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The map label for this gene is ribH

Identifier: 109946872

GI number: 109946872

Start: 210731

End: 211201

Strand: Reverse

Name: ribH

Synonym: Hac_0255

Alternate gene names: 109946872

Gene position: 211201-210731 (Counterclockwise)

Preceding gene: 109946873

Following gene: 109946871

Centisome position: 13.59

GC content: 43.95

Gene sequence:

>471_bases
ATGCAACTTATAGAAGGGAAATTACAACTACAAGGGAATGAAAGAATCGCTATTGTAATCTCGCGCTTCAATCACATTAT
CACAGACAGATTGCAAGAAGGGGCGATTGATTGCTTTAAAAGGCATGGGGGCAATGAAAAGCTTTTAAACCTCGTGCTAG
TGCCTGGAGCTTATGAATTGCCTTTGATTTTAGACAAATTGTTAGAGAGCAAAAAATACGATGGCGTGTGCGTTTTAGGA
GCGATCATTAGAGGGGGGACTCCGCATTTTGACTATGTGAGCGCGGAAGCGACCAAGGGCATTGCCAACACGATGTTAAA
ATACAGCATGCCCGTAAGCTTTGGGGTCCTTACCACAGACAATATTGAACAAGCGATTGAAAGAGCGGGCAGTAAAGCCG
GTAATAGGGGCTTTGAAGCGATGAGCACCCTCATTGAATTATTGAGCTTGTGCCAAACTCTCAAGGGTTAA

Upstream 100 bases:

>100_bases
AACGCCCTAAGCGATGGGGCTAACATGCTCAAACCTAATGAGCTTGAAAGCTTGGTAACCGATATGTTAAAAATCCAAAA
TTTATTTTAAAGGAGTTTTC

Downstream 100 bases:

>100_bases
AATGGCGACACGAACTCAAGCTAGAGGGGCTGTGATTGAATTGTTGTATGCGTTTGAGAGCGGTAATGAAGAAATTAAAA
AAATCGCCCCTAGCATGCTA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MQLIEGKLQLQGNERIAIVISRFNHIITDRLQEGAIDCFKRHGGNEKLLNLVLVPGAYELPLILDKLLESKKYDGVCVLG
AIIRGGTPHFDYVSAEATKGIANTMLKYSMPVSFGVLTTDNIEQAIERAGSKAGNRGFEAMSTLIELLSLCQTLKG

Sequences:

>Translated_156_residues
MQLIEGKLQLQGNERIAIVISRFNHIITDRLQEGAIDCFKRHGGNEKLLNLVLVPGAYELPLILDKLLESKKYDGVCVLG
AIIRGGTPHFDYVSAEATKGIANTMLKYSMPVSFGVLTTDNIEQAIERAGSKAGNRGFEAMSTLIELLSLCQTLKG
>Mature_156_residues
MQLIEGKLQLQGNERIAIVISRFNHIITDRLQEGAIDCFKRHGGNEKLLNLVLVPGAYELPLILDKLLESKKYDGVCVLG
AIIRGGTPHFDYVSAEATKGIANTMLKYSMPVSFGVLTTDNIEQAIERAGSKAGNRGFEAMSTLIELLSLCQTLKG

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=156, Percent_Identity=49.3589743589744, Blast_Score=155, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324429, Length=121, Percent_Identity=38.0165289256198, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_HELAH (Q17Z25)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664100.1
- ProteinModelPortal:   Q17Z25
- SMR:   Q17Z25
- STRING:   Q17Z25
- GeneID:   4177090
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0255
- NMPDR:   fig|382638.8.peg.246
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   NRAGIKA
- PhylomeDB:   Q17Z25
- ProtClustDB:   PRK00061
- BioCyc:   HACI382638:HAC_0255-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 17048; Mature: 17048

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIEGKLQLQGNERIAIVISRFNHIITDRLQEGAIDCFKRHGGNEKLLNLVLVPGAYEL
CCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCH
PLILDKLLESKKYDGVCVLGAIIRGGTPHFDYVSAEATKGIANTMLKYSMPVSFGVLTTD
HHHHHHHHHCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECEEECC
NIEQAIERAGSKAGNRGFEAMSTLIELLSLCQTLKG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLIEGKLQLQGNERIAIVISRFNHIITDRLQEGAIDCFKRHGGNEKLLNLVLVPGAYEL
CCCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCH
PLILDKLLESKKYDGVCVLGAIIRGGTPHFDYVSAEATKGIANTMLKYSMPVSFGVLTTD
HHHHHHHHHCCCCCCEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECEEECC
NIEQAIERAGSKAGNRGFEAMSTLIELLSLCQTLKG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA