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The map label for this gene is lon [H]

Identifier: 110680150

GI number: 110680150

Start: 2828247

End: 2830658

Strand: Reverse

Name: lon [H]

Synonym: RD1_2950

Alternate gene names: 110680150

Gene position: 2830658-2828247 (Counterclockwise)

Preceding gene: 110680151

Following gene: 110680149

Centisome position: 68.49

GC content: 55.64

Gene sequence:

>2412_bases
ATGCAAGAGCCTCTTAACGCCTCATATCCAGTATTACCGCTGCGCGACATCGTGGTTTTCCCACATATGATCGTCCCCCT
TTTCGTAGGGCGTGATAAATCAGTGCGCGCACTTGAAGAGGTGATGTCAGACGATAAGCAGATACTTCTGTCGAGCCAGA
TCGACCCGGGCGAAGACGATCCCGACAGCGACGGTATTTTCAAGGCCGGCGTTCTCGCCAACGTGCTGCAACTGCTGAAA
TTACCCGATGGCACGGTGAAAGTGCTGGTCGAAGGACAGGCGCGGGTCCGGATCTCTGAATACATCGAAAACGACAGCTT
TTTTGAAGCTCGGGCGGAGTATCTCACTGAAATGCCCGGCGATTTAGCCACGACAGAGGCGCTACTGCGCACGGTTACGG
ATGAGTTTGAGCGCTATGCCAAGGTCAAAAAGAACGTGCCCGAGGAGGCGCTTGCAGCGGTTGGCGAATCGACAGAGCCG
GCCAAACTTGCAGACCTCGTGGCAGGGCACCTTGGCATAGAAGTCGCACAAAAGCAGGATCTGCTCGAGACGCTCAGCGT
GTCTGAGCGGCTTGAGAAAGTCTATGGTTTGATGCAGGGCGAGATGTCCGTGCTTCAGGTCGAAAAGAAGATCAAGACGC
GCGTCAAGTCGCAGATGGAGCGAACGCAGCGCGAATATTATCTGAATGAACAGATGAAGGCGATCCAGCAGGAGCTTGGC
GATGGTGAGGACGGCAAGAATGAAGTGGCCGAACTTGAGGCAAAGATTGCCGACACCAAGCTGAGCAAAGAGGCGCGTGA
AAAGGCCGAAGCGGAGATCAAGAAACTCAAGAACATGAGCCCGATGTCTGCCGAGGCGACCGTCGTGCGCAATTATCTCG
ACTGGATGCTGTCGATCCCCTGGGGCACCAAATCGCGCGTCAAAAAAGACCTGAGCCGTGCGCAAAAGATTTTGGATGAT
GATCACTTTGGCCTCGAAAAAGTCAAAGAACGGATCGTGGAATATCTGGCGGTGCAGCAACGCTCGACCAAGATAAAGGG
GCCGATCATGTGTCTCGTCGGGCCTCCCGGCGTGGGTAAGACGTCTTTGGGCAAATCCGTGGCGCGTGCGACGGGCCGAG
AGTTCATACGCATCAGCCTCGGTGGTGTGCGGGACGAATCCGAGATTCGCGGGCATCGCCGCACGTATATCGGTTCCATG
CCTGGCAAGATCATCCAGGCTCTGAAGAAAGCGAAAACAACCAACCCGCTGATCCTTCTCGATGAAATCGACAAGATGGG
GCAGGATTTCCGCGGCGATCCGGCTTCCGCCATGCTCGAGGTTCTGGATCCGGAACAGAACGCCACCTTTGTGGATCATT
ATCTGGAGGTCGAGTACGACCTGTCGAATGTGATGTTCCTGACCACATCCAACAGTTACAACATGCCAGGCCCATTGCTT
GACCGCATGGAGATCATTCCGCTTGCTGGGTACACGGAAGATGAAAAGCGTGAGATTGCCAAGCAGCACCTTATCCCCAA
GCAAATCAAGAACCATGGCCTCAAGGCCAAGGAATTTGAGTTGCAGGACAGTGCGTTAAGCGAAATGATCCGCACCTATA
CGCGGGAAGCGGGCGTGCGGAATCTGGAACGCGAAATCGCCAAGGTGGCGCGAAAATCCCTGACCAAGATTATCAAGAAA
GAGGCCGAAACGGTATCCGTCACTGATGAGAACCTCGACGAATTTCTTGGGGTGAAGAAGTACCGCTATGGTCTGGCCGA
GAAGGAAGACCAGATCGGTGTTGTGACCGGGCTTGCCTATACGTCGGTCGGCGGGGAGCTTTTGAGCATTGAAGCGCTGC
GCTTGCCGGGCAAAGGTCGGATGAAGACCACGGGCAAACTGGGCGATGTCATGAAGGAATCCATTGATGCGGCATCAAGC
TATGTGCGTTCGGTCAGCCCACAGATTGGGGTGAAGCCGCCACAGTTCGACCGCATTGATATTCACGTGCATGTTCCCGA
CGGCGCGACGCCCAAGGATGGTCCGTCTGCCGGTCTTGCCATGGTGACTTCCATCGTGTCTGTGCTTACGCAGATTCCGG
TGCGCAAGGATATCGCCATGACCGGTGAGGTATCGCTGCGGGGCAATGCCATGCCGATCGGCGGTTTGAAAGAAAAGCTT
CTTGCGGCGCTGCGCGGGGGGATCACGACCGTGCTGATCCCCGAGGAAAATGCCAAGGACCTGCCGGAGATACCCGACAA
CGTAAAAGAAGGGTTGAACATTATCCCCGTGTCCCATGTGTCCGAGGTTCTTGAACATGCGCTGATCAGCAAGCCCGAGG
GGATTGAATGGGATCAGGAAGCCGAAGATGCCGCTGCGGCGGCGGCTTTGGCGCGTTCGAGCGATACAAGTGACAGCGCC
ACAGCGCACTGA

Upstream 100 bases:

>100_bases
AGGGGATATGCGCCCCATTTTAACTTTCGTGAAACGGAGATGGACAAGCGTTGCTGCACGGGCAGGACCAGTTCCATCTT
GCCAAAAACAAGGAAAGAGC

Downstream 100 bases:

>100_bases
TCTGTTTCGCAGATACCGGTAAATAAAGGCGCGCCGTCATGGTGCGCCTTTTTTCTTCGCGAAAGAACTATGCCCTTGCC
GCTGGGTGAACAGATAGGCG

Product: ATP-dependent protease La, putative

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 803; Mature: 803

Protein sequence:

>803_residues
MQEPLNASYPVLPLRDIVVFPHMIVPLFVGRDKSVRALEEVMSDDKQILLSSQIDPGEDDPDSDGIFKAGVLANVLQLLK
LPDGTVKVLVEGQARVRISEYIENDSFFEARAEYLTEMPGDLATTEALLRTVTDEFERYAKVKKNVPEEALAAVGESTEP
AKLADLVAGHLGIEVAQKQDLLETLSVSERLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQQELG
DGEDGKNEVAELEAKIADTKLSKEAREKAEAEIKKLKNMSPMSAEATVVRNYLDWMLSIPWGTKSRVKKDLSRAQKILDD
DHFGLEKVKERIVEYLAVQQRSTKIKGPIMCLVGPPGVGKTSLGKSVARATGREFIRISLGGVRDESEIRGHRRTYIGSM
PGKIIQALKKAKTTNPLILLDEIDKMGQDFRGDPASAMLEVLDPEQNATFVDHYLEVEYDLSNVMFLTTSNSYNMPGPLL
DRMEIIPLAGYTEDEKREIAKQHLIPKQIKNHGLKAKEFELQDSALSEMIRTYTREAGVRNLEREIAKVARKSLTKIIKK
EAETVSVTDENLDEFLGVKKYRYGLAEKEDQIGVVTGLAYTSVGGELLSIEALRLPGKGRMKTTGKLGDVMKESIDAASS
YVRSVSPQIGVKPPQFDRIDIHVHVPDGATPKDGPSAGLAMVTSIVSVLTQIPVRKDIAMTGEVSLRGNAMPIGGLKEKL
LAALRGGITTVLIPEENAKDLPEIPDNVKEGLNIIPVSHVSEVLEHALISKPEGIEWDQEAEDAAAAAALARSSDTSDSA
TAH

Sequences:

>Translated_803_residues
MQEPLNASYPVLPLRDIVVFPHMIVPLFVGRDKSVRALEEVMSDDKQILLSSQIDPGEDDPDSDGIFKAGVLANVLQLLK
LPDGTVKVLVEGQARVRISEYIENDSFFEARAEYLTEMPGDLATTEALLRTVTDEFERYAKVKKNVPEEALAAVGESTEP
AKLADLVAGHLGIEVAQKQDLLETLSVSERLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQQELG
DGEDGKNEVAELEAKIADTKLSKEAREKAEAEIKKLKNMSPMSAEATVVRNYLDWMLSIPWGTKSRVKKDLSRAQKILDD
DHFGLEKVKERIVEYLAVQQRSTKIKGPIMCLVGPPGVGKTSLGKSVARATGREFIRISLGGVRDESEIRGHRRTYIGSM
PGKIIQALKKAKTTNPLILLDEIDKMGQDFRGDPASAMLEVLDPEQNATFVDHYLEVEYDLSNVMFLTTSNSYNMPGPLL
DRMEIIPLAGYTEDEKREIAKQHLIPKQIKNHGLKAKEFELQDSALSEMIRTYTREAGVRNLEREIAKVARKSLTKIIKK
EAETVSVTDENLDEFLGVKKYRYGLAEKEDQIGVVTGLAYTSVGGELLSIEALRLPGKGRMKTTGKLGDVMKESIDAASS
YVRSVSPQIGVKPPQFDRIDIHVHVPDGATPKDGPSAGLAMVTSIVSVLTQIPVRKDIAMTGEVSLRGNAMPIGGLKEKL
LAALRGGITTVLIPEENAKDLPEIPDNVKEGLNIIPVSHVSEVLEHALISKPEGIEWDQEAEDAAAAAALARSSDTSDSA
TAH
>Mature_803_residues
MQEPLNASYPVLPLRDIVVFPHMIVPLFVGRDKSVRALEEVMSDDKQILLSSQIDPGEDDPDSDGIFKAGVLANVLQLLK
LPDGTVKVLVEGQARVRISEYIENDSFFEARAEYLTEMPGDLATTEALLRTVTDEFERYAKVKKNVPEEALAAVGESTEP
AKLADLVAGHLGIEVAQKQDLLETLSVSERLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQQELG
DGEDGKNEVAELEAKIADTKLSKEAREKAEAEIKKLKNMSPMSAEATVVRNYLDWMLSIPWGTKSRVKKDLSRAQKILDD
DHFGLEKVKERIVEYLAVQQRSTKIKGPIMCLVGPPGVGKTSLGKSVARATGREFIRISLGGVRDESEIRGHRRTYIGSM
PGKIIQALKKAKTTNPLILLDEIDKMGQDFRGDPASAMLEVLDPEQNATFVDHYLEVEYDLSNVMFLTTSNSYNMPGPLL
DRMEIIPLAGYTEDEKREIAKQHLIPKQIKNHGLKAKEFELQDSALSEMIRTYTREAGVRNLEREIAKVARKSLTKIIKK
EAETVSVTDENLDEFLGVKKYRYGLAEKEDQIGVVTGLAYTSVGGELLSIEALRLPGKGRMKTTGKLGDVMKESIDAASS
YVRSVSPQIGVKPPQFDRIDIHVHVPDGATPKDGPSAGLAMVTSIVSVLTQIPVRKDIAMTGEVSLRGNAMPIGGLKEKL
LAALRGGITTVLIPEENAKDLPEIPDNVKEGLNIIPVSHVSEVLEHALISKPEGIEWDQEAEDAAAAAALARSSDTSDSA
TAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=657, Percent_Identity=42.9223744292237, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=38.0645161290323, Blast_Score=506, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=768, Percent_Identity=59.5052083333333, Blast_Score=935, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=42.8790199081164, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=535, Percent_Identity=40, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=689, Percent_Identity=40.0580551523948, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24666867, Length=651, Percent_Identity=42.8571428571429, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221513036, Length=651, Percent_Identity=42.8571428571429, Blast_Score=528, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88538; Mature: 88538

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEPLNASYPVLPLRDIVVFPHMIVPLFVGRDKSVRALEEVMSDDKQILLSSQIDPGEDD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEHHCCCCCCCCC
PDSDGIFKAGVLANVLQLLKLPDGTVKVLVEGQARVRISEYIENDSFFEARAEYLTEMPG
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
DLATTEALLRTVTDEFERYAKVKKNVPEEALAAVGESTEPAKLADLVAGHLGIEVAQKQD
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLETLSVSERLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQQELG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGEDGKNEVAELEAKIADTKLSKEAREKAEAEIKKLKNMSPMSAEATVVRNYLDWMLSIP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
WGTKSRVKKDLSRAQKILDDDHFGLEKVKERIVEYLAVQQRSTKIKGPIMCLVGPPGVGK
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
TSLGKSVARATGREFIRISLGGVRDESEIRGHRRTYIGSMPGKIIQALKKAKTTNPLILL
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEH
DEIDKMGQDFRGDPASAMLEVLDPEQNATFVDHYLEVEYDLSNVMFLTTSNSYNMPGPLL
HHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHEEEEECCCCEEEEEECCCCCCCCHHH
DRMEIIPLAGYTEDEKREIAKQHLIPKQIKNHGLKAKEFELQDSALSEMIRTYTREAGVR
HCHHEEECCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLEREIAKVARKSLTKIIKKEAETVSVTDENLDEFLGVKKYRYGLAEKEDQIGVVTGLAY
HHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHH
TSVGGELLSIEALRLPGKGRMKTTGKLGDVMKESIDAASSYVRSVSPQIGVKPPQFDRID
HHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
IHVHVPDGATPKDGPSAGLAMVTSIVSVLTQIPVRKDIAMTGEVSLRGNAMPIGGLKEKL
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCEEECCCCCCCCHHHHHH
LAALRGGITTVLIPEENAKDLPEIPDNVKEGLNIIPVSHVSEVLEHALISKPEGIEWDQE
HHHHHCCCEEEEECCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCH
AEDAAAAAALARSSDTSDSATAH
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQEPLNASYPVLPLRDIVVFPHMIVPLFVGRDKSVRALEEVMSDDKQILLSSQIDPGEDD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHEEHHCCCCCCCCC
PDSDGIFKAGVLANVLQLLKLPDGTVKVLVEGQARVRISEYIENDSFFEARAEYLTEMPG
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
DLATTEALLRTVTDEFERYAKVKKNVPEEALAAVGESTEPAKLADLVAGHLGIEVAQKQD
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLETLSVSERLEKVYGLMQGEMSVLQVEKKIKTRVKSQMERTQREYYLNEQMKAIQQELG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGEDGKNEVAELEAKIADTKLSKEAREKAEAEIKKLKNMSPMSAEATVVRNYLDWMLSIP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
WGTKSRVKKDLSRAQKILDDDHFGLEKVKERIVEYLAVQQRSTKIKGPIMCLVGPPGVGK
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
TSLGKSVARATGREFIRISLGGVRDESEIRGHRRTYIGSMPGKIIQALKKAKTTNPLILL
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEH
DEIDKMGQDFRGDPASAMLEVLDPEQNATFVDHYLEVEYDLSNVMFLTTSNSYNMPGPLL
HHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHEEEEECCCCEEEEEECCCCCCCCHHH
DRMEIIPLAGYTEDEKREIAKQHLIPKQIKNHGLKAKEFELQDSALSEMIRTYTREAGVR
HCHHEEECCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLEREIAKVARKSLTKIIKKEAETVSVTDENLDEFLGVKKYRYGLAEKEDQIGVVTGLAY
HHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHH
TSVGGELLSIEALRLPGKGRMKTTGKLGDVMKESIDAASSYVRSVSPQIGVKPPQFDRID
HHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
IHVHVPDGATPKDGPSAGLAMVTSIVSVLTQIPVRKDIAMTGEVSLRGNAMPIGGLKEKL
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCEEECCCCCCCCHHHHHH
LAALRGGITTVLIPEENAKDLPEIPDNVKEGLNIIPVSHVSEVLEHALISKPEGIEWDQE
HHHHHCCCEEEEECCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCH
AEDAAAAAALARSSDTSDSATAH
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10762258; 11481430 [H]