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The map label for this gene is prsA [H]

Identifier: 109947252

GI number: 109947252

Start: 593179

End: 594114

Strand: Reverse

Name: prsA [H]

Synonym: Hac_0677

Alternate gene names: 109947252

Gene position: 594114-593179 (Counterclockwise)

Preceding gene: 109947253

Following gene: 109947248

Centisome position: 38.23

GC content: 43.8

Gene sequence:

>936_bases
ATGAAAATGCGTGGGTTTAAGATTTTTTCAGGGAGCGCTCACCCTGTATTTGGCAAAGAAGTAGCAAGGCATTTAGGCGT
TCCCTTATCCAAAGCGATGATTGGGAGATTCAGCGATGGCGAAATCAATATCCAGATCAGCGAATCGGTGCGCGGTAAAG
ATATTTTTATTATCCAGCCCACTTGCGTGCCTGTCAATAACAATTTAATGGAATTATTGATCATGGTAGATGCTTTAAGG
CGCAGTTCGGCCAATTCTATCACGGCGGTGTTGCCGTATTTTGGCTATGCAAGACAGGACAGAAAAGCGGCTCCAAGAGT
GCCTATCACGGCTAAAATGGTCGCTAATTTGATGCAAGAAGTGGGGATTGAAAGGATCATTACGATGGATTTGCATGCTG
GGCAAATCCAAGGCTTTTTTGATGTGCCGGTGGATAATTTATACGGCTCTATCGTTTTTAGAGACTATATCCGCTCTAAA
GCGCTCAAAAACCCAGTGATCGCCAGCCCTGATGTGGGTGGGGTTACAAGAGCTAGGTATTTTGCTAATCAAATGGGCTT
GGATTTAATCATCGTGGATAAGCGCCGTGAAAAAGCCAATGAAAGCGAAGTGATGAATATTATCGGCTCTGTGCAAGGGC
GAGATGTGATTTTAGTGGATGATATGATCGATACTGCAGGCACGATCTGTAAAGCCGCTCTCGCTTTAAAAGAGCAAGGG
GCGACTTCTGTGATGGCGTTAGGCACACATGCGGTTTTGAGTGGGAATGCATTCAAGCGCATTAAAGAAAGTGCGTTAGA
TGAAGTGGTGGTGAGCAATTCCATTCCTTTAGCTCAAAAATGCGATAAAATCACCACTTTAAGTGTAGTGCCCTTATTTG
CAGAAGTCATTAGAAGGATTTATCATAACGAAAGCGTTCAATCGCTTTTCACTTAA

Upstream 100 bases:

>100_bases
TGCATTAAAAAACTTATTAGAAAAGGATCTTGGTTGAAAATTAACGCTTTTAGTTTTGGTGTGTTACAATTATTTTTAAT
CCATTTAGGGAGTGTAAGCA

Downstream 100 bases:

>100_bases
AAAGGGGATCAAAAGAAGTGTGGGAGTGGTGGATTCTGTAGGACTTGAACCTACGACCAATCGGTTATGAGCCGAGTGCT
CTGACCAGCTGAGCTAAGAA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKMRGFKIFSGSAHPVFGKEVARHLGVPLSKAMIGRFSDGEINIQISESVRGKDIFIIQPTCVPVNNNLMELLIMVDALR
RSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQEVGIERIITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSK
ALKNPVIASPDVGGVTRARYFANQMGLDLIIVDKRREKANESEVMNIIGSVQGRDVILVDDMIDTAGTICKAALALKEQG
ATSVMALGTHAVLSGNAFKRIKESALDEVVVSNSIPLAQKCDKITTLSVVPLFAEVIRRIYHNESVQSLFT

Sequences:

