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The map label for this gene is aroE

Identifier: 109946863

GI number: 109946863

Start: 203172

End: 203963

Strand: Direct

Name: aroE

Synonym: Hac_0244

Alternate gene names: 109946863

Gene position: 203172-203963 (Clockwise)

Preceding gene: 109946862

Following gene: 109946864

Centisome position: 13.07

GC content: 39.39

Gene sequence:

>792_bases
ATGGGTTTAAAATCTTTTGGGGTTTTAGGAAATCCCATCAAGCATTCCAAATCGCCCCTAATCCATAACGCTTGTTTTTT
GACCTTTCAAAAGGAATTGGGGTTTTTGGGGCATTACCACCCTATATTACTCCCTTTAGAAAGCCATATCAAAAACGAGT
TTTTGAATTTAGGGCTTAGTGGGGCTAATGTAACCTTGCCCTTTAAAGAAAGGGCGTTTCAAGTTTGCGATAAAATCAAG
GGTATAGCACTTGAATGCGGAGCAGTCAATACGCTTGTTTTAGAAAATGATGAGCTTGTGGGTTACAATACCGACGCTTT
AGGGTTTTATCTTTCTTTAAAGCAAAAAAACTATCAAAGTGCTTTGATTTTAGGCTCTGGAGGGAGCGCTAAAGCCCTAG
CGTGCGAGTTAAAAAAACGAGGTTTAAAAGTGAGCGTGTTGAACCGCTCCACTAAGGGCTTGGATTTTTTCCAAAACTTG
GGTTGTGCATGCTTCACTACCACTCCTAAAGGTGCTTTTGATTTGATCATTAACGCCACTTCAGCGAGTTTGAATAACGA
ATTGCCTTTGGATAAAGAGGTTTTGAAAGGGTATTTTAAAGAGAGCCGGCTCGCTTATGATTTGGCGTATGGGTTTTTAA
CGCCCTTTTTGTCTCTAGCCAAAGAATTAAAACTCCCCTTTCAAGACGGAAAAGGCATGCTCATCTATCAAGCCTCTTTA
AGTTTTGAAAAATTTAGCTCTTCTCAAATCTCTTATTCAAAAGCGTTTGAAATCATGCGAAGTGTTTTTTGA

Upstream 100 bases:

>100_bases
GTTTTAGAAATCCAAAAAGATTGGGCTGAAGTTGAATTCACTAAAGAAACAAAGGGCTATGTGTTTTTAAAGTATTTAAA
AAAGGTTGAATAGAACAGCA

Downstream 100 bases:

>100_bases
TGCAAGGGTTTTTAAGAAGCTTGTTTTTTGGGGTTAAAAAGATCCCTAAACCATTCGCCCCCTTAATAAGAAAGGGCGTT
TTAAAAGAAACGCTTGAATT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MGLKSFGVLGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESHIKNEFLNLGLSGANVTLPFKERAFQVCDKIK
GIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQSALILGSGGSAKALACELKKRGLKVSVLNRSTKGLDFFQNL
GCACFTTTPKGAFDLIINATSASLNNELPLDKEVLKGYFKESRLAYDLAYGFLTPFLSLAKELKLPFQDGKGMLIYQASL
SFEKFSSSQISYSKAFEIMRSVF

Sequences:

>Translated_263_residues
MGLKSFGVLGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESHIKNEFLNLGLSGANVTLPFKERAFQVCDKIK
GIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQSALILGSGGSAKALACELKKRGLKVSVLNRSTKGLDFFQNL
GCACFTTTPKGAFDLIINATSASLNNELPLDKEVLKGYFKESRLAYDLAYGFLTPFLSLAKELKLPFQDGKGMLIYQASL
SFEKFSSSQISYSKAFEIMRSVF
>Mature_262_residues
GLKSFGVLGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESHIKNEFLNLGLSGANVTLPFKERAFQVCDKIKG
IALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQSALILGSGGSAKALACELKKRGLKVSVLNRSTKGLDFFQNLG
CACFTTTPKGAFDLIINATSASLNNELPLDKEVLKGYFKESRLAYDLAYGFLTPFLSLAKELKLPFQDGKGMLIYQASLS
FEKFSSSQISYSKAFEIMRSVF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=256, Percent_Identity=32.8125, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=25.177304964539, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320332, Length=272, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_HELAH (Q17Z34)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664091.1
- ProteinModelPortal:   Q17Z34
- STRING:   Q17Z34
- GeneID:   4176936
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0244
- NMPDR:   fig|382638.8.peg.236
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- PhylomeDB:   Q17Z34
- ProtClustDB:   PRK00258
- BioCyc:   HACI382638:HAC_0244-MONOMER
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 28932; Mature: 28801

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: ACT_SITE 69-69

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLKSFGVLGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESHIKNEFLNLGLS
CCCCCCCCCCCCCCCCCCCCEEHHHHEEEHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCC
GANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQS
CCEEEECHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEEEECCCCEEEEEEEECCCCCE
ALILGSGGSAKALACELKKRGLKVSVLNRSTKGLDFFQNLGCACFTTTPKGAFDLIINAT
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEEECCCCCCEEEEEEEC
SASLNNELPLDKEVLKGYFKESRLAYDLAYGFLTPFLSLAKELKLPFQDGKGMLIYQASL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
SFEKFSSSQISYSKAFEIMRSVF
CHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
GLKSFGVLGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESHIKNEFLNLGLS
CCCCCCCCCCCCCCCCCCCEEHHHHEEEHHHHCCCCCCCCEEEEHHHHHHHHHHHCCCC
GANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQS
CCEEEECHHHHHHHHHHHHCCEEEECCCEEEEEEECCCEEEECCCCEEEEEEEECCCCCE
ALILGSGGSAKALACELKKRGLKVSVLNRSTKGLDFFQNLGCACFTTTPKGAFDLIINAT
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEEECCCCCCEEEEEEEC
SASLNNELPLDKEVLKGYFKESRLAYDLAYGFLTPFLSLAKELKLPFQDGKGMLIYQASL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
SFEKFSSSQISYSKAFEIMRSVF
CHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA