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The map label for this gene is fadE [H]

Identifier: 110681103

GI number: 110681103

Start: 3827487

End: 3828635

Strand: Direct

Name: fadE [H]

Synonym: RD1_3970

Alternate gene names: 110681103

Gene position: 3827487-3828635 (Clockwise)

Preceding gene: 110681102

Following gene: 110681104

Centisome position: 92.61

GC content: 58.66

Gene sequence:

>1149_bases
ATGAACCAGCACACCTCCACATGGATGACGGATGAGCATCTGATGATTGCGGATATGACGGCGCAGTTCATCACCAACGA
ATGGTCCCCGAAATTCGAGAAATGGCGCAAGCAGGGCCAGATGGACCGCGAAACATGGGCGCAGGCAGGCGAATTAGGTT
TGCTGTGTCCCTCCATCCCCGAGGAATATGGCGGCGCAGGCGGCGATTTCGGCCATGAGGCCGCGATCCTGATCGAAGCG
GCACGCGCAAACCTCGCAAGTTGGGGGCATGGCATCCACTCAGGCATCGTGGCGCATTACCTGCTCGCCTACGGCACTGA
GGATCAGAAAAACCGCTGGCTGCCGAAGATGGTGTCGGGCGAGATGGTCGGCGCGCTTGCCATGACTGAACCCTCCACCG
GGTCGGACGTGCAAAGCATCAAGACCAAGGCGGTCAAGGACGGCAACGCCTACAAGCTGTCGGGCCAGAAAACCTTTATC
ACCAATGGCCAGCATGCCAATCTGATCATCGTCGCGGCAAAAACCGACCCTGCCGAAGGGTCCAAAGGCGTGTCGCTCGT
GGTTGTCGAAACCGAGGGCGCCGACGGGTTCAAACGGGGGCGTAACCTTGAAAAGGTCGGGCTGCATGCCTCTGACACGT
CAGAACTGTTTTTCGATGACGTGGAAATCCCGCCCGAGAACATTCTTGGCGGTGCCGAGGGGCAGGGATTTTACCAGATG
ATGCAGCAGTTGCCGCAGGAACGGCTGATCATCGCCTGCGGGGCGGTGGGTGCCATCGAGGGCGCTGTCGAGCGCACGAT
TACCTATTGCAAGGAGCGTGAAGCCTTCGGCGGGCCGCTCACACAGTTTCAGAACACAAGGTTCAAGCTGGCCGAATGCA
AGACCAAGGCCGCTGTCGCGCGCGCCTTTCTGGATGACTGCATGGTCGCGCATCTGCGCGGGGAGTTGAGCGTCGAAAAG
GCCGCGATGGCCAAATACTGGATCACGGACACGCAGGGCGAGGTTCTGGACGAATGTGTGCAACTGCATGGCGGATATGG
TTTCATGCAGGAATATGCGATTGCCGAAATGTGGGCAGACGCGCGGGTGCAACGCATCTACGGCGGTACAAACGAAATCA
TGAAAGAGTTGATTGCGCGCTCCTTATGA

Upstream 100 bases:

>100_bases
GCTTCCCCGCCGGGCCTGCCCGCAAGGTCAAAACCGCGCCCATACGCATCTTTGCAACACGTCGTTTTGGCGTCGCCATA
TCGAAAGAGGGTATCTTGAG

Downstream 100 bases:

>100_bases
GCAGCATGCAGCTTAGAGCGCCTTGGGAGGGGCGATGAGATATGACAATCAAACTCTATTGTTTTGGGGAAAGCGGAAAC
GCCTATAAGGCCGCCCTCGC

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNQHTSTWMTDEHLMIADMTAQFITNEWSPKFEKWRKQGQMDRETWAQAGELGLLCPSIPEEYGGAGGDFGHEAAILIEA
ARANLASWGHGIHSGIVAHYLLAYGTEDQKNRWLPKMVSGEMVGALAMTEPSTGSDVQSIKTKAVKDGNAYKLSGQKTFI
TNGQHANLIIVAAKTDPAEGSKGVSLVVVETEGADGFKRGRNLEKVGLHASDTSELFFDDVEIPPENILGGAEGQGFYQM
MQQLPQERLIIACGAVGAIEGAVERTITYCKEREAFGGPLTQFQNTRFKLAECKTKAAVARAFLDDCMVAHLRGELSVEK
AAMAKYWITDTQGEVLDECVQLHGGYGFMQEYAIAEMWADARVQRIYGGTNEIMKELIARSL

Sequences:

