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The map label for this gene is mmsB [H]

Identifier: 110680189

GI number: 110680189

Start: 2865473

End: 2867398

Strand: Direct

Name: mmsB [H]

Synonym: RD1_2991

Alternate gene names: 110680189

Gene position: 2865473-2867398 (Clockwise)

Preceding gene: 110680188

Following gene: 110680190

Centisome position: 69.33

GC content: 61.63

Gene sequence:

>1926_bases
ATGTCAGATATCGTAATCCGCCAAACAGCACATGCCGGGCGCATCACCCTCGCCCGCCCCGAAGCGCTCAATGCGATGAC
CTATGAGATGTGCCTGCAGATCGAAGCGGCGCTGGACAGATGGGCCAGGGATGAGAGGATTGCTCTGGTTGTTCTGGACG
CCGAGGGGGACAAAGCCTTTTGCGCAGGCGGGGATATCGCGCAGCTCTACGAAACAGGCATGGCCGGGGATTATGCGTTC
GGGCAGCGGTTCTGGGCCGACGAATACCGCCTGAATGCAAAGATTTTCAACTACCCCAAGCCGGTGATCTCGTTTTTGCA
AGGCTTCACCATGGGCGGCGGCGTTGGTCTGGGGTGTCACGGCACGCATCGCATCGTGGGAGAGAGCAGCAGGATCGCCA
TGCCGGAATGCGGCATCGGGCTGATCCCGGATGTGGGCGGCACTTTGATCCTTGCGCTCGCACCAGGGCGTGTTGGCGAA
TACCTCGGCACGACCGGATATCGGATGGGCCCTGCGGATGCGCTCTTTGCCGGGTTCGCAGATCATTTCATTCCCCAAGA
CGCATGGCCCGGCCTGATTGCGCAGCTCGAAGACGGCGCATCTGTGGACATCATCAAGCACGCCGCACAGGACCCGGACG
CGAGCGCATTGGCGGACCTGCAGCCTGAAATCGAGCGACACTTCGCGGGCGAAGGGCTGAGCGATATTCTCACCACTTTG
CAAACCGATGACAGTGACTTTGCAAAGGACACGCTCAAGCTGCTTCACCGCAACAGCCCACTGGCAATGGCGTGCACGGT
CGAGGTGCTGCACCGGCTACGCGGTCCAACGCTGAGCATGGCCAAGGCGCTGGATCACGAATACCGCTTTACCTATCGCG
CGATGCAGCATGGCGATTTGCTGGAAGGCATTCGCGCCGCTATCATCGACAAGGACCGCACGCCAAAATGGCAATATGCC
GATATGCGCGTCCCTGCGATTGCTGTCAGCAAGATGTTGATGCCGCTGGGAAAAAACGCACTCACCTTGGAGGATGTCGC
GATGACAAAAACGAACGTTGGCTTTATCGGGCTGGGGAACATGGGCGCACCAATGGCGGCGAATCTCGCCAAGGCGGGCC
TGCATGTGATCGGCTATGACACGGCTGGCACGACGGCAGAAGGCGTCACACAAGCACAAAGCGCGATTGAAGCCGCACAA
GGGGCCGACATCGTTTTGAGCATGCTGCCCAATGGTGCTATTCTGCGCGATGTGGCCAGCACGGTGTTGCCGGTGATGAA
GCCGGGGGCCTTGTTTCTCGACTGCTCCACAGTTGATGTGGACAGCGCACGCGCCGTGGCGCAGGCGGCGCGGGACGCAA
GTGTGCAATTCGTTGATGCGCCTGTTTCCGGCGGGGTCGGCGGCGCCGCGGCAGGCACGCTGACGTTCATGGCGGGGGGC
AGTGCCGAGGCCTTCGAAACCGCCCGCCCCTTGTTCGACATCATGGGCCAGAAGGCCGTTCATTGCGGCGCGCCGGGTGC
CGGTCAGGCGGCGAAAATCTGCAATAACATGATCCTCGGGGCCACCATGATCGCCACCTGCGAAGCCTTCGCGCTGGCTG
ATAAACTGGGGCTGGACCGTCAGAAGATGTTCGATGTTGTCAGCACCTCATCGGGCTACAGCTGGTCGATGAACGCCTAT
TGCCCGGCACCCGGCGTCGGCCCGCAAAGCCCGGCCGACAATGATTACACCCCCGGTTTCGCCGCTGAGTTGATGCTCAA
GGACCTCGGCCTGTCGCAACAGGCGGCTGAGGCGGTGGATGCGGATACCCCGATGGGCGCGCGCGCACTCGCGCTCTATC
GCGCCTTTGTCGAGGAGGAAGACGGGCGCGGCAAGGATTTCTCCGCCATGCTGCCACGCTTCACGCAGCGCTCGCGCACA
GAATGA

Upstream 100 bases:

>100_bases
GGGCAGATACCCCATGCAACGGGCACAGGCTGCGCCGTGGCTTGCCTCCCCCCTGCGCGCGCGCAATAAACAGCGTAAAC
CTGAGCCGGAGAGTGCCCCC

Downstream 100 bases:

>100_bases
CATCGGGTGATGGCATGCGCCCCCGTTCCTCGCCGGGCTTCGAACCCCGAGGGGCAACGACGGCCCAACAGGCAGAAACA
AGCCATTAAGGCGAAAACCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSDIVIRQTAHAGRITLARPEALNAMTYEMCLQIEAALDRWARDERIALVVLDAEGDKAFCAGGDIAQLYETGMAGDYAF
GQRFWADEYRLNAKIFNYPKPVISFLQGFTMGGGVGLGCHGTHRIVGESSRIAMPECGIGLIPDVGGTLILALAPGRVGE
YLGTTGYRMGPADALFAGFADHFIPQDAWPGLIAQLEDGASVDIIKHAAQDPDASALADLQPEIERHFAGEGLSDILTTL
QTDDSDFAKDTLKLLHRNSPLAMACTVEVLHRLRGPTLSMAKALDHEYRFTYRAMQHGDLLEGIRAAIIDKDRTPKWQYA
DMRVPAIAVSKMLMPLGKNALTLEDVAMTKTNVGFIGLGNMGAPMAANLAKAGLHVIGYDTAGTTAEGVTQAQSAIEAAQ
GADIVLSMLPNGAILRDVASTVLPVMKPGALFLDCSTVDVDSARAVAQAARDASVQFVDAPVSGGVGGAAAGTLTFMAGG
SAEAFETARPLFDIMGQKAVHCGAPGAGQAAKICNNMILGATMIATCEAFALADKLGLDRQKMFDVVSTSSGYSWSMNAY
CPAPGVGPQSPADNDYTPGFAAELMLKDLGLSQQAAEAVDADTPMGARALALYRAFVEEEDGRGKDFSAMLPRFTQRSRT
E

Sequences:

>Translated_641_residues
MSDIVIRQTAHAGRITLARPEALNAMTYEMCLQIEAALDRWARDERIALVVLDAEGDKAFCAGGDIAQLYETGMAGDYAF
GQRFWADEYRLNAKIFNYPKPVISFLQGFTMGGGVGLGCHGTHRIVGESSRIAMPECGIGLIPDVGGTLILALAPGRVGE
YLGTTGYRMGPADALFAGFADHFIPQDAWPGLIAQLEDGASVDIIKHAAQDPDASALADLQPEIERHFAGEGLSDILTTL
QTDDSDFAKDTLKLLHRNSPLAMACTVEVLHRLRGPTLSMAKALDHEYRFTYRAMQHGDLLEGIRAAIIDKDRTPKWQYA
DMRVPAIAVSKMLMPLGKNALTLEDVAMTKTNVGFIGLGNMGAPMAANLAKAGLHVIGYDTAGTTAEGVTQAQSAIEAAQ
GADIVLSMLPNGAILRDVASTVLPVMKPGALFLDCSTVDVDSARAVAQAARDASVQFVDAPVSGGVGGAAAGTLTFMAGG
SAEAFETARPLFDIMGQKAVHCGAPGAGQAAKICNNMILGATMIATCEAFALADKLGLDRQKMFDVVSTSSGYSWSMNAY
CPAPGVGPQSPADNDYTPGFAAELMLKDLGLSQQAAEAVDADTPMGARALALYRAFVEEEDGRGKDFSAMLPRFTQRSRT
E
>Mature_640_residues
SDIVIRQTAHAGRITLARPEALNAMTYEMCLQIEAALDRWARDERIALVVLDAEGDKAFCAGGDIAQLYETGMAGDYAFG
QRFWADEYRLNAKIFNYPKPVISFLQGFTMGGGVGLGCHGTHRIVGESSRIAMPECGIGLIPDVGGTLILALAPGRVGEY
LGTTGYRMGPADALFAGFADHFIPQDAWPGLIAQLEDGASVDIIKHAAQDPDASALADLQPEIERHFAGEGLSDILTTLQ
TDDSDFAKDTLKLLHRNSPLAMACTVEVLHRLRGPTLSMAKALDHEYRFTYRAMQHGDLLEGIRAAIIDKDRTPKWQYAD
MRVPAIAVSKMLMPLGKNALTLEDVAMTKTNVGFIGLGNMGAPMAANLAKAGLHVIGYDTAGTTAEGVTQAQSAIEAAQG
ADIVLSMLPNGAILRDVASTVLPVMKPGALFLDCSTVDVDSARAVAQAARDASVQFVDAPVSGGVGGAAAGTLTFMAGGS
AEAFETARPLFDIMGQKAVHCGAPGAGQAAKICNNMILGATMIATCEAFALADKLGLDRQKMFDVVSTSSGYSWSMNAYC
PAPGVGPQSPADNDYTPGFAAELMLKDLGLSQQAAEAVDADTPMGARALALYRAFVEEEDGRGKDFSAMLPRFTQRSRTE

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=300, Percent_Identity=41.3333333333333, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI37594471, Length=339, Percent_Identity=34.8082595870207, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI37594469, Length=310, Percent_Identity=33.5483870967742, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI40556376, Length=277, Percent_Identity=27.0758122743682, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI194097323, Length=174, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI145693186, Length=299, Percent_Identity=31.1036789297659, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI1786719, Length=270, Percent_Identity=30, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=30.9278350515464, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789092, Length=298, Percent_Identity=31.8791946308725, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI221142681, Length=174, Percent_Identity=32.7586206896552, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787659, Length=189, Percent_Identity=26.984126984127, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1787660, Length=146, Percent_Identity=36.986301369863, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=354, Percent_Identity=34.7457627118644, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI25144157, Length=354, Percent_Identity=34.7457627118644, Blast_Score=198, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17557316, Length=296, Percent_Identity=39.1891891891892, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI25145438, Length=172, Percent_Identity=30.8139534883721, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=183, Percent_Identity=29.5081967213115, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=189, Percent_Identity=38.0952380952381, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28571730, Length=323, Percent_Identity=39.0092879256966, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI28571729, Length=323, Percent_Identity=39.0092879256966, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=40.625, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=40.625, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28574115, Length=285, Percent_Identity=22.4561403508772, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129971, Length=191, Percent_Identity=29.3193717277487, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24653477, Length=191, Percent_Identity=29.3193717277487, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 67827; Mature: 67696

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIVIRQTAHAGRITLARPEALNAMTYEMCLQIEAALDRWARDERIALVVLDAEGDKAF
CCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEE
CAGGDIAQLYETGMAGDYAFGQRFWADEYRLNAKIFNYPKPVISFLQGFTMGGGVGLGCH
ECCCCHHHHHHCCCCCCHHHHHHHCCHHHEECCEEECCCHHHHHHHHCCCCCCCEEECCC
GTHRIVGESSRIAMPECGIGLIPDVGGTLILALAPGRVGEYLGTTGYRMGPADALFAGFA
CCCCEECCCCCEECCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHH
DHFIPQDAWPGLIAQLEDGASVDIIKHAAQDPDASALADLQPEIERHFAGEGLSDILTTL
HHCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHH
QTDDSDFAKDTLKLLHRNSPLAMACTVEVLHRLRGPTLSMAKALDHEYRFTYRAMQHGDL
CCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCHH
LEGIRAAIIDKDRTPKWQYADMRVPAIAVSKMLMPLGKNALTLEDVAMTKTNVGFIGLGN
HHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCEEEECC
MGAPMAANLAKAGLHVIGYDTAGTTAEGVTQAQSAIEAAQGADIVLSMLPNGAILRDVAS
CCCCHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHH
TVLPVMKPGALFLDCSTVDVDSARAVAQAARDASVQFVDAPVSGGVGGAAAGTLTFMAGG
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHCEEEEEECC
SAEAFETARPLFDIMGQKAVHCGAPGAGQAAKICNNMILGATMIATCEAFALADKLGLDR
CHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QKMFDVVSTSSGYSWSMNAYCPAPGVGPQSPADNDYTPGFAAELMLKDLGLSQQAAEAVD
HHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHC
ADTPMGARALALYRAFVEEEDGRGKDFSAMLPRFTQRSRTE
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDIVIRQTAHAGRITLARPEALNAMTYEMCLQIEAALDRWARDERIALVVLDAEGDKAF
CCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEE
CAGGDIAQLYETGMAGDYAFGQRFWADEYRLNAKIFNYPKPVISFLQGFTMGGGVGLGCH
ECCCCHHHHHHCCCCCCHHHHHHHCCHHHEECCEEECCCHHHHHHHHCCCCCCCEEECCC
GTHRIVGESSRIAMPECGIGLIPDVGGTLILALAPGRVGEYLGTTGYRMGPADALFAGFA
CCCCEECCCCCEECCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHH
DHFIPQDAWPGLIAQLEDGASVDIIKHAAQDPDASALADLQPEIERHFAGEGLSDILTTL
HHCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHH
QTDDSDFAKDTLKLLHRNSPLAMACTVEVLHRLRGPTLSMAKALDHEYRFTYRAMQHGDL
CCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHCCHH
LEGIRAAIIDKDRTPKWQYADMRVPAIAVSKMLMPLGKNALTLEDVAMTKTNVGFIGLGN
HHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCEEEECC
MGAPMAANLAKAGLHVIGYDTAGTTAEGVTQAQSAIEAAQGADIVLSMLPNGAILRDVAS
CCCCHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHH
TVLPVMKPGALFLDCSTVDVDSARAVAQAARDASVQFVDAPVSGGVGGAAAGTLTFMAGG
HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHCEEEEEECC
SAEAFETARPLFDIMGQKAVHCGAPGAGQAAKICNNMILGATMIATCEAFALADKLGLDR
CHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QKMFDVVSTSSGYSWSMNAYCPAPGVGPQSPADNDYTPGFAAELMLKDLGLSQQAAEAVD
HHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHC
ADTPMGARALALYRAFVEEEDGRGKDFSAMLPRFTQRSRTE
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]