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The map label for this gene is algC [H]

Identifier: 109946830

GI number: 109946830

Start: 176660

End: 178048

Strand: Reverse

Name: algC [H]

Synonym: Hac_0209

Alternate gene names: 109946830

Gene position: 178048-176660 (Counterclockwise)

Preceding gene: 109946831

Following gene: 109946807

Centisome position: 11.46

GC content: 40.46

Gene sequence:

>1389_bases
ATGGACATTAGCATTTTTAGAGAATATGATATTAGAGGCATTTATCCGACCACTTTAGATGAAAAGAGCGCTTTTAGTAT
CGGCGTGGAGTTAGGAAAAATCATGCGGAAATACGATAAAAGCGTGTTTGTAGGGCATGACGCAAGGGTGCATGGGCGTT
TTTTGTTTGAAGCTTTGAGCGCGGGGCTGCAATCAAGCGGCTTGAAAGTGTATGATTTAGGGCTAATCCCCACGCCGGTA
GCGTATTTTGCAGCTTTTAATGCAATCAATGGTATCCAATGCCCTAACTCTATCATGATCACCGGCTCTCACAACCCCAA
AGAATACAACGGCTTTAAAATCACGCTCAATCAAAACCCGTTTTATGGCAAGGAGATTCAAGCTTTAAAAGACACGCTTT
TAAGCACTAAACACAAAATCCAACCTTTAAAAGAAATCCCAGAAAAAGTCAATGCTCTAGAAGCGTATCACCGCTATTTG
ATCAAGGATTTTAAGCATTTAAAGAATCTTAAATACAAGATTGCTTTAGATTTTGGTAATGGCGTGGGGGCGTTAGGACT
AGAGCCTATTTTAAAGGCTTTAAACATTGAATTTAGCAGCCTTTATAGCGATCCTGATGGCAATTTTCCTAACCACCACC
CAGACCCTAGCGAAGCGAAAAACTTACAGGATTTGCAAGTGCACATGCAAAAAAACGCTATGGCTGTAGGCTTTGCTTTT
GATGGCGATGCGGACAGGATTGCGATGCTAAGCTCTCATCACACTTATGCGGGCGATGAATTAGCGATTTTATTCGCTAA
ACGCTTGCATGCTCAAGGCATTACTCCCTTTGTGATAGGCGAAGTCAAATGCTCTCAAATGATGTATAACACGATTAACA
CTTTTGGTAAGACGCTCATGTATAAAACCGGGCATAGCAATTTAAAAATCAAACTTAAAGAAACCAATGCACATTTTGCG
GCTGAAATGAGCGGGCATATCTTTTTCAAAGAGCGTTATTTTGGCTATGATGACGCTCTTTATGCATGTTTAAGGGCTTT
AGAATTATTGCTTGAACAAAGTCCAAGCGATTTGGAAAACACCATTAAAAACCTCCCCTATTCCTACACCACGCCTGAAG
AAAAAATCGCCGTGAGCGAAGAAGAAAAATTTGAAATCATTCATAACTTGCAAGAAGCACTTAAAAACCCGCCAAGTCAT
TTCCCTAAAATCAAAGGGATAATTAACATTGATGGCGTGAGAGTGGTTTTTAAACATGGTTTTGGGCTTATTCGTGCAAG
CAACACCACCCCCTTTTTAGTCACTCGCTTTGAAGGCAAGGATGAAAAAACGGCGTTAGAATATAAAAGGGCGTTGCTTG
GGTTGCTTCAAATTTCTTCTATGAAGTAA

Upstream 100 bases:

>100_bases
AAGTTTAGAAAAATGCGTTCAATTGAAACAAAATCCAACAAACGCATGGCAAAATTTATGCGAACAAGGTTTAAGTTTAT
TCAAAAACAAGGAGTTTTAA

Downstream 100 bases:

>100_bases
TCCTCATCAATATCATCAGGAATATTCTCCTTTAATAAGTGTGGGGCATGTTCTTTGATGCTTGTTATAACAGCACTGGG
TTTTATTGTATTGACATCTC

Product: hypothetical protein

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRKYDKSVFVGHDARVHGRFLFEALSAGLQSSGLKVYDLGLIPTPV
AYFAAFNAINGIQCPNSIMITGSHNPKEYNGFKITLNQNPFYGKEIQALKDTLLSTKHKIQPLKEIPEKVNALEAYHRYL
IKDFKHLKNLKYKIALDFGNGVGALGLEPILKALNIEFSSLYSDPDGNFPNHHPDPSEAKNLQDLQVHMQKNAMAVGFAF
DGDADRIAMLSSHHTYAGDELAILFAKRLHAQGITPFVIGEVKCSQMMYNTINTFGKTLMYKTGHSNLKIKLKETNAHFA
AEMSGHIFFKERYFGYDDALYACLRALELLLEQSPSDLENTIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQEALKNPPSH
FPKIKGIINIDGVRVVFKHGFGLIRASNTTPFLVTRFEGKDEKTALEYKRALLGLLQISSMK

Sequences:

>Translated_462_residues
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRKYDKSVFVGHDARVHGRFLFEALSAGLQSSGLKVYDLGLIPTPV
AYFAAFNAINGIQCPNSIMITGSHNPKEYNGFKITLNQNPFYGKEIQALKDTLLSTKHKIQPLKEIPEKVNALEAYHRYL
IKDFKHLKNLKYKIALDFGNGVGALGLEPILKALNIEFSSLYSDPDGNFPNHHPDPSEAKNLQDLQVHMQKNAMAVGFAF
DGDADRIAMLSSHHTYAGDELAILFAKRLHAQGITPFVIGEVKCSQMMYNTINTFGKTLMYKTGHSNLKIKLKETNAHFA
AEMSGHIFFKERYFGYDDALYACLRALELLLEQSPSDLENTIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQEALKNPPSH
FPKIKGIINIDGVRVVFKHGFGLIRASNTTPFLVTRFEGKDEKTALEYKRALLGLLQISSMK
>Mature_462_residues
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRKYDKSVFVGHDARVHGRFLFEALSAGLQSSGLKVYDLGLIPTPV
AYFAAFNAINGIQCPNSIMITGSHNPKEYNGFKITLNQNPFYGKEIQALKDTLLSTKHKIQPLKEIPEKVNALEAYHRYL
IKDFKHLKNLKYKIALDFGNGVGALGLEPILKALNIEFSSLYSDPDGNFPNHHPDPSEAKNLQDLQVHMQKNAMAVGFAF
DGDADRIAMLSSHHTYAGDELAILFAKRLHAQGITPFVIGEVKCSQMMYNTINTFGKTLMYKTGHSNLKIKLKETNAHFA
AEMSGHIFFKERYFGYDDALYACLRALELLLEQSPSDLENTIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQEALKNPPSH
FPKIKGIINIDGVRVVFKHGFGLIRASNTTPFLVTRFEGKDEKTALEYKRALLGLLQISSMK

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=472, Percent_Identity=27.5423728813559, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789566, Length=438, Percent_Identity=24.4292237442922, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 51992; Mature: 51992

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRKYDKSVFVGHDARVHGRFLFEALS
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
AGLQSSGLKVYDLGLIPTPVAYFAAFNAINGIQCPNSIMITGSHNPKEYNGFKITLNQNP
HCHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCC
FYGKEIQALKDTLLSTKHKIQPLKEIPEKVNALEAYHRYLIKDFKHLKNLKYKIALDFGN
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
GVGALGLEPILKALNIEFSSLYSDPDGNFPNHHPDPSEAKNLQDLQVHMQKNAMAVGFAF
CCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCEEEEEEE
DGDADRIAMLSSHHTYAGDELAILFAKRLHAQGITPFVIGEVKCSQMMYNTINTFGKTLM
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHEE
YKTGHSNLKIKLKETNAHFAAEMSGHIFFKERYFGYDDALYACLRALELLLEQSPSDLEN
EECCCCCEEEEEEECCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHH
TIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQEALKNPPSHFPKIKGIINIDGVRVVFKHG
HHHHCCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEEECCC
FGLIRASNTTPFLVTRFEGKDEKTALEYKRALLGLLQISSMK
CEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDISIFREYDIRGIYPTTLDEKSAFSIGVELGKIMRKYDKSVFVGHDARVHGRFLFEALS
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHH
AGLQSSGLKVYDLGLIPTPVAYFAAFNAINGIQCPNSIMITGSHNPKEYNGFKITLNQNP
HCHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCC
FYGKEIQALKDTLLSTKHKIQPLKEIPEKVNALEAYHRYLIKDFKHLKNLKYKIALDFGN
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
GVGALGLEPILKALNIEFSSLYSDPDGNFPNHHPDPSEAKNLQDLQVHMQKNAMAVGFAF
CCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCEEEEEEE
DGDADRIAMLSSHHTYAGDELAILFAKRLHAQGITPFVIGEVKCSQMMYNTINTFGKTLM
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHEE
YKTGHSNLKIKLKETNAHFAAEMSGHIFFKERYFGYDDALYACLRALELLLEQSPSDLEN
EECCCCCEEEEEEECCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHH
TIKNLPYSYTTPEEKIAVSEEEKFEIIHNLQEALKNPPSHFPKIKGIINIDGVRVVFKHG
HHHHCCCCCCCCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEEECCC
FGLIRASNTTPFLVTRFEGKDEKTALEYKRALLGLLQISSMK
CEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]