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The map label for this gene is ipk

Identifier: 109946798

GI number: 109946798

Start: 148888

End: 149694

Strand: Reverse

Name: ipk

Synonym: Hac_0175

Alternate gene names: 109946798

Gene position: 149694-148888 (Counterclockwise)

Preceding gene: 109946799

Following gene: 109946797

Centisome position: 9.63

GC content: 36.43

Gene sequence:

>807_bases
TTGACGCATGCTTTTGAAGTTTATCCTAAAGTCAATATTTTTTTAAAAATCCTTTACAAAGAAGGGGCTTATCATAAGCT
CATCTCTCGCATGTGTTTAGTCAAAGGCCAGTTAAAAGACATTATTAGCGTTAAAAACGCGCCTTCGTTTTGCTTAAAAG
GGAATTTTGACTGCCCTTTAGAAGAAAACTCGCTTTTTAAAGCCCTCCAAATTTTAAAAAATTTTTTAAAATCAAAAAAA
CTCTCACATTCTGTTATCAAATCCCTAGACACCCTAGCGATTGAAGTGGAAAAAAACATCCCCACTCAAGCTGGGTTAGG
TGGTGGGAGCACTGATGCTGGAGGGCTATTGTATCATTTGAATCAAATTTTTGATTTACGCTTGAATTTAGAAGAGCTTT
ATACTATAGGATCTTTAGTGGGTGCGGACACTAACTTTTTCATCTCGCAATATAAAAGCGCTAACGCCACTTCTTATGGT
GAAGTCATTGAAAATTTTGAAGAAAAGCCTTTAGAAAATCGTCTAGAAATCTATGTGCCGGATAATATTTTTTGCAGCAC
CAAAGCCGTTTATCAAGCTTATAAGCCCAAAACTTGTTTTTATCAAGCTAAAGAATGGCTTAAAAAACCAAGTTTAGAAT
GCTTAAAAACTTGTGATAGAAGCGAATTAAACGATCTTTTAAAACCAGCTTTACTCACCCATCAAGCTTTAAAGGATATA
GAGAGCCAATTGGGTAAGGAGTGGTTTTTTAGCGGGAGTGGGAGCGCGTTTTTTAGGCTAAAGCCCACTCAAAAAGGGAG
CGAATGA

Upstream 100 bases:

>100_bases
TGCGCGCTGAACTCAAAGAGGCCATTGTGAGCGAAAACCAAAAAGCTTCTGCTTCCGTAGATGAAAGCTTGTTAGAAAAC
ATCAAAAAGGTCATTAAGCC

Downstream 100 bases:

>100_bases
AACTTATTGCCAGCAATAAAAAAGCCTATTTTGATTATGAAATTTTGGAGACTTTAGAAGCAGGATTGGTGCTTTTAGGC
TCTGAAGTCAAGGCTTTGAG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTHAFEVYPKVNIFLKILYKEGAYHKLISRMCLVKGQLKDIISVKNAPSFCLKGNFDCPLEENSLFKALQILKNFLKSKK
LSHSVIKSLDTLAIEVEKNIPTQAGLGGGSTDAGGLLYHLNQIFDLRLNLEELYTIGSLVGADTNFFISQYKSANATSYG
EVIENFEEKPLENRLEIYVPDNIFCSTKAVYQAYKPKTCFYQAKEWLKKPSLECLKTCDRSELNDLLKPALLTHQALKDI
ESQLGKEWFFSGSGSAFFRLKPTQKGSE

Sequences:

>Translated_268_residues
MTHAFEVYPKVNIFLKILYKEGAYHKLISRMCLVKGQLKDIISVKNAPSFCLKGNFDCPLEENSLFKALQILKNFLKSKK
LSHSVIKSLDTLAIEVEKNIPTQAGLGGGSTDAGGLLYHLNQIFDLRLNLEELYTIGSLVGADTNFFISQYKSANATSYG
EVIENFEEKPLENRLEIYVPDNIFCSTKAVYQAYKPKTCFYQAKEWLKKPSLECLKTCDRSELNDLLKPALLTHQALKDI
ESQLGKEWFFSGSGSAFFRLKPTQKGSE
>Mature_267_residues
THAFEVYPKVNIFLKILYKEGAYHKLISRMCLVKGQLKDIISVKNAPSFCLKGNFDCPLEENSLFKALQILKNFLKSKKL
SHSVIKSLDTLAIEVEKNIPTQAGLGGGSTDAGGLLYHLNQIFDLRLNLEELYTIGSLVGADTNFFISQYKSANATSYGE
VIENFEEKPLENRLEIYVPDNIFCSTKAVYQAYKPKTCFYQAKEWLKKPSLECLKTCDRSELNDLLKPALLTHQALKDIE
SQLGKEWFFSGSGSAFFRLKPTQKGSE

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_HELAH (Q17Z99)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664026.1
- ProteinModelPortal:   Q17Z99
- SMR:   Q17Z99
- STRING:   Q17Z99
- GeneID:   4177683
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0175
- NMPDR:   fig|382638.8.peg.172
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   ECLKTCD
- ProtClustDB:   PRK04181
- BioCyc:   HACI382638:HAC_0175-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 30259; Mature: 30128

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAFEVYPKVNIFLKILYKEGAYHKLISRMCLVKGQLKDIISVKNAPSFCLKGNFDCPL
CCCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
EENSLFKALQILKNFLKSKKLSHSVIKSLDTLAIEVEKNIPTQAGLGGGSTDAGGLLYHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHH
NQIFDLRLNLEELYTIGSLVGADTNFFISQYKSANATSYGEVIENFEEKPLENRLEIYVP
HHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
DNIFCSTKAVYQAYKPKTCFYQAKEWLKKPSLECLKTCDRSELNDLLKPALLTHQALKDI
CCCEECHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ESQLGKEWFFSGSGSAFFRLKPTQKGSE
HHHHCHHHEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
THAFEVYPKVNIFLKILYKEGAYHKLISRMCLVKGQLKDIISVKNAPSFCLKGNFDCPL
CCCEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
EENSLFKALQILKNFLKSKKLSHSVIKSLDTLAIEVEKNIPTQAGLGGGSTDAGGLLYHL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHH
NQIFDLRLNLEELYTIGSLVGADTNFFISQYKSANATSYGEVIENFEEKPLENRLEIYVP
HHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
DNIFCSTKAVYQAYKPKTCFYQAKEWLKKPSLECLKTCDRSELNDLLKPALLTHQALKDI
CCCEECHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ESQLGKEWFFSGSGSAFFRLKPTQKGSE
HHHHCHHHEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA