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The map label for this gene is uvrB

Identifier: 109947030

GI number: 109947030

Start: 370104

End: 372080

Strand: Direct

Name: uvrB

Synonym: Hac_0427

Alternate gene names: 109947030

Gene position: 370104-372080 (Clockwise)

Preceding gene: 109947029

Following gene: 109947037

Centisome position: 23.82

GC content: 38.75

Gene sequence:

>1977_bases
ATGCCATTATTTGATTTAAAAAGCCCTTATTCACTAGCTGGTGATCAGCCCCAAGCCATAGATACCTTAACGAAGAGCTT
AAAAAATAAAAACCATTACCAAACTCTCGTGGGCGTTACAGGGAGCGGTAAGACTTACACGATGGCTAATATCATCGCTC
AAACCAACAAACCCACTTTGATCATGAGCCATAATAAAACCTTATGCGCACAGCTTTATAGCGAGTTTAAGGCGTTTTTC
CCGCACAATAGAGTGGAGTATTTTATCTCCCACTTTGATTACTACCAGCCTGAGAGCTATATCCCTAGAAGGGATTTATT
CATTGAAAAAGACAGCTCTATTAATGACGATTTGGAGCGTTTGAGATTGAGCGCGACCACCTCACTTTTAGGTTATGACG
ATGTGATTGTGATAGCGAGCGTATCGGCTAATTATGGTTTGGGTAACCCTGAAGAATATTTGAAAGTCATGGAAAAAATC
AAAGTGGGTGAGAAGCGTGCTTACAAGAGCTTTTTACTCAAACTAGTGGAAATGGGGTATAGCCGTAATGAAGTGGTGTT
TGATAGGGGGAGTTTTAGAGCGATGGGGGAATGCGTGGATATTTTCCCCGCTTATAATGATGCAGAATTTATTAGGATTG
AATTTTTTGGCGATGAGATAGAAAGGATTGCGGTCTTTGACGCCTTAGAAAGAAATGAAATCAAGCGATTAGATTCTGTC
ATGCTTTATGCGGCTAGTCAATTTGCAGTAGGGAGTGAGAGGTTAAATTTAGCCATTAAAAGCATTGAAGATGAGCTTGC
TTTAAGATTGAAATTTTTTAAAGAGCAGGATAAAATTCTTGAATACAACCGCCTTAAACAACGCACCGAGCATGATTTAG
AAATGATTAGTGCAACCGGTGTGTGTAAGGGTATTGAAAATTACGCACGCCATTTTACAGGTAAAGCCCCTAACGAAACA
CCTTTTTGTTTGTTTGATTATTTAGGGATATTTGAGCGAGAGTTTTTAGTCATTGTAGATGAAAGCCATGTGAGTTTGCC
GCAATTTGGGGGGATGTATGCAGGGGATATGAGCAGGAAAAGCGTTTTAGTGGAATATGGCTTTAGATTGCCTAGTGCTT
TAGACAACCGCCCCCTAAAATTTGATGAATTTATCCATAAAAATTGCCAATTCCTTTTTGTGTCCGCTACGCCCAATAAA
CTAGAATTAGAGCTTTCTAAAAAGAATGTCGCTGAGCAAATCATTCGTCCTACTGGGCTTTTAGACCCTAAATTTGAAGT
GCGAGACAGCGATAAACAAGTCCAAGATTTATTTGATGAAATCAAATTAGTGGTGGCTAGAGATGAAAGGGTTTTGATTA
CCACGCTCACTAAAAAAATGGCAGAAGAATTGTGTAAATACTATGCTGAATGGGGCTTGAAGGTGCGTTATATGCATAGC
GAAATTGATGCGATTGAAAGAAATCACATTATCCGCTCTTTAAGGCTTAAAGAATTTGATGTTTTAATAGGGATCAATCT
TTTAAGAGAAGGGTTGGATTTACCTGAAGTGTCTTTAGTAGCAATCATGGATGCGGATAAAGAAGGGTTTTTAAGGAGTG
AAACAAGCCTCATTCAAACCATGGGGCGAGCCGCTAGAAACGCTAACGGAAAGGTTTTATTATACGCTAAAAAAATCACT
CAAAGCATGCAAAAAGCCTTTGAGACCACTACCTACAGACGCGCCAAGCAAGAAGAATTTAACAAACTCCATAATATCAC
CCCTAAAACCGTTACACGCGCTTTAGAAGAGGAATTGAAATTAAGAGATGATGAGACTAAAATCGCTAAAGCTTTGAAAA
AGGACAAAATACCTAAAAGTGAAAGAGAGAAAATCATTAAAGAGTTGGATAAAAAAATGCGAGAATGCGCGAAAAATTTG
GATTTTGAAGAAGCGATGCACTTGAGAGATGAAATCGCTAAATTAAGAACGCTCTAA

Upstream 100 bases:

>100_bases
AGCTAAACAAACGATTGTTATCAAAACATTGATTTTTTTGAGTTTGAATAAGGCGTGTTAAAAACTACTATAATACCCCT
AAAAAATGCGAGTTTAAAAG

Downstream 100 bases:

>100_bases
AAACTATAAGTGTAGTTGAAATAAATTGCATAATTGCGCCTGAAATCAACCCGATACAACAAGCTATTAATCCCATATTC
CAAAAATCGCAAAACTTTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MPLFDLKSPYSLAGDQPQAIDTLTKSLKNKNHYQTLVGVTGSGKTYTMANIIAQTNKPTLIMSHNKTLCAQLYSEFKAFF
PHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKI
KVGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRAMGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALERNEIKRLDSV
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKILEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNET
PFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNK
LELELSKKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
EIDAIERNHIIRSLRLKEFDVLIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKIT
QSMQKAFETTTYRRAKQEEFNKLHNITPKTVTRALEEELKLRDDETKIAKALKKDKIPKSEREKIIKELDKKMRECAKNL
DFEEAMHLRDEIAKLRTL

Sequences:

>Translated_658_residues
MPLFDLKSPYSLAGDQPQAIDTLTKSLKNKNHYQTLVGVTGSGKTYTMANIIAQTNKPTLIMSHNKTLCAQLYSEFKAFF
PHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKI
KVGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRAMGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALERNEIKRLDSV
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKILEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNET
PFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNK
LELELSKKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
EIDAIERNHIIRSLRLKEFDVLIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKIT
QSMQKAFETTTYRRAKQEEFNKLHNITPKTVTRALEEELKLRDDETKIAKALKKDKIPKSEREKIIKELDKKMRECAKNL
DFEEAMHLRDEIAKLRTL
>Mature_657_residues
PLFDLKSPYSLAGDQPQAIDTLTKSLKNKNHYQTLVGVTGSGKTYTMANIIAQTNKPTLIMSHNKTLCAQLYSEFKAFFP
HNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLERLRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIK
VGEKRAYKSFLLKLVEMGYSRNEVVFDRGSFRAMGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALERNEIKRLDSVM
LYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKILEYNRLKQRTEHDLEMISATGVCKGIENYARHFTGKAPNETP
FCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRKSVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKL
ELELSKKNVAEQIIRPTGLLDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHSE
IDAIERNHIIRSLRLKEFDVLIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQTMGRAARNANGKVLLYAKKITQ
SMQKAFETTTYRRAKQEEFNKLHNITPKTVTRALEEELKLRDDETKIAKALKKDKIPKSEREKIIKELDKKMRECAKNLD
FEEAMHLRDEIAKLRTL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=52.3952095808383, Blast_Score=675, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_HELAH (Q17YL7)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664258.1
- ProteinModelPortal:   Q17YL7
- STRING:   Q17YL7
- GeneID:   4176695
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0427
- NMPDR:   fig|382638.8.peg.416
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   HACI382638:HAC_0427-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 75990; Mature: 75859

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFDLKSPYSLAGDQPQAIDTLTKSLKNKNHYQTLVGVTGSGKTYTMANIIAQTNKPTL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEHHHHHHCCCCCEE
IMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLER
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
LRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKSFLLKLVEMGY
HHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SRNEVVFDRGSFRAMGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALERNEIKRLDSV
CCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKILEYNRLKQRTEHDLEMISATG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHH
SVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSKKNVAEQIIRPTGL
HHHHHHCCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCC
LDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
CCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHH
EIDAIERNHIIRSLRLKEFDVLIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGRAARNANGKVLLYAKKITQSMQKAFETTTYRRAKQEEFNKLHNITPKTVTRALEEELK
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDDETKIAKALKKDKIPKSEREKIIKELDKKMRECAKNLDFEEAMHLRDEIAKLRTL
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLFDLKSPYSLAGDQPQAIDTLTKSLKNKNHYQTLVGVTGSGKTYTMANIIAQTNKPTL
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEHHHHHHCCCCCEE
IMSHNKTLCAQLYSEFKAFFPHNRVEYFISHFDYYQPESYIPRRDLFIEKDSSINDDLER
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
LRLSATTSLLGYDDVIVIASVSANYGLGNPEEYLKVMEKIKVGEKRAYKSFLLKLVEMGY
HHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SRNEVVFDRGSFRAMGECVDIFPAYNDAEFIRIEFFGDEIERIAVFDALERNEIKRLDSV
CCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
MLYAASQFAVGSERLNLAIKSIEDELALRLKFFKEQDKILEYNRLKQRTEHDLEMISATG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCKGIENYARHFTGKAPNETPFCLFDYLGIFEREFLVIVDESHVSLPQFGGMYAGDMSRK
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHH
SVLVEYGFRLPSALDNRPLKFDEFIHKNCQFLFVSATPNKLELELSKKNVAEQIIRPTGL
HHHHHHCCCCCHHHCCCCCCHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHCCCCC
LDPKFEVRDSDKQVQDLFDEIKLVVARDERVLITTLTKKMAEELCKYYAEWGLKVRYMHS
CCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEEHH
EIDAIERNHIIRSLRLKEFDVLIGINLLREGLDLPEVSLVAIMDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
MGRAARNANGKVLLYAKKITQSMQKAFETTTYRRAKQEEFNKLHNITPKTVTRALEEELK
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LRDDETKIAKALKKDKIPKSEREKIIKELDKKMRECAKNLDFEEAMHLRDEIAKLRTL
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA