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The map label for this gene is trpC [H]

Identifier: 110680394

GI number: 110680394

Start: 3078447

End: 3079259

Strand: Direct

Name: trpC [H]

Synonym: RD1_3213

Alternate gene names: 110680394

Gene position: 3078447-3079259 (Clockwise)

Preceding gene: 110680393

Following gene: 110680395

Centisome position: 74.48

GC content: 60.76

Gene sequence:

>813_bases
ATGACACAGACGATCCTTGATAAAATCAAAGCCTACAAACTCGAAGAGATTGCCCGCGACAAAGCCGAAACGCCGCTTGA
GGCGGTGGAGGCCTTGGCGCGAGAAGCCAGCCCCGTGCGCCCCTTTGCCGAAGCTCTGTTCCGGGCCTCGACCGAAGGCT
ATGGGCTGATCGCCGAGATCAAGAAAGCCAGCCCTTCCAAGGGTCTGATCCGCGCGGATTTTGACCCCGCGGTGCTGGCG
GCGGCCTATGCGGAAGGCGGTGCGACCTGTTTGTCGGTGCTGACCGACACGCCCAGTTTTCAGGGGGCCAAGGACTACCT
CGTGGCAGCGCGTGCGGCTTGCGATCTGCCGGTGTTGCGCAAGGATTTCATGTATGACCCCTATCAGGTGGCCGAGGCGC
GCAGTCTGGGTGCCGATTGCATCCTGATCATCCTCGCCTCCGTCAGTGATGCGCAGGCGCAGGAACTGGAAGAGGCCGCG
TCCGAATGGGGCATGGATTGCCTGCTCGAAGTGCATGACGCCGAAGAGCTTGAGCGCGCCAGCATGCTGAAGAGTCGACT
GATGGGCATCAACAATCGCAACCTCAAGACCTTTGAGACCACGCTGGACACGACGCGGCAATTGTCCAAATCCGTGCCGG
CGGATCGGCTGATCGTGTCTGAATCCGGCTTGAACACGCCCGAGGAACTGGCCGATATCGCCCGCTATGGCGCGCGTATC
TTCCTGATCGGGGAAAGCCTGATGCGGCAGGATGATGTGACGCTGGCCACGAAAAAGCTGCTTGAGAAACCTGCCATGGC
GGGGGGGATGTAG

Upstream 100 bases:

>100_bases
GGCGCGGCTTTTTCGGCTCCCGCCCCTTCAGCCGGGTGAATGACTGGTTGCAGGCGCAGGGCCATCAGGCCATAAACTGG
AGCAATCCGCCGGAGGCCCC

Downstream 100 bases:

>100_bases
CGTGAGCGGCAAGCTGACCCATTTTGATGGCAAGGGCGATGCCCAGATGGTGAATGTGGGGGACAAAGCGATCACGGACC
GGATCGCGGTGGCCACATGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTQTILDKIKAYKLEEIARDKAETPLEAVEALAREASPVRPFAEALFRASTEGYGLIAEIKKASPSKGLIRADFDPAVLA
AAYAEGGATCLSVLTDTPSFQGAKDYLVAARAACDLPVLRKDFMYDPYQVAEARSLGADCILIILASVSDAQAQELEEAA
SEWGMDCLLEVHDAEELERASMLKSRLMGINNRNLKTFETTLDTTRQLSKSVPADRLIVSESGLNTPEELADIARYGARI
FLIGESLMRQDDVTLATKKLLEKPAMAGGM

Sequences:

>Translated_270_residues
MTQTILDKIKAYKLEEIARDKAETPLEAVEALAREASPVRPFAEALFRASTEGYGLIAEIKKASPSKGLIRADFDPAVLA
AAYAEGGATCLSVLTDTPSFQGAKDYLVAARAACDLPVLRKDFMYDPYQVAEARSLGADCILIILASVSDAQAQELEEAA
SEWGMDCLLEVHDAEELERASMLKSRLMGINNRNLKTFETTLDTTRQLSKSVPADRLIVSESGLNTPEELADIARYGARI
FLIGESLMRQDDVTLATKKLLEKPAMAGGM
>Mature_269_residues
TQTILDKIKAYKLEEIARDKAETPLEAVEALAREASPVRPFAEALFRASTEGYGLIAEIKKASPSKGLIRADFDPAVLAA
AYAEGGATCLSVLTDTPSFQGAKDYLVAARAACDLPVLRKDFMYDPYQVAEARSLGADCILIILASVSDAQAQELEEAAS
EWGMDCLLEVHDAEELERASMLKSRLMGINNRNLKTFETTLDTTRQLSKSVPADRLIVSESGLNTPEELADIARYGARIF
LIGESLMRQDDVTLATKKLLEKPAMAGGM

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=260, Percent_Identity=40, Blast_Score=167, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=274, Percent_Identity=34.6715328467153, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29337; Mature: 29206

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTILDKIKAYKLEEIARDKAETPLEAVEALAREASPVRPFAEALFRASTEGYGLIAEI
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHH
KKASPSKGLIRADFDPAVLAAAYAEGGATCLSVLTDTPSFQGAKDYLVAARAACDLPVLR
HHCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHH
KDFMYDPYQVAEARSLGADCILIILASVSDAQAQELEEAASEWGMDCLLEVHDAEELERA
HHHCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHCHHHHHHH
SMLKSRLMGINNRNLKTFETTLDTTRQLSKSVPADRLIVSESGLNTPEELADIARYGARI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHCCEE
FLIGESLMRQDDVTLATKKLLEKPAMAGGM
EEECHHHHHHCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQTILDKIKAYKLEEIARDKAETPLEAVEALAREASPVRPFAEALFRASTEGYGLIAEI
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHH
KKASPSKGLIRADFDPAVLAAAYAEGGATCLSVLTDTPSFQGAKDYLVAARAACDLPVLR
HHCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHH
KDFMYDPYQVAEARSLGADCILIILASVSDAQAQELEEAASEWGMDCLLEVHDAEELERA
HHHCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHCHHHHHHH
SMLKSRLMGINNRNLKTFETTLDTTRQLSKSVPADRLIVSESGLNTPEELADIARYGARI
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHCCEE
FLIGESLMRQDDVTLATKKLLEKPAMAGGM
EEECHHHHHHCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA