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The map label for this gene is adhC [C]

Identifier: 110681072

GI number: 110681072

Start: 3798695

End: 3799786

Strand: Direct

Name: adhC [C]

Synonym: RD1_3937

Alternate gene names: 110681072

Gene position: 3798695-3799786 (Clockwise)

Preceding gene: 110681071

Following gene: 110681073

Centisome position: 91.91

GC content: 64.01

Gene sequence:

>1092_bases
ATGCAAAAAGTAAGAGCCGCCGTGTGCCATGAGTTCGCAGCGCCGCTGGTGGTCGAGGACATCTTGCTGCGCCCCCCGGA
ACGTAGCGAGGTCGAGGTCACCCTTGACGCCGTCGCGATTTGTCACTCCGACATTTCATTCGCGCAAGGCGCTTGGGGGG
GATCGCTGCCGGCCGTCTATGGACATGAAGCCGCCGGGCGCGTCACAACCCTCGGCGCGGGTGTTACCGGTCTGAACACG
GGCGACAGCGTCGTTGTCACCCTGATCCGCGCCTGTGGCACCTGCGGTAGCTGCGCGGGCGGCAAACCGACGCTCTGCGA
CACGCCCTATGACGGGGACGCCGGGCCAATCACAACCGCCGACGGGGGCAGGCTGCATCAGGCGATGGCCACCGGTGGTT
TCGCGGAAAAGGTCGTGGTTGCGCAAAATCAGGTGGTCCGCATTGACCCTGCTGTGCCCAAGGACGCGGCCAGCCTGATC
GCTTGTGGCGTCATCACAGGTGTGGGGGCCGTGGTGAACGCGGCGAACCTGCGCGCCGGGCAGGACGTCGTTGTAATCGG
TGCCGGAGGTGTCGGATTGAACGCGATACAAGGGGCGCGGATCGCAGGCGCGCGCCGCATCGTAGCCATCGACATGAGCG
AGGAAAAGCTGGAAACAGCCAAGGATTTCGGCGCGACACACGGCGTTCTGGGCACAACGGACAAACCGTGGCGCGCGGCA
TTTGAGGCCTTGGGCGGGCGCGGTGCGGACGCGGTCATCGTTACCGTCGGTGCAATCCCCGCCTATGATCAGGCACCGCG
CTACCTTGCCGCTGGCGGCAAGATCGTGATGGTCGGGATGCCCCATTCCGGTGCCAAATCCAGCTATGAACCGGTCGTTC
TGGCCGCATTGGGACAGGGCATGGTCGGCTCGAAGATGGGCGATGTGGTGATCCAGCGGGACATCCCCTGGATGGTCGAC
CTCTACCTGCAGGGACGCCTGAAACTGGATGAGCTGATCTCCGGGCGCTGGTCCTTGGATCAGATCAACGAGGCGATTGC
AGATACCAAGACAGGTGCCGCGCGACGCAATGTGATCGTGTTCGACACCTAG

Upstream 100 bases:

>100_bases
GGCACCAGTTGGCTTTCGTCGCGTTCGGGCTTGCGCATGACCCGGCATTTAGTAACGCTGGCCAGACAGAAACAGGAAGC
ACCGGGGAGATCACCAGATC

Downstream 100 bases:

>100_bases
CGGGTCAAGCCAAGAGGGAACAGAAATGAAGCTGAAAGACCTCGACGTGATCATCACGGCCCCACCGGCGCCCGGCTGGG
GCGGGCGGTATTGGATTTTG

Product: dehydrogenase, putative

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MQKVRAAVCHEFAAPLVVEDILLRPPERSEVEVTLDAVAICHSDISFAQGAWGGSLPAVYGHEAAGRVTTLGAGVTGLNT
GDSVVVTLIRACGTCGSCAGGKPTLCDTPYDGDAGPITTADGGRLHQAMATGGFAEKVVVAQNQVVRIDPAVPKDAASLI
ACGVITGVGAVVNAANLRAGQDVVVIGAGGVGLNAIQGARIAGARRIVAIDMSEEKLETAKDFGATHGVLGTTDKPWRAA
FEALGGRGADAVIVTVGAIPAYDQAPRYLAAGGKIVMVGMPHSGAKSSYEPVVLAALGQGMVGSKMGDVVIQRDIPWMVD
LYLQGRLKLDELISGRWSLDQINEAIADTKTGAARRNVIVFDT

Sequences:

>Translated_363_residues
MQKVRAAVCHEFAAPLVVEDILLRPPERSEVEVTLDAVAICHSDISFAQGAWGGSLPAVYGHEAAGRVTTLGAGVTGLNT
GDSVVVTLIRACGTCGSCAGGKPTLCDTPYDGDAGPITTADGGRLHQAMATGGFAEKVVVAQNQVVRIDPAVPKDAASLI
ACGVITGVGAVVNAANLRAGQDVVVIGAGGVGLNAIQGARIAGARRIVAIDMSEEKLETAKDFGATHGVLGTTDKPWRAA
FEALGGRGADAVIVTVGAIPAYDQAPRYLAAGGKIVMVGMPHSGAKSSYEPVVLAALGQGMVGSKMGDVVIQRDIPWMVD
LYLQGRLKLDELISGRWSLDQINEAIADTKTGAARRNVIVFDT
>Mature_363_residues
MQKVRAAVCHEFAAPLVVEDILLRPPERSEVEVTLDAVAICHSDISFAQGAWGGSLPAVYGHEAAGRVTTLGAGVTGLNT
GDSVVVTLIRACGTCGSCAGGKPTLCDTPYDGDAGPITTADGGRLHQAMATGGFAEKVVVAQNQVVRIDPAVPKDAASLI
ACGVITGVGAVVNAANLRAGQDVVVIGAGGVGLNAIQGARIAGARRIVAIDMSEEKLETAKDFGATHGVLGTTDKPWRAA
FEALGGRGADAVIVTVGAIPAYDQAPRYLAAGGKIVMVGMPHSGAKSSYEPVVLAALGQGMVGSKMGDVVIQRDIPWMVD
LYLQGRLKLDELISGRWSLDQINEAIADTKTGAARRNVIVFDT

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=32.6145552560647, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=33.5149863760218, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI262073058, Length=367, Percent_Identity=31.8801089918256, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI71743840, Length=367, Percent_Identity=31.8801089918256, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=31.3513513513514, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=30.7065217391304, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=29.5392953929539, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=30, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=29.6791443850267, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=33.0623306233062, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790045, Length=348, Percent_Identity=27.2988505747126, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=25.561797752809, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788407, Length=358, Percent_Identity=27.0949720670391, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=260, Percent_Identity=30.3846153846154, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786518, Length=363, Percent_Identity=26.9972451790634, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786825, Length=256, Percent_Identity=32.03125, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787863, Length=328, Percent_Identity=26.219512195122, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788073, Length=262, Percent_Identity=26.3358778625954, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=26.9005847953216, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI226510992, Length=352, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082401, Length=148, Percent_Identity=34.4594594594595, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790718, Length=331, Percent_Identity=24.773413897281, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=372, Percent_Identity=33.6021505376344, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=33.4224598930481, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17565904, Length=357, Percent_Identity=32.2128851540616, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17562584, Length=284, Percent_Identity=29.2253521126761, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=250, Percent_Identity=29.2, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=313, Percent_Identity=27.7955271565495, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=376, Percent_Identity=33.2446808510638, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319621, Length=357, Percent_Identity=28.8515406162465, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=28.3236994219653, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=347, Percent_Identity=28.5302593659942, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=351, Percent_Identity=26.2108262108262, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=337, Percent_Identity=27.5964391691395, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=327, Percent_Identity=28.4403669724771, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=221, Percent_Identity=29.8642533936652, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=327, Percent_Identity=28.4403669724771, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=307, Percent_Identity=25.7328990228013, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323980, Length=310, Percent_Identity=24.8387096774194, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=320, Percent_Identity=26.25, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=370, Percent_Identity=33.5135135135135, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI17137530, Length=234, Percent_Identity=32.0512820512821, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17737897, Length=234, Percent_Identity=32.0512820512821, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37246; Mature: 37246

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVRAAVCHEFAAPLVVEDILLRPPERSEVEVTLDAVAICHSDISFAQGAWGGSLPAVY
CCHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCCHHHCCCCCCCCCCCC
GHEAAGRVTTLGAGVTGLNTGDSVVVTLIRACGTCGSCAGGKPTLCDTPYDGDAGPITTA
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEECC
DGGRLHQAMATGGFAEKVVVAQNQVVRIDPAVPKDAASLIACGVITGVGAVVNAANLRAG
CCCHHHHHHHCCCCHHEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
QDVVVIGAGGVGLNAIQGARIAGARRIVAIDMSEEKLETAKDFGATHGVLGTTDKPWRAA
CCEEEEECCCCCCHHHCCCEECCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCHHHHH
FEALGGRGADAVIVTVGAIPAYDQAPRYLAAGGKIVMVGMPHSGAKSSYEPVVLAALGQG
HHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEEEECCCC
MVGSKMGDVVIQRDIPWMVDLYLQGRLKLDELISGRWSLDQINEAIADTKTGAARRNVIV
CCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEE
FDT
EEC
>Mature Secondary Structure
MQKVRAAVCHEFAAPLVVEDILLRPPERSEVEVTLDAVAICHSDISFAQGAWGGSLPAVY
CCHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCCHHHCCCCCCCCCCCC
GHEAAGRVTTLGAGVTGLNTGDSVVVTLIRACGTCGSCAGGKPTLCDTPYDGDAGPITTA
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEECC
DGGRLHQAMATGGFAEKVVVAQNQVVRIDPAVPKDAASLIACGVITGVGAVVNAANLRAG
CCCHHHHHHHCCCCHHEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
QDVVVIGAGGVGLNAIQGARIAGARRIVAIDMSEEKLETAKDFGATHGVLGTTDKPWRAA
CCEEEEECCCCCCHHHCCCEECCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCHHHHH
FEALGGRGADAVIVTVGAIPAYDQAPRYLAAGGKIVMVGMPHSGAKSSYEPVVLAALGQG
HHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEEEECCCC
MVGSKMGDVVIQRDIPWMVDLYLQGRLKLDELISGRWSLDQINEAIADTKTGAARRNVIV
CCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEE
FDT
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]