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The map label for this gene is lldD [H]

Identifier: 110680957

GI number: 110680957

Start: 3685494

End: 3686597

Strand: Direct

Name: lldD [H]

Synonym: RD1_3814

Alternate gene names: 110680957

Gene position: 3685494-3686597 (Clockwise)

Preceding gene: 110680956

Following gene: 110680965

Centisome position: 89.17

GC content: 60.87

Gene sequence:

>1104_bases
ATGGGAGCGACCATCCACAGCTATGACGACGCCCGCCGCATCGCGCGGCGGCGTCTGCCTTGGATGGTCTTTGACTACAT
TGACGGGGCGGCGGGCAATGGCGTGGCCGAAGCGCGCAACCTCGCCGCCCTGCGAGACGTCGAATTGCAGCCGCGTGTGC
TGCGCAACGTTGCGCGTCGCGACATCGGTGTGCAGGTGTTTGAGCACGCGGGCCAAGCTCCCTTTGGCATCAGCCCGATG
GGTATGTGCAATCTGTCAGGTCCCGGCGCAGATGTGATGCTGGCGCGCATTGCTGCGAAACATCAGGTGCCTGTCGGTGT
CTCGACCGTTGCGTCCACCTCACTGGAAACGATGATCGAAGAGGCGCAGGGACACGCCTGGTTTCAGCTCTACTTTTCCG
GGGATGGCAGCGGCACGGCCAAGCTGGTGGAACGCGCCAAGGCTGCTGGATACAAAACCCTGATCATGACGCTGGATGTG
CCCGAAGTTGGCCGACGTCCGCGCGAATTGCGGCGCGGGTTCAAGATGCCGTTCAAAATCGGGCCGATGCAATTCATCGA
CTTTGCCCTGCATCCGCGCTGGTCCCTCTCCAGCCTCATGGCAGGCGCGCCCGATCTGGCGAACTTCCAGACACCGGAGT
TTACCTTTGATCGAACCGAAAGCCGCGCGGCCGCAGATTGGGATTTTCTCAAGCGTTTGCGGGACAGTTGGGATGGCCAT
CTGGTGGCCAAAGGTGTGACAGATGTGGTCGATGCCTTGCGATTGAAAGCGCAGGGTGTTGACGCCATTCAGGTCTCAAC
CCATGGCGGACGACAGTTGGACAGCGCGCCGCCCCCGATCCTTGCACTCAAACGCATACGCGACGCCATCGGCCCGCAGT
ATCCCCTGTTTTATGACACCGGGATGCGGTCGGGTGAAGACGTGGTCAAAGCCTATCAAATGGGTGCTGATTTTGTCTTT
TTTGGTCGCGCGATGCAGTTTGCGATTGCCGCAGGCGGGCGCGACGGGCTTGCGCAATATTGGGACTTGCTGGCAGATGA
GGTCAGCCTCACCCTGGCCCAGATGGGTTTGACCACCCTCCCCATCAACCGCGATGTGACCTGA

Upstream 100 bases:

>100_bases
GTCGTGAAATGCGACAGCGGCAACATCAAGCTGCCTGTGATCACCATGGACCCGGTCGTCATTCGCGACCGCTTCATGAA
GGCGGTTCAGGCCTGATCTG

Downstream 100 bases:

>100_bases
TGAACGCCGGCGACAGCGTCCCACGAAATACCACAAACATCACGTAACGCATTCAACGCTCTGATGTAAGGCAGCGTTAC
GCTATGCAGGTTCTTCGCAT

Product: L-lactate dehydrogenase (cytochrome), putative

Products: NA

Alternate protein names: L(+)-mandelate dehydrogenase; MDH [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MGATIHSYDDARRIARRRLPWMVFDYIDGAAGNGVAEARNLAALRDVELQPRVLRNVARRDIGVQVFEHAGQAPFGISPM
GMCNLSGPGADVMLARIAAKHQVPVGVSTVASTSLETMIEEAQGHAWFQLYFSGDGSGTAKLVERAKAAGYKTLIMTLDV
PEVGRRPRELRRGFKMPFKIGPMQFIDFALHPRWSLSSLMAGAPDLANFQTPEFTFDRTESRAAADWDFLKRLRDSWDGH
LVAKGVTDVVDALRLKAQGVDAIQVSTHGGRQLDSAPPPILALKRIRDAIGPQYPLFYDTGMRSGEDVVKAYQMGADFVF
FGRAMQFAIAAGGRDGLAQYWDLLADEVSLTLAQMGLTTLPINRDVT

Sequences:

>Translated_367_residues
MGATIHSYDDARRIARRRLPWMVFDYIDGAAGNGVAEARNLAALRDVELQPRVLRNVARRDIGVQVFEHAGQAPFGISPM
GMCNLSGPGADVMLARIAAKHQVPVGVSTVASTSLETMIEEAQGHAWFQLYFSGDGSGTAKLVERAKAAGYKTLIMTLDV
PEVGRRPRELRRGFKMPFKIGPMQFIDFALHPRWSLSSLMAGAPDLANFQTPEFTFDRTESRAAADWDFLKRLRDSWDGH
LVAKGVTDVVDALRLKAQGVDAIQVSTHGGRQLDSAPPPILALKRIRDAIGPQYPLFYDTGMRSGEDVVKAYQMGADFVF
FGRAMQFAIAAGGRDGLAQYWDLLADEVSLTLAQMGLTTLPINRDVT
>Mature_366_residues
GATIHSYDDARRIARRRLPWMVFDYIDGAAGNGVAEARNLAALRDVELQPRVLRNVARRDIGVQVFEHAGQAPFGISPMG
MCNLSGPGADVMLARIAAKHQVPVGVSTVASTSLETMIEEAQGHAWFQLYFSGDGSGTAKLVERAKAAGYKTLIMTLDVP
EVGRRPRELRRGFKMPFKIGPMQFIDFALHPRWSLSSLMAGAPDLANFQTPEFTFDRTESRAAADWDFLKRLRDSWDGHL
VAKGVTDVVDALRLKAQGVDAIQVSTHGGRQLDSAPPPILALKRIRDAIGPQYPLFYDTGMRSGEDVVKAYQMGADFVFF
GRAMQFAIAAGGRDGLAQYWDLLADEVSLTLAQMGLTTLPINRDVT

Specific function: Reduction of (S)-mandelate to benzoylformate [H]

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=354, Percent_Identity=29.3785310734463, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7705393, Length=354, Percent_Identity=29.3785310734463, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI11068137, Length=357, Percent_Identity=28.8515406162465, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1790033, Length=366, Percent_Identity=32.5136612021858, Blast_Score=187, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI193208036, Length=358, Percent_Identity=28.4916201117318, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32566217, Length=296, Percent_Identity=27.3648648648649, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323587, Length=366, Percent_Identity=27.8688524590164, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI78707188, Length=353, Percent_Identity=31.4447592067989, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281363140, Length=353, Percent_Identity=31.4447592067989, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI78707190, Length=353, Percent_Identity=31.4447592067989, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.99.31 [H]

Molecular weight: Translated: 40254; Mature: 40122

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATIHSYDDARRIARRRLPWMVFDYIDGAAGNGVAEARNLAALRDVELQPRVLRNVARR
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
DIGVQVFEHAGQAPFGISPMGMCNLSGPGADVMLARIAAKHQVPVGVSTVASTSLETMIE
HHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
EAQGHAWFQLYFSGDGSGTAKLVERAKAAGYKTLIMTLDVPEVGRRPRELRRGFKMPFKI
HHCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCHHHCCCHHHHHCCCCCCEEE
GPMQFIDFALHPRWSLSSLMAGAPDLANFQTPEFTFDRTESRAAADWDFLKRLRDSWDGH
CCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCE
LVAKGVTDVVDALRLKAQGVDAIQVSTHGGRQLDSAPPPILALKRIRDAIGPQYPLFYDT
EEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEC
GMRSGEDVVKAYQMGADFVFFGRAMQFAIAAGGRDGLAQYWDLLADEVSLTLAQMGLTTL
CCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
PINRDVT
CCCCCCC
>Mature Secondary Structure 
GATIHSYDDARRIARRRLPWMVFDYIDGAAGNGVAEARNLAALRDVELQPRVLRNVARR
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
DIGVQVFEHAGQAPFGISPMGMCNLSGPGADVMLARIAAKHQVPVGVSTVASTSLETMIE
HHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
EAQGHAWFQLYFSGDGSGTAKLVERAKAAGYKTLIMTLDVPEVGRRPRELRRGFKMPFKI
HHCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCHHHCCCHHHHHCCCCCCEEE
GPMQFIDFALHPRWSLSSLMAGAPDLANFQTPEFTFDRTESRAAADWDFLKRLRDSWDGH
CCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCE
LVAKGVTDVVDALRLKAQGVDAIQVSTHGGRQLDSAPPPILALKRIRDAIGPQYPLFYDT
EEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEC
GMRSGEDVVKAYQMGADFVFFGRAMQFAIAAGGRDGLAQYWDLLADEVSLTLAQMGLTTL
CCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
PINRDVT
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2271624 [H]