>Translated_311_residues
MKMRGFKIFSGSAHPVFGKEVARHLGVPLSKAMIGRFSDGEINIQISESVRGKDIFIIQPTCVPVNNNLMELLIMVDALR
RSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQEVGIERIITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSK
ALKNPVIASPDVGGVTRARYFANQMGLDLIIVDKRREKANESEVMNIIGSVQGRDVILVDDMIDTAGTICKAALALKEQG
ATSVMALGTHAVLSGNAFKRIKESALDEVVVSNSIPLAQKCDKITTLSVVPLFAEVIRRIYHNESVQSLFT
>Mature_311_residues
MKMRGFKIFSGSAHPVFGKEVARHLGVPLSKAMIGRFSDGEINIQISESVRGKDIFIIQPTCVPVNNNLMELLIMVDALR
RSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQEVGIERIITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSK
ALKNPVIASPDVGGVTRARYFANQMGLDLIIVDKRREKANESEVMNIIGSVQGRDVILVDDMIDTAGTICKAALALKEQG
ATSVMALGTHAVLSGNAFKRIKESALDEVVVSNSIPLAQKCDKITTLSVVPLFAEVIRRIYHNESVQSLFT

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=47.1337579617834, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=47.1337579617834, Blast_Score=294, Evalue=9e-80,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=46.8152866242038, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=46.6876971608833, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI4506133, Length=341, Percent_Identity=37.8299120234604, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=36.6279069767442, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI310128524, Length=141, Percent_Identity=32.6241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310115209, Length=141, Percent_Identity=32.6241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310118259, Length=141, Percent_Identity=32.6241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310119946, Length=141, Percent_Identity=32.6241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=54.6325878594249, Blast_Score=351, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17554702, Length=316, Percent_Identity=45.8860759493671, Blast_Score=293, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=46.1783439490446, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=316, Percent_Identity=45.8860759493671, Blast_Score=292, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=46.2783171521036, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=32.8402366863905, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=42.5396825396825, Blast_Score=276, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=42.3566878980892, Blast_Score=276, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=43.8095238095238, Blast_Score=259, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=200, Percent_Identity=40.5, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=112, Percent_Identity=42.8571428571429, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=45.3968253968254, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=42.3076923076923, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=36.7521367521368, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=36.7521367521368, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=36.7521367521368, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=36.7521367521368, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24651462, Length=199, Percent_Identity=39.6984924623116, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24651464, Length=199, Percent_Identity=39.6984924623116, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45552010, Length=199, Percent_Identity=39.6984924623116, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34107; Mature: 34107

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMRGFKIFSGSAHPVFGKEVARHLGVPLSKAMIGRFSDGEINIQISESVRGKDIFIIQP
CCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCEEEEECC
TCVPVNNNLMELLIMVDALRRSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQE
EEEECCCHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VGIERIITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSKALKNPVIASPDVGGVTRARY
CCHHEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
FANQMGLDLIIVDKRREKANESEVMNIIGSVQGRDVILVDDMIDTAGTICKAALALKEQG
HHHHCCCEEEEEECCHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCC
ATSVMALGTHAVLSGNAFKRIKESALDEVVVSNSIPLAQKCDKITTLSVVPLFAEVIRRI
CCEEEECCCHHEECCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
YHNESVQSLFT
HCCHHHHHHCC
>Mature Secondary Structure
MKMRGFKIFSGSAHPVFGKEVARHLGVPLSKAMIGRFSDGEINIQISESVRGKDIFIIQP
CCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCEEEEECC
TCVPVNNNLMELLIMVDALRRSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQE
EEEECCCHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VGIERIITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSKALKNPVIASPDVGGVTRARY
CCHHEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
FANQMGLDLIIVDKRREKANESEVMNIIGSVQGRDVILVDDMIDTAGTICKAALALKEQG
HHHHCCCEEEEEECCHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCC
ATSVMALGTHAVLSGNAFKRIKESALDEVVVSNSIPLAQKCDKITTLSVVPLFAEVIRRI
CCEEEECCCHHEECCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHH
YHNESVQSLFT
HCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]