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The map label for this gene is xdh [C]

Identifier: 110680780

GI number: 110680780

Start: 3487525

End: 3488559

Strand: Direct

Name: xdh [C]

Synonym: RD1_3623

Alternate gene names: 110680780

Gene position: 3487525-3488559 (Clockwise)

Preceding gene: 110680779

Following gene: 110680797

Centisome position: 84.38

GC content: 60.97

Gene sequence:

>1035_bases
ATGCCCCAAGCTCTCGTATTGGAAGAAAAGGGCAGACTTGCCCTGCGCGAGATAGACCTCGACACCGCCCTTGGTCCGCA
TGACGTCAGAATTGCGGTGCACACGGTCGGTGTCTGTGGCAGCGATGTGCATTACTACACCCATGGGAAAATCGGCCCGT
TCGTCGTAAAGGAGCCGATGGTGCTGGGCCATGAGGCCGCGGGCACCGTGGTGGAGGTCGGCACCGCCGTGTCCCATCTG
CAAAAAGGCGACCGGGTCTGTATGGAGCCGGGCATCCCCGATCCGAACTCCCGCGCGGCCAAATTGGGCATCTATAACGT
GGATCCCGCCGTGCGGTTTTGGGCGACGCCGCCGATCCACGGCTGCCTGACGCCTGAAGTCGTCCATCCGGCCAAATTCA
CCTACGCCCTGCCGGACAATGTGACCTTCGGGGAGGGCGCGATGGTCGAGCCCTTTGCCATCGGCATGCAGGCCGCGTTT
CGCGCGAAGATCAAACCGGGCGATGTGGCCCTGGTGCAGGGCGCCGGCCCGATCGGCATGATGGTCGCGCTGGCCGCATT
GGCGGGTGGCTGTTCCAAAGTGGTCATCACCGATTTTGCCGAGCCCAAGCTGGACCTGATCGGCCAGTATGACGCCATTG
TTCCGATCAATCTGGGCGATGACAACGCGGTTGCAAGGATCGAGGCCGAAACAGGCGGCTGGGGCTGTGACCTTGTGTTT
GAATGCTCAGGGGCGGCGCAAGCCATCCTACAAGCCCCGCAATTTGTCTGCCCCGGCGGGGCTATTGTTCTGGTGGGCAT
GCCGGTGGAGCCTGTGCCGATGGACATCGTCTCCCTTCAGGCCAAGGAAGTGCGGCTGGAAACCGTTTTCCGCTACGCCA
ATGTCTATGACCGCGCCATCAATCTGATCGCATCGGGCAAGGTTGATCTGAAACCGCTGATTTCAGAGACGTTCGCGTTT
TCCGACAGTATTGCGGCCTTTGACCGGGCCGTGGAACAGCGGCCAGCGGATGTGAAATTGCAAATCACGTTTTGA

Upstream 100 bases:

>100_bases
CACTGCATGTCACCGTGGACAAACAAACCAGCCATATTTTCGACCAACAGTCGGAGACCTGTTTGACCAGCGCACCCTAA
GGAACTGTGAAAGGCCAATT

Downstream 100 bases:

>100_bases
CGGGCTTAATGCGTCATGCCAAAAACCTCGATCATGTAACGCTGTCTGAAATCAAAGATTTCAACGTGTTACCTAATACT
CGATGTTTCAGGTATTTCGT

Product: D-xylulose reductase, putative

Products: NA

Alternate protein names: Xylitol dehydrogenase; XDH [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPQALVLEEKGRLALREIDLDTALGPHDVRIAVHTVGVCGSDVHYYTHGKIGPFVVKEPMVLGHEAAGTVVEVGTAVSHL
QKGDRVCMEPGIPDPNSRAAKLGIYNVDPAVRFWATPPIHGCLTPEVVHPAKFTYALPDNVTFGEGAMVEPFAIGMQAAF
RAKIKPGDVALVQGAGPIGMMVALAALAGGCSKVVITDFAEPKLDLIGQYDAIVPINLGDDNAVARIEAETGGWGCDLVF
ECSGAAQAILQAPQFVCPGGAIVLVGMPVEPVPMDIVSLQAKEVRLETVFRYANVYDRAINLIASGKVDLKPLISETFAF
SDSIAAFDRAVEQRPADVKLQITF

Sequences:

>Translated_344_residues
MPQALVLEEKGRLALREIDLDTALGPHDVRIAVHTVGVCGSDVHYYTHGKIGPFVVKEPMVLGHEAAGTVVEVGTAVSHL
QKGDRVCMEPGIPDPNSRAAKLGIYNVDPAVRFWATPPIHGCLTPEVVHPAKFTYALPDNVTFGEGAMVEPFAIGMQAAF
RAKIKPGDVALVQGAGPIGMMVALAALAGGCSKVVITDFAEPKLDLIGQYDAIVPINLGDDNAVARIEAETGGWGCDLVF
ECSGAAQAILQAPQFVCPGGAIVLVGMPVEPVPMDIVSLQAKEVRLETVFRYANVYDRAINLIASGKVDLKPLISETFAF
SDSIAAFDRAVEQRPADVKLQITF
>Mature_343_residues
PQALVLEEKGRLALREIDLDTALGPHDVRIAVHTVGVCGSDVHYYTHGKIGPFVVKEPMVLGHEAAGTVVEVGTAVSHLQ
KGDRVCMEPGIPDPNSRAAKLGIYNVDPAVRFWATPPIHGCLTPEVVHPAKFTYALPDNVTFGEGAMVEPFAIGMQAAFR
AKIKPGDVALVQGAGPIGMMVALAALAGGCSKVVITDFAEPKLDLIGQYDAIVPINLGDDNAVARIEAETGGWGCDLVFE
CSGAAQAILQAPQFVCPGGAIVLVGMPVEPVPMDIVSLQAKEVRLETVFRYANVYDRAINLIASGKVDLKPLISETFAFS
DSIAAFDRAVEQRPADVKLQITF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=306, Percent_Identity=41.8300653594771, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=24.0997229916898, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=24.0997229916898, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788073, Length=317, Percent_Identity=40.6940063091483, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI1790718, Length=346, Percent_Identity=28.0346820809249, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790045, Length=309, Percent_Identity=30.7443365695793, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788075, Length=341, Percent_Identity=26.6862170087977, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1787863, Length=334, Percent_Identity=27.2455089820359, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=26.4264264264264, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788407, Length=332, Percent_Identity=25.6024096385542, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082125, Length=262, Percent_Identity=26.3358778625954, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=317, Percent_Identity=44.4794952681388, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17562878, Length=309, Percent_Identity=43.3656957928803, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6323099, Length=345, Percent_Identity=40, Blast_Score=251, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6319955, Length=335, Percent_Identity=39.7014925373134, Blast_Score=236, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322619, Length=335, Percent_Identity=39.7014925373134, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6319257, Length=356, Percent_Identity=26.123595505618, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=359, Percent_Identity=25.9052924791086, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=303, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=318, Percent_Identity=38.9937106918239, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17737897, Length=318, Percent_Identity=38.0503144654088, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI45550770, Length=305, Percent_Identity=30.8196721311475, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45551930, Length=305, Percent_Identity=30.8196721311475, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221457811, Length=305, Percent_Identity=30.8196721311475, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.9 [H]

Molecular weight: Translated: 36490; Mature: 36358

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQALVLEEKGRLALREIDLDTALGPHDVRIAVHTVGVCGSDVHYYTHGKIGPFVVKEPM
CCCEEEEECCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCEEEECCE
VLGHEAAGTVVEVGTAVSHLQKGDRVCMEPGIPDPNSRAAKLGIYNVDPAVRFWATPPIH
EECCCCCCCEEEHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEECCCCEEEEECCCCC
GCLTPEVVHPAKFTYALPDNVTFGEGAMVEPFAIGMQAAFRAKIKPGDVALVQGAGPIGM
CCCCCCCCCCCEEEEECCCCCEECCCCEECHHHHCCHHHEEEECCCCCEEEEECCCCHHH
MVALAALAGGCSKVVITDFAEPKLDLIGQYDAIVPINLGDDNAVARIEAETGGWGCDLVF
HHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEE
ECSGAAQAILQAPQFVCPGGAIVLVGMPVEPVPMDIVSLQAKEVRLETVFRYANVYDRAI
ECCCHHHHHHCCCCEECCCCEEEEEECCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHH
NLIASGKVDLKPLISETFAFSDSIAAFDRAVEQRPADVKLQITF
HHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure 
PQALVLEEKGRLALREIDLDTALGPHDVRIAVHTVGVCGSDVHYYTHGKIGPFVVKEPM
CCEEEEECCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCCCEEEECCE
VLGHEAAGTVVEVGTAVSHLQKGDRVCMEPGIPDPNSRAAKLGIYNVDPAVRFWATPPIH
EECCCCCCCEEEHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEECCCCEEEEECCCCC
GCLTPEVVHPAKFTYALPDNVTFGEGAMVEPFAIGMQAAFRAKIKPGDVALVQGAGPIGM
CCCCCCCCCCCEEEEECCCCCEECCCCEECHHHHCCHHHEEEECCCCCEEEEECCCCHHH
MVALAALAGGCSKVVITDFAEPKLDLIGQYDAIVPINLGDDNAVARIEAETGGWGCDLVF
HHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEE
ECSGAAQAILQAPQFVCPGGAIVLVGMPVEPVPMDIVSLQAKEVRLETVFRYANVYDRAI
ECCCHHHHHHCCCCEECCCCEEEEEECCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHH
NLIASGKVDLKPLISETFAFSDSIAAFDRAVEQRPADVKLQITF
HHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]