALIPKYQTEGSSGFDLHAVENAVIKPHSVGLVRIGICLSLEVGYELQVRTRSGLALNHQVMVLNSPGTV
DNDYRGEIKVILANLSDKDFTIQVGDRIAQGVVQKTYKAEFIECEQLDETSRGSGGFGSTGVSKA

Sequences:

>Translated_145_residues
MKIKIQKIHPNALIPKYQTEGSSGFDLHAVENAVIKPHSVGLVRIGICLSLEVGYELQVRTRSGLALNHQVMVLNSPGTV
DNDYRGEIKVILANLSDKDFTIQVGDRIAQGVVQKTYKAEFIECEQLDETSRGSGGFGSTGVSKA
>Mature_145_residues
MKIKIQKIHPNALIPKYQTEGSSGFDLHAVENAVIKPHSVGLVRIGICLSLEVGYELQVRTRSGLALNHQVMVLNSPGTV
DNDYRGEIKVILANLSDKDFTIQVGDRIAQGVVQKTYKAEFIECEQLDETSRGSGGFGSTGVSKA

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI4503423, Length=141, Percent_Identity=36.1702127659575, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI70906444, Length=141, Percent_Identity=36.1702127659575, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI70906441, Length=141, Percent_Identity=36.1702127659575, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790071, Length=147, Percent_Identity=34.6938775510204, Blast_Score=87, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71988561, Length=141, Percent_Identity=39.0070921985816, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319729, Length=140, Percent_Identity=37.1428571428571, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19921126, Length=140, Percent_Identity=35, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583610, Length=140, Percent_Identity=35, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_HELAH (Q17WJ4)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664981.1
- ProteinModelPortal:   Q17WJ4
- SMR:   Q17WJ4
- STRING:   Q17WJ4
- GeneID:   4176385
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1228
- NMPDR:   fig|382638.8.peg.1193
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   ESSILTE
- PhylomeDB:   Q17WJ4
- ProtClustDB:   PRK00601
- BioCyc:   HACI382638:HAC_1228-MONOMER
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15755; Mature: 15755

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: BINDING 75-75 BINDING 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKIQKIHPNALIPKYQTEGSSGFDLHAVENAVIKPHSVGLVRIGICLSLEVGYELQVR
CEEEEEEECCCCCCCCEECCCCCCEEEEECCCCEECCCCCCEEEEEEEEEEECCCEEEEE
TRSGLALNHQVMVLNSPGTVDNDYRGEIKVILANLSDKDFTIQVGDRIAQGVVQKTYKAE
ECCCEEECEEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCC
FIECEQLDETSRGSGGFGSTGVSKA
EEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIKIQKIHPNALIPKYQTEGSSGFDLHAVENAVIKPHSVGLVRIGICLSLEVGYELQVR
CEEEEEEECCCCCCCCEECCCCCCEEEEECCCCEECCCCCCEEEEEEEEEEECCCEEEEE
TRSGLALNHQVMVLNSPGTVDNDYRGEIKVILANLSDKDFTIQVGDRIAQGVVQKTYKAE
ECCCEEECEEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCC
FIECEQLDETSRGSGGFGSTGVSKA
EEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA