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The map label for this gene is hmgA [H]

Identifier: 110680804

GI number: 110680804

Start: 3514405

End: 3515754

Strand: Direct

Name: hmgA [H]

Synonym: RD1_3651

Alternate gene names: 110680804

Gene position: 3514405-3515754 (Clockwise)

Preceding gene: 110680802

Following gene: 110680805

Centisome position: 85.03

GC content: 59.11

Gene sequence:

>1350_bases
ATGAAAGACCTAGATATCGCGCCTCTTGTCCAGGCTGATGGCGGGCTGACGAATCCTGGCTACATGCCCGGATTTGGCAA
TGATTTCGAGACCGAAGCCCTGCCCGGCGCCTTGCCTCAGGGCATGAACAGCCCGCAAAAATGCAATTATGGGCTATATG
GCGAGCAGCTTTCCGGCACCGCCTTTACCGATGTGCGCCCCGAGCGCACGTGGTGTTATCGCATCCGCCCGTCGGTCAAG
CACTCCCACCGCTATGAGAGGATTGACCTGCCGCATTTCCGCTCTGCGCCCGACATCCATCCGGATGTGACGTCACTGGG
CCAATACCGCTGGGATCCGATCCCGCATACGGATGAGCCACTGACATGGCTGACGGGCATGCGCACCATGACGACGGCGG
GTGATGTGAACACACAGGTGGGCATGGCCTCCCACGTTTATCTCGTGACCCAATCCATGCAGGACGCCTATTTCTTCTCT
GCGGACAGCGAGATGCTTGTCTTGCCCCAGGAAGGCCGCCTGCGTTTCGCGACCGAATTGGGGATCATCGACCTTGAACC
CAAGGAAATCGCGATCATCCCGCGTGGTCTGGTTTACCGTGTGGAATTGCTGGACGGGCCTGCGCGCGGCTTTGTCTGTG
AAAACTACGGCCAGAAGTTCGAACTGCCGGGCCGCGGCCCCATCGGTGCCAACTGCATGGCCAACCCGCGCGATTTCAAG
GCACCGGTTGCCGCCTTTGAGGACCGCGAAGTGCCCTCAACCGTCACGGTCAAGTGGTGTGGGCAGTTTCACCAGACCAA
GATCGGGCAAAGCCCGCTCGACGTGGTGGCCTGGCACGGCAACTACGCGCCCTACAAATACGATCTGCGCAATTATTGCC
CAGTCGGTGCGATCCTGTTTGACCACCCCGACCCGTCGATTTTCACGGTTCTCACCGCACCTTCTGGTCAACCCGGCACG
GCGAATATCGACTTTGTGCTCTTCCGCGAGCGCTGGATGGTGATGGAGGATACCTTCCGCCCGCCTTGGTATCACAAGAA
TATCATGTCCGAGCTGATGGGCAATATCTATGGCGAGTATGACGCCAAACCGCAGGGTTTTGTGCCCGGCGGGATCAGCC
TCCACAACATGATGCTGCCCCATGGCCCTGACCGCGAAGCCTTTGAGAAAGCTTCCAACGCCAACCTCGGCCCGGACAAG
CTGCACAACACCATGTCCTTCATGTTCGAGACCCGCTTCCCCCAGCAACTGACCCAGTTCGCGGGCAAGGAAGCGCCGCT
GCAGGACGATTACATCAATTGCTGGGCGGACATCGAAAAGAAATTCGACGGCACGCCGGGCAAGAAGTAA

Upstream 100 bases:

>100_bases
TCGTTGCAAGTGAAACGAATTTGACCCACCCGTCAAAGCCGGTTTAAACGCACCGTCACTCGCATCGGTGCCGACCACAT
AAAACGTGAGGAGACATGCC

Downstream 100 bases:

>100_bases
GCGCCATGCTGACGCTCTATTCCTATTGGCGATCCACCACATCCTACCGGGTGCGGGTGGCGCTGAACCTCAAGGGGCTG
TCTTATCGGACAGTCCCGGT

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKDLDIAPLVQADGGLTNPGYMPGFGNDFETEALPGALPQGMNSPQKCNYGLYGEQLSGTAFTDVRPERTWCYRIRPSVK
HSHRYERIDLPHFRSAPDIHPDVTSLGQYRWDPIPHTDEPLTWLTGMRTMTTAGDVNTQVGMASHVYLVTQSMQDAYFFS
ADSEMLVLPQEGRLRFATELGIIDLEPKEIAIIPRGLVYRVELLDGPARGFVCENYGQKFELPGRGPIGANCMANPRDFK
APVAAFEDREVPSTVTVKWCGQFHQTKIGQSPLDVVAWHGNYAPYKYDLRNYCPVGAILFDHPDPSIFTVLTAPSGQPGT
ANIDFVLFRERWMVMEDTFRPPWYHKNIMSELMGNIYGEYDAKPQGFVPGGISLHNMMLPHGPDREAFEKASNANLGPDK
LHNTMSFMFETRFPQQLTQFAGKEAPLQDDYINCWADIEKKFDGTPGKK

Sequences:

>Translated_449_residues
MKDLDIAPLVQADGGLTNPGYMPGFGNDFETEALPGALPQGMNSPQKCNYGLYGEQLSGTAFTDVRPERTWCYRIRPSVK
HSHRYERIDLPHFRSAPDIHPDVTSLGQYRWDPIPHTDEPLTWLTGMRTMTTAGDVNTQVGMASHVYLVTQSMQDAYFFS
ADSEMLVLPQEGRLRFATELGIIDLEPKEIAIIPRGLVYRVELLDGPARGFVCENYGQKFELPGRGPIGANCMANPRDFK
APVAAFEDREVPSTVTVKWCGQFHQTKIGQSPLDVVAWHGNYAPYKYDLRNYCPVGAILFDHPDPSIFTVLTAPSGQPGT
ANIDFVLFRERWMVMEDTFRPPWYHKNIMSELMGNIYGEYDAKPQGFVPGGISLHNMMLPHGPDREAFEKASNANLGPDK
LHNTMSFMFETRFPQQLTQFAGKEAPLQDDYINCWADIEKKFDGTPGKK
>Mature_449_residues
MKDLDIAPLVQADGGLTNPGYMPGFGNDFETEALPGALPQGMNSPQKCNYGLYGEQLSGTAFTDVRPERTWCYRIRPSVK
HSHRYERIDLPHFRSAPDIHPDVTSLGQYRWDPIPHTDEPLTWLTGMRTMTTAGDVNTQVGMASHVYLVTQSMQDAYFFS
ADSEMLVLPQEGRLRFATELGIIDLEPKEIAIIPRGLVYRVELLDGPARGFVCENYGQKFELPGRGPIGANCMANPRDFK
APVAAFEDREVPSTVTVKWCGQFHQTKIGQSPLDVVAWHGNYAPYKYDLRNYCPVGAILFDHPDPSIFTVLTAPSGQPGT
ANIDFVLFRERWMVMEDTFRPPWYHKNIMSELMGNIYGEYDAKPQGFVPGGISLHNMMLPHGPDREAFEKASNANLGPDK
LHNTMSFMFETRFPQQLTQFAGKEAPLQDDYINCWADIEKKFDGTPGKK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=434, Percent_Identity=46.0829493087558, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17507969, Length=430, Percent_Identity=48.6046511627907, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583650, Length=435, Percent_Identity=44.8275862068966, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 50497; Mature: 50497

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLDIAPLVQADGGLTNPGYMPGFGNDFETEALPGALPQGMNSPQKCNYGLYGEQLSGT
CCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AFTDVRPERTWCYRIRPSVKHSHRYERIDLPHFRSAPDIHPDVTSLGQYRWDPIPHTDEP
EEECCCCCCEEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHCCEECCCCCCCCCC
LTWLTGMRTMTTAGDVNTQVGMASHVYLVTQSMQDAYFFSADSEMLVLPQEGRLRFATEL
HHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCEEEEECCCCEEEECCCCCEEEEEEC
GIIDLEPKEIAIIPRGLVYRVELLDGPARGFVCENYGQKFELPGRGPIGANCMANPRDFK
CEEEECCCEEEEECCCEEEEEEEECCCCCCCEECCCCCEEECCCCCCCCCCCCCCCHHCC
APVAAFEDREVPSTVTVKWCGQFHQTKIGQSPLDVVAWHGNYAPYKYDLRNYCPVGAILF
CCHHHCCCCCCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCEEECHHCCCCCCEEEE
DHPDPSIFTVLTAPSGQPGTANIDFVLFRERWMVMEDTFRPPWYHKNIMSELMGNIYGEY
ECCCCCEEEEEECCCCCCCCCCEEEEEEECCEEEEHHCCCCCHHHHHHHHHHHHHHCCCC
DAKPQGFVPGGISLHNMMLPHGPDREAFEKASNANLGPDKLHNTMSFMFETRFPQQLTQF
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHH
AGKEAPLQDDYINCWADIEKKFDGTPGKK
CCCCCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKDLDIAPLVQADGGLTNPGYMPGFGNDFETEALPGALPQGMNSPQKCNYGLYGEQLSGT
CCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AFTDVRPERTWCYRIRPSVKHSHRYERIDLPHFRSAPDIHPDVTSLGQYRWDPIPHTDEP
EEECCCCCCEEEEEECCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHCCEECCCCCCCCCC
LTWLTGMRTMTTAGDVNTQVGMASHVYLVTQSMQDAYFFSADSEMLVLPQEGRLRFATEL
HHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCEEEEECCCCEEEECCCCCEEEEEEC
GIIDLEPKEIAIIPRGLVYRVELLDGPARGFVCENYGQKFELPGRGPIGANCMANPRDFK
CEEEECCCEEEEECCCEEEEEEEECCCCCCCEECCCCCEEECCCCCCCCCCCCCCCHHCC
APVAAFEDREVPSTVTVKWCGQFHQTKIGQSPLDVVAWHGNYAPYKYDLRNYCPVGAILF
CCHHHCCCCCCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCEEECHHCCCCCCEEEE
DHPDPSIFTVLTAPSGQPGTANIDFVLFRERWMVMEDTFRPPWYHKNIMSELMGNIYGEY
ECCCCCEEEEEECCCCCCCCCCEEEEEEECCEEEEHHCCCCCHHHHHHHHHHHHHHCCCC
DAKPQGFVPGGISLHNMMLPHGPDREAFEKASNANLGPDKLHNTMSFMFETRFPQQLTQF
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHH
AGKEAPLQDDYINCWADIEKKFDGTPGKK
CCCCCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10220173; 11481430 [H]