>Translated_382_residues
MNQHTSTWMTDEHLMIADMTAQFITNEWSPKFEKWRKQGQMDRETWAQAGELGLLCPSIPEEYGGAGGDFGHEAAILIEA
ARANLASWGHGIHSGIVAHYLLAYGTEDQKNRWLPKMVSGEMVGALAMTEPSTGSDVQSIKTKAVKDGNAYKLSGQKTFI
TNGQHANLIIVAAKTDPAEGSKGVSLVVVETEGADGFKRGRNLEKVGLHASDTSELFFDDVEIPPENILGGAEGQGFYQM
MQQLPQERLIIACGAVGAIEGAVERTITYCKEREAFGGPLTQFQNTRFKLAECKTKAAVARAFLDDCMVAHLRGELSVEK
AAMAKYWITDTQGEVLDECVQLHGGYGFMQEYAIAEMWADARVQRIYGGTNEIMKELIARSL
>Mature_382_residues
MNQHTSTWMTDEHLMIADMTAQFITNEWSPKFEKWRKQGQMDRETWAQAGELGLLCPSIPEEYGGAGGDFGHEAAILIEA
ARANLASWGHGIHSGIVAHYLLAYGTEDQKNRWLPKMVSGEMVGALAMTEPSTGSDVQSIKTKAVKDGNAYKLSGQKTFI
TNGQHANLIIVAAKTDPAEGSKGVSLVVVETEGADGFKRGRNLEKVGLHASDTSELFFDDVEIPPENILGGAEGQGFYQM
MQQLPQERLIIACGAVGAIEGAVERTITYCKEREAFGGPLTQFQNTRFKLAECKTKAAVARAFLDDCMVAHLRGELSVEK
AAMAKYWITDTQGEVLDECVQLHGGYGFMQEYAIAEMWADARVQRIYGGTNEIMKELIARSL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=46.8085106382979, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=35.0923482849604, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=37.0262390670554, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4501859, Length=376, Percent_Identity=30.5851063829787, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=32.010582010582, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=30.7894736842105, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4557231, Length=367, Percent_Identity=33.7874659400545, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI187960098, Length=367, Percent_Identity=33.7874659400545, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI76496475, Length=352, Percent_Identity=34.9431818181818, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI4557235, Length=352, Percent_Identity=34.9431818181818, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI21361497, Length=373, Percent_Identity=31.9034852546917, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4503943, Length=388, Percent_Identity=29.1237113402062, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=30, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI48976061, Length=290, Percent_Identity=28.6206896551724, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI211971008, Length=290, Percent_Identity=28.6206896551724, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI38505218, Length=292, Percent_Identity=27.3972602739726, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI87081958, Length=374, Percent_Identity=29.144385026738, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786223, Length=373, Percent_Identity=27.6139410187668, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081702, Length=370, Percent_Identity=22.1621621621622, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=33.9522546419098, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=30.8310991957105, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=31.0991957104558, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=364, Percent_Identity=33.2417582417582, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=30.9333333333333, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=31.6195372750643, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=31.6195372750643, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17570075, Length=369, Percent_Identity=33.0623306233062, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=30.1333333333333, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71985184, Length=348, Percent_Identity=33.0459770114943, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=34.0501792114695, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=34.3612334801762, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=303, Percent_Identity=32.6732673267327, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=384, Percent_Identity=27.34375, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71982178, Length=270, Percent_Identity=27.037037037037, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=29.553264604811, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=25.5144032921811, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=32.4538258575198, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21356377, Length=382, Percent_Identity=32.4607329842932, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=30.2387267904509, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=31.266149870801, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24646207, Length=383, Percent_Identity=31.0704960835509, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281363737, Length=382, Percent_Identity=32.1989528795811, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=28.4595300261097, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41879; Mature: 41879

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQHTSTWMTDEHLMIADMTAQFITNEWSPKFEKWRKQGQMDRETWAQAGELGLLCPSIP
CCCCCCCEECCCCEEEHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCEECCCCC
EEYGGAGGDFGHEAAILIEAARANLASWGHGIHSGIVAHYLLAYGTEDQKNRWLPKMVSG
HHHCCCCCCCCCCHHEEEEHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHCCCCHHHHCC
EMVGALAMTEPSTGSDVQSIKTKAVKDGNAYKLSGQKTFITNGQHANLIIVAAKTDPAEG
HHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCEEEEEECCCCCCC
SKGVSLVVVETEGADGFKRGRNLEKVGLHASDTSELFFDDVEIPPENILGGAEGQGFYQM
CCCEEEEEEEECCCCHHHHCCCHHHHCCCCCCCCHHEECCCCCCHHHCCCCCCCCHHHHH
MQQLPQERLIIACGAVGAIEGAVERTITYCKEREAFGGPLTQFQNTRFKLAECKTKAAVA
HHHCCHHCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHH
RAFLDDCMVAHLRGELSVEKAAMAKYWITDTQGEVLDECVQLHGGYGFMQEYAIAEMWAD
HHHHHHHHHHHHHCCCHHHHHHHHHHEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ARVQRIYGGTNEIMKELIARSL
HHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNQHTSTWMTDEHLMIADMTAQFITNEWSPKFEKWRKQGQMDRETWAQAGELGLLCPSIP
CCCCCCCEECCCCEEEHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCEECCCCC
EEYGGAGGDFGHEAAILIEAARANLASWGHGIHSGIVAHYLLAYGTEDQKNRWLPKMVSG
HHHCCCCCCCCCCHHEEEEHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHCCCCHHHHCC
EMVGALAMTEPSTGSDVQSIKTKAVKDGNAYKLSGQKTFITNGQHANLIIVAAKTDPAEG
HHHEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCEEEEEECCCCCCC
SKGVSLVVVETEGADGFKRGRNLEKVGLHASDTSELFFDDVEIPPENILGGAEGQGFYQM
CCCEEEEEEEECCCCHHHHCCCHHHHCCCCCCCCHHEECCCCCCHHHCCCCCCCCHHHHH
MQQLPQERLIIACGAVGAIEGAVERTITYCKEREAFGGPLTQFQNTRFKLAECKTKAAVA
HHHCCHHCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHH
RAFLDDCMVAHLRGELSVEKAAMAKYWITDTQGEVLDECVQLHGGYGFMQEYAIAEMWAD
HHHHHHHHHHHHHCCCHHHHHHHHHHEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ARVQRIYGGTNEIMKELIARSL
HHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]