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The map label for this gene is pth

Identifier: 110681038

GI number: 110681038

Start: 3767598

End: 3768299

Strand: Direct

Name: pth

Synonym: RD1_3900

Alternate gene names: 110681038

Gene position: 3767598-3768299 (Clockwise)

Preceding gene: 110681037

Following gene: 110681039

Centisome position: 91.16

GC content: 59.4

Gene sequence:

>702_bases
GTGAAACTGATCGTTGGGTTGGGCAATCCGGGCCCGAAATACGCCGGTCACAGGCATAATATCGGCTTCATGGCGCTGGA
CCGTATCGCCGCGGATCACGGCTTTGGCGCGTGGAAAGACAAGCACCAGGGCAGTCTCAGCGAGGGGCGTTTTGGCAGTG
ACCGTGCGGTCTTGCTGAAACCGCTAACCTTCATGAACAACTCGGGTCAATCGGTTCAGGCGGCGATGCGCTTTTACAAA
CTTGAACCGGAGGATGTGATTGTCCTGCATGATGAGATCGACCTCGCACCGGGCAAAGTGAAATACAAGACCGGCGGCGG
GCATGCAGGTCACAATGGGCTACGCTCGATCCATGCGCATATCGGGCCTGAATACGCGCGCGTCAGGCTGGGGGTTGGCC
ATCCGGGGCACAAGGACCGCGTACCCGGCTATGTATTGCACGATTTTGCCAAAGCGGATCAGGATTGGCTGGATGATGTG
TTGCGCGGTGTCAGCGACGGTGCGCCCTTTCTTGCCACCACTGAGGCTGCAAAATTCAGCAACGCGGTTGCGCTGCGCGT
GTCGCCCCGCCGTTCCGGCACCGGGCAAAAGGGCAAGGACAAACCACCCGCGCCCGCAAAACAACAGGCGACGGCGACCA
AGGCAGAACCCGAACCCGACACGCGTTCTGCACTGCAAAAGCTGATGGAACGCTTCAAGTGA

Upstream 100 bases:

>100_bases
CCAGTCAACGCGATAAGCTATGCGGGGCCCTTTGCGGCCCCGTATTTCGTTTTGGATCATGCTCGGCTATGCTGCACCGC
AATATGGAGGAAACCGTCGC

Downstream 100 bases:

>100_bases
ACATACGAGACGCGTTTGCCGATCAGGCGATCAGCTGCGCGCGCCTTGGTTCGCCCTTCATGGGACAACTGCTGGGCATT
CTTGCGGATCACTGGCCTGC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKLIVGLGNPGPKYAGHRHNIGFMALDRIAADHGFGAWKDKHQGSLSEGRFGSDRAVLLKPLTFMNNSGQSVQAAMRFYK
LEPEDVIVLHDEIDLAPGKVKYKTGGGHAGHNGLRSIHAHIGPEYARVRLGVGHPGHKDRVPGYVLHDFAKADQDWLDDV
LRGVSDGAPFLATTEAAKFSNAVALRVSPRRSGTGQKGKDKPPAPAKQQATATKAEPEPDTRSALQKLMERFK

Sequences:

>Translated_233_residues
MKLIVGLGNPGPKYAGHRHNIGFMALDRIAADHGFGAWKDKHQGSLSEGRFGSDRAVLLKPLTFMNNSGQSVQAAMRFYK
LEPEDVIVLHDEIDLAPGKVKYKTGGGHAGHNGLRSIHAHIGPEYARVRLGVGHPGHKDRVPGYVLHDFAKADQDWLDDV
LRGVSDGAPFLATTEAAKFSNAVALRVSPRRSGTGQKGKDKPPAPAKQQATATKAEPEPDTRSALQKLMERFK
>Mature_233_residues
MKLIVGLGNPGPKYAGHRHNIGFMALDRIAADHGFGAWKDKHQGSLSEGRFGSDRAVLLKPLTFMNNSGQSVQAAMRFYK
LEPEDVIVLHDEIDLAPGKVKYKTGGGHAGHNGLRSIHAHIGPEYARVRLGVGHPGHKDRVPGYVLHDFAKADQDWLDDV
LRGVSDGAPFLATTEAAKFSNAVALRVSPRRSGTGQKGKDKPPAPAKQQATATKAEPEPDTRSALQKLMERFK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=35.7142857142857, Blast_Score=101, Evalue=6e-22,
Organism=Escherichia coli, GI1787455, Length=164, Percent_Identity=42.6829268292683, Blast_Score=112, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321983, Length=150, Percent_Identity=31.3333333333333, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ROSDO (Q161I4)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_684045.1
- ProteinModelPortal:   Q161I4
- SMR:   Q161I4
- STRING:   Q161I4
- GeneID:   4198786
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_3900
- NMPDR:   fig|375451.6.peg.3624
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   TAQSSEM
- PhylomeDB:   Q161I4
- ProtClustDB:   PRK05426
- BioCyc:   RDEN375451:RD1_3900-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 25266; Mature: 25266

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIVGLGNPGPKYAGHRHNIGFMALDRIAADHGFGAWKDKHQGSLSEGRFGSDRAVLLK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEE
PLTFMNNSGQSVQAAMRFYKLEPEDVIVLHDEIDLAPGKVKYKTGGGHAGHNGLRSIHAH
CHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHH
IGPEYARVRLGVGHPGHKDRVPGYVLHDFAKADQDWLDDVLRGVSDGAPFLATTEAAKFS
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECHHHHCC
NAVALRVSPRRSGTGQKGKDKPPAPAKQQATATKAEPEPDTRSALQKLMERFK
CEEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLIVGLGNPGPKYAGHRHNIGFMALDRIAADHGFGAWKDKHQGSLSEGRFGSDRAVLLK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEE
PLTFMNNSGQSVQAAMRFYKLEPEDVIVLHDEIDLAPGKVKYKTGGGHAGHNGLRSIHAH
CHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHH
IGPEYARVRLGVGHPGHKDRVPGYVLHDFAKADQDWLDDVLRGVSDGAPFLATTEAAKFS
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECHHHHCC
NAVALRVSPRRSGTGQKGKDKPPAPAKQQATATKAEPEPDTRSALQKLMERFK
CEEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA