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The map label for this gene is hemH

Identifier: 109947087

GI number: 109947087

Start: 432073

End: 433089

Strand: Reverse

Name: hemH

Synonym: Hac_0490

Alternate gene names: 109947087

Gene position: 433089-432073 (Counterclockwise)

Preceding gene: 109947090

Following gene: 109947086

Centisome position: 27.87

GC content: 37.76

Gene sequence:

>1017_bases
ATGAATTTAGCCCAAGAAAACCTTAACAGCCCAAACAACCTAGGAAATAACGCCACAAAATCCCCTAAAGAAACGGTCAT
TCTTTTGAATATGGGAGGGCCTAACAGCCTTTATGAAGTGGGGGTGTTTTTAAAAAACATGTTTGATGACCCCTTTATCC
TTACCATTAAAAATAATTTCATGCGTAAAATGGTGGGTAAAATGATTGTCAATAGCCGCATAGAAAAATCCAAAAAGATC
TATGAAAAATTAGGAGGCAAATCCCCTTTAACGCCTATCACATTCGCCCTTACGGAGCGTTTGAATGAATTAGATCCTTC
TCGTTTTTACACTTATGCGATGCGTTATACCCCCCCTTATGCGTCCATGGTGTTGCAAGATTTAGCTTTAAAAGAGGTAG
AAAGCCTAGTGTTTTTTTCTATGTATCCTCAATATTCTAGCACCACCACCCTTTCTAGTTTCAATGACGCTTTTAACGCC
CTAAAATCTTTAGAAACTTTCCGCCCTAAAGTGCGAGTGATAGAGCGCTTTTATGCGAGCGAAAAACTTAATGAAATCAT
TTTAAACACGATTTTAAGCACCCTAAACAACCACAAAAGCCAAGATTTTGTCTTAATCTTTTCAGTCCATGGCTTACCTA
AAAGCATTATTGACGCAGGCGATACTTACCAGCAAGAATGCGAACACCATGTGGATTTGTTAAAAGATTTGATGCGACAA
AAAAATATCCATTTTAAACAGGTTTTACTCTCTTACCAATCCAAGCTAGGACCCATGAAATGGTTAGAGCCAAGCACTGA
AGGATTGATAGAAAAGCACCGCAAATCTAACATTATCATCTACCCTTTGGCTTTTACGATTGACAATTCTGAAACGCTCT
ATGAGTTAGAGATACAATACCGCTTAATGGCAGCACGCCTAGCGATTAAAGAATATTTAGTTTGTCCGTGTTTAAACGAC
TCCATAGAGTTTGCAAAGTTCATCATTGAATTAGTGAAAAATCTTAAAGATGAGTGA

Upstream 100 bases:

>100_bases
ACAGAATCTTGTGTGTTTAGCGCTTGCAAACTCATCTTTAAGTATAAATTTCCTTTTAGTGATTTATGTTTGATTAAGCC
TTTTATTCTATCATGCAACA

Downstream 100 bases:

>100_bases
AACTTGCATAAAAAAGCGATTATTGTAGTAAGATATTGAGTTTCAAATTATGACAAAAAAGTTATTGCAAAAAAGGTTAT
TTTATGTTTTCATTTTCTTA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MNLAQENLNSPNNLGNNATKSPKETVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKI
YEKLGGKSPLTPITFALTERLNELDPSRFYTYAMRYTPPYASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNA
LKSLETFRPKVRVIERFYASEKLNEIILNTILSTLNNHKSQDFVLIFSVHGLPKSIIDAGDTYQQECEHHVDLLKDLMRQ
KNIHFKQVLLSYQSKLGPMKWLEPSTEGLIEKHRKSNIIIYPLAFTIDNSETLYELEIQYRLMAARLAIKEYLVCPCLND
SIEFAKFIIELVKNLKDE

Sequences:

>Translated_338_residues
MNLAQENLNSPNNLGNNATKSPKETVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKI
YEKLGGKSPLTPITFALTERLNELDPSRFYTYAMRYTPPYASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNA
LKSLETFRPKVRVIERFYASEKLNEIILNTILSTLNNHKSQDFVLIFSVHGLPKSIIDAGDTYQQECEHHVDLLKDLMRQ
KNIHFKQVLLSYQSKLGPMKWLEPSTEGLIEKHRKSNIIIYPLAFTIDNSETLYELEIQYRLMAARLAIKEYLVCPCLND
SIEFAKFIIELVKNLKDE
>Mature_338_residues
MNLAQENLNSPNNLGNNATKSPKETVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKKI
YEKLGGKSPLTPITFALTERLNELDPSRFYTYAMRYTPPYASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNA
LKSLETFRPKVRVIERFYASEKLNEIILNTILSTLNNHKSQDFVLIFSVHGLPKSIIDAGDTYQQECEHHVDLLKDLMRQ
KNIHFKQVLLSYQSKLGPMKWLEPSTEGLIEKHRKSNIIIYPLAFTIDNSETLYELEIQYRLMAARLAIKEYLVCPCLND
SIEFAKFIIELVKNLKDE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=333, Percent_Identity=31.8318318318318, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=31.8318318318318, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=23.4375, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324750, Length=333, Percent_Identity=28.8288288288288, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=28.955223880597, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24651774, Length=268, Percent_Identity=29.1044776119403, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45552018, Length=105, Percent_Identity=36.1904761904762, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_HELAH (Q17YG0)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664315.1
- ProteinModelPortal:   Q17YG0
- SMR:   Q17YG0
- STRING:   Q17YG0
- GeneID:   4177426
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0490
- NMPDR:   fig|382638.8.peg.479
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   GLPERHL
- PhylomeDB:   Q17YG0
- ProtClustDB:   PRK00035
- BioCyc:   HACI382638:HAC_0490-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 38942; Mature: 38942

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAQENLNSPNNLGNNATKSPKETVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNF
CCCCHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECHHH
MRKMVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNELDPSRFYTYAMRYTPPY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEEEECCCH
ASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVRVIERFYAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLNEIILNTILSTLNNHKSQDFVLIFSVHGLPKSIIDAGDTYQQECEHHVDLLKDLMRQ
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
KNIHFKQVLLSYQSKLGPMKWLEPSTEGLIEKHRKSNIIIYPLAFTIDNSETLYELEIQY
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCEEEEEHHHH
RLMAARLAIKEYLVCPCLNDSIEFAKFIIELVKNLKDE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLAQENLNSPNNLGNNATKSPKETVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNF
CCCCHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECHHH
MRKMVGKMIVNSRIEKSKKIYEKLGGKSPLTPITFALTERLNELDPSRFYTYAMRYTPPY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHEEEEEEECCCH
ASMVLQDLALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVRVIERFYAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLNEIILNTILSTLNNHKSQDFVLIFSVHGLPKSIIDAGDTYQQECEHHVDLLKDLMRQ
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
KNIHFKQVLLSYQSKLGPMKWLEPSTEGLIEKHRKSNIIIYPLAFTIDNSETLYELEIQY
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEEEEECCCCEEEEEHHHH
RLMAARLAIKEYLVCPCLNDSIEFAKFIIELVKNLKDE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA