BacMap

Definition	Helicobacter acinonychis str. Sheeba chromosome, complete genome.
Accession	NC_008229
Length	1,553,927

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The map label for this gene is ppi [H]

Identifier: 109946800

GI number: 109946800

Start: 149934

End: 150422

Strand: Reverse

Name: ppi [H]

Synonym: Hac_0177

Alternate gene names: 109946800

Gene position: 150422-149934 (Counterclockwise)

Preceding gene: 109946802

Following gene: 109946799

Centisome position: 9.68

GC content: 42.13

Gene sequence:

>489_bases
ATGGATCCAATTAAAACTTATGAGATTAAAGAAGAAGAGCTTGTAAAATCTGCTTACGCTACGATCAAAACCAATAAAGG
TAATATCACTCTAGAGCTTTTTTACAAAGATGCACCCCAAACGGTCAGTAACTTTGTCACTCTAGCTAAAGAGAGCTTTT
ATGATGGGCTTAATTTCCATCGTGTGGTTGCAGGCTTTGTGGCTCAAGGGGGTTGTCCTTATGGCACAGGCACAGGCGGA
CCAGGGCATCGCATTAAATGCGAAGTGGTTCATAACCCCAACAAGCACAAAAGAGGCTCTATTTCTATGGCGCATGCTGG
AAGAGACACAGGAGGGAGTCAATTTTTCTTGTGTTTTGTGGATTTGCCCCATTTAGATGGCGAGCATACCGTGTTTGGTA
AAATCACTAACGCAGAAGGTCTTAGCGTTTTGGATAAAATCAAACAAGGCGATATTATAGAGAGCGTTGAGTTTAGCACC
TCTCTATAA

Upstream 100 bases:

>100_bases
GATTTCAAAGACATCCTAAATTACTATCGGCTAAAATACCATTTGCTTTAATTTATTGCTATAATAGAAAATTTGAATAA
CAAAAGTTAAAGGTTTATCT

Downstream 100 bases:

>100_bases
AAAAGATTAAAGATGCTCATACTCAGCCGCAAAGTTAATGAAGGGATTGTCATTGACGATCACATTCATATTAAAGTCGT
TTCCATAGATAGAGGGAGCG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MDPIKTYEIKEEELVKSAYATIKTNKGNITLELFYKDAPQTVSNFVTLAKESFYDGLNFHRVVAGFVAQGGCPYGTGTGG
PGHRIKCEVVHNPNKHKRGSISMAHAGRDTGGSQFFLCFVDLPHLDGEHTVFGKITNAEGLSVLDKIKQGDIIESVEFST
SL

Sequences:

>Translated_162_residues
MDPIKTYEIKEEELVKSAYATIKTNKGNITLELFYKDAPQTVSNFVTLAKESFYDGLNFHRVVAGFVAQGGCPYGTGTGG
PGHRIKCEVVHNPNKHKRGSISMAHAGRDTGGSQFFLCFVDLPHLDGEHTVFGKITNAEGLSVLDKIKQGDIIESVEFST
SL
>Mature_162_residues
MDPIKTYEIKEEELVKSAYATIKTNKGNITLELFYKDAPQTVSNFVTLAKESFYDGLNFHRVVAGFVAQGGCPYGTGTGG
PGHRIKCEVVHNPNKHKRGSISMAHAGRDTGGSQFFLCFVDLPHLDGEHTVFGKITNAEGLSVLDKIKQGDIIESVEFST
SL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=118, Percent_Identity=44.0677966101695, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI7706339, Length=129, Percent_Identity=39.5348837209302, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI24308049, Length=135, Percent_Identity=42.2222222222222, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=39.8496240601504, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI4758950, Length=130, Percent_Identity=43.0769230769231, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI4826932, Length=146, Percent_Identity=38.3561643835616, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI22547212, Length=132, Percent_Identity=43.1818181818182, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7657473, Length=132, Percent_Identity=43.1818181818182, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547215, Length=132, Percent_Identity=43.1818181818182, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI4505991, Length=129, Percent_Identity=44.1860465116279, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=38.4615384615385, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI20911035, Length=139, Percent_Identity=33.0935251798561, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI310127646, Length=130, Percent_Identity=37.6923076923077, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI310114371, Length=130, Percent_Identity=37.6923076923077, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI310119221, Length=130, Percent_Identity=37.6923076923077, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI6631100, Length=137, Percent_Identity=37.2262773722628, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI256017253, Length=119, Percent_Identity=41.1764705882353, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI221139811, Length=119, Percent_Identity=41.1764705882353, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI256017251, Length=119, Percent_Identity=41.1764705882353, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310129267, Length=130, Percent_Identity=36.9230769230769, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI310120620, Length=130, Percent_Identity=36.9230769230769, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI169164185, Length=130, Percent_Identity=35.3846153846154, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI169163623, Length=130, Percent_Identity=35.3846153846154, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI310110104, Length=130, Percent_Identity=36.9230769230769, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI178057341, Length=119, Percent_Identity=40.3361344537815, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI169163387, Length=130, Percent_Identity=35.3846153846154, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI42560244, Length=128, Percent_Identity=36.71875, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI5031987, Length=130, Percent_Identity=38.4615384615385, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI209417936, Length=116, Percent_Identity=38.7931034482759, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI30102944, Length=116, Percent_Identity=38.7931034482759, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI219842199, Length=116, Percent_Identity=38.7931034482759, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI5454154, Length=138, Percent_Identity=36.231884057971, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI45439316, Length=130, Percent_Identity=37.6923076923077, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI303305009, Length=129, Percent_Identity=37.984496124031, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI5174637, Length=129, Percent_Identity=37.984496124031, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1789763, Length=135, Percent_Identity=39.2592592592593, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786736, Length=139, Percent_Identity=35.9712230215827, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=139, Percent_Identity=41.0071942446043, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71997782, Length=129, Percent_Identity=43.4108527131783, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17506311, Length=146, Percent_Identity=40.4109589041096, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17532641, Length=144, Percent_Identity=34.7222222222222, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17506307, Length=131, Percent_Identity=48.0916030534351, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=36.6412213740458, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=36.6412213740458, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17552780, Length=130, Percent_Identity=43.0769230769231, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32563659, Length=139, Percent_Identity=33.8129496402878, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565860, Length=138, Percent_Identity=40.5797101449275, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17566266, Length=136, Percent_Identity=36.7647058823529, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551282, Length=150, Percent_Identity=37.3333333333333, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17551284, Length=150, Percent_Identity=37.3333333333333, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17559074, Length=136, Percent_Identity=36.7647058823529, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17552782, Length=137, Percent_Identity=35.7664233576642, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=130, Percent_Identity=36.1538461538462, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=132, Percent_Identity=39.3939393939394, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=132, Percent_Identity=38.6363636363636, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320510, Length=133, Percent_Identity=39.0977443609023, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320359, Length=132, Percent_Identity=38.6363636363636, Blast_Score=71, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323246, Length=142, Percent_Identity=33.8028169014084, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922376, Length=147, Percent_Identity=37.4149659863946, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21357249, Length=128, Percent_Identity=41.40625, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17986117, Length=132, Percent_Identity=39.3939393939394, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI19922912, Length=132, Percent_Identity=43.1818181818182, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=32.5757575757576, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130249, Length=129, Percent_Identity=41.8604651162791, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355677, Length=145, Percent_Identity=35.1724137931034, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45549139, Length=129, Percent_Identity=40.3100775193798, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24650807, Length=130, Percent_Identity=36.9230769230769, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136360, Length=147, Percent_Identity=38.7755102040816, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=37.984496124031, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=37.984496124031, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17647301, Length=133, Percent_Identity=33.8345864661654, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586038, Length=137, Percent_Identity=33.5766423357664, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17680; Mature: 17680

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPIKTYEIKEEELVKSAYATIKTNKGNITLELFYKDAPQTVSNFVTLAKESFYDGLNFH
CCCCCCCCCCHHHHHHHHHHEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCHH
RVVAGFVAQGGCPYGTGTGGPGHRIKCEVVHNPNKHKRGSISMAHAGRDTGGSQFFLCFV
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEE
DLPHLDGEHTVFGKITNAEGLSVLDKIKQGDIIESVEFSTSL
ECCCCCCCEEEEEEEECCCCHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure
MDPIKTYEIKEEELVKSAYATIKTNKGNITLELFYKDAPQTVSNFVTLAKESFYDGLNFH
CCCCCCCCCCHHHHHHHHHHEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCHH
RVVAGFVAQGGCPYGTGTGGPGHRIKCEVVHNPNKHKRGSISMAHAGRDTGGSQFFLCFV
HHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEE
DLPHLDGEHTVFGKITNAEGLSVLDKIKQGDIIESVEFSTSL
ECCCCCCCEEEEEEEECCCCHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]