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The map label for this gene is map [H]

Identifier: 109946778

GI number: 109946778

Start: 134411

End: 135172

Strand: Direct

Name: map [H]

Synonym: Hac_0155

Alternate gene names: 109946778

Gene position: 134411-135172 (Clockwise)

Preceding gene: 109946777

Following gene: 109946779

Centisome position: 8.65

GC content: 42.91

Gene sequence:

>762_bases
ATGGCGATCTCTATCAAAAGCCCAAAAGAAATCAAAGCGTTAAGAAAAGCTGGGGAATTGACGGCTCAAGCGTTAGCTCT
TTTGGAGCGAGAAGTAAGGCTTGGTGTTTCACTTTTAGAGTTGGATAAAATGGCTGAAGACTTTATCCAATCTCTTGGGG
CTAGACCTGCTTTTAAGGGGCTTTATGGTTTCCCTAATTCTGTGTGCATGTCCTTAAATGAGGTGGTTATTCATGGCATT
CCTACGGATTATGTTCTACAAGAGGGGGATATTATAGGCTTGGATTTGGGGGTGGAGGCGGATGGTTATTATGGCGATTC
AGCTCTCACGCTCCCTATAGGTGCAATAAGCCCACAAGATGAAAAATTGCTCGCTTGCTCTAAAGAGAGTTTAATGCATG
CTATTGATTCAATTAGAGTGGGCATGCATTTTAAAGAATTGAGCCAGATTTTAGAGAACGCTATTATAGAAAGGGGCTTT
GTGCCTTTGAAGGGATTTTGTGGGCATGGCATTGGTAAAAAACCCCATGAAGAACCAGAGATCCCTAACTACCTAGAAAA
AGGCGTCAAAGCTAATAGTGGCCCTAAAATCAAGGAGGGCATGGTATTTTGTTTAGAGCCTATGGTGTGTCAAAAACAGG
GCGAGTCTAAAATATTGGCGGATAAGTGGAGCGTGGTTTCAGTGGATGGGCTTAACACAAGCCACCATGAGCATACTATC
GCCATAGTTGGCAATAAAGCAGTGATTCTTACGGAGTGTTAA

Upstream 100 bases:

>100_bases
CGGTGCTGATTGTGGTTCAAGTCGCTATTGATACCATGAAAAAGATTGAAGCACAAGTTTATATGAGCAAGTATAAGACT
TTAAGTGCGGTGGGCTTTTA

Downstream 100 bases:

>100_bases
TGGCAAGAGATGATGTTATAGAAGTGGATGGGAAAGTGATTGAGGCGTTGCCTAACGCTACCTTTAAAGTAGAGTTAGAC
AACAAGCATGTGGTGTTGTG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MAISIKSPKEIKALRKAGELTAQALALLEREVRLGVSLLELDKMAEDFIQSLGARPAFKGLYGFPNSVCMSLNEVVIHGI
PTDYVLQEGDIIGLDLGVEADGYYGDSALTLPIGAISPQDEKLLACSKESLMHAIDSIRVGMHFKELSQILENAIIERGF
VPLKGFCGHGIGKKPHEEPEIPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGESKILADKWSVVSVDGLNTSHHEHTI
AIVGNKAVILTEC

Sequences:

>Translated_253_residues
MAISIKSPKEIKALRKAGELTAQALALLEREVRLGVSLLELDKMAEDFIQSLGARPAFKGLYGFPNSVCMSLNEVVIHGI
PTDYVLQEGDIIGLDLGVEADGYYGDSALTLPIGAISPQDEKLLACSKESLMHAIDSIRVGMHFKELSQILENAIIERGF
VPLKGFCGHGIGKKPHEEPEIPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGESKILADKWSVVSVDGLNTSHHEHTI
AIVGNKAVILTEC
>Mature_252_residues
AISIKSPKEIKALRKAGELTAQALALLEREVRLGVSLLELDKMAEDFIQSLGARPAFKGLYGFPNSVCMSLNEVVIHGIP
TDYVLQEGDIIGLDLGVEADGYYGDSALTLPIGAISPQDEKLLACSKESLMHAIDSIRVGMHFKELSQILENAIIERGFV
PLKGFCGHGIGKKPHEEPEIPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGESKILADKWSVVSVDGLNTSHHEHTIA
IVGNKAVILTEC

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=32.4, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=33.8645418326693, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1786364, Length=253, Percent_Identity=37.5494071146245, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1788728, Length=209, Percent_Identity=24.4019138755981, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=29.8804780876494, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=34.2629482071713, Blast_Score=145, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21355531, Length=250, Percent_Identity=30, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27432; Mature: 27301

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISIKSPKEIKALRKAGELTAQALALLEREVRLGVSLLELDKMAEDFIQSLGARPAFKG
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHH
LYGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEADGYYGDSALTLPIGAISPQD
HCCCCHHHHHHHHHHEEECCCHHHEEECCCEEEEEECCCCCCEECCCEEEEEECCCCCCC
EKLLACSKESLMHAIDSIRVGMHFKELSQILENAIIERGFVPLKGFCGHGIGKKPHEEPE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
IPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGESKILADKWSVVSVDGLNTSHHEHTI
CCHHHHHCCCCCCCCCHHHCHHEECCCHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEE
AIVGNKAVILTEC
EEECCCEEEEECC
>Mature Secondary Structure 
AISIKSPKEIKALRKAGELTAQALALLEREVRLGVSLLELDKMAEDFIQSLGARPAFKG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCHHH
LYGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEADGYYGDSALTLPIGAISPQD
HCCCCHHHHHHHHHHEEECCCHHHEEECCCEEEEEECCCCCCEECCCEEEEEECCCCCCC
EKLLACSKESLMHAIDSIRVGMHFKELSQILENAIIERGFVPLKGFCGHGIGKKPHEEPE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
IPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGESKILADKWSVVSVDGLNTSHHEHTI
CCHHHHHCCCCCCCCCHHHCHHEECCCHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEE
AIVGNKAVILTEC
EEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]